167
Views
0
CrossRef citations to date
0
Altmetric
Retina and Choroid

Repeatability of Rod-Mediated Dark Adaptation Testing in Normal Aging and Early and Intermediate Age-Related Macular Degeneration

, , , , & ORCID Icon
Pages 725-730 | Received 08 Nov 2023, Accepted 26 Feb 2024, Published online: 04 Mar 2024

References

  • Tan CS, K NW, Chay IW, Ting DS, Sadda SR. Current AMD interventions are focused on slowing advanced age-related macular degeneration (nAMD): a review of emerging treatment options. Clin Ophthalmol. 2022;16:917–933. doi: 10.2147/OPTH.S231913.
  • Heier JS, Lad EM, Holz FG, Rosenfeld PJ, Guymer RH, Boyer D, Grossi F, Baumal CR, Korobelnik JF, Slakter JS, et al. Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials. Lancet. 2023;402(10411):1434–1448. doi: 10.1016/S0140-6736(23)01520-9.
  • Kang C. Avacincaptad pegol: first approval. Drugs. 2023;83(15):1447–1453. doi: 10.1007/s40265-023-01948-8.
  • Lad EM, Fang V, Tessier M, Rautanen A, Gayan J, Stinnett SS, Luhmann UFO. Longitudinal evaluation of visual function impairments in early and intermediate age-related macular degeneration patients. Ophthalmol Sci. 2022;2(3):100173. doi: 10.1016/j.xops.2022.100173.
  • Curcio CA, Medeiros NE, Millican CL. Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1996;37(7):1236–1249.
  • Razavi H, Walton R, Gillies M, Guymer R,. Seven-year trends in visual acuity at first presentation in patients with neovascular AMD. Ophthalmology. 2017;124(2):270–272. doi: 10.1016/j.ophtha.2016.08.013.
  • Steinmetz RL, Haimovici R, Jubb C, Fitzke FW, Bird AC. Symptomatic abnormalities of dark adaptation in patients with age-related Bruch’s membrane change. Br J Ophthalmol. 1993;77(9):549–554. doi: 10.1136/bjo.77.9.549.
  • Owsley C, Jackson GR, White MF, Feist R, Edwards D. Delays in rod-mediated dark adaptation in early age-related maculopathy. Ophthalmology. 2001;108(7):1196–1202. doi: 10.1016/s0161-6420(01)00580-2.
  • Owsley C, McGwin G, Jackson G, Kallies K, Clark M. Cone- and rod-mediated dark adaptation impairment in age-related maculopathy. Ophthalmology. 2007;114(9):1728–1735. doi: 10.1016/j.ophtha.2006.12.023.
  • Owsley C, McGwin GJ, Clark ME, Jackson GR, CallahanMA, Kline LB, Witherspoon CD, Curcio CA. Delayed rod-mediated dark adaptation is a functional biomarker for incident early age-related macular degeneration. Ophthalmology. 2016;123(2):344–351. doi: 10.1016/j.ophtha.2015.09.041.
  • Owsley C, Swain TA, McGwin G, Clark ME, Kar D, Crosson JN, Curcio C. How vision is impaired from aging to early and intermediate age-related macular degeneration: insights from ALSTAR2 baseline. Transl Vis Sci Technol. 2022;11(7):17. doi: 10.1167/tvst.11.7.17.
  • Lamb TD, Pugh ENJ. Dark adaptation and the retinoid cycle of vision. Prog Retin Eye Res. 2004;23(3):307–380. doi: 10.1016/j.preteyeres.2004.03.001.
  • Jackson GR, Edwards JG. A short-duration dark adaptation protocol for assessment of age-related maculopathy. J Ocul Biol Dis Infor. 2008;1(1):7–11. doi: 10.1007/s12177-008-9002-6.
  • Curcio CA, Millican CL, Allen KA, Kalina RE. Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci. 1993;34(12):3278–3296.
