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Original Articles

Upper airway and skin symptoms in allergic and non-allergic asthma: Results from the Swedish GA2LEN study

, PhD, MD, , MD, , PhD, MD, , PhD, MD, , PhD, MD, , PhD, MD, , PhD, MD ORCID Icon, , PhD, , PhD, MD & , PhD, MD show all
Pages 275-283 | Received 09 Jan 2017, Accepted 29 Apr 2017, Published online: 26 May 2017

References

  • Accordini S, Corsico AG, Braggion M, Gerbase MW, Gislason D, Gulsvik A, et al. The cost of persistent asthma in Europe: an international population-based study in adults. Int Arch Allergy Immunol. 2013;160:93–101.
  • Global Initiative for Asthma. 2017 GINA Report, Global Strategy for Asthma Management and Prevention. 2017; Available from: http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention/ [last accessed 12 April 2017].
  • Romanet-Manent S, Charpin D, Magnan A, Lanteaume A, Vervloet D; EGEA Cooperative Group. Allergic vs nonallergic asthma: what makes the difference? Allergy. 2002;57:607–613.
  • Amin K, Lúdvíksdóttir D, Janson C, Nettelbladt O, Björnsson E, Roomans GM, et al. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group. Am J Respir Crit Care Med. 2000;162:2295–2301.
  • Lúdvíksdóttir D, Janson C, Högman M, Hedenström H, Björnsson E, Boman G. Exhaled nitric oxide and its relationship to airway responsiveness and atopy in asthma. BHR-Study Group. Respir Med. 1999;93:552–556.
  • Olafsdottir IS, Gislason T, Thjodleifsson B, Olafsson I, Gislason D, Jögi R, et al. C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study. Thorax. 2005;60:451–454.
  • Janson C. Phenotypes of obstructive lung disease. Clin Respir J. 2008;2 Suppl 1:88–91.
  • Rönmark E, Jönsson E, Platts-Mills T, Lundbäck B. Different pattern of risk factors for atopic and nonatopic asthma among children–report from the Obstructive Lung Disease in Northern Sweden Study. Allergy. 1999;54:926–935.
  • Janson C, Kalm-Stephens P, Foucard T, Alving K, Nordvall SL. Risk factors associated with allergic and non-allergic asthma in adolescents. Clin Respir J. 2007;1:16–22.
  • Porsbjerg C, Menzies-Gow A. Co-morbidities in severe asthma: Clinical impact and management. Respirology 2017 ( in press)
  • Braunstahl GJ, Fokkens WJ, Overbeek SE, KleinJan A, Hoogsteden HC, Prins JB. Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways. Clin Exp Allergy. 2003;33:579–587.
  • Bousquet J, Vignola AM, Demoly P. Links between rhinitis and asthma. Allergy. 2003;58:691–706.
  • Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010;126:466–476.
  • Hens G, Vanaudenaerde BM, Bullens DM, Piessens M, Decramer M, Dupont LJ, et al. Sinonasal pathology in nonallergic asthma and COPD: ‘united airway disease’ beyond the scope of allergy. Allergy. 2008;63:261–267.
  • Bjerg A, Ekerljung L, Middelveld R, Dahlén SE, Forsberg B, Franklin K, et al. Increased prevalence of symptoms of rhinitis but not of asthma between 1990 and 2008 in Swedish adults: comparisons of the ECRHS and GA²LEN surveys. PLoS One. 2011;6:e16082.
  • Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T, et al. Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe. Allergy. 2012;67:91–98.
  • Obaseki D, Potts J, Joos G, Baelum J, Haahtela T, Ahlström M, et al. The relation of airway obstruction to asthma, chronic rhinosinusitis and age: results from a population survey of adults. Allergy. 2014;69:1205–1214.
  • Johansson SG, Flohr C, Wahlgren CF, Williams H. Role of immunoglobulin E sensitization in eczema, previously referred to as atopic dermatitis. Expert Rev Clin Immunol. 2005;1:257–262.
  • Sinisgalli S, Collins MS, Schramm CM. Clinical Features Cannot Distinguish Allergic from Non-allergic Asthma in Children. J Asthma 2012;49:51–56.
  • Ek A, Middelveld RJ, Bertilsson H, Bjerg A, Ekerljung L, Malinovschi A, et al. Chronic rhinosinusitis in asthma is a negative predictor of quality of life: results from the Swedish GA(2)LEN survey. Allergy. 2013;68:1314–1321.
  • Burney PG, Laitinen LA, Perdrizet S, Huckauf H, Tattersfield AE, Chinn S, et al. Validity and repeatability of the IUATLD (1984) Bronchial Symptoms Questionnaire: an international comparison. Eur Respir J. 1989;2:940–945.
  • Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012;(23):1–298.
  • Harrop J, Chinn S, Verlato G, Olivieri M, Norbäck D, Wjst M, et al. Eczema, atopy and allergen exposure in adults: a population-based study. Clin Exp Allergy. 2007;37:526–535.
  • Heinzerling LM, Burbach GJ, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S, et al. GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. Allergy. 2009;64:1498–1506.
  • ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. American Thoracic Society; European Respiratory Society. Am J Respir Crit Care Med. 2005;171:912–930.
  • Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005;26:319–338.
  • Juniper EF, O'Byrne PM, Guyatt GH, Ferrie PJ, King DR. Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999;14:902–907.
  • Kariyawasam HH, Rotiroti G. Allergic rhinitis, chronic rhinosinusitis and asthma: unravelling a complex relationship. Curr Opin Otolaryngol Head Neck Surg. 2013;21:79–86.
  • Braunstahl GJ. Chronic rhinosinusitis, nasal polyposis and asthma: the united airways concept reconsidered? Clin Exp Allergy. 2011;41:1341–1343.
  • Feng CH, Miller MD, Simon RA. The united allergic airway: connections between allergic rhinitis, asthma, and chronic sinusitis. Am J Rhinol Allergy. 2012;26:187–190.
  • Hopper JL, Bui QM, Erbas B, Matheson MC, Gurrin LC, Burgess JA, et al. Does eczema in infancy cause hay fever, asthma, or both in childhood? Insights from a novel regression model of sibling data. J Allergy Clin Immunol. 2012;130:1117–1122.
  • Hellings PW, Fokkens WJ, Akdis C, Bachert C, Cingi C, Dietz de Loos D, et al. Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today? Allergy. 2013;68:1–7.
  • Müller S, Marenholz I, Lee YA, Sengler C, Zitnik SE, Griffioen RW, et al. Association of Filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population. Pediatr Allergy Immunol. 2009;20:358–361.
  • Enomoto H, Hirata K, Otsuka K, Kawai T, Takahashi T, Hirota T, et al. Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study. J Hum Genet. 2008;53:615–621.
  • Mackenzie KJ, Anderton SM, Schwarze J. Viral respiratory tract infections and asthma in early life; cause and effect? Clin Exp Allergy. 2914;44:9–19.
  • Sigurs N, Aljassim F, Kjellman B, Robinson PD, Sigurbergsson F, Bjarnason R, et al. Asthma and allergy patterns over 18 sources after severe RSV bronchiolitis in the first source of life. Thorax. 2010;65:1045–1052.
  • Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178:667–672.
  • Hedman L, Andersson M, Bjerg A, Forsberg B, Lundbäck B, Rönmark E. Environmental risk factors related to the incidence of wheeze and asthma in adolescence. Clin Exp Allergy. 2015;45:184–191.
  • Lee YL, Hsiue TR, Lee CH, Su HJ, Guo YL. Home exposures, parental atopy, and occurrence of asthma symptoms in adulthood in southern Taiwan. Chest. 2006;129:300–308.
  • Eriksson J, Ekerljung L, Lötvall J, Pullerits T, Wennergren G, Rönmark E, et al. Growing up on a farm leads to lifelong protection against allergic rhinitis. Allergy. 2010;65:1397–403.
  • Campbell BE, Lodge CJ, Lowe AJ, Burgess JA, Matheson MC, et al. Exposure to ‘farming’ and objective markers of atopy: a systematic review and meta-analysis. Clin Exp Allergy. 2015;45:744–757.
  • Lötvall J, Ekerljung L, Lundbäck B. Multi-symptom asthma is closely related to nasal blockage, rhinorrhea and symptoms of chronic rhinosinusitis-evidence from the West Sweden Asthma Study. Respir Res. 2010;11:163.
  • Appleton SL, Adams RJ, Wilson DH, Taylor AW, Ruffin RE; North West Adelaide Health Study Team. Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. J Allergy Clin Immunol. 2006;118:1284–1291.
  • Nieves A, Magnan A, Boniface S, Proudhon H, Lanteaume A, Romanet S, et al. ARIA. Phenotypes of asthma revisited upon the presence of atopy. Respir Med. 2005;99:347–354.
  • Knudsen TB, Thomsen SF, Nolte H, Backer V. A population-based clinical study of allergic and non-allergic asthma. J Asthma. 2009;46:91–94.
  • Chastang J, Baiz N, Parnet L, Cadwallader JS, De Blay F, Caillaud D, et al. Changes in body mass index during childhood and risk of various asthma phenotypes: a retrospective analysis. Pediatr Allergy Immunol 2017 ( in press)
  • Ludviksdottir D, Diamant Z, Alving K, Bjermer L, Malinovschi A. Clinical aspects of using exhaled NO in asthma diagnosis and management. Clin Respir J. 2012;6:193–207.
  • Bjermer L, Alving K, Diamant Z, Magnussen H, Pavord I, Piacentini G, et al. Current evidence and future research needs for FeNO measurement in respiratory diseases. Respir Med. 2014;108:830–841.
  • Malinovschi A, Janson C, Högman M, Rolla G, Torén K, Norbäck D, et al. Both allergic and nonallergic asthma are associated with increased FE(NO) levels, but only in never-smokers. Allergy. 2009;64:55–61.
  • Pekkanen J, Lampi J, Genuneit J, Hartikainen AL, Järvelin MR. Analyzing atopic and non-atopic asthma. Eur J Epidemiol. 2012;27:281–286.
  • Tomassen P1, Newson RB, Hoffmans R, Lötvall J, Cardell LO, Gunnbjörnsdóttir M, et al. Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis - a GA² LEN study. Allergy. 2011;66:556–61.

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