Advanced search
Publication Cover
Journal of Asthma Volume 58, 2021 - Issue 1
Submit an article Journal homepage
151
Views
2
CrossRef citations to date
0
Altmetric
Treatment

Efficacy and safety of tratinterol hydrochloride tablets in bronchial asthma: a randomized double-blind and multicenter clinical trial

Lingfei Konga The Institute Respiratory Disease, The First Hospital of China Medical University, Shenyang, China
, MD,
Yanhong Zhaob Heze Municipal Hospital, Heze, Shandong, China
, MSc,
Yan Wangc Haihe Hospital, Tianjin, China
, MSc,
Xiaoyue Changd The Center Hospital of Baotou, Baotou, Neimenggu, China
, MSc,
Liying Cuie The Affiliated Hospital of Inner Mongolia Medical University, Huhehaote, Inner Mongolia, China
, MSc,
Guozhong Guf Daqing General Hospital Group Oilfield General Hospital, Daqing, Heilongjiang, China
, MSc,
Zhuang Mag The General Hospital of Shenyang Military, Shenyang, Liaoning, China
, MD,
Qiang Luh People's Hospital of Tianjin, Tianjin, China
, MSc,
Liying Zhoui Lanzhou University Second Hospital, Lanzhou, Gansu, China
, MSc,
Lianming Dingj The 251stHospital of PLA, Zhangjiakou, Hebei, China
, MSc,
Zhenshan Wangk The Second Hospital of Dalian Medical University, Dalian, Liaoning, China
, MD,
Yuxia Shaol The Second Affiliated Hospital of Harbin Medical University, HarBin, Heilongjiang, China
, MSc,
Huaping Tangm Qingdao Municipal Hospital, Qingdao, Shandong, China
, MD,
Chunyu Zhangn The Center Hospital of Siping, Siping, Jilin, China
, MSc,
Fuxin Huio Wu Xi People's Hospital, Wuxi, Jiangsu, China
, MSc,
Xiaodong Meip Anhui Provincial Hospital, Hefei, Anhui, China
, MSc,
Jianbao Xinq Xiehe Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
, MSc,
Jianmin Huor The First Affiliated Hospital of HarBin Medical University, HarBin, Heilongjiang, China
, MD,
Shenghua Suns Respiratory Department, The Third Xiangya Hospital, Changsha, Hunan, China
, MD,
Sainan Zhut The Department of Health Statistics, Peking University, Beijing, China;
, MD,
Chen Yaot The Department of Health Statistics, Peking University, Beijing, China;
, MD,
Guijie Duu Shenyang Pharmaceutical University, Shenyang, Liaoning, China
, MSc,
Maosheng Chengv The Company of Jinzhou Jiutai Pharmaceutical Co., Ltd, Jinzhou, Liaoning, China
, MD &
Jian Kangx Respiratory Department, The Institute Respiratory Disease, The First Hospital of China Medical University, Shenyang, ChinaCorrespondence[email protected]
, MD show all
Pages 85-92 | Received 14 Apr 2019, Accepted 31 Aug 2019, Published online: 14 Oct 2019

