777
Views
23
CrossRef citations to date
0
Altmetric
Research Articles

Evaluation of hemato-biochemical, antioxidant enzymes as biochemical biomarkers and genotoxic potential of glyphosate in freshwater fish (Labeo rohita)

ORCID Icon, ORCID Icon, , , , ORCID Icon & ORCID Icon show all
Pages 646-667 | Received 30 Apr 2020, Accepted 27 May 2021, Published online: 10 Jun 2021

References

  • Hussain R, Farah A, Javed MT, et al. Clinico-hematological, serum biochemical, genotoxic and histopathological effects of trichlorfon in adult cockerels. Toxin Rev. 2019. DOI:10.1080/15569543.2019.1673422.
  • Ghaffar A, Hussain R, Noreen S, et al. Concentration and time-related pathological and genotoxic studies on thiamethaxam in fresh water fish (Labeo rohita) in Pakistan. Pak Vet J. 2020;40:151–156.
  • Fumetti SV, Blaurock K. Effects of the herbicide Roundup® on the metabolic activity of Gammarus fossarum Koch, 1836 (Crustacea; Amphipoda). Ecotoxicology. 2018;27:1249–1260.
  • Vandenberg LN, Blumberg B, Antoniou MN, et al. Is it time to reassess current safety standards for glyphosate-based herbicides? J Epidemiol Comm Health. 2017;71:613–618.
  • Islam SMM, Rahman MA, Nahar S, et al. Acute toxicity of an organophosphate insecticide sumithion to striped catfish Pangasianodon hypophthalmus. Toxicol Rep. 2019;6:957–962.
  • Rahman MS, Islam SMM, Haque A, et al. Toxicity of the organophosphate insecticide sumithion to embryo and larvae of Zebrafish. Toxicol Rep. 2020;7:317–323.
  • Leem YH, Oh S, Kang HJ, et al. BPA-toxicity via superoxide anion overload and a deficit in b-catenin signaling in human bone mesenchymal stem cells. Environ Toxicol. 2017;32:344–352.
  • Verma G, Khan MF, Akhtar W, et al. Molecular interactions of bisphenols and analogs with glucocorticoid biosynthetic pathway enzymes: an in-silico approach. Toxicol Mech Methods. 2018;28:1–10.
  • Sivashanmugam P, Mullainadhan V, Karundevi B. Concentration-dependent effect of bisphenol-α on insulin signaling molecules in cardiac muscle of adult male rat. Chem Biol Interact. 2017;266:10–16.
  • Islam SMM, Rohani MF, Zabed SA, et al. Acute effects of chromium on hemato-biochemical parameters and morphology of erythrocytes in striped catfish Pangasianodon hypophthalmus. Toxicol. Reports. 2020;7:664–670.
  • Shahjahan M, Rahman MS, Islam SMM, et al. Increase in water temperature increases acute toxicity of sumithion causing nuclear and cellular abnormalities in peripheral erythrocytes of zebrafish Danio rerio. Environ Sci Pollut Res. 2019;26:36903–36912. DOI:10.1007/s11356-019-06886-1.
  • Baylis AD. Why glyphosate is a global herbicide: strengths, weaknesses and prospects. Pest Manage Sci. 2000;56:299–308.
  • Benbrook CM. Trends in glyphosate herbicide use in the United States and globally. Environ Sci Europe. 2016;28:3. DOI:10.1186/s12302-016-0070-0.
  • Arregui MC, Lenardón A, Sanchez D, et al. Monitoring glyphosate residues in transgenic glyphosate-resistant soybean. Pest Manag Sci. 2004;60:163–166.
  • Bøhn T, Cuhra M, Traavik T, et al. Compositional differences in soybeans on the market: glyphosate accumulates in Roundup ready GM soybeans. Food Chem. 2014;153:207–215.
  • Jasmin J, Rahman MM, Rahman MM. Haematological changes in Labeo rohita (H.) due to exposure of pesticides, difenoconazole and thiamethoxam. Int J Contemp Res Rev. 2018;9:20199–20205.
  • Mugni H, Paracampo A, Solis M, et al. Acute toxicity of roundup to the nontarget organism Hyalella curvispina. laboratory and field study. Toxicol Environ Chem. 2015;96:1054–1063.
