422
Views
4
CrossRef citations to date
0
Altmetric
Retina

A Meta-Analysis of Cardiovascular Events Associated with Intravitreal Anti-VEGF Treatment in Patients with Retinal Vein Occlusion

ORCID Icon, , , , , , & show all
Pages 615-622 | Received 30 Jul 2019, Accepted 25 Oct 2019, Published online: 07 Nov 2019

References

  • Ehlers JP, Fekrat S. Retinal vein occlusion: beyond the acute event. Surv Ophthalmol. 2011;56:281–99.
  • O’Mahoney PR, Wong DT, Ray JG. Retinal vein occlusion and traditional risk factors for atherosclerosis. Arch Ophthalmol. 2008;126:692–99.
  • Li M, Hu X, Huang J. Impact of retinal vein occlusion on stroke incidence: A meta-analysis. J Am Heart Assoc. 2016;5(12):e004703(12). doi:10.1161/jaha.116.004703.
  • Khan Z, Almeida DR, Rahim K, Belliveau MJ, Bona M, Gale J. 10-year framingham risk in patients with retinal vein occlusion: A systematic review and meta-analysis. Can J Ophthalmol. 2013;48:40–45.e41.
  • Pe’er J, Shweiki D, Itin A, Hemo I, Gnessin H, Keshet E. Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. Lab Invest. 1995;72:638–45.
  • Semeraro F, Morescalchi F, Duse S, Parmeggiani F, Gambicorti E, Costagliola C. Aflibercept in wet amd: specific role and optimal use. Drug Des Devel Ther. 2013;7:711–22.
  • Brechner RJ, Rosenfeld PJ, Babish JD, Caplan S. Pharmacotherapy for neovascular age-related macular degeneration: an analysis of the 100% 2008 medicare fee-for-service part b claims file. Am J Ophthalmol. 2011;151:887–895.e881.
  • Hahn P, Fekrat S. Best practices for treatment of retinal vein occlusion. Curr Opin Ophthalmol. 2012;23:175–81.
  • Rong AJ, Swaminathan SS, Vanner EA, Parrish RK. Predictors of neovascular glaucoma in central retinal vein occlusion. Am J Ophthalmol. 2019. doi:10.1016/j.ajo.2019.02.038.
  • Ruckman J, Green LS, Beeson J, Waugh S, Gillette WL, Henninger DD, Claesson-Welsh L, Janjić N. 2ʹ-fluoropyrimidine rna-based aptamers to the 165-amino acid form of vascular endothelial growth factor (vegf165). Inhibition of receptor binding and vegf-induced vascular permeability through interactions requiring the exon 7-encoded domain. J Biol Chem. 1998;273:20556–67.
  • Marchetti C, Muzii L, Romito A, Benedetti PP. First-line treatment of women with advanced ovarian cancer: focus on bevacizumab. Onco Targets Ther. 2019;12:1095–103.
  • Lee JH, Emelogu I, Kukreja K, Ali FS, Nogueras-Gonzalez G, Lum P, Coronel E, Ross W, Raju GS, Lynch P, et al. Safety and efficacy of metal stents for malignant colonic obstruction in patients treated with bevacizumab. Gastrointest Endosc. 2019. doi:10.1016/j.gie.2019.02.016.
  • Papadopoulos Z. Aflibercept: A review of its effect on the treatment of exudative age-related macular degeneration. Eur J Ophthalmol. 2019. doi:10.1177/1120672119832432.
  • Veritti D, Sarao V, Missiroli F, Ricci F, Lanzetta P. Twelve-month outcomes of intravitreal aflibercept for neovascular age-related macular degeneration: fixed versus as-needed dosing. Retina. 2018. doi:10.1097/IAE.0000000000002299.
  • Stewart MW. Clinical and differential utility of vegf inhibitors in wet age-related macular degeneration: focus on aflibercept. Clin Ophthalmol. 2012. doi:10.2147/opth.s33372.
  • Chen X, Chen Y, Cai X, Zhang D, Fan L, Qiu H, Zhang B, Guo G. Efficacy and safety of bevacizumab in elderly patients with advanced colorectal cancer: A meta-analysis. J Cancer Res Ther. 2017;13:869–77.
  • Zhao T, Wang X, Xu T, Xu X, Liu Z. Bevacizumab significantly increases the risks of hypertension and proteinuria in cancer patients: A systematic review and comprehensive meta-analysis. Oncotarget. 2017;8:51492–506.
  • Shin S, Noh Y. Increased risk of adverse drug events secondary to bevacizumab treatment in patients with advanced or metastatic breast cancer: A meta-analysis of randomized controlled trials. Ther Clin Risk Manag. 2018;14:833–47.
  • Zarbin MA. Anti-vegf agents and the risk of arteriothrombotic events. Asia Pac J Ophthalmol (Phila). 2018;7:63–67.
  • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. PLoS Med. 2009;6(7):e1000097. doi:10.1371/journal.pmed.1000097.
  • Collaborative overview of randomised trials of antiplatelet therapy–i: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet trialists’ collaboration. BMJ (Clinical Research ed). 1994;308(6921):81–106.
  • Clark WL, Boyer DS, Heier JS, Brown DM, Haller JA, Vitti R, Kazmi H, Berliner AJ, Erickson K, Chu KW, et al. Intravitreal aflibercept for macular edema following branch retinal vein occlusion: 52-week results of the vibrant study. Ophthalmology. 2016;123(2):330‐336. doi:10.1016/j.ophtha.2015.09.035.
  • Figueroa MS. New perspectives in the approach to central retinal vein occlusion. Arch Soc Esp Oftalmol. 2015;90(Suppl 1):15–23. doi:10.1016/s0365-6691(15)30005-8.
