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Extra-Ocular and Sclera

Lacrimal Gland as a Target Organ for Adenovirus Gene Therapy Encoding Erythropoietin for Dry Eye Induced by Benzalkonium Chloride

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Pages 1314-1319 | Received 29 Apr 2020, Accepted 12 Feb 2021, Published online: 30 Mar 2021

References

  • Lemp MA, Wolfley DE. The lacrimal apparatus. In: Hart WM Jr, editor. The lacrimal apparatus. Adler’s physiology of the eye. St. Louis: MosbyYear Book, Inc. (pp. 18–28), 1992. Saint Louis, MO.
  • Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004;78(3):409–16. doi:10.1016/j.exer.2003.09.003.
  • Voutetakis A, Kok MR, Zheng C, Bossis I, Wang J, Cotrim AP, Marracino N, Goldsmith CM, Chiorini JA, Loh YP, et al. Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc Natl Acad Sci U S A. 2004;101(9):3053–58. doi:10.1073/pnas.0400136101.
  • Baum BJ, Alevizos I, Zheng C, Cotrim AP, Liu S, McCullagh L, Goldsmith CM, Burbelo PD, Citrin DE, Mitchell JB, et al. Early responses to adenoviral-mediated transfer of the aquaporin-1 cdna for radiation-induced salivary hypofunction. Proc Natl Acad Sci U S A. 2012;109(47):19403–07. doi:10.1073/pnas.1210662109.
  • Baum BJ, Voutetakis A, Wang J. Salivary glands: novel target sites for gene therapeutics. Trends Mol Med. 2004;10(12):585–90. doi:10.1016/j.molmed.2004.10.003.
  • Zheng C, Cotrim AP, Sunshine AN, Sugito T, Liu L, Sowers A, Mitchell JB, Baum BJ. Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cdna to mouse submandibular glands. Clin Cancer Res. 2009;15(14):4641–48. doi:10.1158/1078-0432.CCR-09-0819.
  • Chang JH, Gabison EE, Kato T, Azar DT. Corneal neovascularization. Curr Opin Ophthalmol. 2001;12(4):242–49. doi:10.1097/00055735-200108000-00002.
  • Maddula S, Davis DK, Maddula S, Burrow MK, Ambati BK. Horizons in therapy for corneal angiogenesis. Ophthalmology. 2011;118(3):591–99. doi:10.1016/j.ophtha.2011.01.041.
  • Marques DL, Alves M, Modulo CM, Silva LECM, Reinach P, Rocha EM. Lacrimal osmolarity and ocular surface in experimental model of dry eye caused by toxicity. Rev Bras Oftalmol. 2015;74(2):68–72. doi:10.5935/0034-7280.20150016.
  • Lin Z, Liu X, Zhou T, Wang Y, Bai L, He H, Liu Z. A mouse dry eye model induced by topical administration of benzalkonium chloride. Mol Vis. 2011;17:257–64.
  • Alves M, Reinach PS, Paula JS, Vellasco E Cruz AA, Bachette L, Faustino J, Aranha FP, Vigorito A, De Souza CA, Rocha EM. Comparison of diagnostic tests in distinct well-defined conditions related to dry eye disease. PLoS One. 2014;9(5):e97921. doi:10.1371/journal.pone.0097921.
  • Baffa Ldo P, Ricardo JR, Dias AC, Modulo CM, Braz AM, De Paula JS, Rodrigues Mde L, Rocha EM. Tear film and ocular surface alterations in chronic users of antiglaucoma medications. Arq Bras Oftalmol. 2008;71(1):18–21. doi:10.1590/S0004-27492008000100004.
  • Baum BJ, Adriaansen J, Cotrim AP, Goldsmith CM, Perez P, Qi S, Rowzee AM, Zheng C. Gene therapy of salivary diseases. Methods Mol Biol. 2010;666:3–20.
  • Perez P, Rowzee AM, Zheng C, Adriaansen J, Baum BJ. Salivary epithelial cells: an unassuming target site for gene therapeutics. Int J Biochem Cell Biol. 2010;42(6):773–77. doi:10.1016/j.biocel.2010.02.012.
  • Arcasoy MO. The non-haematopoietic biological effects of erythropoietin. Br J Haematol. 2008;141(1):14–31. doi:10.1111/j.1365-2141.2008.07014.x.
  • Brines M, Cerami A. Discovering erythropoietin’s extra-hematopoietic functions: biology and clinical promise. Kidney Int. 2006;70(2):246–50. doi:10.1038/sj.ki.5001546.
  • Rocha EM, Cotrim AP, Zheng C, Riveros PP, Baum BJ, Chiorini JA. Recovery of radiation-induced dry eye and corneal damage by pretreatment with adenoviral vector-mediated transfer of erythropoietin to the salivary glands in mice. Hum Gene Ther. 2013;24(4):417–23. doi:10.1089/hum.2012.111.
  • Zheng C, Vitolo JM, Zhang W, Mineshiba F, Chiorini JA, Baum BJ. Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements. Mol Ther. 2008;16(6):1089–97. doi:10.1038/mt.2008.56.
  • Banin E, Obolensky A, Piontek E, Falk H, Pikarsky E, Pe’er J, Panet A, Chowers I. Gene delivery by viral vectors in primary cultures of lacrimal gland tissue. Invest Ophthalmol Vis Sci. 2003;44(4):1529–33. doi:10.1167/iovs.02-0529.
  • Hodges RR, Raddassi I, Zoukhri D, Toker A, Kazlauskas A, Dartt DA. Effect of overexpression of constitutively active pkcalpha on rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci. 2004;45(11):3974–81. doi:10.1167/iovs.04-0508.
  • Trousdale MD, Zhu Z, Stevenson D, Schechter JE, Ritter T, Mircheff AK. Expression of tnf inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. J Autoimmune Dis. 2005;2:6–12. doi:10.1186/1740-2557-2-6.
  • Zhu Z, Stevenson D, Ritter T, Schechter JE, Mircheff AK, Kaslow HR, Trousdale MD. Expression of il-10 and tnf-inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes. Cornea. 2002;21(2):210–14. doi:10.1097/00003226-200203000-00018.
  • Loeliger MM, Mackintosh A, De Matteo R, Harding R, Rees SM. Erythropoietin protects the developing retina in an ovine model of endotoxin-induced retinal injury. Invest Ophthalmol Vis Sci. 2011;52(5):2656–61. doi:10.1167/iovs.10-6455.
  • Kase S, Osaki M, Jin XH, Ohgami K, Yoshida K, Saito W, Takahashi S, Nakanishi K, Ito H, Ohno S. Increased expression of erythropoietin receptor in human pterygial tissues. Int J Mol Med. 2007;20:699–702.
  • Nominato LF, Dias AC, Dias LC, Fantucci MZ, Mendes Da Silva LEC, Murashima AA, Rocha EM. Prevention of corneal neovascularization by adenovirus encoding human vascular endothelial growth factor soluble receptor (s-vegfr1) in lacrimal gland. Invest Ophthalmol Vis Sci. 2018;59(15):6036–44. doi:10.1167/iovs.17-22322.
  • Sullivan DA, Rocha EM, Aragona P, Clayton JA, Ding J, Golebiowski B, Hampel U, McDermott AM, Schaumberg DA, Srinivasan S, et al. Tfos dews ii sex, gender, and hormones report. Ocul Surf. 2017;15(3):284–333.

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