  • Belo MSS, Pignati W, Dores EFGC, et al. Pesticide use in soybean production in Mato Grosso state, Brazil: a preliminary occupational and environmental risk characterization. Rev Brasileira de Saúde Ocup. 2012;125:78–88.
  • Rebelo RM, Caldas ED. Environmental risk assessment of aquatic systems affected by pesticide use. Química Nova. 2014;37:1199–1208.
  • Uddin MH, Shahjahan M, Ruhul AAKM, et al. Impacts of organophosphate pesticide, sumithion on water quality and benthic invertebrates in aquaculture ponds. Aquacul Reports. 2016;3:88–92.
  • Bostock J, McAndrew B, Richards R, et al. Aquaculture: global status and trends. Philos Trans R Soc Lond; B Biol Sci. 2010;365:2897–2912.
  • Nardi J, Moras PB, Koeppe C, et al. Prepubertal subchronic exposure to soy milk and glyphosate leads to endocrine disruption. Food Chem Toxicol. 2017;100:247–252.
  • Roy NM C, Ochs J B. Glyphosate induces neurotoxicity in Zebra fish. Environ Toxicol Pharmacol. 2016;42:45–54.
  • Conrad A, Schr€oter-Kermani CHW, Hoppe H, et al. Glyphosate in German adults - time trend (2001 to 2015) of human exposure to a widely used herbicide. Int J Hyg Environ Health. 2017;220:8–16.
  • Rueppel ML, Brightwell BB, Schaefer J, et al. Metabolism and degradation of glyphosate in soil and water. J Agric Food Chem. 1977;25:517–528.
  • Williams GM, Kroes R, Munro IC. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regulatory Toxicol Pharmacol. 2000;31:117–165.
  • Hussain R, Mahmood F, Khan A, et al. Genotoxic and pathological effects of malathion in male Japanese quail (Coturnix japonica). Pak J Agric Sci. 2015;52:1143–1149.
  • Zhang S, Xu J, Kuang X, et al. Biological impacts of glyphosate on morphology, embryo biomechanics and larval behavior in zebrafish (Danio rerio). Chemosphere. 2017;181:270–280.
  • Qureshi IZ, Bibi A, Shahid S, et al. Exposure to sub-acute doses of fipronil and buprofezin in combination or alone induces biochemical, hematological, histopathological and genotoxic damage in common carp (Cyprinus carpio L). Aquatic Toxicol. 2016;179:103–114.
  • Ghazanfar M, Shahid S, Qureshi IZ. Vitamin C attenuates biochemical and genotoxic damage in common carp (Cyprinus carpio) upon joint exposure to combined toxic doses of fipronil and buprofezin insecticides. Aquatic Toxicol. 2018;196:43–52.
  • Ghaffar A, Hussain R, Aslam M, et al. Arsenic and urea in combination alters the hematology, biochemistry and protoplasm in exposed Rahu fish (Labeorohita) (Hamilton, 1822). Turk J Fish Aquatic Sci. 2016;16:289–296.
  • Ghaffar A, Hussain R, Abbas G, et al. Assessment of genotoxic and pathologic potentials of fipronil insecticide in Labeo rohita (Hamilton, 1822). Toxin Rev. 2019. DOI:10.1080/15569543.2019.1684321.
  • Zhang L, Rana I, Shaffer RM, et al. Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence. Mutat Res. 2019;781:186–206.
  • Herek JS, Vargas L, Trindade SAR, et al. Can environmental concentrations of glyphosate affect survival and cause malformation in amphibians? Effects from a glyphosate-based herbicide on Physalaemus cuvieri and P. gracilis (Anura: Leptodactylidae). Environ Sci Pollut Res. 2020;27:22619–22630.
  • Khan A, Aalim MM, Khan MZ, et al. Does distillery yeast sludge ameliorate moldy feed toxic effects in white leghorn hens? Toxin Rev. 2017;36:275–235.
  • Gul ST, Ahamd I, Saleemi MK, et al. Toxico-pathological effects of thiamethoxam on hemato-biochemical and productive performance of commercial laying hens. Pak Vet J. 2020;40:449–454.
  • Hussain R, Ali F, Rafique A, et al. Exposure to sub-acute concentrations of glyphosate induce clinico-hematological, serum biochemical and genotoxic damage in adult cockerels. Pak Vet J. 2019;39:181–186.
