218
Views
3
CrossRef citations to date
0
Altmetric
Retina

The Effects of Adjuvant Tamoxifen Use on Macula Pigment Epithelium Optical Density, Visual Acuity and Retinal Thickness in Patients with Breast Cancer

, , , ORCID Icon &
Pages 623-628 | Received 26 Apr 2019, Accepted 25 Oct 2019, Published online: 13 Nov 2019

References

  • Cheung KL. Endocrine therapy for breast cancer: an overview. Breast. 2007;16(4):327–43. doi:10.1016/j.breast.2007.03.004.
  • Cammarata PR, Chu S, Moor A, Wang Z, Yang S-H, Simpkins JW. Subcellular distribution of native estrogen receptor α and β subtypes in cultured human lens epithelial cells. Exp Eye Res. 2004;78:861–71.
  • Suzuki T, Kinoshita Y, Tachibana M, Matsushima Y, Kobayashi Y, Adachi W, Sotozono C, Kinoshita S. Expression of sex steroid hormone receptors in human cornea. Curr Eye Res. 2001;22(1):28–33. doi:10.1076/ceyr.22.1.28.6980.
  • Spelsberg H, Klueppel M, Reinhard T, Glaeser M, Niederacher D, Beckmann MW, Sundmacher R. Detection of Oestrogen receptors (ER) α and β in conjunctiva, lacrimal gland, and tarsal plates. Eye. 2004;18(7):729. doi:10.1038/sj.eye.6701314.
  • Sullivan DA. Tearful relationships? Sex, hormones, the lacrimal gland, and aqueous-deficient dry eye. Ocul Surf. 2004;2(2):92–123. doi:10.1016/S1542-0124(12)70147-7.
  • Auw-Haedrich C, Feltgen N. Estrogen receptor expression in meibomian glands and its correlation with age and dry-eye parameters. Graefes Arch Clin Exp Ophthalmol. 2003;241(9):705–09. doi:10.1007/s00417-003-0699-4.
  • Esmaeli B, Harvey JT, Hewlett B. Immunohistochemical evidence for estrogen receptors in meibomian glands. Ophthalmology. 2000;107(1):180–84. doi:10.1016/S0161-6420(99)00040-8.
  • Munaut C, Lambert V, Noël A, Frankenne F, Deprez M, Foidart J-M, Rakic J-M. Presence of oestrogen receptor type β in human retina. Br J Ophthalmol. 2001;85(7):877–82. doi:10.1136/bjo.85.7.877.
  • Marin-Castano ME, Elliot SJ, Potier M, Karl M, Striker LJ, Striker GE, Csaky KG, Cousins SW. Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2003;44(1):50–59. doi:10.1167/iovs.01-1276.
  • Kaarniranta K, Machalinska A, Vereb Z, Salminen A, Petrovski G, Kauppinen A. Estrogen signalling in the pathogenesis of age-related macular degeneration. Curr Eye Res. 2015;40(2):226–33. doi:10.3109/02713683.2014.925933.
  • Gupta PD, Johar SK, Nagpal K, Vasavada AR. Sex hormone receptors in the human eye. Surv Ophthalmol. 2005;50(3):274–84. doi:10.1016/j.survophthal.2005.02.005.
  • Ogueta SB, Schwartz SD, Yamashita CK, Farber DB. Estrogen receptor in the human eye: influence of gender and age on gene expression. Invest Ophthalmol Vis Sci. 1999;40:1906–11.
  • Garcia‐Segura LM. Aromatase in the brain: not just for reproduction anymore. J Neuroendocrinol. 2008;20:705–12.
  • Hughes ZA, Liu F, Marquis K, Muniz L, Pangalos MN, Ring RH, Whiteside GT, Brandon NJ. Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders. Curr Mol Pharmacol. 2009;2(3):215–36. doi:10.2174/1874467210902030215.
  • Morissette M, Le Saux M, D’Astous M, Jourdain S, Al Sweidi S, Morin N, Estrada-Camarena E, Mendez P, Garcia-Segura LM, Di Paolo T. Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain. J Steroid Biochem Mol Biol. 2008;108(3–5):327–38. doi:10.1016/j.jsbmb.2007.09.011.
