Younger Age and Albuminuria are Associated with Proliferative Diabetic Retinopathy and Diabetic Macular Edema in the South Indian GeNetics of DiAbeTic Retinopathy (SIGNATR) Study

References

• Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, IDF Diabetes Atlas Committee, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9. Diabetes Res Clin Pract. 2019;157:107843. doi:10.1016/j.diabres.2019.107843.
   PubMed Web of Science ®Google Scholar
• Sinclair A, Saeedi P, Kaundal A, Karuranga S, Malanda B, Williams R. Diabetes and global ageing among 65–99-year-old adults: findings from the International Diabetes Federation Diabetes Atlas, 9. Diabetes Res Clin Pract. 2020;162:108078. doi:10.1016/j.diabres.2020.108078.
   PubMed Web of Science ®Google Scholar
• Darivemula S, Nagoor K, Patan SK, Reddy NB, Deepthi CS, Chittooru CS. Prevalence and its associated determinants of diabetic peripheral neuropathy (DPN) in individuals having type-2 diabetes mellitus in rural South India. Indian J Community Med. 2019;44(2):88–91. doi:10.4103/ijcm.IJCM_207_18.
   PubMed Web of Science ®Google Scholar
• Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, Meta-Analysis for Eye Disease (META-EYE) Study Group, et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556–564. doi:10.2337/dc11-1909.
   PubMed Web of Science ®Google Scholar
• Ramachandran A, Mary S, Yamuna A, Murugesan N, Snehalatha C. High prevalence of diabetes and cardiovascular risk factors associated with urbanization in India. Diabetes Care. 2008;31(5):893–898. doi:10.2337/dc07-1207.
   PubMed Web of Science ®Google Scholar
• Ramachandran A, Snehalatha C. Current scenario of diabetes in India. J Diabetes. 2009;1(1):18–28. doi:10.1111/j.1753-0407.2008.00004.x.
   PubMed Web of Science ®Google Scholar
• Agarwal S, Raman R, Paul PG, Rani PK, Uthra S, Gayathree R, McCarty C, Kumaramanickavel G, Sharma T. Sankara Nethralaya-Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS 1): study design and research methodology. Ophthalmic Epidemiol. 2005;12(2):143–153. doi:10.1080/09286580590932734.
   PubMed Web of Science ®Google Scholar
• Namperumalsamy P, Kim R, Vignesh TP, Nithya N, Royes J, Gijo T, Thulasiraj RD, Vijayakumar V. Prevalence and risk factors for diabetic retinopathy: a population-based assessment from Theni District, south India. Br J Ophthalmol. 2009;93(4):429–434. doi:10.1136/bjo.2008.147934.
   PubMed Web of Science ®Google Scholar
• Raman R, Ganesan S, Pal SS, Gella L, Kulothungan V, Sharma T. Incidence and progression of diabetic retinopathy in urban India: Sankara Nethralaya-Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS II), report 1. Ophthalmic Epidemiol. 2017;24(5):294–302. doi:10.1080/09286586.2017.1290257.
   PubMed Web of Science ®Google Scholar
• Raman R, Ganesan S, Pal SS, Kulothungan V, Sharma T. Prevalence and risk factors for diabetic retinopathy in rural India. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study III (SN-DREAMS III), report no 2. BMJ Open Diabetes Res Care. 2014;2(1):e000005. doi:10.1136/bmjdrc-2013-000005.
   PubMedGoogle Scholar
• Raman R, Vaitheeswaran K, Vinita K, Sharma T. Is prevalence of retinopathy related to the age of onset of diabetes? Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Report No. 5. Ophthalmic Res. 2011;45(1):36–41. doi:10.1159/000314720.
   PubMed Web of Science ®Google Scholar
• Rani PK, Raman R, Gupta A, Pal SS, Kulothungan V, Sharma T. Albuminuria and diabetic retinopathy in type 2 diabetes mellitus Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetic Study (SN-DREAMS, report 12). Diabetol Metab Syndr. 2011;3(1):9. doi:10.1186/1758-5996-3-9.
   PubMed Web of Science ®Google Scholar
• Rema M, Premkumar S, Anitha B, Deepa R, Pradeepa R, Mohan V. Prevalence of diabetic retinopathy in urban India: the Chennai Urban Rural Epidemiology Study (CURES) eye study, I. Invest Ophthalmol Vis Sci. 2005;46(7):2328–2333. doi:10.1167/iovs.05-0019.
   PubMed Web of Science ®Google Scholar
• ECotDaCoD M. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26:S5–S20. doi:10.2337/diacare.26.2007.s5.
   PubMed Web of Science ®Google Scholar
• Wilkinson CP, Ferris FL, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT, Global Diabetic Retinopathy Project Group Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110(9):1677–1682. doi:10.1016/S0161-6420(03)00475-5.
   PubMed Web of Science ®Google Scholar
• McHugh M. Interrater reliability: the kappa statistic. Biochem Med. 2012;22(3):276–282. doi:10.11613/BM.2012.031.
   PubMed Web of Science ®Google Scholar
• Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs–an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991;98(5 Suppl):786–806.
