HNF4A Negatively Regulated Posterior Capsular Opacification via Transcriptional Inhibition of MMP2

References

• Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S. Age-related cataract. Lancet. 2005;365(9459):599–609. doi:10.1016/S0140-6736(05)17911-2.
   PubMed Web of Science ®Google Scholar
• Schaumberg DA, Dana MR, Christen WG, Glynn RJ. A systematic overview of the incidence of posterior capsule opacification. Ophthalmology. 1998;105(7):1213–1221. doi:10.1016/S0161-6420(98)97023-3.
   PubMed Web of Science ®Google Scholar
• Wormstone IM, Wang L, Liu CS. Posterior capsule opacification. Exp Eye Res. 2009;88(2):257–269.
   PubMed Web of Science ®Google Scholar
• Wormstone IM, Wormstone YM, Smith AJO, Eldred JA. Posterior capsule opacification: what’s in the bag? Prog Retin Eye Res. 2021;82:100905. doi:10.1016/j.preteyeres.2020.100905.
   PubMed Web of Science ®Google Scholar
• Konopinska J, Mlynarczyk M, Dmuchowska DA, Obuchowska I. Posterior capsule opacification: a review of experimental studies. J Clin Med. 2021;10(13):2847. doi: 10.3390/jcm10132847.
   Web of Science ®Google Scholar
• Marcantonio JM, Vrensen GF. Cell biology of posterior capsular opacification. Eye. 1999;13 (3):484–488. doi:10.1038/eye.1999.126.
   PubMed Web of Science ®Google Scholar
• Novotny GE, Pau H. Myofibroblast-like cells in human anterior capsular cataract. Virchows Arch A Pathol Anat Histopathol. 1984;404(4):393–401.
   PubMedGoogle Scholar
• Lovicu FJ, Ang S, Chorazyczewska M, McAvoy JW. Deregulation of lens epithelial cell proliferation and differentiation during the development of TGFbeta-induced anterior subcapsular cataract. Dev Neurosci. 2004;26(5-6):446–455. doi:10.1159/000082286.
   PubMed Web of Science ®Google Scholar
• Li JH, Wang NL, Wang JJ. Expression of matrix metalloproteinases of human lens epithelial cells in the cultured lens capsule bag. Eye. 2008;22(3):439–444. doi:10.1038/sj.eye.6702735.
   PubMed Web of Science ®Google Scholar
• Wong TT, Daniels JT, Crowston JG, Khaw PT. MMP inhibition prevents human lens epithelial cell migration and contraction of the lens capsule. Br J Ophthalmol. 2004;88(7):868–872. doi:10.1136/bjo.2003.034629.
   PubMed Web of Science ®Google Scholar
• Eldred JA, Hodgkinson LM, Dawes LJ, Reddan JR, Edwards DR, Wormstone IM. MMP2 activity is critical for TGFbeta2-induced matrix contraction–implications for fibrosis. Invest Ophthalmol Vis Sci. 2012;53(7):4085–4098.
   PubMed Web of Science ®Google Scholar
• Awasthi N, Wang-Su ST, Wagner BJ. Downregulation of MMP-2 and -9 by proteasome inhibition: a possible mechanism to decrease LEC migration and prevent posterior capsular opacification. Invest Ophthalmol Vis Sci. 2008;49(5):1998–2003. doi:10.1167/iovs.07-0624.
   PubMed Web of Science ®Google Scholar
• Pittayapruek P, Meephansan J, Prapapan O, Komine M, Ohtsuki M. Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci. 2016;17(6):868. doi:10.3390/ijms17060868.
