References
- Gustafsson PM, Watson L, Davis KJ, Rabe KF. Poor asthma control in children: evidence from epidemiological surveys and implications for clinical practice. Int J Clin Pract. 2006;60(3):321–334. doi:https://doi.org/10.1111/j.1368-5031.2006.00798.x.
- Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2020. Available from: www.ginasthma.org [last accessed 4 February 2021].
- Asthma: diagnosis, monitoring and chronic asthma management. NICE guideline. Available from: https://www.nice.org.uk/guidance/ng80/resources/asthma-diagnosis-monitoring-and-chronic-asthma-managementpdf-1837687975621 [last accessed 1 June 2021].
- Amin S, Soliman M, McIvor A, Cave A, Cabrera C. Understanding patient perspectives on medication adherence in asthma: a targeted review of qualitative studies. Patient Prefer Adherence. 2020;14:541–551. doi:https://doi.org/10.2147/PPA.S234651.
- Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980-2007. Pediatrics. 2009;123 Suppl 3:S131–S145. doi:https://doi.org/10.1542/peds.2008-2233C.
- Dennis RJ, Caraballo L, García E, Rojas MX, Rondon MA, Pérez A, Aristizabal G, Peñaranda A, Barragan AM, Ahumada V, et al. Prevalence of asthma and other allergic conditions in Colombia 2009-2010: a cross-sectional study. BMC Pulm Med. 2012;12:17. doi:https://doi.org/10.1186/1471-2466-12-17.
- National Center for Health Statistics. Compressed Mortality File, 1999-2016 (machine readable data file and documentation, CD‑ROM Series 20, No. 2V) as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Hyattsville, MD: Centers for Disease Control and Prevention; 2017.
- Lane S, Molina J, Plusa T. An international observational prospective study to determine the cost of asthma exacerbations (COAX). Res Med. 2006;100(3):434–450. doi:https://doi.org/10.1016/j.rmed.2005.06.012.
- Rodriguez-Martinez CE, Sossa-Briceño MP, Castro-Rodriguez JA. Predictors of response to medications for asthma in pediatric patients: a systematic review of the literature. Pediatr Pulmonol. 2020;55(6):1320–1331.
- Chipps BE, Bacharier LB, Farrar JR, Jackson DJ, Murphy KR, Phipatanakul W, Szefler SJ, Teague WG, Zeiger RS. The pediatric asthma yardstick: practical recommendations for a sustained step-up in asthma therapy for children with inadequately controlled asthma. Ann Allergy Asthma Immunol. 2018;120(6):559–579.e11. doi:https://doi.org/10.1016/j.anai.2018.04.002.
- Ahmed H, Turner S. Severe asthma in children-a review of definitions, epidemiology, and treatment options in 2019. Pediatr Pulmonol. 2019;54(6):778–787. doi:https://doi.org/10.1002/ppul.24317.
- Israel E. Implementing the guidelines: what do you do when the rubber hits the road?J Allergy Clin Immunol. 2020;146(6):1271–1274. doi:https://doi.org/10.1016/j.jaci.2020.10.010.
- Szefler SJ. Update on the NAEPPCC Asthma Guidelines: the wait is over, or is it?J Allergy Clin Immunol. 2020;146(6):1275–1280. doi:https://doi.org/10.1016/j.jaci.2020.01.025.
- Teague WG, Lawrence MG, Shirley D-AT, Garrod AS, Early SV, Payne JB, Wisniewski JA, Heymann PW, Daniero JJ, Steinke JW, et al. Lung lavage granulocyte patterns and clinical phenotypes in children with severe, therapy-resistant asthma. J Allergy Clin Immunol Pract. 2019;7(6):1803–1812.e10. doi:https://doi.org/10.1016/j.jaip.2018.12.027.
- Bel EH. Measuring adherence to inhaled corticosteroids in asthma: getting closer!Am J Respir Crit Care Med. 2012;186(11):1067–1068. doi:https://doi.org/10.1164/rccm.201209-1746ED.
- Bender B, Wamboldt FS, O’Connor SL, Rand C, Szefler S, Milgrom H, Wamboldt MZ. Measurement of children’s asthma medication adherence by self report, mother report, canister weight, and Doser CT. Ann Allergy Asthma Immunol. 2000;85(5):416–421. doi:https://doi.org/10.1016/S1081-1206(10)62557-4.
