Comparison of 0.3% Hypotonic and Isotonic Sodium Hyaluronate Eye Drops in the Treatment of Experimental Dry Eye

References

• Schaumberg DA, Sullivan DA, Buring JE, Dana MR. Prevalence of dry eye syndrome among US women. Am J Ophthalmol 2003;136:318–326.
   PubMed Web of Science ®Google Scholar
• Research in dry eye: report of the research subcommittee of the international dry eye workshop. Ocul Surf. 2007;5:179–193.
   Google Scholar
• Baudouin C. A new approach for better comprehension of diseases of the ocular surface [in French]. J Fr Ophtalmol 2007;30:239–246.
   PubMed Web of Science ®Google Scholar
• Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci 2006;47:3293–3302.
   PubMed Web of Science ®Google Scholar
• Gilbard JP, Rossi SR, Gray KL, Hanninen LA, Kenyon KR. Tear film osmolarity and ocular surface disease in two rabbit models for keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 1988;29:374–378.
   PubMed Web of Science ®Google Scholar
• Li DQ, Luo L, Chen Z, Kim HS, Song XJ, Pflugfelder SC. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res 2006;82:588–596.
   PubMed Web of Science ®Google Scholar
• Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci 2004;45:4302–4311.
   PubMed Web of Science ®Google Scholar
• Solomon A, Dursun D, Liu Z, Xie Y, Macri A, Pflugfelder SC. Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci 2001;42:2283–2292.
   PubMed Web of Science ®Google Scholar
• Choi W, Li Z, Oh HJ, Im SK, Lee SH, Park SH, et al. Expression of CCR5 and its ligands CCL3, -4, and -5 in the tear film and ocular surface of patients with dry eye disease. Curr Eye Res 2012;37:12–17.
   PubMed Web of Science ®Google Scholar
• Jackson DC, Zeng W, Wong CY, Mifsud EJ, Williamson NA, Downie LE, et al. Tear interferon-gamma as a biomarker for evaporative dry eye disease. Invest Ophthalmol Vis Sci 2016;57:4824–4830.
   PubMed Web of Science ®Google Scholar
• Yoon KC, Park CS, You IC, Choi HJ, Lee KH, Im SK, et al. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci 2010;51:643–650.
   PubMed Web of Science ®Google Scholar
• Versura P, Profazio V, Schiavi C, Campos EC. Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro models. Invest Ophthalmol Vis Sci 2011;52:5488–5496.
   PubMed Web of Science ®Google Scholar
• Luo L, Li DQ, Pflugfelder SC. Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea 2007;26:452–460.
   PubMed Web of Science ®Google Scholar
• Gilbard JP, Farris RL. Tear osmolarity and ocular surface disease in keratoconjunctivitis sicca. Arch Ophthalmol 1979;97:1642–1646.
   PubMed Web of Science ®Google Scholar
• Bruix A, Adán A, Casaroli-Marano RP. Efficacy of sodium carboxymethylcellulose in the treatment of dry eye syndrome [in Spanish]. Arch Soc Esp Oftalmol 2006;81:85–92.
   PubMedGoogle Scholar
• Baudouin C, Aragona P, Messmer EM, Tomlinson A, Calonge M, Boboridis KG, et al. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting. Ocul Surf 2013;11:246–258.
   PubMed Web of Science ®Google Scholar
• Iester M, Orsoni GJ, Gamba G, Taffara M, Mangiafico P, Giuffrida S, et al. Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca. Eye (Lond) 2000;14:892–898.
   PubMed Web of Science ®Google Scholar
• Aragona P, Di Stefano G, Ferreri F, Spinella R, Stilo A. Sodium hyaluronate eye drops of different osmolarity for the treatment of dry eye in Sjögren’s syndrome patients. Br J Ophthalmol 2002;86:879–884.
   PubMed Web of Science ®Google Scholar
• Papa V, Aragona P, Russo S, Di Bella A, Russo P, Milazzo G. Comparison of hypotonic and isotonic solutions containing sodium hyaluronate on the symptomatic treatment of dry eye patients. Ophthalmologica 2001;215:124–127.
   PubMed Web of Science ®Google Scholar
• Evangelista M, Koverech A, Messano M, Pescosolido N. Comparison of three lubricant eye drop solutions in dry eye patients. Optom Vis Sci 2011;88:1439–1444.
