Temporal Change in Pro-Inflammatory Cytokine Expression from Immortalized Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

References

• Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo C-K, Liu Z, Nelson JD, Nichols JJ, Tsubota K, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017;15(3):276–283. doi:10.1016/j.jtos.2017.05.008.
   PubMed Web of Science ®Google Scholar
• Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, Na K-S, Schaumberg D, Uchino M, Vehof J, et al. TFOS DEWS II epidemiology report. Ocul Surf. 2017;15(3):334–365. doi:10.1016/j.jtos.2017.05.003.
   PubMed Web of Science ®Google Scholar
• Yu J, Asche CV, Fairchild CJ. The economic burden of dry eye disease in the United States: a decision tree analysis. Cornea. 2011;30(4):379–387. doi:10.1097/ICO.0b013e3181f7f363.
   PubMed Web of Science ®Google Scholar
• Yang W, Luo Y, Wu S, Niu X, Yan Y, Qiao C, Ming W, Zhang Y, Wang H, Chen D, et al. Estimated annual economic burden of dry eye disease based on a multi-center analysis in china: a retrospective study. Front Med. 2021;8:771352.
   Web of Science ®Google Scholar
• Chan C, Ziai S, Myageri V, Burns JG, Prokopich CL. Economic burden and loss of quality of life from dry eye disease in Canada. BMJ Open Ophthalmol. 2021;6(1):e000709. doi:10.1136/bmjophth-2021-000709.
   PubMed Web of Science ®Google Scholar
• Uchino M, Schaumberg DA. Dry eye disease: impact on quality of life and vision. Curr Ophthalmol Rep. 2013;1(2):51–57. doi:10.1007/s40135-013-0009-1.
   PubMedGoogle Scholar
• Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, Knop E, Markoulli M, Ogawa Y, Perez V, et al. TFOS DEWS II pathophysiology report. Ocul Surf. 2017;15(3):438–510. doi:10.1016/j.jtos.2017.05.011.
   PubMed Web of Science ®Google Scholar
• Sullivan BD, Whitmer D, Nichols KK, Tomlinson A, Foulks GN, Geerling G, Pepose JS, Kosheleff V, Porreco A, Lemp MA. An objective approach to dry eye disease severity. Invest Ophthalmol Vis Sci. 2010;51(12):6125–6130. doi:10.1167/iovs.10-5390.
   PubMed Web of Science ®Google Scholar
• Liu H, Begley C, Chen M, Bradley A, Bonanno J, McNamara NA, Nelson JD, Simpson T. A link between tear instability and hyperosmolarity in dry eye. Invest Ophthalmol Vis Sci. 2009;50(8):3671–3679. doi:10.1167/iovs.08-2689.
   PubMed Web of Science ®Google Scholar
• Baudouin C, Aragona P, Messmer EM, Tomlinson A, Calonge M, Boboridis KG, Akova YA, Geerling G, Labetoulle M, Rolando M. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the ocean group meeting. Ocul Surf. 2013;11(4):246–258. doi:10.1016/j.jtos.2013.07.003.
   PubMed Web of Science ®Google Scholar
• Luo L, Li D-Q, Corrales RM, Pflugfelder SC. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 2005;31(5):186–193. doi:10.1097/01.icl.0000162759.79740.46.
   PubMedGoogle Scholar
• Li D-Q, Luo L, Chen Z, Kim H-S, Song XJ, Pflugfelder SC. JNK and ERK map kinases mediate induction of IL-1β, TNF-α and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006;82(4):588–596. doi:10.1016/j.exer.2005.08.019.
   PubMed Web of Science ®Google Scholar
• Li D-Q, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45(12):4302–4311. doi:10.1167/iovs.04-0299.
   PubMed Web of Science ®Google Scholar
• Deng R, Hua X, Li J, Chi W, Zhang Z, Lu F, Zhang L, Pflugfelder SC, Li D-Q. Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells. PLoS One. 2015;10(5):e0126561. doi:10.1371/journal.pone.0126561.
   PubMed Web of Science ®Google Scholar
• Roda M, Corazza I, Bacchi Reggiani ML, Pellegrini M, Taroni L, Giannaccare G, Versura P. Dry eye disease and tear cytokine levels—a meta-analysis. Int J Mol Sci. 2020;21(9):3111. doi:10.3390/ijms21093111.
   PubMed Web of Science ®Google Scholar
• Li JM, Lu R, Zhang Y, Lin J, Hua X, Pflugfelder SC, Li DQ. IL-36alpha/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress. Ocul Surf. 2021;22:163–171. doi:10.1016/j.jtos.2021.08.012.
