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Original Article

An Endothelin Type A Receptor Antagonist Reverses Upregulated VEGF and ICAM-1 Levels in Streptozotocin-Induced Diabetic Rat Retina

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Pages 79-89 | Received 15 Jul 2005, Accepted 21 Oct 2005, Published online: 02 Jul 2009

REFERENCES

  • Aiello L P, Avery R L, Arrigg P G, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994; 331: 1480–1487, [CSA]
  • Tolentino M J, Miller J W, Gragoudas E S, et al. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology. 1996; 103: 1820–1828, [CSA]
  • Schlingemann R O, van Hinsbergh V W. Role of vascular permeability factor/vascular endothelial growth factor in eye disease. Br J Ophthalmol. 1997; 81: 501–512, [CSA]
  • Miyamoto K, Hiroshiba N, Tsujikawa A, Ogura Y. In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci. 1998; 39: 2190–2194, [CSA]
  • Kinukawa Y, Shimura M, Tamai M. Quantifying leukocyte dynamics and plugging in retinal microcirculation of streptozotosin-induced diabetic rats. Curr Eye Res. 1999; 18: 49–55, [CSA], [CROSSREF]
  • Miyamoto K, Khosrof S, Bursell S E, et al. Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1). Am J Pathol. 2000; 156: 1733–1739, [CSA]
  • Ishida S, Usui T, Yamashiro K, et al. VEGF164 is proinflammatory in the diabetic retina. Invest Ophthalmol Vis Sci. 2003; 44: 2155–2162, [CSA], [CROSSREF]
  • Joussen A M, Murata T, Tsujikawa A, et al. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol. 2001; 158: 147–152, [CSA]
  • Miyamoto K, Khosrof S, Bursell S E, et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci USA. 1999; 96: 10836–10841, [CSA], [CROSSREF]
  • Aiello L P. Clinical implications of vascular growth factors in proliferative retinopathies. Curr Opin Ophthalmol. 1997; 8: 19–31, [CSA]
  • Chakrabarti S, Sima A A. Endothelin-1 and endothelin-3-like immunoreactivity in the eyes of diabetic and non-diabetic BB/W rats. Diabetes Res Clin Pract. 1997; 37: 109–120, [CSA], [CROSSREF]
  • Takagi C, Bursell S E, Lin Y W, et al. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1. Invest Ophthalmol Vis Sci. 1996; 37: 2504–2518, [CSA]
  • Yokota T, Ma R C, Park J Y, et al. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003; 52: 838–845, [CSA]
  • Chakravarthy U, Hayes R G, Stitt A W, Douglas A. Endothelin expression in ocular tissues of diabetic and insulin-treated rats. Invest Ophthalmol Vis Sci. 1997; 38: 2144–2151, [CSA]
  • Chakrabarti S, Gan X T, Merry A, et al. Augmented retinal endothelin-1, endothelin-3, endothelinA and endothelinB gene expression in chronic diabetes. Curr Eye Res. 1998; 17: 301–307, [CSA], [CROSSREF]
  • Cukiernik M, Hileeto D, Evans T, et al. Vascular endothelial growth factor in diabetes induced early retinal abnormalities. Diabetes Res Clin Pract. 2004; 65: 197–208, [CSA], [CROSSREF]
  • Deng D, Evans T, Mukherjee K, et al. Diabetes-induced vascular dysfunction in the retina: role of endothelins. Diabetologia. 1999; 42: 1228–1234, [CSA], [CROSSREF]
  • Evans T, Xi Deng D, Mukherjee K, et al. Endothelins, their receptors, and retinal vascular dysfunction in galactose-fed rats. Diabetes Res Clin Pract. 2000; 48: 75–85, [CSA], [CROSSREF]
  • Gilbert R E, Vranes D, Berka J L, et al. Vascular endothelial growth factor and its receptors in control and diabetic rat eyes. Lab Invest. 1998; 78: 1017–1027, [CSA]
  • Murata T, Nakagawa K, Khalil A, et al. The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas. Lab Invest. 1996; 74: 819–825, [CSA]
  • Sone H, Kawakami Y, Okuda Y, et al. Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes. Diabetologia. 1997; 40: 726–730, [CSA], [CROSSREF]
  • Hammes H P, Lin J, Bretzel R G, et al. Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat. Diabetes. 1998; 47: 401–406, [CSA]
  • Segawa Y, Shirao Y, Yamagishi S, et al. Upregulation of retinal vascular endothelial growth factor mRNAs in spontaneously diabetic rats without ophthalmoscopic retinopathy. A possible participation of advanced glycation end products in the development of the early phase of diabetic retinopathy. Ophthalmic Res 1998; 30: 333–339, [CSA], [CROSSREF]
