A Rabbit Dry Eye Model Induced by Subcutaneous Scopolamine

References

• Tsubota K, Yokoi N, Shimazaki J, Watanabe H, Dogru M, Yamada M, Kinoshita S, Kim H-M, Tchah H-W, Hyon JY, et al. New perspectives on dry eye definition and diagnosis: a consensus report by the Asia Dry Eye Society. Ocul Surf. 2017;15(1):65–76. doi: 10.1016/j.jtos.2016.09.003.
   PubMed Web of Science ®Google Scholar
• Lemp MA. Report of the national eye institute/industry workshop on clinical trials in dry eyes. Clao J. 1995;21(4):221–232.
   PubMedGoogle Scholar
• Lemp MA. Recent developments in dry eye management. Ophthalmology. 1987;94(10):1299–1304. doi: 10.1016/s0161-6420(87)80015-5.
   PubMed Web of Science ®Google Scholar
• Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo C-K, Liu Z, Nelson JD, Nichols JJ, Tsubota K, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017;15(3):276–283. doi: 10.1016/j.jtos.2017.05.008.
   PubMed Web of Science ®Google Scholar
• Tsubota K, Yokoi N, Watanabe H, Dogru M, Kojima T, Yamada M, Kinoshita S, Kim H-M, Tchah H-W, Hyon JY, et al. A new perspective on dry eye classification: proposal by the Asia Dry Eye Society. Eye Contact Lens. 2020;46 Suppl 1(1):S2–S13. doi: 10.1097/ICL.0000000000000643.
   PubMedGoogle Scholar
• Qin DY, Wang LX, Deng YP. Transgenic dry eye mouse models: powerful tools to study dry eye disease. Int J Ophthalmol. 2022;15(4):635–645. doi: 10.18240/ijo.2022.04.18.
   PubMed Web of Science ®Google Scholar
• Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME, Pflugfelder SC. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002;43(3):632–638.
   PubMed Web of Science ®Google Scholar
• Viau S, Maire M-A, Pasquis B, Grégoire S, Fourgeux C, Acar N, Bretillon L, Creuzot-Garcher CP, Joffre C. Time course of ocular surface and lacrimal gland changes in a new scopolamine-induced dry eye model. Graefes Arch Clin Exp Ophthalmol. 2008;246(6):857–867. doi: 10.1007/s00417-008-0784-9.
   PubMed Web of Science ®Google Scholar
• Xiao B, Wang Y, Reinach PS, Ren Y, Li J, Hua S, Lu H, Chen W. Dynamic ocular surface and lacrimal gland changes induced in experimental murine dry eye. PLoS One. 2015;10(1):e0115333. doi: 10.1371/journal.pone.0115333.
   PubMed Web of Science ®Google Scholar
• Yang F-M, Fan D, Yang X-Q, Zhu F-H, Shao M-J, Li Q, Liu Y-T, Lin Z-M, Cao S-Q, Tang W, et al. The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-kappaB/NLRP3 signaling. Acta Pharmacol Sin. 2021;42(4):593–603. doi: 10.1038/s41401-020-0484-5.
   PubMed Web of Science ®Google Scholar
• Chen Y, Pu J, Li X, Lian L, Ge C, Liu Z, Wang W, Hou L, Chen W, Li J. Aim2 deficiency ameliorates lacrimal gland destruction and corneal epithelium defects in an experimental dry eye model. Invest Ophthalmol Vis Sci. 2023;64(3):26. doi: 10.1167/iovs.64.3.26.
   Web of Science ®Google Scholar
• Honkanen R, Huang W, Huang L, Kaplowitz K, Weissbart S, Rigas B. A new rabbit model of chronic dry eye disease induced by complete surgical dacryoadenectomy. Curr Eye Res. 2019;44(8):863–872. doi: 10.1080/02713683.2019.1594933.
   PubMed Web of Science ®Google Scholar
• Zernii EY, Baksheeva VE, Iomdina EN, Averina OA, Permyakov SE, Philippov PP, Zamyatnin AA, Senin II. Rabbit models of ocular diseases: new relevance for classical approaches. CNS Neurol Disord Drug Targets. 2016;15(3):267–291. doi: 10.2174/1871527315666151110124957.
   PubMed Web of Science ®Google Scholar
• Qiu J-, Y JJ, Zhou S-Y, Liu F, Chen J-Q. An experimental of rabbit tear-deficient dry eye model by subcutaneous injection of scopolamine hydrobromide. Ophthalmol Chin. 2009;18(6):404–409.
   Google Scholar
• Hodges RR, Dartt DA. Regulatory pathways in lacrimal gland epithelium. Int Rev Cytol. 2003;231:129–196. doi: 10.1016/s0074-7696(03)31004-6.