   PubMed Web of Science ®Google Scholar
• Lopez-Cano JJ, Gonzalez-Cela-Casamayor MA, Andres-Guerrero V, Herrero-Vanrell R, Benitez-Del-Castillo JM, Molina MI. Combined hyperosmolarity and inflammatory conditions in stressed human corneal epithelial cells and macrophages to evaluate osmoprotective agents as potential DED treatments. Exp Eye Res. 2021;211:108723. doi:10.1016/j.exer.2021.108723.
   PubMed Web of Science ®Google Scholar
• Liu Z, Chen D, Chen X, Bian F, Qin W, Gao N, Xiao Y, Li J, Pflugfelder SC, Li DQ. Trehalose induces autophagy against inflammation by activating TFEB signaling pathway in human corneal epithelial cells exposed to hyperosmotic stress. Invest Ophthalmol Vis Sci. 2020;61(10):26. doi:10.1167/iovs.61.10.26.
   PubMed Web of Science ®Google Scholar
• Zibandeh N, Yıldız E, Özer B, Taş AY, Sahin A. Androgen suppresses hyperosmolarity-induced inflammatory mediators in human corneal epithelial cells. Cornea. 2020;39(7):886–891. doi:10.1097/ICO.0000000000002291.
   PubMed Web of Science ®Google Scholar
• Kim YH, Oh TW, Park E, Yim NH, Park KI, Cho WK, Ma JY. Anti-inflammatory and anti-apoptotic effects of Acer palmatum Thumb. extract, KIOM-2015EW, in a hyperosmolar-stress-induced in vitro dry eye model. Nutrients. 2018;10(3):282. doi:10.3390/nu10030282.
   PubMed Web of Science ®Google Scholar
• Hua X, Su Z, Deng R, Lin J, Li DQ, Pflugfelder SC. Effects of l-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress. Curr Eye Res. 2015;40(7):657–667. doi:10.3109/02713683.2014.957776.
   PubMed Web of Science ®Google Scholar
• Igarashi T, Fujimoto C, Suzuki H, Ono M, Iijima O, Takahashi H, Takahashi H. Short-time exposure of hyperosmolarity triggers interleukin-6 expression in corneal epithelial cells. Cornea. 2014;33(12):1342–1347. doi:10.1097/ICO.0000000000000256.
   PubMed Web of Science ®Google Scholar
• Khandekar N, Willcox MD, Shih S, Simmons P, Vehige J, Garrett Q. Decrease in hyperosmotic stress-induced corneal epithelial cell apoptosis by L-carnitine. Mol Vis. 2013;19:1945–1956.
   PubMed Web of Science ®Google Scholar
• Cavet ME, Harrington KL, Ward KW, Zhang J-Z. Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells. Mol Vis. 2010;16:1791–1800.
   PubMed Web of Science ®Google Scholar
• Chen M, Hu DN, Pan Z, Lu CW, Xue CY, Aass I. Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways. Exp Eye Res. 2010;90(3):437–443. doi:10.1016/j.exer.2009.12.004.
   PubMed Web of Science ®Google Scholar
• Griffith M, Osborne R, Munger R, Xiong X, Doillon CJ, Laycock NL, Hakim M, Song Y, Watsky MA. Functional human corneal equivalents constructed from cell lines. Science. 1999;286(5447):2169–2172. doi:10.1126/science.286.5447.2169.
   PubMed Web of Science ®Google Scholar
• Garrett Q, Khandekar N, Shih S, Flanagan JL, Simmons P, Vehige J, Willcox MD. Betaine stabilizes cell volume and protects against apoptosis in human corneal epithelial cells under hyperosmotic stress. Exp Eye Res. 2013;108:33–41. doi:10.1016/j.exer.2012.12.001.
   PubMed Web of Science ®Google Scholar
• Wang C, Shi X, Chen X, Wu H, Zhang H, Xie J, Yang X, Gou Z, Ye J. 17-Beta-estradiol inhibits hyperosmolarity-induced proinflammatory cytokine elevation via the p38 MAPK pathway in human corneal epithelial cells. Mol Vis. 2012;18:1115–1122.
   PubMed Web of Science ®Google Scholar
• Cavet ME, Harrington KL, Vollmer TR, Ward KW, Zhang JZ. Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells. Mol Vis. 2011;17:533–542.