  • Ali S, Ijaz M, Ahmed A, et al. Prevalence and associated risk factors of bovine babesiosis in Lahore. Pakistan. Agrobiol Rec. 2020;2:17–23.
  • Ambreen A, Zia MA, Asgher M, et al. Purification of robust asparaginase from Capsicum annum and its therapeutic efficacy in leukemia. Pak Vet J. 2019;39:428–432.
  • Malak NML, AwadAllah YHA, Zaki HMBA. Using histological and chemical methods for detection of unauthorized tissues addition in emulsion type meat product. Int J Vet Sci. 2020;9:438–442.
  • Elbayoumy MK, Allam AM, Omara ST, et al. Role of artesunate in potentiation of β-lactam against methicillin resistant Staphylococcus aureus (MRSA) isolated from bovine mastitis and its histopathology impact in-vivo study. Int J Vet Sci. 2020;9:337–342.
  • Hayashi I, Morishita Y, Imai K, et al. High-throughput spectrophotometric assay of reactive oxygen species in serum. Mutat Res. 2007;631:55–61.
  • Iqbal M, Sharma S, Rezazadeh H, et al. Glutathione metabolizing enzymes and oxidative stress in ferric nitrilotriacetate mediated hepatic injury. Redox Rep: Commun Free Radic Res. 1996;2:385–391.
  • Jollow D, Mitchell J, Zampaglione N, et al. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology. 1974;11:151–169.
  • Chance B, Maehly A. Assay of catalases and peroxidases. Methods Enzymol. 1955;2:764–775.
  • Weng Q, Li B, Liu Z, et al. ACTH induces oxidative stress and decreases DNA methylation of Fkbp5 in Suhuai sow. Pak Vet J. 2019;39(3):401–405.
  • Abdel-Saeed H, Salem NY. Evaluation of total antioxidant capacity, malondialdehyde, catalase, proteins, zinc, copper and IgE response in ovine verminous pneumonia. Int J Vet Sci. 2019;8:255–258.
  • Bridi D, Altenhofen S, Gonzalez JB, et al. Glyphosate and Roundup® alter morphology and behavior in zebra fish. Toxicology. 2017;392:32–39.
  • Lugowska K. The effects of Roundup on gametes and early development of common carp (Cyprinus carpio L). Fish Physiol Biochem. 2018;44:1109–1117.
  • Ma J, Li X. Alteration in the cytokine levels and histopathological damage in common carp induced by glyphosate. Chemosphere. 2018;128:293–298.
  • Velasques R, Sandrini J, Rosa C. Roundup® in zebrafish: effects on oxidative status and gene expression. Zebrafish. 2016;13:432–441.
  • Braz-Mota S, Sadauskas-Henrique H, Duarte RM, et al. Roundup® exposure promotes gills and liver impairments, DNA damage and inhibition of brain cholinergic activity in the Amazon teleost fish Colossoma macropomum. Chemosphere. 2015;135:53–60.
  • Sanchez J, Varela J, Corcini C, et al. Effects of Roundup formulations on biochemical biomarkers and male sperm quality of the live bearing Jenynsia multidentata. Chemosphere. 2017;177:200–210.
  • Jiraungkoorskul W, Upatham S, Kruatrachue M, et al. Histopathological effects of roundup, a glyphosate herbicide, on Nile tilapia (Oreochromis niloticus). Sci Asia. 2002;28:121–127.
  • Jiraungkoorskul W, Upatham ES, Kruatrachue M, et al. Biochemical and histopathological effects of glyphosate herbicide on Nile tilapia (Oreochromis niloticus). Environ Toxicol. 2003;18:260–267.
  • Persch TSP, da Silva PR, Dos Santos SHD, et al. Changes in intermediate metabolism and oxidative balance parameters in sexually matured three-barbeled catfishes exposed to herbicides from rice crops (Roundup®, Primoleo® and Facet®). Environ Toxicol Pharmacol. 2018;58:170–179.
  • Li MH, Ruan LY, Zhou JW, et al. Metabolic profiling of goldfish (Carassius auratis) after long-term glyphosate-based herbicide exposure. Aquatic Toxicol. 2017;188:159–169.
  • Neelima P, Cyril L, Kumar AJ, et al. Histopathological alterations in gill, liver and kidney of Cyprinus carpio (Linn.) exposed to cypermethrin (25%EC). Int J Adv Res Biol Sci. 2015;2:34–40.
