References
- Holly FJ, Lemp MA. Tear physiology and dry eyes. Surv Ophthalmol 1977;22:69–87.
- Tiffany JM. Viscoelastic properties of human tears and polymer solutions. Adv Exp Med Biol 1994;350:267–270.
- Tiffany JM. Composition and biophysical properties of the tear film: knowledge and uncertainty. Adv Exp Med Biol 1994;350:231–238.
- Pflugfelder SC, Liu Z, Monroy D, Li DQ, Carvajal ME, Price-Schiavi SA et al. Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest Ophthalmol Vis Sci 2000;41:1316–1326.
- Watanabe H. Significance of mucin on the ocular surface. Cornea 2002;21(Suppl 1):S17–S22.
- Danjo Y, Watanabe H, Tisdale AS, George M, Tsumura T, Abelson MB et al. Alteration of mucin in human conjunctival epithelia in dry eye. Invest Ophthalmol Vis Sci 1998;39:2602–2609.
- Jumblatt JE, Jumblatt MM. Detection and quantification of conjunctival mucins. Adv Exp Med Biol 1998;438:239–246.
- Yokoi N, Kato H, Kinoshita S. Facilitation of tear fluid secretion by 3% diquafosol ophthalmic solution in normal human eyes. Am J Ophthalmol 2014;157:85–92.
- Nakamura M, Imanaka T, Sakamoto A. Diquafosol ophthalmic solution for dry eye treatment. Adv Ther 2012;29:579–589.
- Shimazaki-Den S, Iseda H, Dogru M, Shimazaki J. Effects of diquafosol sodium eye drops on tear film stability in short BUT type of dry eye. Cornea 2013;32:1120–1125.
- Fujihara T, Murakami T, Fujita H, Nakamura M, Nakata K. Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Invest Ophthalmol Vis Sci 2001;42:96–100.
- Murakami T, Fujihara T, Horibe Y, Nakamura M. Diquafosol elicits increases in net Cl- transport through P2Y2 receptor stimulation in rabbit conjunctiva. Ophthalmic Res 2004;36:89–93.
- Kamiya K, Nakanishi M, Ishii R, Kobashi H, Igarashi A, Sato N et al. Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study. Eye (Lond) 2012;26:1363–1368.
- Matsumoto Y, Ohashi Y, Watanabe H, Tsubota K; Diquafosol Ophthalmic Solution Phase 2 Study. Efficacy and safety of diquafosol ophthalmic solution in patients with dry eye syndrome: a Japanese phase 2 clinical trial. Ophthalmology 2012;119:1954–1960.
- Argueso P, Balaram M, Spurr-Michaud S, Keutmann HT, Dana MR, Gipson IK. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome. Invest Ophthalmol Vis Sci 2002;43:1004–1011.
- Terakado K, Yogo T, Kohara Y, Soeta S, Nezu Y, Harada Y et al. Conjunctival expression of the P2Y2 receptor and the effects of 3% diquafosol ophthalmic solution in dogs. Vet J 2014;202:48–52.
- Zhao H, Jumblatt JE, Wood TO, Jumblatt MM. Quantification of MUC5AC protein in human tears. Cornea 2001;20:873–877.
- Barabino S, Shen L, Chen L, Rashid S, Rolando M, Dana MR. The controlled-environment chamber: a new mouse model of dry eye. Invest Ophthalmol Vis Sci 2005;46:2766–2771.
- Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME et al. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 2002;43:632–638.
- Eom Y, Song JS, Lee DY, Kim MK, Kang BR, Heo JH, et al. Effect of Titanium Dioxide Nanoparticle Exposure on the Ocular Surface: An Animal Study. Ocul Surf 2016;14:224–232
- Miyake G, Ota I, Miyake K, Zako M, Iwaki M. Effects of topical diquafosol pretreatment on intraoperative corneal wetting. J Cataract Refract Surg 2014;40:1682–1688.
- Ahn MH, Kang CM, Park CS, Park SJ, Rhim T, Yoon PO et al. Titanium dioxide particle-induced goblet cell hyperplasia: association with mast cells and IL-13. Respir Res 2005;6:34.
- Mantelli F, Tiberi E, Micera A, Lambiase A, Visintini F, Bonini S. MUC5AC overexpression in tear film of neonates. Graefes Arch Clin Exp Ophthalmol 2007;245:1377–1381.
- The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5:75–92.
