Physiological and pathological covariates of persistent concussion-related fatigue: results from two regression methodologies

References

• van der Naalt J, Timmerman ME, de Koning ME, van der Horn HJ, Scheenen ME, Jacobs B, Hageman G, Yilmaz T, Roks G, Spikman JM. Early predictors of outcome after mild traumatic brain injury (UPFRONT): an observational cohort study. Lancet Neurol. 2017;16(7):532–40. doi:10.1016/S1474-4422(17)30117-5.
   PubMed Web of Science ®Google Scholar
• Harrington DE, Malec J, Cicerone K, Katz HT. Current perceptions of rehabilitation professionals towards mild traumatic brain injury. Arch Phys Med Rehabil. 1993;74(6):579–86. doi:10.1016/0003-9993(93)90155-4.
   PubMed Web of Science ®Google Scholar
• Pape TL, Herrold AA, Smith B, Babcock-Parziale J, Harp J, Shandera-Ochsner A, Jenkins S, Evans CT, Schleenbaker R, High WM. Algorithm for symptom attribution and classification following possible mild traumatic brain injury. J Head Trauma Rehabil. 2016;31(6):E10–E22. doi:10.1097/HTR.0000000000000220.
   PubMed Web of Science ®Google Scholar
• Cassidy JD, Cancelliere C, Carroll LJ, Côté P, Hincapié CA, Holm LW, Hartvigsen J, Donovan J, Nygren-de Boussard C, Kristman VL, et al. Systematic review of self-reported prognosis in adults after mild traumatic brain injury: results of the international collaboration on mild traumatic brain injury prognosis. Arch Phys Med Rehabil. 2014;95(3 Suppl):S132–51. doi:10.1016/j.apmr.2013.08.299.
   PubMedGoogle Scholar
• Ponsford J, Cameron P, Fitzgerald M, Grant M, Mikocka-Walus A. Long-term outcomes after uncomplicated mild traumatic brain injury: a comparison with trauma controls. J Neurotrauma. 2011;28(6):937–46. doi:10.1089/neu.2010.1516.
   PubMed Web of Science ®Google Scholar
• BIONIC Research Group, Theadom A, Parag V, Dowell T, McPherson K, Starkey N, Barker-Collo S, Jones K, Ameratunga S, Feigin VL. Persistent problems 1 year after mild traumatic brain injury: a longitudinal population study in New Zealand. Br J Gen Pract. 2016;66(642):e16–23. doi:10.3399/bjgp16X683161.
   PubMed Web of Science ®Google Scholar
• Clark AL, Delano-Wood L, Sorg SF, Werhane ML, Hanson KL, Schiehser DM. Cognitive fatigue is associated with reduced anterior internal capsule integrity in veterans with history of mild to moderate traumatic brain injury. Brain Imaging Behav. 2017;11(5):1548–54. doi:10.1007/s11682-016-9594-6.
   PubMed Web of Science ®Google Scholar
• Palm S, Rönnbäck L, Johansson B. Long-term mental fatigue after traumatic brain injury and impact on employment status. J Rehabil Med. 2017;49(3):228–33. doi:10.2340/16501977-2190.
   PubMed Web of Science ®Google Scholar
• Schiehser DM, Delano-Wood L, Jak AJ, Hanson KL, Sorg SF, Orff H, Clark AL. Predictors of cognitive and physical fatigue in post-acute mild–moderate traumatic brain injury. Neuropsychol Rehabil. 2017;27(7):1031–46. doi:10.1080/09602011.2016.1215999.
   PubMed Web of Science ®Google Scholar
• Mollayeva T, Shapiro CM, Cassidy JD, Mollayeva S, Colantonio A. Assessment of mild traumatic brain injury/concussion-related fatigue, alertness, and daytime sleepiness: a diagnostic modeling study. Neuropsych. 2017;7:86–104. DOI:10.4172/Neuropsychiatry.1000184.
   Google Scholar
• Chong CD, Schwedt TJ. Research imaging of brain structure and function after concussion. Headache. 2018;58:827–35. doi:10.1111/head.13269. Epub ahead of print.
   PubMed Web of Science ®Google Scholar
• Mullally WJ. Concussion. Am J Med. 2017;130(8):885–92. doi:10.1016/j.amjmed.2017.04.016.
