Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice

References

• Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. 2007. “The impact of traumatic brain injuries: a global perspective.” NeuroRehabilitation 22(5): 341–53.
   PubMed Web of Science ®Google Scholar
• Carroll LJ, Cassidy JD, Peloso PM, Borg J, von Holst H, Holm L, Paniak C, Pepin M. Injury WHOCCTFoMTB.2004. “Prognosis for mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury.” J Rehabil Med 43: 84–105.
   PubMed Web of Science ®Google Scholar
• Faden AI, Loane DJ. 2015. “Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?” Neurotherapeutics 12 (1): 143–50. doi: 10.1007/s13311-014-0319-5.
   PubMed Web of Science ®Google Scholar
• Rapoport MJ, McCullagh S, Shammi P, Feinstein A. 2005. “Cognitive impairment associated with major depression following mild and moderate traumatic brain injury.” J Neuropsychiatry Clin Neurosci 17 (1): 61–65. doi: 10.1176/jnp.17.1.61.
   PubMed Web of Science ®Google Scholar
• Blennow K, Hardy J, Zetterberg H. 2012. “The neuropathology and neurobiology of traumatic brain injury.” Neuron 76 (5): 886–99. doi: 10.1016/j.neuron.2012.11.021.
   PubMed Web of Science ®Google Scholar
• Ragnarsson KT. 2002. “Results of the NIH consensus conference on “rehabilitation of persons with traumatic brain injury”.” Restor Neurol Neurosci 20(3–4): 103–08.
   PubMed Web of Science ®Google Scholar
• Shultz SR, McDonald SJ, Vonder Haar C, Meconi A, Vink R, Van Donkelaar P, Taneja C, Iverson GL, Christie BR. 2016. “The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies.” Neurosci Biobehav Rev76: 396–414. doi: 10.1016/j.neubiorev.2016.09.014.
   PubMed Web of Science ®Google Scholar
• Shojo H, Kaneko Y, Mabuchi T, Kibayashi K, Adachi N, Borlongan CV. 2010. “Genetic and histologic evidence implicates role of inflammation in traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury.” Neuroscience 171 (4): 1273–82. doi: 10.1016/j.neuroscience.2010.10.018.
   PubMed Web of Science ®Google Scholar
• Streit WJ, Mrak RE, Griffin WS. 2004. “Microglia and neuroinflammation: a pathological perspective.” J Neuroinflammation 1 (1): 14. doi: 10.1186/1742-2094-1-14.
   PubMed Web of Science ®Google Scholar
• Carson MJ, Thrash JC, Walter B. 2006. “The cellular response in neuroinflammation: the role of leukocytes, microglia and astrocytes in neuronal death and survival.” Clin Neurosci Res 6 (5): 237–45. doi: 10.1016/j.cnr.2006.09.004.
   PubMed Web of Science ®Google Scholar
• Hicks RR, Smith DH, Lowenstein DH, Saint Marie R, McIntosh TK. 1993. “Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus.” J Neurotrauma 10 (4): 405–14. doi: 10.1089/neu.1993.10.405.
   PubMed Web of Science ®Google Scholar
• Nimmo AJ, Cernak I, Heath DL, Hu X, Bennett CJ, Vink R. 2004. “Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats.” Neuropeptides 38 (1): 40–47. doi: 10.1016/j.npep.2003.12.003.
   PubMed Web of Science ®Google Scholar
• Wright DK, Trezise J, Kamnaksh A, Bekdash R, Johnston LA, Ordidge R, Semple BD, Gardner AJ, Stanwell P, O’Brien TJ, et al. 2016. “Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury.” Sci Rep 6: 28713. doi: 10.1038/srep28713.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Mahmood A, Chopp M. 2013. “Animal models of traumatic brain injury.” Nat Rev Neurosci 14 (2): 128–42. doi: 10.1038/nrn3407.
   PubMed Web of Science ®Google Scholar
• Sinson G, Perri BR, Trojanowski JQ, Flamm ES, McIntosh TK. 1997. “Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury.” J Neurosurg 86 (3): 511–18. doi: 10.3171/jns.1997.86.3.0511.
   PubMed Web of Science ®Google Scholar
• Fox GB, Fan L, Levasseur RA, Faden AI. 1998. “Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse.” J Neurotrauma 15 (8): 599–614. doi: 10.1089/neu.1998.15.599.