- Morton RW, Everard ML, Elphick HE. Adherence in childhood asthma: the elephant in the room. Arch Dis Child. 2014;99(10):949–953. doi:https://doi.org/10.1136/archdischild-2014-306243.
- Rand CS, Wise RA. Measuring adherence to asthma medication regimens. Am J Respir Crit Care Med. 1994;149(2 Pt 2):S69–S76. discussion S7-8. doi:https://doi.org/10.1164/ajrccm/149.2_Pt_2.S69.
- Martin LR, Williams SL, Haskard KB, Dimatteo MR. The challenge of patient adherence. Ther Clin Risk Manag. 2005;1(3):189–199.
- Hui RWH. Inhaled corticosteroid-phobia and childhood asthma: current understanding and management implications. Paediatr Respir Rev. 2020;33:62–66. doi:https://doi.org/10.1016/j.prrv.2019.03.009.
- Sumino K, Cabana MD. Medication adherence in asthma patients. Curr Opin Pulmonary Med. 2013;19(1):49–53.
- De Geest S, Sabaté E. Adherence to long-term therapies: evidence for action. Eur J Cardiovasc Nurs. 2003;2(4):323–323. doi:https://doi.org/10.1016/S1474-5151(03)00091-4.
- Zar HJ, Levin ME. Challenges in treating pediatric asthma in developing countries. Paediatr Drugs. 2012;14(6):353–359. doi:https://doi.org/10.2165/11597420-000000000-00000.
- Boulet LP, Vervloet D, Magar Y, Foster JM. Adherence: the goal to control asthma. Clin Chest Med. 2012;33(3):405–417. doi:https://doi.org/10.1016/j.ccm.2012.06.002.
- Meichenbaum D, Turk TC. Facilitating treatment adherence. New York: Springer; 1987.
- DiMatteo MR. Enhancing patient adherence to medical recommendations. JAMA. 1994;271(1):79–83. doi:https://doi.org/10.1001/jama.271.1.79.
- McQuaid EL, Everhart RS, Seifer R, Kopel SJ, Mitchell DK, Klein RB, Esteban CA, Fritz GK, Canino G. Medication adherence among Latino and non-Latino white children with asthma. Pediatrics. 2012;129(6):e1404–e1410. doi:https://doi.org/10.1542/peds.2011-1391.
- Burgess SW, Sly PD, Morawska A, Devadason SG. Assessing adherence and factors associated with adherence in young children with asthma. Respirology (Carlton, Vic.). 2008;13(4):559–563. doi:https://doi.org/10.1111/j.1440-1843.2008.01292.x.
- Lasmar L, Camargos P, Bousquet J, Goulart E, Sakurai E, Carvalhais M. Factors related to lower adherence rates to inhaled corticosteroids in children and adolescents: a prospective randomized cohort study. J Trop Pediatr. 2009;55(1):20–25. doi:https://doi.org/10.1093/tropej/fmn067.
- Rand CS. Adherence to asthma therapy in the preschool child. Allergy. 2002;57 Suppl 74:48–57. doi:https://doi.org/10.1034/j.1398-9995.57.s74.7.x.
- Koster ES, Wijga AH, Koppelman GH, Postma DS, Brunekreef B, De Jongste JC, Smit HA, Hoekstra MO, Raaijmakers JAM, Maitland-van der Zee A-H, et al. Uncontrolled asthma at age 8: the importance of parental perception towards medication. Pediatr Allergy Immunol. 2011;22(5):462–468. doi:https://doi.org/10.1111/j.1399-3038.2011.01150.x.
- Lee J, Tay TR, Radhakrishna N, Hore-Lacy F, Mackay A, Hoy R, Dabscheck E, O’Hehir R, Hew M. Nonadherence in the era of severe asthma biologics and thermoplasty. Eur Respir J. 2018;51(4):1701836. doi:https://doi.org/10.1183/13993003.01836-2017.
- Quittner AL, Modi AC, Lemanek KL, Ievers-Landis CE, Rapoff MA. Evidence-based assessment of adherence to medical treatments in pediatric psychology. J Pediatr Psychol. 2008;33(9):916–936. Discussion 37–8. doi:https://doi.org/10.1093/jpepsy/jsm064.