   PubMed Web of Science ®Google Scholar
• Katz DI, Cohen SI, Alexander MP. Mild traumatic brain injury. Handb Clin Neurol. 2015;127:131–56. DOI:10.1016/B978-0-444-52892-6.00009-X.
   PubMedGoogle Scholar
• Mollayeva T, Kendzerska T, Mollayeva S, Shapiro CM, Colantonio A, Cassidy JD. A systematic review of fatigue in patients with traumatic brain injury: the course, predictors and consequences. Neurosci Biobehav Rev. 2014;47:684–716. DOI:10.1016/j.neubiorev.2014.10.024.
   PubMed Web of Science ®Google Scholar
• de Leon MB, Kirsch NL, Maio RF, Tan-Schriner CU, Millis SR, Frederiksen S, Tanner CL, Breer ML. Baseline predictors of fatigue 1 year after mild head injury. Arch Phys Med Rehabil. 2009;90(6):956–65. doi:10.1016/j.apmr.2008.12.016.
   PubMed Web of Science ®Google Scholar
• Ponsford JL, Downing MG, Olver J, Ponsford M, Acher R, Carty M, Spitz G. Longitudinal follow-up of patients with traumatic brain injury: outcome at two, five, and ten years post-injury. J Neurotrauma. 2014;31(1):64–77. doi:10.1089/neu.2013.2997.
   PubMed Web of Science ®Google Scholar
• Sendroy-Terrill M, Whiteneck GG, Brooks CA. Aging with traumatic brain injury: cross-sectional follow-up of people receiving inpatient rehabilitation over more than 3 decades. Arch Phys Med Rehabil. 2010;91(3):489–97. doi:10.1016/j.apmr.2009.11.011.
   PubMed Web of Science ®Google Scholar
• Brickell TA, Lippa SM, French LM, Kennedy JE, Bailie JM, Lange RT. Female service members and symptom reporting after combat and non-combat-related mild traumatic brain injury. J Neurotrauma. 2017;34(2):300–12. doi:10.1089/neu.2016.4403.
   PubMed Web of Science ®Google Scholar
• Brown DA, Elsass JA, Miller AJ, Reed LE, Reneker JC. Differences in symptom reporting between males and females at baseline and after a sports-related concussion: a systematic review and meta-analysis. Sports Med. 2015;45(7):1027–40. doi:10.1007/s40279-015-0335-6.
   PubMed Web of Science ®Google Scholar
• Sigurdardottir S, Andelic N, Roe C, Schanke AK. Cognitive recovery and predictors of functional outcome 1 year after traumatic brain injury. J Int Neuropsychol Soc. 2009 Sep;15(5):740–50. doi:10.1017/S1355617709990452.
   PubMed Web of Science ®Google Scholar
• Mott TF, McConnon ML, Rieger BP. Subacute to chronic mild traumatic brain injury. Am Fam Physician. 2012;86(11):1045–51.
   PubMed Web of Science ®Google Scholar
• Kelly DF, McArthur DL, Levin H, Swimmer S, Dusick JR, Cohan P, Wang C, Swerdloff R. Neurobehavioral and quality of life changes associated with growth hormone insufficiency after complicated mild, moderate, or severe traumatic brain injury. J Neurotrauma. 2006;23(6):928–42. doi:10.1089/neu.2006.23.928.
   PubMed Web of Science ®Google Scholar
• Dawson DR, Schwartz ML, Winocur G, Stuss DT. Return to productivity following traumatic brain injury: cognitive, psychological, physical, spiritual, and environmental correlates. Disabil Rehabil. 2007 Feb 28;29(4):301–13. doi:10.1080/09638280600756687.
   PubMed Web of Science ®Google Scholar
• Weber E, Spirou A, Chiaravalloti N, Lengenfelder J. Impact of frontal neurobehavioral symptoms on employment in individuals with TBI. Rehabil Psychol. 2018;63(3):383–91. doi:10.1037/rep0000208. Epub 2018 Jul 19.