   PubMed Web of Science ®Google Scholar
• Loane DJ, Faden AI. 2010. “Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies.” Trends Pharmacol Sci 31 (12): 596–604. doi: 10.1016/j.tips.2010.09.005.
   PubMed Web of Science ®Google Scholar
• Kumar A, Loane DJ. 2012. “Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention.” Brain Behav Immun 26 (8): 1191–201. doi: 10.1016/j.bbi.2012.06.008.
   PubMed Web of Science ®Google Scholar
• Hellewell S, Semple BD, Morganti-Kossmann MC. 2016. “Therapies negating neuroinflammation after brain trauma.” Brain Res 1640: (Pt A) 36–56. doi: 10.1016/j.brainres.2015.12.024.
   PubMed Web of Science ®Google Scholar
• Levi-Montalcini R, Angeletti PU. 1968. “Nerve growth factor.” Physiol Rev 48(3): 534–69.
   PubMed Web of Science ®Google Scholar
• Levi-Montalcini R, Cohen S. 1956. “Vitro and in Vivo Effects of a Nerve Growth-Stimulating Agent Isolated from Snake Venom.” Proc Natl Acad Sci U S A 42 (9): 695–99. doi: 10.1073/pnas.42.9.695.
   PubMed Web of Science ®Google Scholar
• Yoon SO, Casaccia-Bonnefil P, Carter B, Chao MV. 1998. “Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.” J Neurosci 18(9): 3273–81.
   PubMed Web of Science ®Google Scholar
• Reichardt LF. 2006. “Neurotrophin-regulated signalling pathways.” Philos Trans R Soc Lond B Biol Sci 361 (1473): 1545–64. doi: 10.1098/rstb.2006.1894.
   PubMed Web of Science ®Google Scholar
• Lv Q, Fan X, Xu G, Liu Q, Tian L, Cai X, Sun W, Wang X, Cai Q, Bao Y, et al. 2013. “Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema following traumatic brain injury in rats.” Brain Res 1493: 80–89. doi: 10.1016/j.brainres.2012.11.028.
   PubMed Web of Science ®Google Scholar
• Lv Q, Lan W, Sun W, Ye R, Fan X, Ma M, Yin Q, Jiang Y, Xu G, Dai J, et al. 2014. “Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats.” Journal of the Neurological Sciences 345 (1–2): 48–55. doi: 10.1016/j.jns.2014.06.037.
   PubMed Web of Science ®Google Scholar
• Kromer LF. 1987. “Nerve growth factor treatment after brain injury prevents neuronal death.” Science 235 (4785): 214–16. doi: 10.1126/science.3798108.
   PubMed Web of Science ®Google Scholar
• Sinson G, Voddi M, McIntosh TK. 1995. “Nerve Growth Factor Administration Attenuates Cognitive but Not Neurobehavioral Motor Dysfunction or Hippocampal Cell Loss Following Fluid-Percussion Brain Injury in Rats.” Journal of Neurochemistry 65 (5): 2209–16. doi: 10.1046/j.1471-4159.1995.65052209.x.
   PubMed Web of Science ®Google Scholar
• Tian L, Guo R, Yue X, Lv Q, Ye X, Wang Z, Chen Z, Wu B, Xu G, Liu X. 2012. “Intranasal administration of nerve growth factor ameliorate β-amyloid deposition after traumatic brain injury in rats.” Brain Research 1440: 47–55. doi: 10.1016/j.brainres.2011.12.059.
   PubMed Web of Science ®Google Scholar
• Dixon CE, Flinn P, Bao J, Venya R, Hayes RL. 1997. “Nerve growth factor attenuates cholinergic deficits following traumatic brain injury in rats.” Exp Neurol 146 (2): 479–90. doi: 10.1006/exnr.1997.6557.
   PubMed Web of Science ®Google Scholar
• Longhi L, Watson DJ, Saatman KE, Thompson HJ, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski JQ, et al. 2004. “Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice.” J Neurotrauma 21 (12): 1723–36. doi: 10.1089/neu.2004.21.1723.
   PubMed Web of Science ®Google Scholar
• Sinson G, Voddi M, McIntosh TK. 1995. “Nerve growth factor administration attenuates cognitive but not neurobehavioral motor dysfunction or hippocampal cell loss following fluid-percussion brain injury in rats.” J Neurochem 65 (5): 2209–16. doi: 10.1046/j.1471-4159.1995.65052209.x.