References

  • Yimin C, Xia Z, Peihong S, Ying Z, Dong-fang Z, Hui-lin Z, Mao-sheng C, Jing-kai GU. Tolerability and pharmacokinetics of tratinterol hydrochloride tablets in healthy subjects after a single dose administration. Chin J Clin Pharmacol 2008;24:25–28.
  • Ying Z, Xia Z, Peihong S, Dongfang Z, Huilin Z, Maosheng C, Jing-kai GU. Tolerability and pharmacokinetics of tratinterol hydrochloride tablets in healthy subjects after multiple dose administration. Chin J Clin Pharmacol 2008;24:407–409.
  • Xia Z, Peihong S, Ying Z, Huilin Z, Maosheng C, Jingkai GU, Yimin C. Influence of pharmacokinetics of tratinterol hydrochloride tablets between administered with food and in fasted state in healthy subjects. Chin J Clin Pharmacol 2008;24:204–206.
  • Li K, Wang Y, Zhang L, Qin F, Guo X, Li F. Simultaneous determination of tratinterol and its metabolites in rat urine and feces by liquid chromatography – tandem mass spectrometry. J Chromatogr B Biomed Sci Appl 2013; 934: 89–96. doi:10.1016/j.jchromb.2013.06.033.
  • Lingfei K, Yuan Y, Yuxia S, Shenghua S, Jiaming L, Jian K. Efficacy and tolerability of tratinterol hydrochloride tablets in bronchial asthma: a multicenter, randomized, double-blind, dose-finding clinical trial. Clin Ther 2014;36:1195–1204. doi:10.1016/j.clinthera.2014.06.020.
  • Chinese Society of Respiratory Diseases. The guidelines of bronchial asthma (for the definition, diagnose, treatment, education and management of asthma). Clin J Tuberc Respir Dis 2008;26:132–138.
  • Global Initiative for Asthma. Global strategy for asthma management and prevention. Updated 2006. [accessed 2014 Sept 5]. http://www.ginasthma.org.
  • Cazzola M, Page CP, Rogliani P, Gabriella Matera M. β2-agonist therapy in lung disease. Am J Respir Crit Care Med 2013;187:690–696. doi:10.1164/rccm.201209-1739PP.
  • Rider CF, King EM, Holden NS, Giembycz MA, Newton R. Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. J Pharmacol Exp Ther 2011;338:860–869. Sep; doi:10.1124/jpet.111.181016.
  • Slattery D, Wong SW, Colin AA. Levalbuterol hydrochloride. Pediatr Pulmonol 2002;33:151–157.
  • Nyberg L, Wong C. Advances in terbutaline pharmacokinetics. Eur J Respit Dis 1984;65:134.
  • GumbhirShah K, Kellerman DJ, DeGraw S, Koch P, Jusko WJ. Pharmacokinetics and pharmacodynamics of cumulative single doses of inhaled salbutamol enantiomers in asthmatic subjects. PulmPharmacol Ther 1999;12:353–362.
  • Mansur AH, Afridi L, Sullivan J, Ayres JG, Wilson D. Continuous terbutaline infusion in severe asthma in adults: a retrospective study of long-term efficacy and safety. J Asthma 2014;51:1076–1078. doi:10.3109/02770903.2014.939281.
  • Chun C, Xiaohong W, Wanzhen Y, et al. Multicenter randomized controlled clinical trial of mabuterol hydrochloride tablets versus procaterol hydrochloride in the treatment of bronchial asthma. Chin J Clin Pharmacol 2011;27:7–10.
  • Qiwu Z, Sudan X. 73 cases of airway hyperresponsiveness of procaterol hydrochloride test results. Clin Pulmonary Med 2009;14:132–133.
  • Hao Z, Zhang Y, Pan L, Su X, Cheng M, Wang M, Zhao H, Wu Y. Comparison of enantiomers of SPFF, a novel beta2-Adrenoceptor agonist, in bronchodilating effect in guinea pigs. Biol Pharm Bull 2008;31:866–872. doi:10.1248/bpb.31.866.
  • Lening G, Che W, Minwei W, Maosheng C, Li P. Effect of 2-(4-amino-3-chloro-5-trifluomethyl-phenyl)-2-tert-butylaminoethanol hydrochloride on airway smooth muscle. Chin New Drugs J 2003;12:1007–1011.
  • Sun Y, Liu M, Zhang J, Jiang Y, Yu W, Fawcett JP, Gu J. Rapid and sensitive assay for tratinterol, a novel beta(2)-adrenoceptor agonist, in human plasma using liquid. J Pharm Biomed Anal 2009;49:1056–1059. doi:10.1016/j.jpba.2009.01.012.
  • Kong L, Liu J, Gu G, Huo J, Ma Z, Shao Y, Sun S, Yuan Y, Zhu S, Yao C, et al. Randomized, Multicenter clinical study of tratinterol hydrochloride tablets for the treatment of bronchial asthma. Clin Ther 2015;37:1248–1258. doi:10.1016/j.clinthera.2015.03.013.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.