   PubMed Web of Science ®Google Scholar
• Clark AL, Sorg SF, Holiday K, Bigler ED, Bangen KJ, Evangelista ND, Bondi MW, Schiehser DM, Delano-Wood L. Fatigue is associated with global and regional thalamic morphometry in veterans with a history of mild traumatic brain injury. J Head Trauma Rehabil. 2018;1. doi:10.1097/HTR.0000000000000377. Epub ahead of print.
   PubMed Web of Science ®Google Scholar
• Mollayeva T, Shapiro CM, Cassidy D, Mollayeva S, Colantonio A. Assessment of mild traumatic brain injury/concussion-related fatigue, alertness, and daytime sleepiness: a diagnostic modeling study. Neuropsychiatry. 2017;7(2):86–104. doi:10.4172/Neuropsychiatry.1000186.
   Google Scholar
• Kaplan GB, Vasterling JJ, Vedak PC. Brain-derived neurotrophic factor in traumatic brain injury, post-traumatic stress disorder, and their comorbid conditions: role in pathogenesis and treatment. Behav Pharmacol. 2010;21(5–6):427–37. doi:10.1097/FBP.0b013e32833d8bc9.
   PubMed Web of Science ®Google Scholar
• Johansson B, Rönnbäck L. Assessment and treatment of mental fatigue after a traumatic brain injury. Neuropsychol Rehabil. 2017;27(7):1047–55. doi:10.1080/09602011.2017.1292921.
   PubMed Web of Science ®Google Scholar
• Kumar RG, Gao S, Juengst SB, Wagner AK, Fabio A. The effects of post-traumatic depression on cognition, pain, fatigue, and headache after moderate-to-severe traumatic brain injury: a thematic review. Brain Inj. 2018;32(4):383–94. doi:10.1080/02699052.2018.
   PubMed Web of Science ®Google Scholar
• Ganti L, Khalid H, Patel PS, Daneshvar Y, Bodhit AN, Peters KR. Who gets post-concussion syndrome? An emergency department-based prospective analysis. Int J Emerg Med. 2014;7:31. DOI:10.1186/s12245-014-0031-6.
   PubMedGoogle Scholar
• Richards KC, Kovach CR. Comorbid nighttime agitation, sleep disturbance, and restless legs syndrome: what next? Res Gerontol Nurs. 2017;10(4):151–53. doi:10.3928/19404921-20170621-01.
   PubMed Web of Science ®Google Scholar
• Castriotta RJ, Atanasov S, Wilde MC, Masel BE, Lai JM, Kuna ST. Treatment of sleep disorders after traumatic brain injury. J Clin Sleep Med. 2009;5(2):137–44.
   PubMed Web of Science ®Google Scholar
• Lu W, Cantor J, Aurora RN, Nguyen M, Ashman T, Spielman L, Ambrose A, Krellman JW, Gordon W. Variability of respiration and sleep during polysomnography in individuals with TBI. NeuroRehabilitation. 2014 Jan 1;35(2):245–51. doi:10.3233/NRE-141117.
   PubMed Web of Science ®Google Scholar
• Barr T, Livingston W, Guardado P, Baxter T, Mysliwiec V, Gill J. Chapter 8 military personnel with traumatic brain injuries and insomnia have reductions in PTSD and improved perceived health following sleep restoration: a relationship moderated by inflammation. Annu Rev Nurs Res. 2015;33:249–66. DOI:10.1891/0739-6686.33.249.
   PubMedGoogle Scholar
• Gardani M, Morfiri E, Thomson A, O’Neill B, McMillan TM. Evaluation of sleep disorders in patients with severe traumatic brain injury during rehabilitation. Arch Phys Med Rehabil. 2015;96(9):1691–7.e3. doi:10.1016/j.apmr.2015.05.006.
   PubMed Web of Science ®Google Scholar
• Mollayeva T, Colantonio A, Cassidy JD, Vernich L, Moineddin R, Shapiro CM. Sleep stage distribution in persons with mild traumatic brain injury: a polysomnographic study according to American Academy of Sleep Medicine standards. Sleep Med. 2017;34:179–92. DOI:10.1016/j.sleep.2017.02.021.
   PubMed Web of Science ®Google Scholar
• Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet. 2004;363(9413):978–88. doi:10.1016/S0140-6736(04)15794-2.
   PubMed Web of Science ®Google Scholar
• Kluger BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology. 2013;80(4):409–16. doi:10.1212/WNL.0b013e31827f07be.
