Downregulation of LOX Overexpression Promotes Retinal Ganglion Cells Survival in an Acute Ocular Hypertension Model

References

• Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311(18):1901–1911. doi: 10.1001/jama.2014.3192.
   PubMed Web of Science ®Google Scholar
• Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res. 2012;31(2):152–181. doi: 10.1016/j.preteyeres.2011.11.002.
   PubMed Web of Science ®Google Scholar
• Reinhard J, Wiemann S, Hildebrandt S, Faissner A. Extracellular matrix remodeling in the retina and optic nerve of a novel glaucoma mouse model. Biology. 2021;10(3):169. doi: 10.3390/biology10030169.
   PubMedGoogle Scholar
• Theocharis AD, Manou D, Karamanos NK. The extracellular matrix as a multitasking player in disease. FEBS J. 2019;286(15):2830–2869. doi: 10.1111/febs.14818.
   PubMed Web of Science ®Google Scholar
• Faissner A, Reinhard J. The extracellular matrix compartment of neural stem and glial progenitor cells. Glia. 2015;63(8):1330–1349. doi: 10.1002/glia.22839.
   PubMed Web of Science ®Google Scholar
• Reinhard J, Joachim SC, Faissner A. Extracellular matrix remodeling during retinal development. Exp Eye Res. 2015;133:132–140. doi: 10.1016/j.exer.2014.07.001.
   PubMed Web of Science ®Google Scholar
• Pena JD, Agapova O, Gabelt BT, Levin LA, Lucarelli MJ, Kaufman PL, Hernandez MR. Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure. Invest Ophthalmol Vis Sci. 2001;42(10):2303–2314.
   PubMed Web of Science ®Google Scholar
• Reinhard J, Renner M, Wiemann S, Shakoor DA, Stute G, Dick HB, Faissner A, Joachim SC. Ischemic injury leads to extracellular matrix alterations in retina and optic nerve. Sci Rep. 2017;7(1):43470. doi: 10.1038/srep43470.
   PubMedGoogle Scholar
• Kagan HM, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003;88(4):660–672. doi: 10.1002/jcb.10413.
   PubMed Web of Science ®Google Scholar
• Wilhelmus MM, Bol JG, van Duinen SG, Drukarch B. Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer’s disease and hereditary cerebral hemorrhage with amyloidosis–Dutch type. Exp Gerontol. 2013;48(2):109–114. doi: 10.1016/j.exger.2012.12.007.
   PubMed Web of Science ®Google Scholar
• Gilad GM, Gilad VH. Beta-aminopropionitrile treatment can accelerate recovery of mice after spinal cord injury. Eur J Pharmacol. 2001;430(1):69–72. doi: 10.1016/s00142999(01)01354-1.
   PubMed Web of Science ®Google Scholar
• Gilad GM, Kagan HM, Gilad VH. Lysyl oxidase, the extracellular matrix-forming enzyme, in rat brain injury sites. Neurosci Lett. 2001;310(1):45–48. doi: 10.1016/s0304-3940(01)02089-4.
   PubMed Web of Science ®Google Scholar
• Martínez-Martínez E, Rodríguez C, Galán M, Miana M, Jurado-López R, Bartolomé MV, Luaces M, Islas F, Martínez-GonzáLez J, López-Andrés N, et al. The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats. J Mol Cell Cardiol. 2016;92:96–104. doi: 10.1016/j.yjmcc.2016.01.012.
   PubMed Web of Science ®Google Scholar
• Oshitari T, Polewski P, Chadda M, Li AF, Sato T, Roy S. Effect of combined antisense oligonucleotides against high-glucose- and diabetes-induced overexpression of extracellular matrix components and increased vascular permeability. Diabetes. 2006;55(1):86–92. doi: 10.2337/diabetes.55.01.06.db05-0186.
   PubMed Web of Science ®Google Scholar
• Chronopoulos A, Tang A, Beglova E, Trackman PC, Roy S. High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function. Diabetes. 2010;59(12):3159–3166. doi: 10.2337/db10-0365.
   PubMed Web of Science ®Google Scholar
• Guo L, Moss SE, Alexander RA, Ali RR, Fitzke FW, Cordeiro MF. Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Invest Ophthalmol Vis Sci. 2005;46(1):175–182. doi: 10.1167/iovs.04-0832.
