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Original Article

Protein Kinase C-Mediated Modulation of Glutamate Transporter Activity in Rat Retina

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Pages 123-131 | Received 31 Aug 2006, Accepted 22 Nov 2006, Published online: 02 Jul 2009

REFERENCES

  • Pow D V. Amino acids and their transporters in the retina. Neurochem Int. 2001; 38: 463–484
  • Sarthy V P, Pignataro L, Pannicke T, et al. Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice. Glia. 2005; 49: 184–196
  • Eliasof S, Arriza J L, Leighton B H, et al. Localization and function of five glutamate transporters cloned from the salamander retina. Vision Res. 1998; 38: 1443–1454
  • Pow D V, Barnett N L. Developmental expression of excitatory amino acid transporter 5: A photoreceptor and bipolar cell glutamate transporter in rat retina. Neurosci Lett. 2000; 280: 21–24
  • Rauen T, Rothstein J D, Wassle H. Differential expression of three glutamate transporter subtypes in the rat retina. Cell Tissue Res. 1996; 286: 325–336
  • Schultz K, Stell W K. Immunocytochemical localization of the high-affinity glutamate transporter, EAAC1, in the retina of representative vertebrate species. Neurosci Lett. 1996; 211: 191–194
  • Wiessner M, Fletcher E L, Fischer F, Rauen T. Localization and possible function of the glutamate transporter, EAAC1, in the rat retina. Cell Tissue Res. 2002; 310: 31–40
  • Reye P, Sullivan R, Fletcher E L, Pow D V. Distribution of two splice variants of the glutamate transporter GLT1 in the retinas of humans, monkeys, rabbits, rats, cats, and chickens. J Comp Neurol. 2002; 445: 1–12
  • Sullivan R, Rauen T, Fischer F, et al. Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis. Glia. 2004; 45: 155–169
  • Harada T, Harada C, Watanabe M, et al. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci USA. 1998; 95: 4663–4666
  • Barnett N L, Pow D V. Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal function. Invest Ophthalmol Vis Sci. 2000; 41: 585–591
  • Ehinger B. Glial and neuronal uptake of GABA, glutamic acid, glutamine and glutathione in the rabbit retina. Exp Eye Res. 1977; 25: 221–234
  • Rauen T, Taylor W R, Kuhlbrodt K, Wiessner M. High-affinity glutamate transporters in the rat retina: a major role of the glial glutamate transporter GLAST-1 in transmitter clearance. Cell Tissue Res. 1998; 291: 19–31
  • Martin K R, Levkovitch-Verbin H, Valenta D, et al. Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat. Invest Ophthalmol Vis Sci. 2002; 43: 2236–2243
  • Osborne N N, Casson R J, Wood J P, et al. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res. 2004; 23: 91–147
  • Woldemussie E, Wijono M, Ruiz G. Muller cell response to laser-induced increase in intraocular pressure in rats. Glia. 2004; 47: 109–119
  • Susarla B T, Seal R P, Zelenaia O, et al. Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini. J Neurochem. 2004; 91: 1151–1163
  • Conradt M, Stoffel W. Inhibition of the high-affinity brain glutamate transporter GLAST-1 via direct phosphorylation. J Neurochem. 1997; 68: 1244–1251
  • Gonzalez M I, Lopez-Colom A M, Ortega A. Sodium-dependent glutamate transport in Muller glial cells: regulation by phorbol esters. Brain Res. 1999; 831: 140–145
  • Gonzalez M I, Ortega A. Regulation of the Na+-dependent high affinity glutamate/aspartate transporter in cultured Bergmann glia by phorbol esters. J Neurosci Res. 1997; 50: 585–590
  • Espinoza-Rojo M, Lopez-Bayghen E, Ortega A. GLAST: gene expression regulation by phorbol esters. Neuroreport. 2000; 11: 2827–2832
  • Bull N D, Barnett N L. Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ. J Neurochem. 2002; 81: 472–480
  • Casado M, Bendahan A, Zafra F, et al. Phosphorylation and modulation of brain glutamate transporters by protein kinase C. J Biol Chem. 1993; 268: 27313–27317
  • Ganel R, Crosson C E. Modulation of human glutamate transporter activity by phorbol ester. J Neurochem. 1998; 70: 993–1000
  • Gonzalez M I, Susarla B T, Robinson M B. Evidence that protein kinase Calpha interacts with and regulates the glial glutamate transporter GLT-1. J Neurochem. 2005; 94: 1180–1188
  • Tan J, Zelenaia O, Correale D, et al. Expression of the GLT-1 subtype of Na+-dependent glutamate transporter: pharmacological characterization and lack of regulation by protein kinase C. J Pharmacol Exp Ther. 1999; 289: 1600–1610