- Sullivan DA, Rocha EM, Ullman MD, Krenzer KL, Gao J, Toda I, et al. Androgen regulation of the meibomian gland. Adv Exp Med Biol 1998;438:327–331.
- Sullivan DA, Wickham LA, Rocha EM, Kelleher RS, da Silveira LA, Toda I. Influence of gender, sex steroid hormones, and the hypothalamic-pituitary axis on the structure and function of the lacrimal gland. Adv Exp Med Biol 1998;438:11–42.
- Jumblatt JE, Jumblatt MM. Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva. Exp Eye Res 1998;67:341–346.
- Goto E, Tseng SC. Differentiation of lipid tear deficiency dry eye by kinetic analysis of tear interference images. Arch Ophthalmol 2003;121:173–180.
- Hong S, Kim T, Chung SH, Kim EK, Seo KY. Recurrence after topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren’s syndrome. J Ocul Pharmacol Ther 2007;23:78–82.
- Marsh P, Pflugfelder SC. Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren syndrome. Ophthalmology 1999;106:811–816.
- Rosenberg ES, Asbell PA. Essential fatty acids in the treatment of dry eye. Ocul Surf 2010;8:18–28.
- Al Mahmood AM, Al-Swailem SA. Essential fatty acids in the treatment of dry eye syndrome: a myth or reality? Saudi J Ophthalmol 2014;28:195–197.
- Sullivan DA, Wickham LA, Rocha EM, Krenzer KL, Sullivan BD, Steagall R et al. Androgens and dry eye in Sjogren’s syndrome. Ann NY Acad Sci 1999;876:312–324.
- Asbell PA, Spiegel S. Ophthalmologist perceptions regarding treatment of moderate-to-severe dry eye: results of a physician survey. Eye Contact Lens 2010;36:33–38.
- Asbell PA. Increasing importance of dry eye syndrome and the ideal artificial tear: consensus views from a roundtable discussion. Curr Med Res Opin 2006;22:2149–2157.
- Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye Workshop (2007). Ocul Surf 2007;5:163–178.
- Alves M, Fonseca EC, Alves MF, Malki LT, Arruda GV, Reinach PS et al. Dry eye disease treatment: a systematic review of published trials and a critical appraisal of therapeutic strategies. Ocul Surf 2013;11:181–192.
- Doughty MJ, Glavin S. Efficacy of different dry eye treatments with artificial tears or ocular lubricants: a systematic review. Ophthalmic Physiol Opt 2009;29:573–583.
- Pflugfelder SC. Integrating restasis into the management of dry eye. Int Ophthalmol Clin 2006;46:101–103.
- Li Y, Kuang K, Yerxa B, Wen Q, Rosskothen H, Fischbarg J. Rabbit conjunctival epithelium transports fluid, and P2Y2(2) receptor agonists stimulate Cl(−) and fluid secretion. Am J Physiol Cell Physiol 2001;281:C595–C602.
- Arita R, Suehiro J, Haraguchi T, Maeda S, Maeda K, Tokoro H et al. Topical diquafosol for patients with obstructive meibomian gland dysfunction. Br J Ophthalmol 2013;97:725–729.
- Tanioka H, Kuriki Y, Sakamoto A, Katsuta O, Kawazu K, Nakamura M. Expression of the P2Y(2) receptor on the rat ocular surface during a 1-year rearing period. Jpn J Ophthalmol 2014;58:515–521.
- Fujihara T, Murakami T, Nagano T, nakamura M, Nakata Kl. INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model. J Ocul Pharmacol Ther 2002;18:363–370.
- Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5:108–152.
- Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J 1995;21:221–232.
- Jain P, Li R, Lama T, Saragovi HU, Cumberlidge G, Meerovitch K. An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye. Exp Eye Res 2011;93:503–512.
- Viau S1, Maire MA, Pasquis B, Grégoire S, Fourgeux C, Acar N, et al. Time course of ocular surface and lacrimal gland changes in a new scopolamine-induced dry eye model. Graefes Arch Clin Exp Ophthalmol 2008;246:857–867.
- Takaoka-Shichijo Y, Nakamura M. Stimulatory effect of diquafosol tetrasodium on the expression of membrane-binding mucin genes in cultured human corneal epithelial cells. AtarashiiGanka 2011;28:425–429.
- Helleboid L, Khatami M, Wei ZG, Rockey JH. Histamine and prostacyclin. Primary and secondary release in allergic conjunctivitis. Invest Ophthalmol Vis Sci 1991;32:2281–2289.