  • Mullins RF, McGwin GJ, Searcey K, Clark ME, Kennedy EL, Curcio CA, Stone EM, Owsley C. The ARMS2 A69S polymorphism is associated with delayed rod-mediated dark adaptation in eyes at risk for incident age-related macular degeneration. Ophthalmology. 2018;126(4):591–600. doi: 10.1016/j.ophtha.2018.10.037.
  • Lee AY, Lee CS, Blazes MS, Owen JP, Bagdasarova Y, Wu Y, Spaide T, Yanagihara RT, Kihara Y, Clark ME, et al. Exploring a structural basis for delayed rod-mediated dark adaptation in age-related macular degeneration via deep learning. Transl Vis Sci Technol. 2020;9(2):62. doi: 10.1167/tvst.9.2.62.
  • Flamendorf J, Agrón E, Wong WT, Thompson D, Wiley HE, Doss EL, Al-Holou S, Ferris FL, Chew EY, Cukras C. Impairments in dark adaptation are associated with age-related macular degeneration severity and reticular pseudodrusen. Ophthalmology. 2015;122(10):2053–2062. doi: 10.1016/j.ophtha.2015.06.023.
  • Sevilla MB, McGwin GJ, Lad EM, Clark M, Yuan EL, Farsiu S, Curcio CA, Owsley C, Toth CA. Relating retinal morphology and function in aging and early to intermediate age-related macular degeneration subjects. Am J Ophthalmol. 2016;165:65–77. doi: 10.1016/j.ajo.2016.02.021.
  • Laíns I, Miller JB, Park DH, Tsikata E, Davoudi S, Rahmani S, Pierce J, Silva R, Chen TC, Kim IK, et al. Structural changes associated with delayed dark adaptation in age-related macular degeneration. Ophthalmology. 2017;124(9):1340–1352. doi: 10.1016/j.ophtha.2017.03.061.
  • Agrón E, Domalpally A, Cukras CA, Clemons TE, Chen Q, Lu Z, Chew EY, Keenan TDL, Reticular pseudodrusen: the third macular risk feature for progression to late age-related macular degeneration. Age-related eye disease Study 2 Report 30. Ophthalmology. 2022;129(10):1107–1119. doi: 10.1016/j.ophtha.2022.05.021.
  • Agrón E, Domalpally A, Cukras CA, Clemons TE, Chen Q, Swaroop A, Lu Z, Chew EY, Keenan TDL. Reticular pseudodrusen status, ARMS2/HTRA1 genotype, and geographic atrophy enlargement. Age-related eye disease Study 2 Report 32. Ophthalmology. 2023;130(5):488–500. doi: 10.1016/j.ophtha.2022.11.026.
  • Zacks DN, Johnson MW. Transretinal pigment migration: an optical coherence tomographic study. Arch Ophthalmol. 2004;122(3):406–408. doi: 10.1001/archopht.122.3.406.
  • Christenbury JG, Folgar FA, O’Connell RV, Chiu SJ, Farsiu S, Toth CA. Progression of intermediate age-related macular degeneration with proliferation and iner retinal migration of hyperreflective foci. Ophthalmology. 2013;120(5):1038–1045. doi: 10.1016/j.ophtha.2012.10.018.
  • Ouyang Y, Heussen FM, Hariri A, Keane PA, Sadda SR. Optical coherence tomography-based observation of the natural history of drusenoid lesion in eyes with dry age-related macular degeneration. Ophthalmology. 2013;120(12):2656–2665. doi: 10.1016/j.ophtha.2013.05.029.
  • Sleiman K, Veerappan M, Winter KP, McCall MN, Yiu G, Farsiu S, Chew EY, Clemons T, Toth CA. Optical coherence tomography predictors of risk for progression to non-neovascular atrophic age-related macular degeneration. Ophthalmology. 2017;124(12):1764–1777. doi: 10.1016/j.ophtha.2017.06.032.
