43
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Changes in Posterior Ocular Structures in Individuals Using Phosphodiesterase 5 Inhibitor

ORCID Icon & ORCID Icon
Received 16 Feb 2024, Accepted 29 May 2024, Published online: 10 Jun 2024

References

  • Kerr NM, Danesh-Meyer HV. Phosphodiesterase inhibitors and the eye. Clin Exp Ophthalmol. 2009;37(5):514–523. doi: 10.1111/j.1442-9071.2009.02070.x.
  • Laties A, Zrenner E. Viagra (sildenafl citrate) and ophthalmology. Prog Retin Eye Res. 2002;21(5):485–506. doi: 10.1016/s1350-9462(02)00013-7.
  • Galiè N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, Fleming T, Parpia T, Burgess G, Branzi A, et al. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med. 2005;353(20):2148–2157. doi: 10.1056/NEJMoa050010.
  • Ravipati G, McClung JA, Aronow WS, Peterson SJ, Frishman WH. Type 5 phosphodiesterase inhibitors in the treatment of erectile dysfunction and cardiovascular disease. Cardiol Rev. 2007;15(2):76–86. doi: 10.1097/01.crd.0000233904.77128.49.
  • Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med. 1998;338(20):1397–1404. doi: 10.1056/NEJM199805143382001.
  • Danesh-Meyer HV, Levin LA. Erectile dysfunction drugs and risk of anterior ischaemic optic neuropathy: casual or causal association? Br J Ophthalmol. 2007;91(11):1551–1555. doi: 10.1136/bjo.2007.125880.
  • Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov. 2006;5(8):689–702. doi: 10.1038/nrd2030.
  • Fraunfelder FW. Visual side effects associated with erectile dysfunction agents. Am J Ophthalmol. 2005;140(4):723–724. doi: 10.1016/j.ajo.2005.02.049.
  • Zurawin JL, Stewart CA, Anaissie JE, Yafi FA, Hellstrom WJ. Avanafil for the treatment of erectile dysfunction. Expert Rev Clin Pharmacol. 2016;9(9):1163–1170. doi: 10.1080/17512433.2016.1212655.
  • Gong B, Ma M, Xie W, Yang X, Huang Y, Sun T, Luo Y, Huang J. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. Int Urol Nephrol. 2017;49(10):1731–1740. doi: 10.1007/s11255-017-1644-5.
  • Diederen RM, La Heij EC, Markerink-van Ittersum M, Kijlstra A, Hendrikse F, de Vente J. Selective blockade of phosphodiesterase types 2, 5 and 9 results in cyclic 3'5’ guanosine monophosphate accumulation in retinal pigment epithelium cells. Br J Ophthalmol. 2007;91(3):379–384. doi: 10.1136/bjo.2006.100628.
  • Donahue SP, Taylor RJ. Pupil-sparing third nerve palsy associated with sildenafl citrate (Viagra). Am J Ophthalmol. 1998;126(3):476–477. doi: 10.1016/s0002-9394(98)00243-8.
  • Brock GB, McMahon CG, Chen KK, Costigan T, Shen W, Watkins V, Anglin G, Whitaker S. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002;168(4 Pt 1):1332–1336. doi: 10.1016/S0022-5347(05)64442-4.
  • Agrawal R, Gupta P, Tan KA, Cheung CM, Wong TY, Cheng CY. Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study. Sci Rep. 2016;6(1):21090. doi: 10.1038/srep21090.
  • Etminan M, Sodhi M, Mikelberg FS, Maberley D. Risk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US. JAMA Ophthalmol. 2022;140(5):480–484. doi: 10.1001/jamaophthalmol.2022.0663.
  • Barroso F, Ribeiro JC, Miranda EP. Phosphodiesterase type 5 inhibitors and visual side effects: a narrative review. J Ophthalmic Vis Res. 2021;16(2):248–259. doi: 10.18502/jovr.v16i2.9088.