   PubMed Web of Science ®Google Scholar
• Neu D, Mairesse O, Montana X, Gilson M, Corazza F, Lefevre N, Linkowski P, Le Bon O, Verbanck P. Dimensions of pure chronic fatigue: psychophysical, cognitive and biological correlates in the chronic fatigue syndrome. Eur J Appl Physiol. 2014;114(9):1841–51. doi:10.1007/s00421-014-2910-1.
   PubMed Web of Science ®Google Scholar
• Epstein LH. Role of behavior theory in behavioral medicine. J Consult Clin Psychol. 1992;60(4):493–98. doi:10.1037/0022-006X.60.4.493.
   PubMed Web of Science ®Google Scholar
• de Vet HCW, Terwee CB, Mokkink LB, Knol DL. Measurement in medicine: a practical guide. Cambridge: Cambridge University Press; 2011.
   Google Scholar
• Cantor JB, Bushnik T, Cicerone K, Dijkers MP, Gordon W, Hammond FM, Kolakowsky-Hayner SA, Lequerica A, Nguyen M, Spielman LA. Insomnia, fatigue, and sleepiness in the first 2 years after traumatic brain injury: an NIDRR TBI model system module study. J Head Trauma Rehabil. 2012;27(6):E1–14. doi:10.1097/HTR.0b013e318270f91e.
   PubMed Web of Science ®Google Scholar
• Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46(10):1121–23. doi:10.1001/archneur.1989.00520460115022.
   PubMed Web of Science ®Google Scholar
• LaChapelle DL, Finlayson MA. An evaluation of subjective and objective measures of fatigue in patients with brain injury and healthy controls. Brain Inj. 1998;12(8):649–59. doi:10.1080/026990598122214.
   PubMed Web of Science ®Google Scholar
• Bushnik T, Englander J, Wright J. Patterns of fatigue and its correlates over the first 2 years after traumatic brain injury. J Head Trauma Rehabil. 2008 Jan-Feb;23(1):25–32. doi:10.1097/01.HTR.0000308718.88214.bb.
   PubMed Web of Science ®Google Scholar
• Crichton AJ, Babl F, Oakley E, Greenham M, Hearps S, Delzoppo C, Hutchison J, Beauchamp M, Anderson VA. Prediction of multidimensional fatigue after childhood brain injury. J Head Trauma Rehabil. 2017;32(2):107–16. doi:10.1097/HTR.0000000000000248.
   PubMed Web of Science ®Google Scholar
• Sinclair KL, Ponsford JL, Rajaratnam SM, Anderson C. Sustained attention following traumatic brain injury: use of the psychomotor vigilance task. J Clin Exp Neuropsychol. 2013;35(2):210–24. doi:10.1080/13803395.2012.762340.
   PubMed Web of Science ®Google Scholar
• Chan V, Mollayeva T, Ottenbacher KJ, Colantonio A. Clinical profile and comorbidity of traumatic brain injury among younger and older men and women: a brief research notes. BMC Res Notes. 2017;10(1):371. doi:10.1186/s13104-017-2682-x.
   PubMedGoogle Scholar
• Norrie J, Heitger M, Leathem J, Anderson T, Jones R, Flett R. Mild traumatic brain injury and fatigue: a prospective longitudinal study. Brain Inj. 2010;24(13–14):1528–38. doi:10.3109/02699052.2010.531687.
   PubMed Web of Science ®Google Scholar
• Tyson SF, Brown P. How to measure fatigue in neurological conditions? A systematic review of psychometric properties and clinical utility of measures used so far. Clin Rehabil. 2014;28(8):804–16. doi:10.1177/0269215514521043.
   PubMed Web of Science ®Google Scholar
• Buchinsky M. Recent advances in quantile regression models: a practical guideline for empirical research. J Hum Resour. 1998;33:88. DOI:10.2307/146316.
   Web of Science ®Google Scholar
• Shapiro SS, Wilk MB, Chen HJ. A comparative study of various tests for normality. J Am Stat Assoc. 1968;63:1343–72. DOI:10.1080/01621459.1968.10480932.