  • Echols BS, Clark ME, Swain TA, Chen L, Kar D, Zhang Y, Sloan KR, McGwin G, Singireddy R, Mays C, et al. Hyperreflective foci and specks are associated with delayed rod-mediated dark adaptation in nonneovascular age-related macular degeneration. Ophthalmol Retina. 2020;4(11):1059–1068. doi: 10.1016/j.oret.2020.05.001.
  • Duic C, Pfau K, Keenan TDL, Wiley H, Thavikulwat A, Chew EY, Cukras C. Hyperreflective foci in age-related macular degeneration are associated with disease severity and functional impairment. Ophthalmol Retina. 2022;7(4):307–317. doi: 10.1016/j.oret.2022.11.006.
  • Kar D, Corradetti G, Swain TA, Clark ME, McGwin GJ, Owsley C, Sadda SR, Curcio C. Choriocapillaris impairment is associated with delayed rod-mediated dark adaptation in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2023;64(12):41. doi: 10.1167/iovs.64.12.41.
  • Owsley C, Huisingh C, Clark ME, Jackson GR, McGwin GJ. Comparison of visual function in older eyes in the earliest stages of age-related macular degeneration to those in normal macular health. Curr Eye Res. 2016;41(2):266–272. doi: 10.3109/02713683.2015.1011282.
  • Cocce KJ, Stinnett SS, Luhmann UFO, Vajzovic L, Horne A, Schuman SG, Toth CA, Cousins SW, Lad EM. Visual function metrics in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints. Am J Ophthalmol. 2018;189:127–138. doi: 10.1016/j.ajo.2018.02.012.
  • Owsley C, Swain TA, McGwin GJ, Clark ME, Kar D, Curcio CA. Biologically guided optimization of test target location for rod-mediated dark adaptation in age-related macular degeneration. Ophthalmol Sci. 2023;3(2):100274. doi: 10.1016/j.xops.2023.100274.
  • Tanaya T, Swain TA, Clark ME, Swanner JC, Lolley VR, Callahan MA, McGwin GJ, Owsley C. Comparing rod-mediated dark adaptation in older adults before and after cataract surgery. Curr Eye Res. 2023;48(5):512–517. doi: 10.1080/02713683.2023.2171438.
  • Curcio CA, McGwin G, JrSadda SR, Hu Z, Clark ME, Sloan KR, Swain T, Crosson JN, Owsley C. Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods. BMC Ophthalmol. 2020;20(1):196. doi: 10.1186/s12886-020-01467-0.
  • Age-Related Eye Disease Study Research Group. The age-related eye disease study severity scale for age-related macular degeneration. AREDS Report No. 17. Arch Ophthalmol. 2005;123:1484–1498.
  • Ferris FLI, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR, Clinical classification of age-related macular degeneration. Ophthalmology. 2013;120(4):844–851. doi: 10.1016/j.ophtha.2012.10.036.
  • Beck RW, Moke PS, Turpin AH, Ferris FL, SanGiovanni JP, Johnson CA, Birch EE, Chandler DL, Cox TA, Blair RC, et al. A computerized method of visual acuity testing: adaptation of the early treatment of diabetic retinopathy study testing protocol. Am J Ophthalmol. 2003;135(2):194–205. doi: 10.1016/s0002-9394(02)01825-1.
  • Pugh ENJ. Rushton’s paradox: rod dark adaptation after flash photolysis. J Physiol. 1975;248(2):413–431. doi: 10.1113/jphysiol.1975.sp010982.
  • Leibrock CS, Reuter T, Lamb TD. Molecular basis of dark adaptation in rod photoreceptors. Eye . 1998;12 (Pt 3b)(3):511–520. :doi: 10.1038/eye.1998.139.
  • Shrout PE, Fleiss JL. Intraclass correlations: uses in assessing rater reliability. Psychol Bull. 1979;86(2):420–428. doi: 10.1037/0033-2909.86.2.420.
  • Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15(2):155–163. doi: 10.1016/j.jcm.2016.02.012.
  • Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;327(8476):307–310. doi: 10.1016/S0140-6736(86)90837-8.
  • Bujang MA, Baharum N. A simplified guide to determinination of sample size requirements for estimating the value of intraclass correlation coefficient: a review. Arch Orofac Sci. 2017;12(1):1–11.
  • Cicchetti DV. Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology. Psychol Assess. 1994;6(4):284–290. doi: 10.1037/1040-3590.6.4.284.
  • Hess K, de Silva T, Grisso P, Wiley H, Thavikulwat AT, Keenan TDL, Chew EY, Cukras C. Evaluation of cone- and rod-mediated parameters of dark adaptation testing as outcome measures in age-related macular degeneration. Ophthalmol Retina. 2022;6(12):1173–1184. doi: 10.1016/j.oret.2022.05.018.
  • Tahir HJ, Rodrigo-Diaz E, Parry NRA, Kelly JMF, Carden D, Aslam TM, Murray IJ. Slowed dark adaptation in early AMD: dual stimulus reveals scotopic and photopic abnormalities. Invest Ophthalmol Vis Sci. 2018;59(4):AMD202–AMD210. doi: 10.1167/iovs.18-24227.
  • Tan RS, Guymer RH, Aung K-Z, Caruso E, Luu CD. Longitudinal assessment of rod function in intermediate age-related macular degeneration with and without reticular pseudodrusen. Invest Ophthalmol Vis Sci. 2019;60(5):1511–1518. doi: 10.1167/iovs.18-26385.
  • Flynn OJ, Jeffrey BG, Cukras CA. Characterization of rod function phenotypes across a range of age-related macular degeneration severities and subretinal drusenoid deposits. Invest Ophthalmol Vis Sci. 2018;59(6):2411–2421. doi: 10.1167/iovs.17-22874.
  • Binns AM, Taylor DJ, Edwards LA, Crabb DP. Determining optimal test parameters for assessing dark adaptation in people with intermediate age-related macular degeneration. Invest Ophthalmol Vis Sci. 2018;59(4):AMD114–AMD121. doi: 10.1167/iovs.18-24211.
  • Finger RP, Schmitz-Valckenberg S, Schmid M, Rubin GS, Dunbar H, Tufail A, Crabb DP, Binns A, Sánchez CI, Margaron P., et al. MACUSTAR: development and clinical validation of function, structural, and patient-reported endpoings in intermediate age-related macular degeneration. Ophthalmologica. 2019;241(2):61–72. doi: 10.1159/000491402.
  • Higgins BE, Montesano G, Dunbar HMP, Binns AM, Taylor DJ, Behning C, Abdirahman A, Schmid MC, Terheyden JH, Zakaria N, et al. Test-retest variability and discriminatory power of measurements from microperimetry and dark adaptation assessment in people with intermediate age-related macular degeneration—A MACUSTAR Study Report. Transl Vis Sci Technol. 2023;12(7):19. doi: 10.1167/tvst.12.7.19.
  • Carrasco M, Evert DL, Chang I, Katz SM. The eccentricity effect: target eccentricity affects performance on conjunction searches. Percept Psychophys. 1995;57(8):1241–1261. doi: 10.3758/bf03208380.
  • Wall M, Johnson CA. Morphology and repeatabiity of automated perimetry using stimulus sizes III, V, and VI. Med Res Arch. 2020;9:1–15.
  • de Koning-Backus APM, Kiefte-de Jong JC, van Rooij JGJ, Uitterlinden AG, Voortman TG, Meester-Smoor MA, Klaver CCW.. Lifestyle intervention randomized controlled trial for age-related macular degeneration (AMD-Life): study design. Nutrients. 2023;15(3):602. doi: 10.3390/nu15030602.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.