   PubMed Web of Science ®Google Scholar
• Wang X, Yang B, She Y, Ye Y. The lncRNA TP73-AS1 promotes ovarian cancer cell proliferation and metastasis via modulation of MMP2 and MMP9. J Cell Biochem. 2018;119(9):7790–7799. doi:10.1002/jcb.27158.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Yan L, Zhu W, Song X, Yang G, Wang S. MMP2/3 promote the growth and migration of laryngeal squamous cell carcinoma via PI3K/Akt-NF-kappaB-mediated epithelial-mesenchymal transformation. J Cell Physiol. 2019;234(9):15847–15855. doi:10.1002/jcp.28242.
   PubMed Web of Science ®Google Scholar
• Wang X, Chang X, He C, Fan Z, Yu Z, Yu B, Wu X, Hou J, Li J, Su L, et al. ATP5B promotes the metastasis and growth of gastric cancer by activating the FAK/AKT/MMP2 pathway. FASEB J. 2021;35(4):e20649.
   PubMed Web of Science ®Google Scholar
• Dong W, Li H, Zhang Y, Yang H, Guo M, Li L, Liu T. Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer. ABBS. 2011;43(11):840–848. doi:10.1093/abbs/gmr085.
   Web of Science ®Google Scholar
• Sladek FM, Zhong WM, Lai E, Darnell JE. Jr. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 1990;4(12b):2353–2365. doi:10.1101/gad.4.12b.2353.
   PubMed Web of Science ®Google Scholar
• Mai H, Liao Y, Luo S, Wei K, Yang F, Shi H. Histone deacetylase HDAC2 silencing prevents endometriosis by activating the HNF4A/ARID1A axis. J Cell Mol Med. 2021;25(21):9972–9982. doi:10.1111/jcmm.16835.
   PubMed Web of Science ®Google Scholar
• Li P, Wang L, Li P, Hu F, Cao Y, Tang D, Ye G, Li H, Wang D. Silencing of long non-coding RNA XIST represses gastric cancer progression through blocking NFkappaB pathway via inhibiting HNF4A-mediated transcription of EPHA1. Cancer Gene Ther. 2021;28(3-4):307–320. doi:10.1038/s41417-020-00220-5.
   PubMed Web of Science ®Google Scholar
• Elhodaky M, Hong LK, Kadkol S, Diamond AM. Selenium-binding protein 1 alters energy metabolism in prostate cancer cells. Prostate. 2020;80(12):962–976. doi:10.1002/pros.24028.
   PubMed Web of Science ®Google Scholar
• Santangelo L, Marchetti A, Cicchini C, Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T, Amicone L, et al. The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4alpha. Hepatology. 2011;53(6):2063–2074. doi:10.1002/hep.24280.
   PubMed Web of Science ®Google Scholar
• Walesky C, Gunewardena S, Terwilliger EF, Edwards G, Borude P, Apte U. Hepatocyte-specific deletion of hepatocyte nuclear factor-4alpha in adult mice results in increased hepatocyte proliferation. Am J Physiol Gastrointest Liver Physiol. 2013;304(1):G26–G37.
   PubMed Web of Science ®Google Scholar
• Chang HR, Nam S, Kook MC, Kim KT, Liu X, Yao H, Jung HR, Lemos R Jr, Seo HH, Park HS, et al. HNF4alpha is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. Gut. 2016;65(1):19–32. doi:10.1136/gutjnl-2014-307918.
   PubMed Web of Science ®Google Scholar
• Li Z, Chen H. miR-34a inhibits proliferation, migration and invasion of paediatric neuroblastoma cells via targeting HNF4alpha. Artif Cells Nanomed Biotechnol. 2019;47(1):3072–3078. doi:10.1080/21691401.2019.1637886.
   PubMed Web of Science ®Google Scholar
• Lv DD, Zhou LY, Tang H. Hepatocyte nuclear factor 4alpha and cancer-related cell signaling pathways: a promising insight into cancer treatment. Exp Mol Med. 2021;53(1):8–18. doi:10.1038/s12276-020-00551-1.