   Web of Science ®Google Scholar
• Ahn KW, Kim S. Variable selection with group structure in competing risks quantile regression. Stat Med. 2018;37(9):1577–86. doi:10.1002/sim.7619.
   PubMed Web of Science ®Google Scholar
• Xiong C, Martin T, Sravanapudi A, Colantonio A, Mollayeva T. Factors associated with return to work in men and women with work-related traumatic brain injury. Disabil Health J. 2016;9(3):439–448. doi:10.1016/j.dhjo.2015.12.002.
   PubMed Web of Science ®Google Scholar
• Bigler ED. Neuropsychology and clinical neuroscience of persistent post-concussive syndrome. J Int Neuropsychol Soc. 2008;14(1):1–22. doi:10.1017/S13556177008017X.
   PubMed Web of Science ®Google Scholar
• McCrory P, Johnston K, Meeuwisse W, Aubry M, Cantu R, Dvorak J, Graf-Baumann T, Kelly J, Lovell M, Schamasch P. Summary and agreement statement of the 2nd International conference on concussion in sport, Prague 2004. Br J Sports Med. 2005;39(4):196–204. doi:10.1136/bjsm.2005.018614.
   PubMed Web of Science ®Google Scholar
• Sturzenegger C, Bassetti CL. The clinical spectrum of narcolepsy with cataplexy: a reappraisal. J Sleep Res. 2004;13(4):395–406. doi:10.1111/j.1365-2869.2004.00422.x.
   PubMed Web of Science ®Google Scholar
• Monk TH, Buysse DJ, Kennedy KS, Pods JM, DeGrazia JM, Miewald JM. Measuring sleep habits without using a diary: the sleep timing questionnaire. Sleep. 2003;26(2):208–12. doi:10.1093/sleep/26.2.208.
   PubMed Web of Science ®Google Scholar
• Fann JR, Bombardier CH, Dikmen S, Esselman P, Warms CA, Pelzer E, Rau H, Temkin N. Validity of the patient health questionnaire-9 in assessing depression following traumatic brain injury. J Head Trauma Rehabil. 2005;20(6):501–11. doi:10.1097/00001199-200511000-00003.
   PubMed Web of Science ®Google Scholar
• Dahm J, Wong D, Ponsford J. Validity of the depression anxiety stress scales in assessing depression and anxiety following traumatic brain injury. J Affect Disord. 2013;151(1):392–96. doi:10.1016/j.jad.2013.06.011.
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington (DC): American Psychiatric Association; 2000.
   Google Scholar
• Bastien CH, Vallières A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2(4):297–307. doi:10.1016/S1389-9457(00)00065-4.
   PubMed Web of Science ®Google Scholar
• Popat RA, Van Den Eeden SK, Tanner CM, Kushida CA, Rama AN, Black JE, Bernstein A, Kasten M, Chade A, Leimpeter A, et al. Reliability and validity of two self-administered questionnaires for screening restless legs syndrome in population-based studies. Sleep Med. 2010;11(2):154–60. doi:10.1016/j.sleep.2009.01.012.
   PubMed Web of Science ®Google Scholar
• Harland NJ, Dawkin MJ, Martin D. Relative utility of a visual analogue scale vs a six-point Likert scale in the measurement of global subject outcome in patients with low back pain receiving physiotherapy. Physiotherapy. 2015;101(1):50–54. doi:10.1016/j.physio.2014.06.004.
   PubMed Web of Science ®Google Scholar
• Myers RH. Classical and modern regression with applications. 2nd ed. Boston (MA): PWS-KENT; 1990.
   Google Scholar
• Dormann CF, Elith J, Bacher S, Buchmann C, Carl G, Carré G, Marquéz JRG, Gruber B, Lafourcade B, Leitão PJ, et al. Collinearity: a review of methods to deal with it and a simulation study evaluating their performance. Ecography (Cop.). 2013;36:27–46. DOI:10.1111/j.1600-0587.2012.07348.x.
   Web of Science ®Google Scholar
• Casson RJ, Farmer LD. Understanding and checking the assumptions of linear regression: a primer for medical researchers. Clin Exp Ophthalmol. 2014;42(6):590–96. doi:10.1111/ceo.12358.