   PubMed Web of Science ®Google Scholar
• Wells JA, Glassman AR, Ayala AR, Jampol LM, Aiello LP, Antoszyk AN, Arnold-Bush B, Baker CW, Bressler NM, Browning DJ. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. New England J Med. 2015;372(13):1193–1203. doi:10.1056/NEJMoa1414264.
   PubMed Web of Science ®Google Scholar
• Piko P, Werissa N, Fiatal S, Sandor J, Adany R. Impact of genetic factors on the age of onset for type 2 diabetes mellitus in addition to the conventional risk factors. JPM. 2020;11(1):6. doi:10.3390/jpm11010006.
   Web of Science ®Google Scholar
• Gujral UP, Pradeepa R, Weber MB, Venkat Narayan KM, Mohan V. Type 2 diabetes in South Asians: similarities and differences with white Caucasian and other populations. Ann N Y Acad Sci. 2013;1281(1):51–63. doi:10.1111/j.1749-6632.2012.06838.x.
   PubMed Web of Science ®Google Scholar
• Qiao Q, Hu G, Tuomilehto J, Nakagami T, Balkau B, Borch-Johnsen K, Ramachandran A, Mohan V, Iyer SR, Tominaga M, DECODA Study Group, et al. Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care. 2003;26(6):1770–1780. doi:10.2337/diacare.26.6.1770.
   PubMed Web of Science ®Google Scholar
• Ramachandran A, Snehalatha C, Kapur A, Vijay V, Mohan V, Das AK, Rao PV, Yajnik CS, Prasanna Kumar KM, Nair JD. High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetologia. 2001;44(9):1094–1101. doi:10.1007/s001250100627.
   PubMed Web of Science ®Google Scholar
• Penman A, Hancock H, Papavasileiou E, James M, Idowu O, Riche DM, Fernandez M, Brauner S, Smith SO, Hoadley S, et al. Risk factors for proliferative diabetic retinopathy in African Americans with type 2 diabetes. Ophthalmic Epidemiol. 2016;23(2):88–93. doi:10.3109/09286586.2015.1119287.
   PubMed Web of Science ®Google Scholar
• Liu E, Kaidonis G, Gillies MC, Abhary S, Essex RW, Chang JH, Pal B, Daniell M, Lake S, Gilhotra J, et al. Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample. Sci Rep. 2019;9(1):612. doi:10.1038/s41598-018-37388-8.
   PubMed Web of Science ®Google Scholar
• Ng KKK, Cheung CYY, Lee C-H, Fong CHY, Kwok KHM, Li KKW, Gangwani RA, Wong IYH, Woo Y-C, Chow W-S, et al. Possible modifying effect of hemoglobin A1c on genetic susceptibility to severe diabetic retinopathy in patients with type 2 diabetes. Invest Ophthalmol Vis Sci. 2020;61(10):7. doi:10.1167/iovs.61.10.7.
   PubMed Web of Science ®Google Scholar
• Nittala MG, Keane PA, Zhang K, Sadda S. Risk factors for proliferative diabetic retinopathy in a Latino American population. Retina. 2014;34(8):1594–1599. doi:10.1097/IAE.0000000000000117.
   PubMed Web of Science ®Google Scholar
• Raman R, Gupta A, Pal SS, Ganesan S, Venkatesh K, Kulothungan V, Sharma T. Prevalence of metabolic syndrome and its influence on microvascular complications in the Indian population with type 2 diabetes mellitus. Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetic Study (SN-DREAMS, report 14). Diabetol Metab Syndr. 2010;2(1):67. doi:10.1186/1758-5996-2-67.
   PubMed Web of Science ®Google Scholar
• Ozawa GY, Bearse MA, Jr, Adams AJ. Male-female differences in diabetic retinopathy? Curr Eye Res. 2015;40(2):234–246. doi:10.3109/02713683.2014.958500.
   PubMed Web of Science ®Google Scholar
• Lee WJ, Sobrin L, Lee MJ, Kang MH, Seong M, Cho H. The relationship between diabetic retinopathy and diabetic nephropathy in a population-based study in Korea (KNHANES V-2, 3). Invest Ophthalmol Vis Sci. 2014;55(10):6547–6553. doi:10.1167/iovs.14-15001.
   PubMed Web of Science ®Google Scholar
• Hsieh Y, Tsai M, Tu S, Hsieh M. Association of abnormal renal profiles and proliferative diabetic retinopathy and diabetic macular edema in an Asian population with type 2 diabetes. JAMA Ophthalmol. 2018;136(1):68–74. doi:10.1001/jamaophthalmol.2017.5202.
   PubMed Web of Science ®Google Scholar
• Brown JC, Solomon SD, Bressler SB, Schachat AP, DiBernardo C, Bressler NM. Detection of diabetic foveal edema: contact lens biomicroscopy compared with optical coherence tomography. Arch Ophthalmol. 2004;122(3):330–335. doi:10.1001/archopht.122.3.330.
   PubMedGoogle Scholar
• Wang YT, Tadarati M, Wolfson Y, Bressler SB, Bressler NM. Comparison of prevalence of diabetic macular edema based on monocular fundus photography vs optical coherence tomography. JAMA Ophthalmol. 2016;134(2):222–228. doi:10.1001/jamaophthalmol.2015.5332.
   PubMed Web of Science ®Google Scholar