  • Ellis E A, Guberski D L, Somogyi-Mann M, Grant M B. Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat. Free Radic Biol Med. 2000; 28: 91–101, [CSA], [CROSSREF]
  • Qaum T, Xu Q, Joussen A M, et al. VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci. 2001; 42: 2408–2413, [CSA]
  • Burgos R, Simo R, Audi L, et al. Vitreous levels of vascular endothelial growth factor are not influenced by its serum concentrations in diabetic retinopathy. Diabetologia. 1997; 40: 1107–1109, [CSA], [CROSSREF]
  • Funatsu H, Yamashita H, Nakanishi Y, Hori S. Angiotensin II and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy. Br J Ophthalmol. 2002; 86: 311–315, [CSA], [CROSSREF]
  • Malecaze F, Clamens S, Simorre-Pinatel V, et al. Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch Ophthalmol. 1994; 112: 1476–1482, [CSA]
  • Cai J, Boulton M. The pathogenesis of diabetic retinopathy: old concepts and new questions. Eye. 2002; 16: 242–260, [CSA], [CROSSREF]
  • Ciulla T A, Harris A, Latkany P, et al. Ocular perfusion abnormalities in diabetes. Acta Ophthalmol Scand. 2002; 80: 468–477, [CSA], [CROSSREF]
  • Matsuura A, Yamochi W, Hirata K, et al. Stimulatory interaction between vascular endothelial growth factor and endothelin-1 on each gene expression. Hypertension. 1998; 32: 89–95, [CSA]
  • Pedram A, Razandi M, Hu R M, Levin E R. Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion. J Biol Chem. 1997; 272: 17097–17103, [CSA], [CROSSREF]
  • Chen S, Apostolova M D, Cherian M G, Chakrabarti S. Interaction of endothelin-1 with vasoactive factors in mediating glucose-induced increased permeability in endothelial cells. Lab Invest. 2000; 80: 1311–1321, [CSA]
  • Salani D, Di Castro V, Nicotra M R, et al. Role of endothelin-1 in neovascularization of ovarian carcinoma. Am J Pathol. 2000; 157: 1537–1547, [CSA]
  • Wulfing P, Kersting C, Tio J, et al. Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer. Clin Cancer Res. 2004; 10: 2393–2400, [CSA], [CROSSREF]
  • Spinella F, Rosano L, Di Castro V, et al. Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1alpha in ovarian carcinoma cells. J Biol Chem. 2002; 277: 27850–27855, [CSA], [CROSSREF]
  • Rosano L, Spinella F, Salani D, et al. Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma. Cancer Res. 2003; 63: 2447–2453, [CSA]
  • Yamashita K, Discher D J, Hu J, et al. Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. J Biol Chem 2001; 276: 12645–12653, [CSA], [CROSSREF]
  • Iglarz M, Silvestre J S, Duriez M, et al. Chronic blockade of endothelin receptors improves ischemia-induced angiogenesis in rat hindlimbs through activation of vascular endothelial growth factor-no pathway. Arterioscler Thromb Vasc Biol. 2001; 21: 1598–1603, [CSA]
  • Hofman P, van Blijswijk B C, Gaillard P J, et al. Endothelial cell hypertrophy induced by vascular endothelial growth factor in the retina: new insights into the pathogenesis of capillary nonperfusion. Arch Ophthalmol. 2001; 119: 861–866, [CSA]
  • Lu M, Perez V L, Ma N, et al. VEGF increases retinal vascular ICAM-1 expression in vivo. Invest Ophthalmol Vis Sci. 1999; 40: 1808–1812, [CSA]
  • King G L, Brownlee M. The cellular and molecular mechanisms of diabetic complications. Endocrinol Metab Clin North Am. 1996; 25: 255–270, [CSA], [CROSSREF]
  • Chakrabarti S, Cukiernik M, Hileeto D, et al. Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy. Diabetes Metab Res Rev. 2000; 16: 393–407, [CSA], [CROSSREF]
  • Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol. 1999; 61: 391–415, [CSA], [CROSSREF]
  • Takei K, Sato T, Nonoyama T, et al. Analysis of vasocontractile responses to endothelin-1 in rabbit retinal vessels using an ETA receptor antagonist and an ETB receptor agonist. Life Sci. 1993; 53: PL111–115, [CSA], [CROSSREF]
  • Chou E, Suzuma I, Way K J, et al. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 2002; 105: 373–379, [CSA], [CROSSREF]
  • Jesmin S, Sakuma I, Salah-Eldin A, et al. Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: a possible cause for erectile dysfunction in diabetes. J Mol Endocrinol 2003; 31: 401–418, [CSA], [CROSSREF]

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