  • Smith IE, Dowsett M. Aromatase inhibitors in breast cancer. N Engl J Med. 2003;348(24):2431–42. doi:10.1056/NEJMra023246.
  • Winer EP, Hudis C, Burstein HJ, Wolff AC, Pritchard KI, Ingle JN, Chlebowski RT, Gelber R, Edge SB, Gralow J. American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor–positive breast cancer: status report 2004. J Clin Oncol. 2005;23(3):619–29. doi:10.1200/JCO.2005.09.121.
  • Shelly W, Draper MW, Krishnan V, Wong M, Jaffe RB. Selective estrogen receptor modulators: an update on recent clinical findings. Obstet Gynecol Surv. 2008;63(3):163–81. doi:10.1097/OGX.0b013e31816400d7.
  • Jordan VC, Brodie AMH. Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer. Steroids. 2007;72(1):7– 25. doi:10.1016/j.steroids.2006.10.009.
  • Musa MA, Khan OF, Cooperwood JS. Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs). Curr Med Chem. 2007;14(11):1249–61. doi:10.2174/092986707780598023.
  • Hall JM, Couse JF, Korach KS. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem. 2001;276(40):36869–72. doi:10.1074/jbc.R100029200.
  • Higgins MJ, Stearns V. CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010;12(1):7–15. doi:10.1007/s11912-009-0076-5.
  • Brauch H, Mürdter TE, Eichelbaum M, Schwab M. Pharmacogenomics of tamoxifen therapy. Clin Chem. 2009;55(10):1770–82. doi:10.1373/clinchem.2008.121756.
  • Early Breast Cancer Trialists’ Collaborative G. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;365(9472):1687–717. doi:10.1016/S0140-6736(05)66544-0.
  • Early Breast Cancer Trialists’ Collaborative G. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet. 2011;378(9793):771–84. doi:10.1016/S0140-6736(11)60993-8.
  • Davies C, Pan H, Godwin J, Gray R, Arriagada R, Raina V, Abraham M, Alencar VHM, Badran A, Bonfill X. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 2013;381(9869):805–16. doi:10.1016/S0140-6736(12)61963-1.
  • Junghans A, Sies H, Stahl W. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Arch Biochem Biophys. 2001;391(2):160–64. doi:10.1006/abbi.2001.2411.
  • van de Kraats J, Kanis MJ, Genders SW, van Norren D. Lutein and zeaxanthin measured separately in the living human retina with fundus reflectometry. Invest Ophthalmol Vis Sci. 2008;49(12):5568–73. doi:10.1167/iovs.08-1939.
  • Barker FM, Snodderly DM, Johnson EJ, Schalch W, Koepcke W, Gerss J, Neuringer M. Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n–3 fatty acids on retinal sensitivity to blue-light–induced damage. Invest Ophthalmol Vis Sci. 2011;52(7):3934–42. doi:10.1167/iovs.10-5898.
  • Arteni -A-A, Fradot M, Galzerano D, Mendes-Pinto MM, Sahel J-A, Picaud S, Robert B, Pascal AA. Structure and conformation of the carotenoids in human retinal macular pigment. PLoS One. 2015;10(8):e0135779. doi:10.1371/journal.pone.0135779.
  • Sasaki M, Ozawa Y, Kurihara T, Kubota S, Yuki K, Noda K, Kobayashi S, Ishida S, Tsubota K. Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. Diabetologia. 2010;53(5):971–79. doi:10.1007/s00125-009-1655-6.
  • Li S-Y, Fu Z-J, Ma H, Jang W-C, So K-F, Wong D, Lo ACY. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2009;50(2):836–43. doi:10.1167/iovs.08-2310.
  • Zengin MO, Cinar E, Kucukerdonmez C. The effect of nicotine on choroidal thickness. Br J Ophthalmol. 2014;98(2):233–37. doi:10.1136/bjophthalmol-2013-304044.
  • Creuzot-Garcher C, Koehrer P, Picot C, Aho S, Bron AM. Comparison of two methods to measure macular pigment optical density in healthy subjects. Invest Ophthalmol Vis Sci. 2014;55(5):2941–46. doi:10.1167/iovs.13-13568.
