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Research Article

Cholesterol-24S-hydroxylase (CYP46A1) Is Specifically Expressed in Neurons of the Neural Retina

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Pages 361-366 | Received 17 Jan 2006, Accepted 06 Oct 2006, Published online: 02 Jul 2009

REFERENCES

  • McCarty C A, Mukesh B N, Fu C L, et al. Risk factors for age-related maculopathy: the Visual Impairment Project. Arch Ophthalmol. 2001; 119: 1455–1462
  • Delcourt C, Michel F, Colvez A, et al. Associations of cardiovascular disease and its risk factors with age-related macular degeneration: the POLA study. Ophthalmic Epidemiol. 2001; 8: 237–249
  • Klein B E, Klein R, Moss S E. Is serum cholesterol associated with progression of diabetic retinopathy or macular edema in persons with younger-onset diabetes of long duration?. Am J Ophthalmol. 1999; 128: 652–654
  • Espinosa-Heidmann D G, Sall J, Hernandez E P, Cousins S W. Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. Invest Ophthalmol Vis Sci 2004; 45: 260–266
  • Ong J M, Zorapapel N C, Aoki A M, et al. Impaired electroretinogram (ERG) response in apolipoprotein E-deficient mice. Curr Eye Res 2003; 27: 15–24
  • Malek G, Li C M, Guidry C, et al. Apolipoprotein B in cholesterolcontaining drusen and basal deposits of human eyes with age-related maculopathy. Am J Pathol 2003; 162: 413–425
  • Ong J M, Zorapapel N C, Rich K A, et al. Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice. Invest Ophthalmol Vis Sci 2001; 42: 1891–1900
  • Curcio C A, Millican C L, Bailey T, Kruth H S. Accumulation of cholesterol with age in human Bruch's membrane. Invest Ophthalmol Vis Sci 2001; 42: 265–274
  • Bjorkhem I, Lutjohann D, Diczfalusy U, et al. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res 1998; 39: 1594–1600
  • Bjorkhem I, Lutjohann D, Breuer O, et al. Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. J Biol Chem 1997; 272: 30178–30184
  • Lund E G, Guileyardo J M, Russell D W. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci USA 1999; 96: 7238–7243
  • Bogdanovic N, Bretillon L, Lund E G, et al. On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neurosci Lett 2001; 314: 45–48
  • Lutjohann D, Papassotiropoulos A, Bjorkhem I, et al. Plasma 24Shydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J Lipid Res. 2000; 41: 195–198
  • Bretillon L, Sidén A, Wahlund L O, et al. Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. Neurosci Lett 2000; 293: 87–90
  • Xie C, Lund E G, Turley S D, et al. Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration. J Lipid Res 2003; 44: 1780–1789
  • Ikeda H, Ueda M, Ikeda M, et al. Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye. Lab Invest 2003; 83: 349–355
  • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156–159
  • Bretillon L, Lütjohann D, Stahle L, et al. Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J Lipid Res 2000; 41: 840–845
  • Lutjohann D, Breuer O, Ahlborg G, et al. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24Shydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci USA 1996; 93: 9799–9804
  • Lund E G, Xie C, Kotti T, et al. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J Biol Chem. 2003; 278: 22980–22988
  • Desai P, DeKosky S T, Kamboh M I. Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease. Neurosci Lett 2002; 328: 9–12
  • Borroni B, Archetti S, Agosti C, et al. Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer disease: from risk factors to disease modulators. Neurobiol Aging. 2004; 25: 747–751
  • Combarros O, Infante J, Llorca J, Berciano J. Genetic association of CYP46 and risk for Alzheimer's disease. Dement Geriatr Cogn Disord 2004; 18: 257–260
  • Wang B, Zhang C, Zheng W, et al. Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese. Neurosci Lett 2004; 369: 104–107

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