   PubMed Web of Science ®Google Scholar
• Tria MA, Fusco M, Vantini G, Mariot R. 1994. “Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats.” Exp Neurol 127 (2): 178–83. doi: 10.1006/exnr.1994.1093.
   PubMed Web of Science ®Google Scholar
• Friden PM, Walus LR, Watson P, Doctrow SR, Kozarich JW, Backman C, Bergman H, Hoffer B, Bloom F, Granholm AC. 1993. “Blood-brain barrier penetration and in vivo activity of an NGF conjugate.” Science 259 (5093): 373–77. doi: 10.1126/science.8420006.
   PubMed Web of Science ®Google Scholar
• Angeletti RH, Aneletti PU, Levi-Montalcini R. 1972. “Selective accumulation of (125 I) labelled nerve growth factor in sympathetic ganglia.” Brain Res 46: 421–25. doi: 10.1016/0006-8993(72)90033-9.
   PubMed Web of Science ®Google Scholar
• Jang SW, Okada M, Sayeed I, Xiao G, Stein D, Jin P, Ye K. 2007. “Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death.” Proc Natl Acad Sci U S A 104 (41): 16329–34. doi: 10.1073/pnas.0706662104.
   PubMed Web of Science ®Google Scholar
• Shen J, Yu Q. 2015. “Gambogic amide selectively upregulates TrkA expression and triggers its activation.” Pharmacol Rep 67 (2): 217–23. doi: 10.1016/j.pharep.2014.09.002.
   PubMed Web of Science ®Google Scholar
• Chan CB, Liu X, Jang SW, Hsu SI, Williams I, Kang S, Chen J, Ye K. 2009. “NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association.” Oncogene 28 (43): 3825–36. doi: 10.1038/onc.2009.236.
   PubMed Web of Science ®Google Scholar
• Scheller KJ, Williams SJ, Lawrence AJ, Jarrott B, Djouma E. 2014. “An improved method to prepare an injectable microemulsion of the galanin-receptor 3 selective antagonist, SNAP 37889, using Kolliphor((R)) HS 15.” MethodsX 1: 212–16. doi: 10.1016/j.mex.2014.09.003.
   PubMedGoogle Scholar
• Scheller KJ, Williams SJ, Lawrence AJ, Djouma E. 2017. “The galanin-3 receptor antagonist, SNAP 37889, suppresses alcohol drinking and morphine self-administration in mice.” Neuropharmacology 118: 1–12. doi: 10.1016/j.neuropharm.2017.03.004.
   PubMed Web of Science ®Google Scholar
• Yang Y, Salayandia VM, Thompson JF, Yang LY, Estrada EY, Yang Y. 2015. “Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery.” J Neuroinflammation 12: 26. doi: 10.1186/s12974-015-0245-4.
   PubMed Web of Science ®Google Scholar
• Singleton RH, Yan HQ, Fellows‐Mayle W, Dixon CE. 2010. “Resveratrol attenuates behavioral impairments and reduces cortical and hippocampal loss in a rat controlled cortical impact model of traumatic brain injury.” J Neurotrauma 27 (6): 1091–99. doi: 10.1089/neu.2010.1291.
   PubMed Web of Science ®Google Scholar
• Simon DW, McGeachy MJ, Bayir H, Clark RS, Loane DJ, Kochanek PM. 2017. “The far-reaching scope of neuroinflammation after traumatic brain injury.” Nat Rev Neurol 13 (3): 171–91. doi: 10.1038/nrneurol.2017.13.
   PubMed Web of Science ®Google Scholar
• Shultz SR, Sun M, Wright DK, Brady RD, Liu S, Beynon S, Schmidt SF, Kaye AH, Hamilton JA, O’Brien TJ, et al. 2015. “Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitrauma.” J Cereb Blood Flow Metab 35 (8): 1339–47. doi: 10.1038/jcbfm.2015.56.
   PubMed Web of Science ®Google Scholar
• Shultz SR, Tan XL, Wright DK, Liu SJ, Semple BD, Johnston L, Jones NC, Cook AD, Hamilton JA, O’Brien TJ. 2014. “Granulocyte-macrophage colony-stimulating factor is neuroprotective in experimental traumatic brain injury.” J Neurotrauma 31 (10): 976–83. doi: 10.1089/neu.2013.3106.