   PubMed Web of Science ®Google Scholar
• Ma K, Xu L, Zhang H, Zhang S, Pu M, Jonas JB. Effect of brimonidine on retinal ganglion cell survival in an optic nerve crush model. Am J Ophthalmol. 2009;147(2):326–331. doi: 10.1016/j.ajo.2008.08.005.
   PubMed Web of Science ®Google Scholar
• Qiu Y, Tao L, Zheng S, Lin R, Fu X, Chen Z, Lei C, Wang J, Li H, Li Q, et al. AAV8-mediated angiotensin-converting enzyme 2 gene delivery prevents experimental autoimmune uveitis by regulating MAPK, NF-κB and STAT3 pathways. Sci Rep. 2016;6(1):31912. doi: 10.1038/srep31912.
   PubMed Web of Science ®Google Scholar
• Coral K, Madhavan J, Pukhraj R, Angayarkanni N. High glucose induced differential expression of lysyl oxidase and its isoform in ARPE-19 cells. Curr Eye Res. 2013;38(1):194–203. doi: 10.3109/02713683.2012.720341.
   PubMed Web of Science ®Google Scholar
• Yang X, Scott HA, Monickaraj F, Xu J, Ardekani S, Nitta CF, Cabrera A, McGuire PG, Mohideen U, Das A, et al. Basement membrane stiffening promotes retinal endothelial activation associated with diabetes. FASEB J. 2016;30(2):601–611. doi: 10.1096/fj.15-277962.
   PubMed Web of Science ®Google Scholar
• Kim D, Mecham RP, Trackman PC, Roy S. Downregulation of lysyl oxidase protects retinal endothelial cells from high glucose-induced apoptosis. Invest Ophthalmol Vis Sci. 2017;58(5):2725–2731. doi: 10.1167/iovs.16-21340.
   PubMed Web of Science ®Google Scholar
• Anastasopoulos E, Coleman AL, Wilson MR, Sinsheimer JS, Yu F, Katafigiotis S, Founti P, Salonikiou A, Pappas T, Koskosas A, et al. Association of LOXL1 polymorphisms with pseudoexfoliation, glaucoma, intraocular pressure, and systemic diseases in a Greek population. The Thessaloniki eye study. Invest Ophthalmol Vis Sci. 2014;55(7):4238–4243. doi: 10.1167/iovs.14-13991.
   PubMed Web of Science ®Google Scholar
• Kasım B, İrkeç M. Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population. Mol Vis. 2013;19:114–120.
   PubMed Web of Science ®Google Scholar
• Guo M, Zhu Y, Shi Y, Meng X, Dong X, Zhang H, Wang X, Du M, Yan H. Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies. Redox Biol. 2022;58:102541. doi: 10.1016/j.redox.2022.102541.
   PubMed Web of Science ®Google Scholar
• Nareshkumar RN, Sulochana KN, Coral K. Inhibition of angiogenesis in endothelial cells by human lysyl oxidase propeptide. Sci Rep. 2018;8(1):10426. doi: 10.1038/s41598018-28745-8.
   PubMedGoogle Scholar
• Li J, Gu X, Ma Y, Calicchio ML, Kong D, Teng YD, Yu L, Crain AM, Vartanian TK, Pasqualini R, et al. Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling. Neuron. 2010;68(1):45–60. doi: 10.1016/j.neuron.2010.08.013.
   PubMed Web of Science ®Google Scholar
• Cheng T, Liu Q, Zhang R, Zhang Y, Chen J, Yu R, Ge G. Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation. J Mol Cell Biol. 2014;6(6):506–515. doi: 10.1093/jmcb/mju039.
   PubMed Web of Science ®Google Scholar
• Hollosi P, Yakushiji JK, Fong KS, Csiszar K, Fong SF. Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells. Int J Cancer. 2009;125(2):318–327. doi: 10.1002/ijc.24308.
   PubMed Web of Science ®Google Scholar
• Vadasz Z, Kessler O, Akiri G, Gengrinovitch S, Kagan HM, Baruch Y, Izhak OB, Neufeld G. Abnormal deposition of collagen around hepatocytes in Wilson’s disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. J Hepatol. 2005;43(3):499–507. doi: 10.1016/j.jhep.2005.02.052.
   PubMed Web of Science ®Google Scholar