  • Davis K E, Straff D J, Weinstein E A, et al. Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. J Neurosci. 1998; 18: 2475–2485
  • Dowd L A, Robinson M B. Rapid stimulation of EAAC1-mediated Na+-dependent L-glutamate transport activity in C6 glioma cells by phorbol ester. J Neurochem. 1996; 67: 508–516
  • Gonzalez M I, Bannerman P G, Robinson M B. Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1. J Neurosci. 2003; 23: 5589–5593
  • Dunlop J, Lou Z, McIlvain H B. Properties of excitatory amino acid transport in the human U373 astrocytoma cell line. Brain Res. 1999; 839: 235–242
  • Trotti D, Peng J B, Dunlop J, Hediger M A. Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters. Brain Res. 2001; 914: 196–203
  • Herbert J M, Augereau J M, Gleye J, Maffrand J P. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990; 172: 993–999
  • Gschwendt M, Muller H J, Kielbassa K, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994; 199: 93–98
  • Castagna M, Takai Y, Kaibuchi K, et al. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem. 1982; 257: 7847–7851
  • Frey M R, Leontieva O, Watters D J, Black J D. Stimulation of protein kinase C-dependent and -independent signaling pathways by bistratene A in intestinal epithelial cells. Biochem Pharmacol. 2001; 61: 1093–1100
  • Griffiths G, Garrone B, Deacon E, et al. The polyether bistratene A activates protein kinase C-delta and induces growth arrest in HL60 cells. Biochem Biophys Res Commun. 1996; 222: 802–808
  • Erecinska M, Troeger M B, Wilson D F, Silver I A. The role of glial cells in regulation of neurotransmitter amino acids in the external environment. II. Mechanism of aspartate transport. Brain Res. 1986; 369: 203–214
  • Flott B, Seifert W. Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain. Glia. 1991; 4: 293–304
  • Storm-Mathisen J, Ottersen O P, Fu-Long T, et al. Metabolism and transport of amino acids studied by immunocytochemistry. Med Biol. 1986; 64: 127–132
  • Beale R, Dutton G R, Currie D N. An ion flux assay of action potential sodium channels in neuron- and glia-enriched cultures of cells dissociated from rat cerebellum. Brain Res. 1980; 183: 241–246
  • Ghazi H, Osborne N N. Agonist-induced stimulation of inositol phosphates in primary rabbit retinal cultures. J Neurochem. 1988; 50: 1851–1858
  • Osborne N N, Beaton D W. Occurrence of serotonin-accumulating neurones in cultures of retina from the human foetus. Neurosci Lett. 1985; 55: 229–232
  • Pow D V, Barnett N L. Changing patterns of spatial buffering of glutamate in developing rat retinae are mediated by the Müller cell glutamate transporter GLAST. Cell Tissue Res. 1999; 297: 57–66
  • Beale R, Osborne N N. Selective uptake of tritiated glycine, GABA and D-aspartate by retinal cells in culture: a study using autoradiography and simultaneous immunofluorescence. Dev Brain Res. 1983; 7: 107–120
  • Rauen T. Diversity of glutamate transporter expression and function in the mammalian retina. Amino Acids. 2000; 19: 53–62
  • Wood J PM, Chidlow G, Graham M, Osborne N N. Energy substrate requirements for survival of rat retinal cells in culture: the importance of glucose and monocarboxylates. J Neurochem. 2005; 93: 686–697
  • Osborne N N, Wood J, Groome N. The occurrence of three calcium-independent protein kinase C subspecies (delta, epsilon and zeta) in retina of different species. Brain Res. 1994; 637: 156–162
  • Susarla B T, Robinson M B. Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. J Neurochem. 2003; 86: 635–645
  • Poitry-Yamate C L, Vutskits L, Rauen T. Neuronal-induced and glutamate-dependent activation of glial glutamate transporter function. J Neurochem. 2002; 82: 987–997
  • Swanson R A, Liu J, Miller J W, et al. Neuronal regulation of glutamate transporter subtype expression in astrocytes. J Neurosci. 1997; 17: 932–940
  • Lortet S, Samuel D, Had-Aissouni L, et al. Effects of PKA and PKC modulators on high affinity glutamate uptake in primary neuronal cell cultures from rat cerebral cortex. Neuropharmacology. 1999; 38: 395–402
  • Daniels K K, Vickroy T W. Reversible activation of glutamate transport in rat brain glia by protein kinase C and an okadaic acid-sensitive phosphoprotein phosphatase. Neurochem Res. 1999; 24: 1017–1025

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