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Retina

Circulating Leukocyte Alterations and the Development/Progression of Diabetic Retinopathy in Type 1 Diabetic Patients - A Pilot Study

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Pages 1144-1154 | Received 14 Oct 2019, Accepted 10 Jan 2020, Published online: 30 Jan 2020

References

  • Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–36. doi:10.1016/S0140-6736(09)62124-3.
  • Wilkinson C, Ferris FL, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110(9):1677–82. doi:10.1016/S0161-6420(03)00475-5.
  • Tang J, Kern TS. Inflammation in diabetic retinopathy. Prog Retin Eye Res. 2011;30(5):343–58. doi:10.1016/j.preteyeres.2011.05.002.
  • Xu H, Chen M, Forrester JV. Para-inflammation in the aging retina. Prog Retin Eye Res. 2009;28(5):348–68. doi:10.1016/j.preteyeres.2009.06.001.
  • Xu H, Chen M. Diabetic retinopathy and dysregulated innate immunity. Vision Res. 2017;139:39–46. doi:10.1016/j.visres.2017.04.013.
  • Chibber R, Ben-Mahmud BM, Chibber S, Kohner EM. Leukocytes in diabetic retinopathy. Curr Diabetes Rev. 2007;3(1):3–14. doi:10.2174/157339907779802139.
  • Zeng H, Green WR, Tso MO. Microglial activation in human diabetic retinopathy. Arch Ophthalmol. 2008;126(2):227–32. doi:10.1001/archophthalmol.2007.65.
  • Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. The Lancet. 2014;383(9911):69–82. doi:10.1016/S0140-6736(13)60591-7.
  • Huang J, Xiao Y, Xu A, Zhou Z. Neutrophils in type 1 diabetes. J Diabetes Investig. 2016;7(5):652–63. doi:10.1111/jdi.2016.7.issue-5.
  • Harsunen M, Puff R, D’Orlando O, Giannopoulou E, Lachmann L, Beyerlein A, von Meyer A, Ziegler AG. Reduced blood leukocyte and neutrophil numbers in the pathogenesis of type 1 diabetes. Horm Metab Res. 2013;45(06):467–70. doi:10.1055/s-0032-1331226.
  • Orban T, Kis J, Szereday L, Engelmann P, Farkas K, Jalahej H, Andras T. Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus. J Autoimmun. 2007;28(4):177–87. doi:10.1016/j.jaut.2007.01.002.
  • Gross JG, Glassman AR, Liu D, Sun JK, Antoszyk AN, Baker CW, Bressler NM, Elman MJ, Ferris FL, Gardner TW. Five-year outcomes of panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy: a randomized clinical trial. JAMA Ophthalmol. 2018;136(10):1138–48. doi:10.1001/jamaophthalmol.2018.3255.
  • Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556–64. doi:10.2337/dc11-1909.
  • Stitt AW, Lois N, Medina RJ, Adamson P, Curtis TM. Advances in our understanding of diabetic retinopathy. Clin Sci. 2013;125(1):1–17. doi:10.1042/CS20120588.
  • Crane IJ, Liversidge J. Mechanisms of leukocyte migration across the blood–retina barrier. Semin Immunopathol. 2008;30(2):165–77. doi:10.1007/s00281-008-0106-7.
  • Anand-Apte B, Hollyfield JG. Developmental anatomy of the retinal and choroidal vasculature. In: Joseph CB, Dean B, editors. The retina and its disorders. Oxford (UK): Academic Press; 2011. p. 179–85.
  • Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol. 2001;158(1):147–52. doi:10.1016/S0002-9440(10)63952-1.
  • Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, Luscinskas FW, Adamis AP. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci. 2000;41:1153–58.
  • Li Y, Smith D, Li Q, Sheibani N, Huang S, Kern T, Nagaraj RH, Lin F. Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012;53(9):5520–26. doi:10.1167/iovs.12-10010.
  • Zhang L, Li Y, Payne J, Srivastava S, Fan X, Fung J, Li X, Kern TS, Lin F. Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients. Sci Rep. 2016;6:20341. doi:10.1038/srep20341.
  • McCourt M, Wang JH, Sookhai S, Redmond HP. Proinflammatory mediators stimulate neutrophil-directed angiogenesis. Arch Surg. 1999;134(12):1325–31. doi:10.1001/archsurg.134.12.1325.
  • Neagoe PE, Brkovic A, Hajjar F, Sirois MG. Expression and release of angiopoietin-1 from human neutrophils: intracellular mechanisms. Growth Factors. 2009;27(6):335–44. doi:10.3109/08977190903155043.
  • Petrovic MG, Korosec P, Kosnik M, Hawlina M. Vitreous levels of interleukin-8 in patients with proliferative diabetic retinopathy. Am J Ophthalmol. 2007;143(1):175–76. doi:10.1016/j.ajo.2006.07.032.
  • Barliya T, Dardik R, Nisgav Y, Dachbash M, Gaton D, Kenet G, Ehrlich R, Weinberger D, Livnat T. Possible involvement of NETosis in inflammatory processes in the eye: evidence from a small cohort of patients. Mol Vis. 2017;23:922–32.
  • Wang L, Zhou X, Yin Y, Mai Y, Wang D, Zhang X. Hyperglycemia induces neutrophil extracellular traps formation through an NADPH oxidase-dependent pathway in diabetic retinopathy. Front Immunol. 2019;9:3076. doi:10.3389/fimmu.2018.03076.
  • Steinbach F, Henke F, Krause B, Thiele B, Burmester GR, Hiepe F. Monocytes from systemic lupus erythematous patients are severely altered in phenotype and lineage flexibility. Ann Rheum Dis. 2000;59(4):283–88. doi:10.1136/ard.59.4.283.
  • Drewry AM, Ablordeppey EA, Murray ET, Beiter ER, Walton AH, Hall MW, Hotchkiss RS. Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study. Crit Care. 2016;20(1):334. doi:10.1186/s13054-016-1505-0.
  • Nagaishi T, Chen Z, Chen L, Iijima H, Nakajima A, Blumberg R. CEACAM1 and the regulation of mucosal inflammation. Mucosal Immunol. 2008;1:S39–42. doi:10.1038/mi.2008.50.
  • DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN. Carcinoembryonic antigen-related cell adhesion molecule 1. Diabetes. 2008;57(9):2296–303. doi:10.2337/db08-0379.
  • Ludewig P, Flachsbarth K, Wegscheid C, Tiegs G, Richard G, Wagener C, Bartsch U, Horst AK. CEACAM1 confers resistance toward oxygen-induced vessel damage in a mouse model of retinopathy of prematurityrole of CEACAM1 in retinal neovascularization. Invest Ophthalmol Vis Sci. 2014;55(12):7950–60. doi:10.1167/iovs.13-13403.
  • Quarona V, Zaccarello G, Chillemi A, Brunetti E, Singh VK, Ferrero E, Funaro A, Horenstein AL, Malavasi F. CD38 and CD157: a long journey from activation markers to multifunctional molecules. Cytometry B Clin Cytom. 2013;84(4):207–17. doi:10.1002/cyto.b.21092.
  • Itoh M, Ishihara K, Hiroi T, Lee BO, Maeda H, Iijima H, Yanagita M, Kiyono H, Hirano T. Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J Immunol. 1998;161:3974–83.

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