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Clinical trial on the effects of amantadine on traumatic brain injury outcome. Is there more than meets the eye?

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References

  • Ghalaenovi H, Fattahi A, Koohpayehzadeh J, Khodadost M, Fatahi N, Taheri M, Azimi A, Rohani S, Rahatlou H. The effects of amantadine on traumatic brain injury outcome: a double-blind, randomized, controlled, clinical trial. Brain Inj. 2018;32(8):1050–1055. doi: 10.1080/02699052. 2018.1476733. Epub 2018 May 23.
  • Sandsmark DK, Elliott JE, Lim MM. Sleep-wake disturbances after traumatic brain injury: synthesis of human and animal studies. Sleep. 2017;40:5.
  • Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med. 2012;366(9):819–26. doi:10.1056/NEJMoa1102609.
  • Donaghy S, Wass PJ. Interrater reliability of the functional assessment measure in a brain injury rehabilitation program. Arch Phys Med Rehabil. 1998;79(10):1231–36.

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