  • Bach NC, Marino DJG, Natale GS, et al. Effects of glyphosate and its commercial formulation, roundup® ultramax, on liver histology of tadpoles of the neotropical frog, Leptodactylus latrans (amphibia: Anura). Chemosphere. 2018;202:289–297.
  • Santos APR D, Rocha TL, Borges CL, et al. A glyphosate-based herbicide induces histomorphological and protein expression changes in the liver of the female guppy Poecilia reticulata. Chemosphere. 2017;168:933–943.
  • El-Murr AE, Imam TS, Hakim Y, et al. Histopathological, immunological, hematological and biochemical effects of fipronil on Niletilapia (Oreochromis niloticus). J Vet Sci Technol. 2015;6:252.
  • de Moura FR, da Silva Lima RR, da Cunha APS, et al. Effects of glyphosate-based herbicide on pintado da Amazônia: hematology, histological aspects, metabolic parameters and genotoxic potential. Environ Toxicol Pharmacol. 2017;56:241–248.
  • Kondera E, Teodorczuk B, Ługowska K, et al. Effect of glyphosate-based herbicide on hematological and hemopoietic parameters in common carp (Cyprinus carpio L). Fish Physiol Biochem. 2018;44:1011–1018.
  • Kreutz LC, Gil Barcellos LJ, de Faria Valle S, et al. Altered hematological and immunological parameters in silver catfish (Rhamdia quelen) following short term exposure to sublethal concentration of glyphosate. Fish Shellfish Immunol. 2011;30:51–57.
  • Gholami-Seyedkolaei SJ, Mirvaghefi A, Farahmand H, et al. Effect of a glyphosate-based herbicide in Cyprinus carpio: assessment of acetylcholinesterase activity, hematological responses and serum biochemical parameters. Ecotoxicol Environ Safety. 2013;98:135–141.
  • Namratha ML, Lakshman M, Jeevanalatha M, et al. Assessment of vitamin c protective activity in glyphosate-induced hepatotoxicity in rats. Pak Vet J. 2020. DOI:10.29261/pakvetj/2021.021.
  • Hong Y, Yang X, Yan G, et al. Effects of glyphosate on immune responses and hemocyte DNA damage of Chinese mitten crab, Eriocheir sinensis. Fish Shellfish Immunol. 2017;71:19–27.
  • Marques A, Guilherme S, Gaivão I, et al. Progression of DNA damage induced by a glyphosate-based herbicide in fish (Anguilla anguilla) upon exposure and post-exposure periods–insights into the mechanisms of genotoxicity and DNA repair. Comp Biochem Physiol Part C: Toxicol Pharmacol. 2014;166:126–133.
  • Tahir R, Ghaffar A, Abbas G, et al. Pesticide induced hematological, biochemical and genotoxic changes in fish: A review. Agrobiol Rec. 2021;3:41–57. DOI:10.47278/journal.abr/2021.005.
  • Guilherme S, Gaivão I, Santos MA, et al. DNA damage in fish (Anguilla anguilla) exposed to a glyphosate-based herbicide –elucidation of organ-specificity and the role of oxidative stress. Mutat Res/Fund Mol Mechanis Mutagenesis. 2012;743:1–9.
  • Ramadan HM, Taha NA, Ahmed HH. Melatonin improves blood biochemical parameters and DNA integrity in the liver and kidney of hyperthyroid male rats. Int J Vet Sci. 2020;9:511–516.
  • Jin J, Kurobe T, Ramírez-Duarte WF, et al. Sub-lethal effects of herbicides penoxsulam, imazamox, fluridone and glyphosate on Delta Smelt (Hypomesus transpacificus). Aquatic Toxicol. 2018;197:79–88.
  • de Moura FR, Brentegani KR, Gemelli A, et al. Oxidative stress in the hybrid fish jundiara (Leiarius marmoratus × Pseudoplatystoma reticulatum) exposed to Roundup Original®. Chemosphere. 2017;185:445–451.
  • Deyashi M, Chakraborty SB. Pesticide induced oxidative stress and the role of antioxidant defense system in animal body. Harvest (Online). 2016;2:1–14.
  • Latif M, Faheem M, Ullah A. Study of oxidative stress and histo-biochemical biomarkers of diethyl phthalate induced toxicity in a cultureable fish, Labeo rohita. Pak Vet J. 2020;40:202–208.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.