   PubMed Web of Science ®Google Scholar
• Wang L, Dai W, Lu L. Hyperosmotic stress-induced corneal epithelial cell death through activation of Polo-like kinase 3 and c-Jun. Invest Ophthalmol Vis Sci. 2011;52(6):3200–3206. doi:10.1167/iovs.10-6485.
   PubMed Web of Science ®Google Scholar
• Bao K, Reinhardt RL. The differential expression of IL-4 and IL-13 and its impact on type-2 immunity. Cytokine. 2015;75(1):25–37. doi:10.1016/j.cyto.2015.05.008.
   PubMed Web of Science ®Google Scholar
• De Paiva CS, Raince JK, McClellan AJ, Shanmugam KP, Pangelinan SB, Volpe EA, Corrales RM, Farley WJ, Corry DB, Li D-Q, et al. Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. Mucosal Immunol. 2011;4(4):397–408. doi:10.1038/mi.2010.82.
   PubMed Web of Science ®Google Scholar
• Jun I, Kim BR, Park SY, Lee H, Kim J, Kim EK, Seo KY, Kim TI. Interleukin-4 stimulates lipogenesis in meibocytes by activating the STAT6/PPARgamma signaling pathway. Ocul Surf. 2020;18(4):575–582. doi:10.1016/j.jtos.2020.04.015.
   PubMed Web of Science ®Google Scholar
• Tait Wojno ED, Hunter CA, Stumhofer JS. The immunobiology of the interleukin-12 family: room for discovery. Immunity. 2019;50(4):851–870. doi:10.1016/j.immuni.2019.03.011.
   PubMed Web of Science ®Google Scholar
• Shivakumar S, Panigrahi T, Shetty R, Subramani M, Ghosh A, Jeyabalan N. Chloroquine protects human corneal epithelial cells from desiccation stress induced inflammation without altering the autophagy flux. Biomed Res Int. 2018;2018:7627329. doi:10.1155/2018/7627329.
   PubMed Web of Science ®Google Scholar
• Lyu N, Zhang J, Dai Y, Xiang J, Li Y, Xu J. Calcitriol inhibits apoptosis via activation of autophagy in hyperosmotic stress stimulated corneal epithelial cells in vivo and in vitro. Exp Eye Res. 2020;200:108210. doi:10.1016/j.exer.2020.108210.
   PubMed Web of Science ®Google Scholar
• Gilbard JP, Farris RL, Santamaria J 2nd. Osmolarity of tear microvolumes in keratoconjunctivitis sicca. Arch Ophthalmol. 1978;96(4):677–681. doi:10.1001/archopht.1978.03910050373015.
   PubMedGoogle Scholar
• Greco D, Vellonen KS, Turner HC, Hakli M, Tervo T, Auvinen P, Wolosin JM, Urtti A. Gene expression analysis in SV-40 immortalized human corneal epithelial cells cultured with an air-liquid interface. Mol Vis. 2010;16:2109–2120.
   PubMed Web of Science ®Google Scholar
• Yamasaki K, Kawasaki S, Young RD, Fukuoka H, Tanioka H, Nakatsukasa M, Quantock AJ, Kinoshita S. Genomic aberrations and cellular heterogeneity in SV40-immortalized human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2009;50(2):604–613. doi:10.1167/iovs.08-2239.
   PubMed Web of Science ®Google Scholar
• Li J, Yang K, Pan X, Peng H, Hou C, Xiao J, Wang Q. Long noncoding RNA MIAT regulates hyperosmotic stress-induced corneal epithelial cell injury via inhibiting the caspase-1-dependent pyroptosis and apoptosis in dry eye disease. J Inflamm Res. 2022;15:3269–3283. doi:10.2147/JIR.S361541.
   PubMed Web of Science ®Google Scholar
• Zhang J, Dai Y, Yang Y, Xu J. Calcitriol alleviates hyperosmotic stress-induced corneal epithelial cell damage via inhibiting the NLRP3-ASC-caspase-1-GSDMD pyroptosis pathway in dry eye disease. J Inflamm Res. 2021;14:2955–2962. doi:10.2147/JIR.S310116.
   PubMed Web of Science ®Google Scholar
• Ren Y, Lu H, Reinach PS, Zheng Q, Li J, Tan Q, Zhu H, Chen W. Hyperosmolarity-induced AQP5 upregulation promotes inflammation and cell death via JNK1/2 activation in human corneal epithelial cells. Sci Rep. 2017;7(1):4727. doi:10.1038/s41598-017-05145-y.
   PubMed Web of Science ®Google Scholar