  • Azzouni F, Abu Samra K. Are phosphodiesterase type 5 inhibitors associated with vision-threatening adverse events? A critical analysis and review of the literature. J Sex Med. 2011;8(10):2894–2903. doi: 10.1111/j.1743-6109.2011.02382.x.
  • Bollinger K, Lee MS. Recurrent visual field defect and ischemic optic neuropathy associated with tadalafil rechallenge. Arch Ophthalmol. 2005;123(3):400–401. doi: 10.1001/archopht.123.3.400.
  • Coscas F, Coscas G, Zucchiatti I, Bandello F, Soubrane G, Souïed E. Optical coherence tomography in tadalafil-associated retinal toxicity. Eur J Ophthalmol. 2012;22(5):853–856. doi: 10.5301/ejo.5000127.
  • Gordon-Bennett P, Rimmer T. Central serous chorioretinopathy following oral tadalafil. Eye. 2012;26(1):168–169. doi: 10.1038/eye.2011.250.
  • Gargallo-Benedicto A, Clemente-Tomás R, Pastor-Espuig M, Alías-Alegre EG, Navarro-Casado MN. Bilateral neurosensory retinal detachment secondary to tadalafil treatment. Arch Soc Esp Oftalmol (Engl Ed). 2022;97(4):234–238. doi: 10.1016/j.oftale.2020.11.015.
  • Capece M, Montorio D, Comune C, Aveta A, Melchionna A, Celentano G, Imbimbo C, Crocetto F, Califano G, Cennamo G. Retinal and optic disc vascular changes in patients using long-term tadalafil: a prospective non-randomized matched-pair study. Diagnostics (Basel). 2021;11(5):802. doi: 10.3390/diagnostics11050802.
  • Beck RW, Servais GE, Hayreh SS. Anterior ischemic optic neuropathy. IX. Cup-to-disc ratio and its role in pathogenesis. Ophthalmology. 1987;94(11):1503–1508.
  • Shir Yen W, Yathavan S, Ramli MA, Siu Wan F, Che Hamzah J. Bilateral sequential Non-arteritic Anterior Ischemic Optic Neuropathy (NAION). Cureus. 2021;13(11):e19408. doi: 10.7759/cureus.19408.
  • Liu B, Zhu L, Zhong J, Zeng G, Deng T. The association between phosphodiesterase type 5 inhibitor use and risk of non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. Sex Med. 2018;6(3):185–192. doi: 10.1016/j.esxm.2018.03.001.
  • Paris G, Sponsel WE, Sandoval SS, Elliott WR, Trigo Y, Sanford DK, Harison JM. Sildenafil increases ocular perfusion. Int Ophthalmol. 2001;23(4-6):355–358. doi: 10.1023/a:1014410932321.
  • Aslan F, Topcuoğlu M, Öktem Ç, Akkoç A, Uçar M. Can subfoveal choroidal thickness replace subjective tests in patients using tadalafil to treat erectile dysfunction? Andrologia. 2020;52(6):e13580. doi: 10.1111/and.13580.
  • Bill A, Sperber GO. Control of retinal and choroidal blood flow. Eye. 1990;4(2):319–325. doi: 10.1038/eye.1990.43.
  • Haefliger IO, Flammer J, Lüscher TF. Nitric oxide and endothelin-1 are important regulators of human ophthalmic artery. Invest Ophthalmol Vis Sci. 1992;33(7):2340–2343.
  • Delaey C, Van De Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res. 2000;32(6):249–256. doi: 10.1159/000055622.
  • Xie J, Ye L, Chen Q, Shi Y, Hu G, Yin Y, Zou H, Zhu J, Fan Y, He J, et al. Choroidal thickness and its association with age, axial length, and refractive error in Chinese adults. Invest Ophthalmol Vis Sci. 2022;63(2):34. doi: 10.1167/iovs.63.2.34.
  • Sabaner MC, Dogan M, Akdogan M, Karadag S, Onur IU, Tasci Aİ, Yigit FU. Evaluation of retinal and choroidal microcirculation alterations after a single dose of oral 5-mg tadalafil: a prospective pilot optical coherence tomography angiography study. J Ocul Pharmacol Ther. 2021;37(7):421–429. doi: 10.1089/jop.2020.0124.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.