   PubMed Web of Science ®Google Scholar
• Song H, Li D, Wang X, Fang E, Yang F, Hu A, Wang J, Guo Y, Liu Y, Li H, et al. HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression. J Hematol Oncol. 2020;13(1):24. doi:10.1186/s13045-020-00857-7.
   PubMed Web of Science ®Google Scholar
• Xiang X, Zhao X, Qu H, Li D, Yang D, Pu J, Mei H, Zhao J, Huang K, Zheng L, et al. Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. Cancer Lett. 2015;359(2):187–197. doi:10.1016/j.canlet.2015.01.008.
   PubMed Web of Science ®Google Scholar
• West-Mays JA, Pino G, Lovicu FJ. Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis. Prog Retin Eye Res. 2010;29(2):135–143. doi:10.1016/j.preteyeres.2009.12.001.
   PubMed Web of Science ®Google Scholar
• Wormstone IM, Eldred JA. Experimental models for posterior capsule opacification research. Exp Eye Res. 2016;142:2–12. doi:10.1016/j.exer.2015.04.021.
   PubMed Web of Science ®Google Scholar
• Qi T, Jing R, Ma B, Hu C, Wen C, Shao Y, Pei C. The E3 ligase RNF157 inhibits lens epithelial cell apoptosis by negatively regulating p53 in age-related cataracts. Invest Ophthalmol Vis Sci. 2022;63(4):11.
   PubMed Web of Science ®Google Scholar
• Jing R, Ma B, Qi T, Hu C, Liao C, Wen C, Shao Y, Pei C. Long noncoding RNA OIP5-AS1 promotes cell apoptosis and cataract formation by blocking POLG expression under oxidative stress. Invest Ophthalmol Vis Sci. 2020;61(12):3. doi:10.1167/iovs.61.12.3.
   PubMed Web of Science ®Google Scholar
• Taiyab A, West-Mays J. Lens fibrosis: understanding the dynamics of cell adhesion signaling in lens epithelial-mesenchymal transition. Front Cell Dev Biol. 2022;10:886053.
   PubMed Web of Science ®Google Scholar
• Wallentin N, Wickstrom K, Lundberg C. Effect of cataract surgery on aqueous TGF-beta and lens epithelial cell proliferation. Invest Ophthalmol Vis Sci. 1998;39(8):1410–1418.
   PubMed Web of Science ®Google Scholar
• Li J, Tang X, Chen X. Comparative effects of TGF-beta2/Smad2 and TGF-beta2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line. Exp Eye Res. 2011;92(3):173–179. doi:10.1016/j.exer.2011.01.009.
   PubMed Web of Science ®Google Scholar
• Saika S, Miyamoto T, Ishida I, Shirai K, Ohnishi Y, Ooshima A, McAvoy JW. TGFbeta-Smad signalling in postoperative human lens epithelial cells. Br J Ophthalmol. 2002;86(12):1428–1433.
   PubMed Web of Science ®Google Scholar
• Shirai K, Saika S, Tanaka T, Okada Y, Flanders KC, Ooshima A, Ohnishi Y. A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling. Mol Vis. 2006;12:681–691.
   PubMed Web of Science ®Google Scholar
• Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113(6):685–700. doi:10.1016/S0092-8674(03)00432-X.
   PubMed Web of Science ®Google Scholar
• Meng F, Li J, Yang X, Yuan X, Tang X. Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury. Int J Mol Med. 2018;42(2):851–860.
   PubMed Web of Science ®Google Scholar
• Banh A, Deschamps PA, Gauldie J, Overbeek PA, Sivak JG, West-Mays JA. Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3. Invest Ophthalmol Vis Sci. 2006;47(8):3450–3460. doi:10.1167/iovs.05-1208.
   PubMed Web of Science ®Google Scholar
• de Lucas S, Lopez-Alcorocho JM, Bartolome J, Carreno V. Nitric oxide and TGF-beta1 inhibit HNF-4alpha function in HEPG2 cells. Biochem Biophys Res Commun. 2004;321(3):688–694.