  • Klein BEK, Klein R, Lee KE. Reproductive exposures, incident age-related cataracts, and age-related maculopathy in women: the beaver dam eye study. Am J Ophthalmol. 2000;130(3):322–26. doi:10.1016/S0002-9394(00)00474-8.
  • Vingerling JR, Dielemans I, Witteman JCM, Hofman A, Grobbee DE, De Jong PTVM. Macular degeneration and early menopause: a case-control study. BMJ. 1995;310(6994):1570–71. doi:10.1136/bmj.310.6994.1570.
  • Smith W, Mitchell P, Wang JJ. Gender, oestrogen, hormone replacement and age‐related macular degeneration: results from the Blue Mountains Eye Study. Aust N Z J Ophthalmol. 1997;25(4):13–15. doi:10.1111/ceo.1997.25.issue-4.
  • Klein R, Rowland ML, Harris MI. Racial/ethnic differences in age-related maculopathy: third National Health and Nutrition Examination Survey. Ophthalmology. 1995;102(3):371–81. doi:10.1016/S0161-6420(95)31012-3.
  • Klein R, Klein BEK, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the beaver dam eye study. Ophthalmology. 1997;104(1):7–21. doi:10.1016/S0161-6420(97)30368-6.
  • Age-Related Eye Disease Study Research G. Risk factors associated with age-related macular degeneration: a case-control study in the age-related eye disease study: age-related eye disease study report number 3. Ophthalmology. 2000;107(12):2224–32. doi:10.1016/s0161-6420(00)00409-7.
  • Nayfield SG, Gorin MB. Tamoxifen-associated eye disease. A Review J Clin Oncol. 1996;14(3):1018–26. doi:10.1200/JCO.1996.14.3.1018.
  • Gorin MB, Day R, Costantino JP, Fisher B, Redmond CK, Wickerham L, Gomolin JES, Margolese RG, Mathen MK, Bowman DM. Long-term tamoxifen citrate use and potential ocular toxicity. Am J Ophthalmol. 1998;125(4):493–501. doi:10.1016/S0002-9394(99)80190-1.
  • Chung H, Kim D, Ahn SH, gone KJ, Lee JY, Lim JY, Yoon YH. Early detection of tamoxifen-induced maculopathy in patients with low cumulative doses of tamoxifen. Ophthalmic Surg Lasers Imaging. 2010.
  • Cronin BG, Lekich CK, Bourke RD. Tamoxifen therapy conveys increased risk of developing a macular hole. Int Ophthalmol. 2005;26(3):101–05. doi:10.1007/s10792-005-5424-3.
  • Eisner A, Toomey MD, Falardeau J, Samples JR, Vetto JT. Differential effects of tamoxifen and anastrozole on optic cup size in breast cancer survivors. Breast Cancer Res Treat. 2007;106(2):161–70. doi:10.1007/s10549-006-9486-3.
  • Lim IL, Loo AVP, Subrayan V, Khang TF, See MH, Alip A, Taib NAM. Dosage-dependent reduction of macular pigment optical density in female breast cancer patients receiving tamoxifen adjuvant therapy. Breast. 2018 Jun;39:117–22. Epub 2018 Apr 13. doi:10.1016/j.breast.2018.04.003.
  • Einar Stefansson, editor. Acta Ophthalmologica, Special Issue: Abstracts from the 2014 European Association for Vision and Eye Research Conference.  EVER 2014 – European Association for Vision & Eye Research Annual Meeting; 2014 Oct 1-4; Nice, France. Copenhagen (Denmark): John Wiley & Sons; 2014.
  • Azar G, Quaranta-El Maftouhi M, Masella JJ, Mauget-Faÿsse M. Macular pigment density variation after supplementation of lutein and zeaxanthin using the Visucam® 200 pigment module: impact of age-related macular degeneration and lens status. J Fr Ophtalmol. 2017;40(4):303–13. doi:10.1016/j.jfo.2016.11.009.
  • Chew EY, Clemons T, SanGiovanni JP, Danis R, Domalpally A, McBee W, Sperduto R, Ferris FL, Group AR. The age-related eye disease study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology. 2012;119(11):2282–89. doi:10.1016/j.ophtha.2012.05.027.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.