   PubMed Web of Science ®Google Scholar
• Bacman S, Perez Leiros C, Sterin-Borda L, Hubscher O, Arana R, Borda E. Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sjogren’s syndrome. Invest Ophthalmol Vis Sci. 1998;39(1):151–156.
   PubMed Web of Science ®Google Scholar
• Waterman SA, Gordon TP, Rischmueller M. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjogren’s syndrome. Arthritis Rheum. 2000;43(7):1647–1654. doi: 10.1002/1529-0131(200007)43:7<1647::AID-ANR31>3.0.CO;2-P.
   PubMedGoogle Scholar
• Matsui M, Motomura D, Karasawa H, Fujikawa T, Jiang J, Komiya Y, Takahashi S, Taketo MM. Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci USA. 2000;97(17):9579–9584. doi: 10.1073/pnas.97.17.9579.
   PubMed Web of Science ®Google Scholar
• Davis FA. The anatomy and histology of the eye and orbit of the rabbit. Trans Am Ophthalmol Soc. 1929;27:400 2–441.
   PubMedGoogle Scholar
• Xiong C, Chen D, Liu J, Liu B, Li N, Zhou Y, Liang X, Ma P, Ye C, Ge J, et al. A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride. Invest Ophthalmol Vis Sci. 2008;49(5):1850–1856. doi: 10.1167/iovs.07-0720.
   PubMed Web of Science ®Google Scholar
• Bron AJ, Evans VE, Smith JA. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea. 2003;22(7):640–650. doi: 10.1097/00003226-200310000-00008.
   PubMed Web of Science ®Google Scholar
• Lin BW, Chen MZ, Fan SX, Chuck RS, Zhou SY. Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye. Invest Ophthalmol Vis Sci. 2014;56(1):45–53. doi: 10.1167/iovs.13-12925.
   PubMed Web of Science ®Google Scholar
• Argüeso P, Balaram M, Spurr-Michaud S, Keutmann HT, Dana MR, Gipson IK. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome. Invest Ophthalmol Vis Sci. 2002;43(4):1004–1011.
   PubMed Web of Science ®Google Scholar
• Johnson ME, Murphy PJ. Changes in the tear film and ocular surface from dry eye syndrome. Prog Retin Eye Res. 2004;23(4):449–474. doi: 10.1016/j.preteyeres.2004.04.003.
   PubMed Web of Science ®Google Scholar
• Brignole F, Pisella PJ, Goldschild M, De Saint Jean M, Goguel A, Baudouin C. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest Ophthalmol Vis Sci. 2000;41(6):1356–1363.
   PubMed Web of Science ®Google Scholar
• Zhao H, Jumblatt JE, Wood TO, Jumblatt MM. Quantification of MUC5AC protein in human tears. Cornea. 2001;20(8):873–877. doi: 10.1097/00003226-200111000-00019.
   PubMed Web of Science ®Google Scholar
• McKenzie RW, Jumblatt JE, Jumblatt MM. Quantification of MUC2 and MUC5AC transcripts in human conjunctiva. Invest Ophthalmol Vis Sci. 2000;41(3):703–708.
   PubMed Web of Science ®Google Scholar
• Fan NW, Dohlman TH, Foulsham W, McSoley M, Singh RB, Chen Y, Dana R. The role of Th17 immunity in chronic ocular surface disorders. Ocul Surf. 2021;19:157–168. doi: 10.1016/j.jtos.2020.05.009.
   PubMed Web of Science ®Google Scholar
• Solomon A, Dursun D, Liu Z, Xie Y, Macri A, Pflugfelder SC. Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci. 2001;42(10):2283–2292.
   PubMed Web of Science ®Google Scholar
• Yoon KC, Jeong IY, Park YG, Yang SY. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome. Cornea. 2007;26(4):431–437. doi: 10.1097/ICO.0b013e31803dcda2.
   PubMed Web of Science ®Google Scholar
• Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009;147(2):198–205 e1. doi: 10.1016/j.ajo.2008.08.032.
   PubMed Web of Science ®Google Scholar
• Pflugfelder SC. Anti-inflammatory therapy of dry eye. Ocul Surf. 2003;1(1):31–36. doi: 10.1016/s1542-0124(12)70005-8.
   PubMedGoogle Scholar
• Sall K, Stevenson OD, Mundorf TK, Reis BL. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology. 2000;107(4):631–639. doi: 10.1016/s0161-6420(99)00176-1.
   PubMed Web of Science ®Google Scholar
• Eickholz P, Kim T-S, Bürklin T, Schacher B, Renggli HH, Schaecken MT, Holle R, Kübler A, Ratka-Krüger P. Non-surgical periodontal therapy with adjunctive topical doxycycline: a double-blind randomized controlled multicenter study. J Clin Periodontol. 2002;29(2):108–117. doi: 10.1034/j.1600-051x.2002.290204.x.
   PubMed Web of Science ®Google Scholar