References
- The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul Surf 2007;5:75–92.
- Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci 2004;45:4302–4311.
- Saleh GM, Hussain B, Woodruff SA, Sharma A, Litwin AS. Tear film osmolarity in epiphora. Ophthal Plast Reconstr Surg 2012;28:338–340.
- Hubert A, Cauliez B, Chedeville A, Husson A, Lavoinne A. Osmotic stress, a proinflammatory signal in Caco-2 cells. Biochimie 2004;86:533–541.
- Farris RL. Tear osmolarity–a new gold standard? Adv Exp Med Biol 1994;350:495–503.
- Burg MB, Ferraris JD, Dmitrieva NI. Cellular response to hyperosmotic stresses. Physiol Rev 2007;87:1441–1474.
- Luo L, Li DQ, Doshi A, Farley W, Corrales RM, Pflugfelder SC. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci 2004;45:4293–4301.
- Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf 2004;2:124–130.
- Lang F, Busch GL, Ritter M, Völkl H, Waldegger S, Gulbins E et al. Functional significance of cell volume regulatory mechanisms. Physiol Rev 1998;78:247–306.
- Ngezahayo A, Kolb HA. Gap junctional permeability is affected by cell volume changes and modulates volume regulation. FEBS Lett 1990;276:6–8.
- Sachs F. Mechanical transduction by membrane ion channels: a mini review. Mol Cell Biochem 1991;104:57–60.
- Stahl U, Willcox M, Stapleton F. Osmolality and tear film dynamics. Clin Exp Optom 2012;95:3–11.
- Bachman WG, Wilson G. Essential ions for maintenance of the corneal epithelial surface. Invest Ophthalmol Vis Sci 1985;26:1484–1488.
- Carney LG, Hill RM. Human tear pH. Diurnal variations. Arch Ophthalmol 1976;94:821–824.
- Lösche M, Möhwald H. Electrostatic interactions in phospholipid membranes: II. Influence of divalent ions on monolayer structure. J Colloid Interface Sci 1989;131:56–67.
- Tiwari S, Askari JA, Humphries MJ, Bulleid NJ. Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking. J Cell Sci 2011;124:1672–1680.
- Wei XE, Markoulli M, Millar TJ, Willcox MD, Zhao Z. Divalent cations in tears, and their influence on tear film stability in humans and rabbits. Invest Ophthalmol Vis Sci 2012;53:3280–3285.