   PubMed Web of Science ®Google Scholar
• Hamm RJ, Pike BR, O’Dell DM, Lyeth BG, Jenkins LW. 1994. “The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury.” J Neurotrauma 11 (2): 187–96. doi: 10.1089/neu.1994.11.187.
   PubMed Web of Science ®Google Scholar
• Johnstone VP, Wright DK, Wong K, O’Brien TJ, Rajan R, Shultz SR. 2015. “Experimental Traumatic Brain Injury Results in Long-Term Recovery of Functional Responsiveness in Sensory Cortex but Persisting Structural Changes and Sensorimotor, Cognitive, and Emotional Deficits.” J Neurotrauma 32 (17): 1333–46. doi: 10.1089/neu.2014.3785.
   PubMed Web of Science ®Google Scholar
• Sofroniew MV, Howe CL, Mobley WC. 2001. “Nerve growth factor signaling, neuroprotection, and neural repair.” Annu Rev Neurosci 24: 1217–81. doi: 10.1146/annurev.neuro.24.1.1217.
   PubMed Web of Science ®Google Scholar
• Shah AG, Friedman MJ, Huang S, Roberts M, Xj L, Li S. 2009. “Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17.” Hum Mol Genet 18 (21): 4141–52. doi: 10.1093/hmg/ddp363.
   PubMed Web of Science ®Google Scholar
• Li S, Kuroiwa T, Ishibashi S, Sun L, Endo S, Ohno K. 2006. “Transient cognitive deficits are associated with the reversible accumulation of amyloid precursor protein after mild traumatic brain injury.” Neurosci Lett 409 (3): 182–86. doi: 10.1016/j.neulet.2006.09.054.
   PubMed Web of Science ®Google Scholar
• Young J, Pionk T, Hiatt I, Geeck K, Smith JS. 2015. “Environmental enrichment aides in functional recovery following unilateral controlled cortical impact of the forelimb sensorimotor area however intranasal administration of nerve growth factor does not.” Brain Res Bull 115: 17–22. doi: 10.1016/j.brainresbull.2015.04.003.
   PubMed Web of Science ®Google Scholar
• Shultz SR, Wright DK, Zheng P, Stuchbery R, Liu SJ, Sashindranath M, Medcalf RL, Johnston LA, Hovens CM, Jones NC, et al. 2015. “Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury.” Brain 138 (Pt 5): 1297–313. doi: 10.1093/brain/awv053.
   PubMed Web of Science ®Google Scholar
• Bao F, Shultz SR, Hepburn JD, Omana V, Weaver LC, Cain DP, Brown A. 2012. “A CD11d monoclonal antibody treatment reduces tissue injury and improves neurological outcome after fluid percussion brain injury in rats.” J Neurotrauma 29 (14): 2375–92. doi: 10.1089/neu.2012.2408.
   PubMed Web of Science ®Google Scholar
• Shultz SR, MacFabe DF, Foley KA, Taylor R, Cain DP. 2012. “Sub-concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral impairments.” Behav Brain Res 229 (1): 145–52. doi: 10.1016/j.bbr.2011.12.015.
   PubMed Web of Science ®Google Scholar
• Dietrich WD, Truettner J, Zhao W, Alonso OF, Busto R, Ginsberg MD. 1999. “Sequential changes in glial fibrillary acidic protein and gene expression following parasagittal fluid-percussion brain injury in rats.” J Neurotrauma 16 (7): 567–81. doi: 10.1089/neu.1999.16.567.
   PubMed Web of Science ®Google Scholar
• Rall JM, Matzilevich DA, Dash PK. 2003. “Comparative analysis of mRNA levels in the frontal cortex and the hippocampus in the basal state and in response to experimental brain injury.” Neuropathol Appl Neurobiol 29 (2): 118–31. doi: 10.1046/j.1365-2990.2003.00439.x.
   PubMed Web of Science ®Google Scholar
• Bi F, Huang C, Tong J, Qiu G, Huang B, Wu Q, Li F, Xu Z, Bowser R, Xia XG, et al. 2013. “Reactive astrocytes secrete lcn2 to promote neuron death.” Proc Natl Acad Sci U S A 110 (10): 4069–74. doi: 10.1073/pnas.1218497110.