   PubMed Web of Science ®Google Scholar
• Troiano P, Monaco G. Effect of hypotonic 0.4% hyaluronic acid drops in dry eye patients: a cross-over study. Cornea 2008;27:1126–1130.
   PubMed Web of Science ®Google Scholar
• Baeyens V, Bron A, Baudouin C; Vismed/Hylovis Study Group. Efficacy of 0.18% hypotonic sodium hyaluronate ophthalmic solution in the treatment of signs and symptoms of dry eye disease. J Fr Ophtalmol 2012;35:412–419.
   PubMed Web of Science ®Google Scholar
• Oh HJ, Li Z, Park SH, Yoon KC. Effect of hypotonic 0.18% sodium hyaluronate eye drops on inflammation of the ocular surface in experimental dry eye. J Ocul Pharmacol Ther 2014;30:533–542.
   PubMed Web of Science ®Google Scholar
• Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME, et al. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 2002;43:632–638.
   PubMed Web of Science ®Google Scholar
• De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME, et al. Corticosteroid and doxycline suppress MMP-9 and inflammatory cytokines expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res 2006;83:526–535.
   PubMed Web of Science ®Google Scholar
• Niederkorn JY, Stern ME, Pflugfelder SC, De Paiva CS, Corrales RM, Gao J, et al. Desiccating stress induces T cell-mediated Sjogren’s syndrome-like lacrimal keratoconjunctivitis. J Immunol 2006;176:3950–3957.
   PubMed Web of Science ®Google Scholar
• Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, et al. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice; effects of desiccating stress. Invest Ophthalmol Vis Sci 2007;48:2561–2569.
   PubMed Web of Science ®Google Scholar
• Yoon KC, Ahn KY, Choi W, Li Z, Choi JS, Lee SH, et al. Tear production and ocular surface changes in experimental dry eye after elimination of desiccating stress. Invest Ophthalmol Vis Sci 2011;52:7267–7273.
   PubMed Web of Science ®Google Scholar
• Pauly A, Brignole-Baudouin F, Labbé A, Liang H, Warnet JM, Baudouin C. New tools for the evaluation of toxic ocular surface changes in the rat. Invest Ophthalmol Vis Sci 2007;48:5473–5483.
   PubMed Web of Science ®Google Scholar
• Johnson ME, Murphy PJ, Boulton M. Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye. Graefes Arch Clin Exp Ophthalmol 2006;244:109–112.
   PubMed Web of Science ®Google Scholar
• Inoue M, Katakami C. The effect of hyaluronic acid on corneal epithelial cell proliferation. Invest Ophthalmol Vis Sci 1993;34:2313–2315.
   PubMed Web of Science ®Google Scholar
• Stuart JC, Linn JG. Dilute sodium hyaluronate (Healon) in the treatment of ocular surface disorders. Ann Ophthalmol 1985;17:190–192.
   PubMed Web of Science ®Google Scholar
• Nishida T, Nakamura M, Mishima H, Otori T. Hyaluronan stimulates corneal epithelial cell migration. Exp Eye Res 1991;53:753–758.
   PubMed Web of Science ®Google Scholar
• Lee HS, Ji YS, Yoon KC. Efficacy of hypotonic 0.18% sodium hyaluronate eye drops in patients with dry eye disease. Cornea 2014;33:946–951.
   PubMed Web of Science ®Google Scholar
• Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, et al. Interferon-γ exacerbates dry eye–induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci 2011;52:6279–6285.
   PubMed Web of Science ®Google Scholar
• De Paiva CS, Schwartz CE, Gjörstrup P, Pflugfelder SC. Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea 2012;31:1299–1303.
   PubMed Web of Science ®Google Scholar
• Pflugfelder SC, De Paiva CS, Moore QL, Volpe EA, Li DQ, Gumus K, et al. Aqueous tear deficiency increases conjunctival interferon-γ (IFN-γ) expression and goblet cell loss. Invest Ophthalmol Vis Sci 2015;56:7545–7550.
   PubMed Web of Science ®Google Scholar
• Stern ME, Siemasko KF, Gao J, Calonge M, Niederkorn JY, Pflugfelder SC. Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease. Ocul Surf 2005;3:S161–S164.
   PubMed Web of Science ®Google Scholar
• Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, et al. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun 2008;30:212–221.
   PubMed Web of Science ®Google Scholar
• De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, et al. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci 2007;48:2553–2560.
   PubMed Web of Science ®Google Scholar