   PubMed Web of Science ®Google Scholar
• Kocherginsky M, He X, Mu Y. Practical confidence intervals for regression quantiles. J Comput Graph Stat. 2005;14:41–55. DOI:10.1198/106186005X27563.
   Web of Science ®Google Scholar
• Kulldorff M, Huang L, Pickle L, Duczmal L. An elliptic spatial scan statistic. Stat Med. 2006;25:3929–43. DOI:10.1002/sim.2490.
   PubMed Web of Science ®Google Scholar
• Austin PC, Steyerberg EW. The number of subjects per variable required in linear regression analyses. J Clin Epidemiol. 2015;68(6):627–36. doi:10.1016/j.jclinepi.2014.12.014.
   PubMed Web of Science ®Google Scholar
• Barrodale I, Roberts FDK. An improved algorithm for discrete l1 linear approximation. SIAM J Numer Anal. 1973;10:839–48. doi:10.1137/0710069.
   Web of Science ®Google Scholar
• Darwent D, Dawson D, Paterson JL, Roach GD, Ferguson SA. Fatigue: it really is about sleep. Accid Anal Prev. 2015;82:20–26. DOI:10.1016/j.aap.2015.05.009.
   PubMed Web of Science ®Google Scholar
• Sargent C, Lastella M, Halson SL, Roach GD. The impact of training schedules on the sleep and fatigue of elite athletes. Chronobiol Int. 2014;31(10):1160–68. doi:10.3109/07420528.2014.957306.
   PubMed Web of Science ®Google Scholar
• Heishman AD, Curtis MA, Saliba EN, Hornett RJ, Malin SK, Weltman AL. Comparing performance during morning vs. afternoon training sessions in intercollegiate basketball players. J Strength Cond Res. 2017 Jun;31(6):1557–1562. doi:10.1519/JSC.0000000000001882.
   Google Scholar
• Jaramillo CA, Eapen BC, McGeary CA, McGeary DD, Robinson J, Amuan M, Pugh MJ. A cohort study examining headaches among veterans of Iraq and Afghanistan wars: associations with traumatic brain injury, PTSD, and depression. Headache. 2016;56(3):528–39. doi:10.1111/head.12726.
   PubMed Web of Science ®Google Scholar
• Lin SY, Stevens MB. The symptom cluster-based approach to individualize patient-centered treatment for major depression. J Am Board Fam Med. 2014;27(1):151–59. doi:10.3122/jabfm.2014.01.130145.
   PubMed Web of Science ®Google Scholar
• Rose DM, Seidler A, Nübling M, Latza U, Brähler E, Klein EM, Wiltink J, Michal M, Nickels S, Wild PS, et al. Associations of fatigue to work-related stress, mental and physical health in an employed community sample. BMC Psychiatry. 2017;17(1):167. doi:10.1186/s12888-017-1237-y.
   PubMed Web of Science ®Google Scholar
• Drake CL, Pillai V, Roth T. Stress and sleep reactivity: a prospective investigation of the stress-diathesis model of insomnia. Sleep. 2014;37(8):1295–304. doi:10.5665/sleep.3916.
   PubMed Web of Science ®Google Scholar
• Mollayeva T, D’Souza A, Mollayeva S. Sleep and psychiatric disorders in persons with mild traumatic brain injury. Curr Psychiatry Rep. 2017;19(8):47. doi:10.1007/s11920-017-0800-z.
   PubMed Web of Science ®Google Scholar
• Mollayeva T, Mollayeva S, Colantonio A. The risk of sleep disorder among persons with mild traumatic brain injury. Curr Neurol Neurosci Rep. 2016;16(6):55. doi:10.1007/s11910-016-0657-2.
   PubMed Web of Science ®Google Scholar
• Touriño C, Eban-Rothschild A, de Lecea L. Optogenetics in psychiatric diseases. Curr Opin Neurobiol. 2013;23(3):430–35. doi:10.1016/j.conb.2013.03.007.
   PubMed Web of Science ®Google Scholar
• Mollayeva T, Shapiro CM. Medication Effects. In: Kushida CA, editors. The encyclopedia of sleep. Vol. 2. Waltham (MA): Academic Press; 2003. p. 330–337.
   Google Scholar
• De Martinis NA, Winokur A. Effects of psychiatric medications on sleep and sleep disorders. CNS Neurol Disord Drug Targets. 2007;6(1):17–29. doi:10.2174/187152707779940835.