   PubMed Web of Science ®Google Scholar
• Wu L, Du Y, Lok J, Lo EH, Xing C. 2015. “Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms.” J Neurochem 132 (6): 622–28. doi: 10.1111/jnc.13023.
   PubMed Web of Science ®Google Scholar
• Lee S, Jha MK, Suk K. 2015. “Lipocalin-2 in the Inflammatory Activation of Brain Astrocytes.” Crit Rev Immunol 35 (1): 77–84. doi: 10.1615/CritRevImmunol.2015012127.
   PubMed Web of Science ®Google Scholar
• Suk K. 2016. “Lipocalin-2 as a therapeutic target for brain injury: an astrocentric perspective.” Prog Neurobiol 144: 158–72. doi: 10.1016/j.pneurobio.2016.08.001.
   PubMed Web of Science ®Google Scholar
• Kao TH, Peng YJ, Salter DM, Lee HS. 2015. “Nerve growth factor increases MMP9 activity in annulus fibrosus cells by upregulating lipocalin 2 expression.” Eur Spine J 24 (9): 1959–68. doi: 10.1007/s00586-014-3675-2.
   PubMed Web of Science ®Google Scholar
• Rink A, Fung KM, Trojanowski JQ, Lee VM, Neugebauer E, McIntosh TK. 1995. “Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.” Am J Pathol 147(6): 1575–83.
   PubMed Web of Science ®Google Scholar
• Raghupathi R, Graham DI, McIntosh TK. 2000. “Apoptosis after traumatic brain injury.” J Neurotrauma 17 (10): 927–38. doi: 10.1089/neu.2000.17.927.
   PubMed Web of Science ®Google Scholar
• Conti AC, Raghupathi R, Trojanowski JQ, McIntosh TK. 1998. “Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period.” J Neurosci 18(15): 5663–72.
   PubMed Web of Science ®Google Scholar
• Yakovlev AG, Knoblach SM, Fan L, Fox GB, Goodnight R, Faden AI. 1997. “Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury.” J Neurosci 17(19): 7415–24.
   PubMed Web of Science ®Google Scholar
• Yakovlev AG, Ota K, Wang G, Movsesyan V, Bao WL, Yoshihara K, Faden AI. 2001. “Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury.” J Neurosci 21(19): 7439–46.
   PubMed Web of Science ®Google Scholar
• Beer R, Franz G, Srinivasan A, Hayes RL, Pike BR, Newcomb JK, Zhao X, Schmutzhard E, Poewe W, Kampfl A. 2000. “Temporal profile and cell subtype distribution of activated caspase-3 following experimental traumatic brain injury.” J Neurochem 75 (3): 1264–73. doi: 10.1046/j.1471-4159.2000.0751264.x.
   PubMed Web of Science ®Google Scholar
• Thompson SN, Gibson TR, Thompson BM, Deng Y, Hall ED. 2006. “Relationship of calpain-mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in mice.” Exp Neurol 201 (1): 253–65. doi: 10.1016/j.expneurol.2006.04.013.
   PubMed Web of Science ®Google Scholar
• Hulsebosch CE, DeWitt DS, Jenkins LW, Prough DS. 1998. “Traumatic brain injury in rats results in increased expression of Gap-43 that correlates with behavioral recovery.” Neurosci Lett 255 (2): 83–86. doi: 10.1016/S0304-3940(98)00712-5.
   PubMed Web of Science ®Google Scholar
• Falo MC, Reeves TM, Phillips LL. 2008. “Agrin expression during synaptogenesis induced by traumatic brain injury.” J Neurotrauma 25 (7): 769–83. doi: 10.1089/neu.2008.0511.
   PubMed Web of Science ®Google Scholar
• Hall KD, Lifshitz J. 2010. “Diffuse traumatic brain injury initially attenuates and later expands activation of the rat somatosensory whisker circuit concomitant with neuroplastic responses.” Brain Res 1323: 161–73. doi: 10.1016/j.brainres.2010.01.067.
   PubMed Web of Science ®Google Scholar
• Ding JY, Kreipke CW, Schafer P, Schafer S, Speirs SL, Rafols JA. 2009. “Synapse loss regulated by matrix metalloproteinases in traumatic brain injury is associated with hypoxia inducible factor-1alpha expression.” Brain Res 1268: 125–34. doi: 10.1016/j.brainres.2009.02.060.
