172
Views
3
CrossRef citations to date
0
Altmetric
Retina and Retinal Vascular Function

Activation of Veratridine Sensitive Sodium Channels, But not Electrical Field Stimulation, Dilates Porcine Retinal Arterioles with Preserved Perivascular Tissue

, , , &
Pages 1497-1502 | Received 18 Dec 2016, Accepted 24 May 2017, Published online: 14 Sep 2017

References

  • Bek T. Regional morphology and pathophysiology of retinal vascular disease. Prog Retin Eye Res 2013;36:247–259.
  • Laties AM. Central retinal artery innervation. Absence of adrenergic innervation to the intraocular branches. Arch Ophthalmol 1967;77(3):405–409.
  • Pournaras CJ, Rungger-Brandle E, Riva CE, Hardarson SH, Stefansson E. Regulation of retinal blood flow in health and disease. Prog Retin Eye Res 2008;27(3):284–330.
  • Metea MR, Newman EA. Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. J Neurosci 2006;26(11):2862–2870.
  • Wang SY, Wang GK. Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cell Signal 2003;15(2):151–159.
  • Kringelholt S, Simonsen U, Bek T. Neurogenic contractions in intraocular porcine ciliary arteries are mediated by α2-adrenoceptors and NPY1 receptors and are inhibited by prostaglandin E2 acting on prejunctional EP4 receptors. Exp Eye Res 2013;107(2):32–36.
  • Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977;411:19–26.
  • Hessellund A, Aalkjaer C, Bek T. Effect of cyclic guanosine-monophosphate on porcine retinal vasomotion. Acta Ophthalmol 2006;84(2):228–233.
  • Kwong K, Carr MJ. Voltage-gated sodium channels. Curr Opin Pharmarcol 2015;22:131–9.
  • Mitra P, Miller RF. Normal and rebound impulse firing in retinal ganglion cells. Vis Neurosci 2007;24(1):79–90.
  • Newman EA. Glial cell regulation of neuronal activity and blood flow in the retina by release of gliotransmitters. Philos Trans R Soc Lond B Biol Sci 2015;370(1672). doi:10.1098/rstb.2014.0195.
  • Catterall WA, Cestèle S, Yarov-Yarovoy V, Yu FH, Konoki K, Scheuer T. Voltage-gated ion channels and gating modifier toxins. Toxicon 2007;49(2):124–141.
  • Skov Jensen P, Jeppesen P, Bek T. Differential diameter responses in macular and peripheral retinal arterioles may contribute to the regional distribution of diabetic retinopathy lesions. Graefes Arch Clin Exp Ophthalmol 2011;249(3):407–412.
  • Misfeldt MW, Aalkjaer C, Simonsen U, Bek T. Novel cellular bouton structure activated by ATP in the vascular wall of porcine retinal arterioles. Invest Ophthalmol Vis Sci 2010;51(12):6681–6687.
  • Misfeldt MW, Pedersen SM, Bek T. Perivascular cells with pericyte characteristics are involved in ATP- and PGE(2)-induced relaxation of porcine retinal arterioles in vitro. Invest Ophthalmol Vis Sci 2013;54(5):3258–3264.
  • Jeppesen P, Aalkjaer C, Bek T. Myogenic response in isolated porcine retinal arterioles. Curr Eye Res 2003;27(4):217–222.
  • Jeppesen P, Aalkjaer C, Bek T. Bradykinin relaxation in small porcine retinal arterioles. Invest Ophthalmol Vis Sci 2002;43(6):1891–1896.
  • Jeppesen P, Aalkjær C, Bek T. Glibenclamide and ouabain inhibit adenosine relaxation in small isolated retinal arterioles. Curr Eye Res 2002;25(1):23–28.
  • Holmgaard K, Aalkjær C, Lambert JD, Bek T. ATP-induced relaxation of porcine retinal arterioles depends on the perivascular retinal tissue and acts via an adenosine receptor. Cur Eye Res 2007;32(4):353–359.
  • Dalsgaard T, Kroigaard C, Misfeldt M, Bek T, Simonsen U. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. Br J Pharmacol 2010;160(6):1496–1508.
  • Holmgaard K, Aalkjaer C, Lambert JD, Hessellund A, Bek T. The relaxing effect of perivascular tissue on porcine retinal arterioles in vitro is mimicked by N-Methyl-D-Aspartate and is blocked by prostaglandin synthesis inhibition. Acta Ophthalmol 2008:86(1):26–33
  • Holmgaard K, Bek T. ATP-induced relaxation of porcine retinal arterioles in vitro depends on prostaglandin E synthesized in the perivascular retinal tissue. Invest Ophthalmol Vis Sci 2010;51(10):5168–5175.
  • Kringelholt S, Holmgaard K, Bek T. Relaxation of porcine retinal arterioles during acute hypoxia in vitro depends on prostaglandin and NO synthesis in the perivascular retina. Curr Eye Res 2013;38(9):965–971.
  • Hansen PO, Kringelholt S, Simonsen U, Bek T. Hypoxia induced relaxation of porcine retinal arerioles in vitro depends on inducible NO synthase and EP4-receptor stimulation in the perivascular retina. Acta Ophthalmol 2015;93(5):457–463.
  • Riis-Vestergaard MJ, Misfeldt MW, Bek T. Dual effects of adenosine on the tone of porcine retinal arterioles in vitro. Invest Ophthalmol Vis Sci 2014;55(3):1630–1636.
  • Granit R. Physiology of vision. Annu Rev Physiol 1950;12:485–502.
  • Greenberg B, Rhoden K, Barnes PJ. Activated oxygen molecules generated by electrical stimulation affect vascular smooth muscle. J Mol Cell Cardiol 1986;18(9):975–981.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.