   PubMed Web of Science ®Google Scholar
• Cozzolino AM, Alonzi T, Santangelo L, Mancone C, Conti B, Steindler C, Musone M, Cicchini C, Tripodi M, Marchetti A. TGFbeta overrides HNF4alpha tumor suppressing activity through GSK3beta inactivation: implication for hepatocellular carcinoma gene therapy. J Hepatol. 2013;58(1):65–72. doi:10.1016/j.jhep.2012.08.023.
   PubMed Web of Science ®Google Scholar
• Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL. Cyclin D as a therapeutic target in cancer. Nat Rev Cancer. 2011;11(8):558–572. doi:10.1038/nrc3090.
   PubMed Web of Science ®Google Scholar
• Montalto FI, Amicis FD. Cyclin D1 in cancer: a molecular connection for cell cycle control, adhesion and invasion in tumor and stroma. Cells. 2020;9(12):2648. doi:10.3390/cells9122648.
   PubMed Web of Science ®Google Scholar
• Xu H, Guan J, Jin Z, Yin C, Wu S, Sun W, Zhang H, Yan B. Mechanical force modulates macrophage proliferation via Piezo1-AKT-Cyclin D1 axis. FASEB J. 2022;36(8):e22423.
   PubMed Web of Science ®Google Scholar
• Wu H, Reizel T, Wang YJ, Lapiro JL, Kren BT, Schug J, Rao S, Morgan A, Herman A, Shekels LL, et al. A negative reciprocal regulatory axis between cyclin D1 and HNF4alpha modulates cell cycle progression and metabolism in the liver. Proc Natl Acad Sci USA. 2020;117(29):17177–17186. doi:10.1073/pnas.2002898117.
   PubMed Web of Science ®Google Scholar
• DeLaForest A, Di Furio F, Jing R, Ludwig-Kubinski A, Twaroski K, Urick A, Pulakanti K, Rao S, Duncan SA. HNF4A regulates the formation of hepatic progenitor cells from human iPSC-derived endoderm by facilitating efficient recruitment of RNA Pol II. Genes. 2018;10(1):21. doi:10.3390/genes10010021.
   PubMed Web of Science ®Google Scholar
• Lu J, Chen Z, Zhao H, Dong H, Zhu L, Zhang Y, Wang J, Zhu H, Cui Q, Qi C, et al. ABAT and ALDH6A1, regulated by transcription factor HNF4A, suppress tumorigenic capability in clear cell renal cell carcinoma. J Transl Med. 2020;18(1):101. doi:10.1186/s12967-020-02268-1.
   PubMed Web of Science ®Google Scholar
• Seomun Y, Kim J, Lee EH, Joo CK. Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells. Biochem J. 2001;358(Pt 1):41–48.
   PubMed Web of Science ®Google Scholar
• Dwivedi DJ, Pino G, Banh A, Nathu Z, Howchin D, Margetts P, Sivak JG, West-Mays JA. Matrix metalloproteinase inhibitors suppress transforming growth factor-beta-induced subcapsular cataract formation. Am J Pathol. 2006;168(1):69–79. doi:10.2353/ajpath.2006.041089.
   PubMed Web of Science ®Google Scholar
• Wormstone IM, Tamiya S, Anderson I, Duncan G. TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci. 2002;43(7):2301–2308.
   PubMed Web of Science ®Google Scholar
• Tholozan FM, Gribbon C, Li Z, Goldberg MW, Prescott AR, McKie N, Quinlan RA. FGF-2 release from the lens capsule by MMP-2 maintains lens epithelial cell viability. MBoC. 2007;18(11):4222–4231. doi:10.1091/mbc.e06-05-0416.
   Web of Science ®Google Scholar
• Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 2000;14(2):163–176. doi:10.1101/gad.14.2.163.
   PubMed Web of Science ®Google Scholar