   PubMedGoogle Scholar
• Dunleavy DL, Brezinova V, Oswald I, Maclean AW, Tinker M. Changes during weeks in effects of tricyclic drugs on the human sleeping brain. Br J Psychiatry. 1972;120(559):663–72. doi:10.1192/bjp.120.559.663.
   PubMed Web of Science ®Google Scholar
• Fischer CW, Elfving B, Lund S, Wegener G. Behavioral and systemic consequences of long-term inflammatory challenge. J Neuroimmunol. 2015;288:40–46. DOI:10.1016/j.jneuroim.2015.08.011.
   PubMed Web of Science ®Google Scholar
• Kempf J, Werth E, Kaiser PR, Bassetti CL, Baumann CR. Sleep-wake disturbances 3 years after traumatic brain injury. J Neurol Neurosurg Psychiatry. 2010;81(12):1402–05. doi:10.1136/jnnp.2009.201913.
   PubMed Web of Science ®Google Scholar
• Khan AA, Gardner CO, Prescott CA, Kendler KS. Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairs. Am J Psychiatry. 2002;159(8):1427–29. doi:10.1176/appi.ajp.159.8.1427.
   PubMed Web of Science ®Google Scholar
• Chervin RD. Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea. Chest. 2000;118:372–79. DOI:10.1378/chest.118.2.372.
   PubMed Web of Science ®Google Scholar
• Lerdal A, Bakken LN, Rasmussen EF, Beiermann C, Ryen S, Pynten S, Drefvelin AS, Dahl AM, Rognstad G, Finset A, et al. Physical impairment, depressive symptoms and pre-stroke fatigue are related to fatigue in the acute phase after stroke. Disabil Rehabil. 2011;33(4):334–42. doi:10.3109/09638288.2010.490867.
   PubMed Web of Science ®Google Scholar
• Ommaya AK, Goldsmith W, Thibault L. Biomechanics and neuropathology of adult and paediatric head injury. Br J Neurosurg. 2002;16(3):220–42. doi:10.1080/02688690220148824.
   PubMed Web of Science ®Google Scholar
• Grobe S, Kakar RS, Smith ML, Mehta R, Baghurst T, Boolani A. Impact of cognitive fatigue on gait and sway among older adults: A literature review. Prev Med Rep. 2017;6:88–93. DOI:10.1016/j.pmedr.2017.02.016.
   PubMedGoogle Scholar
• Liu K, Li B, Qian S, Jiang Q, Li L, Wang W, Zhang G, Sun Y, Sun G. Mental fatigue after mild traumatic brain injury: a 3D-ASL perfusion study. Brain Imaging Behav. 2016;10(3):857–68. doi:10.1007/s11682-015-9492-3.
   PubMed Web of Science ®Google Scholar
• Cikrikcioglu MA, Hursitoglu M, Erkal H, Kınas BE, Sztajzel J, Cakirca M, Arslan AG, Erek A, Halac G, Tukek T. Oxidative stress and autonomic nervous system functions in restless legs syndrome. Eur J Clin Invest. 2011;41(7):734–42. doi:10.1111/j.1365-2362.2010.02461.x.
   PubMed Web of Science ®Google Scholar
• Xiong L, Montplaisir J, Desautels A, Barhdadi A, Turecki G, Levchenko A, Thibodeau P, Dubé MP, Gaspar C, Rouleau GA. Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases. Arch Neurol. 2010;67(5):617–22. doi:10.1001/archneurol.2010.67.
   PubMedGoogle Scholar
• Zhuo Y, Wu Y, Xu Y, Lu L, Li T, Wang X, Li K. Combined resting state functional magnetic resonance imaging and diffusion tensor imaging study in patients with idiopathic restless legs syndrome. Sleep Med. 2017;38:96–103. DOI:10.1016/j.sleep.2017.06.033.
   PubMed Web of Science ®Google Scholar
• Wang HJ, McKeague IW, Qian M. Testing for marginal linear effects in quantile regression. J R Stat Soc Series B Stat Methodol. 2018;80(2):433–52. doi:10.1111/rssb.12258.
   PubMed Web of Science ®Google Scholar