   PubMed Web of Science ®Google Scholar
• Benowitz LI, Routtenberg A. 1997. “GAP-43: an intrinsic determinant of neuronal development and plasticity.” Trends Neurosci 20(2): 84–91.
   PubMed Web of Science ®Google Scholar
• Chin LS, Li L, Ferreira A, Ks K, Greengard P. 1995. “Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice.” Proc Natl Acad Sci U S A 92 (20): 9230–34. doi: 10.1073/pnas.92.20.9230.
   PubMed Web of Science ®Google Scholar
• Garofalo L, Ribeiro-da-Silva A, Cuello AC. 1992. “Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.” Proc Natl Acad Sci U S A 89 (7): 2639–43. doi: 10.1073/pnas.89.7.2639.
   PubMed Web of Science ®Google Scholar
• Burgos I, Cuello AC, Liberini P, Pioro E, Masliah E. 1995. “NGF-mediated synaptic sprouting in the cerebral cortex of lesioned primate brain.” Brain Res 692 (1–2): 154–60. doi: 10.1016/0006-8993(95)00696-N.
   PubMed Web of Science ®Google Scholar
• Tuszynski MH, Sang H, Yoshida K, Fh G. 1991. “Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain.” Ann Neurol 30 (5): 625–36. doi: 10.1002/ana.410300502.
   PubMed Web of Science ®Google Scholar
• Wieloch T, Nikolich K. 2006. “Mechanisms of neural plasticity following brain injury.” Curr Opin Neurobiol 16 (3): 258–64. doi: 10.1016/j.conb.2006.05.011.
   PubMed Web of Science ®Google Scholar
• Nudo RJ. 2003. “Adaptive plasticity in motor cortex: implications for rehabilitation after brain injury.” J Rehabil Med 41: 7–10. doi: 10.1080/16501960310010070.
   PubMed Web of Science ®Google Scholar
• Conte V, Raghupathi R, Watson DJ, Fujimoto S, Royo NC, Marklund N, Stocchetti N, McIntosh TK. 2008. “TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice.” Restor Neurol Neurosci 26(1): 45–56.
   PubMed Web of Science ®Google Scholar
• Oyesiku NM, Evans CO, Houston S, Darrell RS, Smith JS, Fulop ZL, Dixon CE, Stein DG. 1999. “Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain.” Brain Res 833 (2): 161–72. doi: 10.1016/S0006-8993(99)01501-2.
   PubMed Web of Science ®Google Scholar
• O’Dell DM, Raghupathi R, Crino PB, Eberwine JH, McIntosh TK. 2000. “Traumatic brain injury alters the molecular fingerprint of TUNEL-positive cortical neurons In vivo: A single-cell analysis.” J Neurosci 20(13): 4821–28.
   PubMed Web of Science ®Google Scholar
• Cekic M, Johnson SJ, Bhatt VH, Stein DG. 2012. “Progesterone treatment alters neurotrophin/proneurotrophin balance and receptor expression in rats with traumatic brain injury.” Restor Neurol Neurosci 30(2): 115–26.
   PubMed Web of Science ®Google Scholar
• Alder J, Fujioka W, Lifshitz J, Crockett DP, Thakker-Varia S. 2011. “Lateral fluid percussion: model of traumatic brain injury in mice.” J Vis Exp 22(54). pii: 3063. doi:10.3791/3063.
   Web of Science ®Google Scholar
• Tian L, Guo R, Yue X, Lv Q, Ye X, Wang Z, Chen Z, Wu B, Xu G, Liu X. 2012. “Intranasal administration of nerve growth factor ameliorate beta-amyloid deposition after traumatic brain injury in rats.” Brain Res 1440: 47–55. doi: 10.1016/j.brainres.2011.12.059.
   PubMed Web of Science ®Google Scholar
• Lin HW, Saul I, Gresia VL, Neumann JT, Dave KR, Perez-Pinzon MA. 2014. “Fatty acid methyl esters and Solutol HS 15 confer neuroprotection after focal and global cerebral ischemia.” Transl Stroke Res 5 (1): 109–17. doi: 10.1007/s12975-013-0276-z.
   PubMed Web of Science ®Google Scholar