  • Heier JS, Clark WL, Boyer DS, Brown DM, Vitti R, Berliner AJ, Kazmi H, Ma Y, Stemper B, Zeitz O, et al. Intravitreal aflibercept injection for macular edema due to central retinal vein occlusion: two-year results from the copernicus study. Ophthalmology. 2014;121(7):1414–20. doi:10.1016/j.ophtha.2014.01.027.
  • Korobelnik JF, Holz FG, Roider J, Ogura Y, Simader C, Schmidt-Erfurth U, Lorenz K, Honda M, Vitti R, Berliner AJ, et al. Intravitreal aflibercept injection for macular edema resulting from central retinal vein occlusion: one-year results of the phase 3 galileo study. Ophthalmology. 2014;121(1):202‐208. doi:10.1016/j.ophtha.2013.08.012.
  • Pielen A, Clark WL, Boyer DS, Ogura Y, Holz FG, Korobelnik JF, Stemper B, Asmus F, Rittenhouse KD, Ahlers C. Integrated results from the copernicus and galileo studies. Clin Ophthalmol. 2017;11:1533‐1540. doi:10.2147/OPTH.S140665.
  • Tadayoni R, Waldstein SM, Boscia F, Gerding H, Gekkieva M, Barnes E, Das Gupta A, Wenzel A, Pearce I. Sustained benefits of ranibizumab with or without laser in branch retinal vein occlusion: 24-month results of the brighter study. Ophthalmology. 2017;124(12):1778–87. doi:10.1016/j.ophtha.2017.06.027.
  • Thach AB, Yau L, Hoang C, Tuomi L. Time to clinically significant visual acuity gains after ranibizumab treatment for retinal vein occlusion: bravo and cruise trials. Ophthalmology. 2014;121(5):1059–66. doi:10.1016/j.ophtha.2013.11.022.
  • Boyer D, Heier J, Brown DM, Clark WL, Vitti R, Berliner AJ, Groetzbach G, Zeitz O, Sandbrink R, Zhu X, et al. Vascular endothelial growth factor trap-eye for macular edema secondary to central retinal vein occlusion: six-month results of the phase 3 copernicus study. Ophthalmology. 2012;119(5):1024–32.
  • Kim AS, Johnston SC. Global variation in the relative burden of stroke and ischemic heart disease. Circulation. 2011;124:314–23.
  • Bennett DA. Methodology of the global and regional burden of stroke study. Neuroepidemiology. 2012;38:30–40.
  • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25:581–611.
  • Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, et al. Vegf-b inhibits apoptosis via vegfr-1-mediated suppression of the expression of bh3-only protein genes in mice and rats. J Clin Invest. 2008;118(3):913–23.
  • Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, et al. Vascular endothelial growth factor-b acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation. 2010;122(17):1725–33.
  • Funk M, Karl D, Georgopoulos M, Benesch T, Sacu S, Polak K, Zlabinger GJ, Schmidt-Erfurth U. Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab. Ophthalmology. 2009;116:2393–99.
  • Wong TY, Liew G, Mitchell P. Clinical update: new treatments for age-related macular degeneration. Lancet. 2007;370:204–06.
  • Thulliez M, Angoulvant D, Le Lez ML, Jonville-Bera AP, Pisella PJ, Gueyffier F, Bejan-Angoulvant T. Cardiovascular events and bleeding risk associated with intravitreal antivascular endothelial growth factor monoclonal antibodies: systematic review and meta-analysis. JAMA Ophthalmol. 2014;132:1317–26.
  • Nguyen QD, Shah SM, Hafiz G, Quinlan E, Sung J, Chu K, Cedarbaum JM, Campochiaro PA. A phase i trial of an iv-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology. 2006;113:1522–e1.
  • Dixon JA, Oliver SC, Olson JL, Mandava N. Vegf trap-eye for the treatment of neovascular age-related macular degeneration. Expert Opin Investig Drugs. 2009;18:1573–80.
  • Zhang M, Zhang J, Yan M, Li H, Yang C, Yu D. Recombinant anti-vascular endothelial growth factor fusion protein efficiently suppresses choridal neovasularization in monkeys. Mol Vis. 2008;14:37–49.
  • Zehetner C, Kirchmair R, Huber S, Kralinger MT, Kieselbach GF. Plasma levels of vascular endothelial growth factor before and after intravitreal injection of bevacizumab, ranibizumab and pegaptanib in patients with age-related macular degeneration, and in patients with diabetic macular oedema. Br J Ophthalmol. 2013;97:454–59.
  • Ciombor KK, Berlin J, Chan E. Aflibercept. Clin Cancer Res. 2013;19:1920–25.
  • Louzier V, Raffestin B, Leroux A, Branellec D, Caillaud J, Levame M, Eddahibi S, Adnot S. Role of vegf-b in the lung during development of chronic hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003;284:L926–L937.
  • Berger AR, Cruess AF, Altomare F, Chaudhary V, Colleaux K, Greve M, Kherani A, Mandelcorn ED, Parsons H, Rhéaume MA, et al. Optimal treatment of retinal vein occlusion: canadian expert consensus. Ophthalmologica. 2015;234(1):6–25.
  • Pulido JS, Flaxel CJ, Adelman RA, Hyman L, Folk JC, Olsen TW. Retinal vein occlusions preferred practice pattern((r)) guidelines. Ophthalmology. 2016;123:P182–P208.
  • Sivaprasad S, Amoaku WM, Hykin P. The royal college of ophthalmologists guidelines on retinal vein occlusions: executive summary. Eye. 2016;30:642–642.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.