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Pharmacotherapy

Dupilumab in patients with uncontrolled asthma: type 2 biomarkers might be predictors of therapeutic efficacy

, BD, , BD, , MD, , BD & , PhDORCID Icon

References

  • Zayed Y, Kheiri B, Banifadel M, Hicks M, Aburahma A, Hamid K, Bachuwa G, Chandran A. Dupilumab safety and efficacy in uncontrolled asthma: a systematic review and meta-analysis of randomized clinical trials. Journal of Asthma 2018;1:1–10. doi: 10.1080/02770903.2018.1520865.
  • Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, et al. Dupilumab in persistent asthma with elevated eosinophil levels. New England Journal of Medicine 2013;368:2455–2466.
  • Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. The Lancet 2016;388:31–44.
  • Castro M, Corren J, Pavord ID, Maspero J, Wenzel S, Rabe KF, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. The New England Journal of Medicine 2018;378:2486–2496.
  • Rabe KF, Nair P, Brusselle G, Maspero JF, Castro M, Sher L, Zhu H, et al. Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma. The New England Journal of Medicine 2018;378:2475–2485.
  • Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ (Clin Res ed) 2015;350:g7647.

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