- Jochmann A, Artusio L, Jamalzadeh A, Nagakumar P, Delgado-Eckert E, Saglani S, Bush A, Frey U, Fleming LJ. Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children. Eur Respir J. 2017;50(6):1700910. doi:https://doi.org/10.1183/13993003.00910-2017.
- Bender BG, Rand C. Medication non-adherence and asthma treatment cost. Curr Opin Allergy Clin Immunol. 2004;4(3):191–195. doi:https://doi.org/10.1097/00130832-200406000-00009.
- Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet (London, England). 2012;380(9842):651–659. doi:https://doi.org/10.1016/S0140-6736(12)60988-X.
- Foster JM, Smith L, Bosnic-Anticevich SZ, Usherwood T, Sawyer SM, Rand CS, Reddel HK. Identifying patient-specific beliefs and behaviours for conversations about adherence in asthma. Intern Med J. 2012;42(6):e136–e144. doi:https://doi.org/10.1111/j.1445-5994.2011.02541.x.
- Hulley SB, Cummings SR. Diseño de la investigación clínica. Un enfoque epidemiológico. Barcelona: Ediciones Doyma S.A.; 1993.
- Pearce CJ, Fleming L. Adherence to medication in children and adolescents with asthma: methods for monitoring and intervention. Expert Rev Clin Immunol. 2018;14(12):1055–1063. doi:https://doi.org/10.1080/1744666X.2018.1532290.
- Rodriguez Martinez CE, Sossa MP, Rand CS. Validation of a questionnaire for assessing adherence to metered-dose inhaler use, in asthmatic children. Pediatr Asthma Allergy Immunol. 2007;20(4):243–253. doi:https://doi.org/10.1089/pai.2007.001.
- Janežič A, Locatelli I, Kos M. Criterion validity of 8-item Morisky Medication Adherence Scale in patients with asthma. PloS One. 2017;12(11):e0187835. doi:https://doi.org/10.1371/journal.pone.0187835.
- Garcia-Marcos PW, Brand PL, Kaptein AA, Klok T. Is the MARS questionnaire a reliable measure of medication adherence in childhood asthma?J Asthma. 2016;53(10):1085–1089. doi:https://doi.org/10.1080/02770903.2016.1180699.
- Duke T, Yano E, Hutchinson A, Hwaihwanje I, Aipit J, Tovilu M, Uluk T, Rongap T, Vetuna B, Lagani W, et al. Large-scale data reporting of paediatric morbidity and mortality in developing countries: it can be done. Arch Dis Child. 2016;101(4):392–397. doi:https://doi.org/10.1136/archdischild-2015-309353.
- Schattner A. Who cares for empathy?QJM. 2012;105(3):287–290. doi:https://doi.org/10.1093/qjmed/hcr215.
- van Dellen QM, Stronks K, Bindels PJ, Ory FG, van Aalderen WM. Adherence to inhaled corticosteroids in children with asthma and their parents. Respir Med. 2008;102(5):755–763. doi:https://doi.org/10.1016/j.rmed.2007.12.005.
- Conn KM, Halterman JS, Lynch K, Cabana MD. The impact of parents’ medication beliefs on asthma management. Pediatrics. 2007;120(3):e521–e526. doi:https://doi.org/10.1542/peds.2006-3023.
- Peterson-Sweeney K, McMullen A, Yoos HL, Kitzman H. Parental perceptions of their child’s asthma: management and medication use. J Pediatr Health Care. 2003;17(3):118–125. doi:https://doi.org/10.1067/mph.2003.31.
- Clifford S, Barber N, Horne R. Understanding different beliefs held by adherers, unintentional nonadherers, and intentional nonadherers: application of the Necessity-Concerns Framework. J Psychosomatic Res. 2008;64(1):41–46. doi:https://doi.org/10.1016/j.jpsychores.2007.05.004.
- Rubin BK, Zhao W, Winders TA. What do patients want from their asthma care doctors?Paediatr Respir Rev. 2018;27:86–89. doi:https://doi.org/10.1016/j.prrv.2017.11.002.
- Klok T, Brand PL, Bomhof-Roordink H, Duiverman EJ, Kaptein AA. Parental illness perceptions and medication perceptions in childhood asthma, a focus group study. Acta Paediatrica (Oslo, Norway). 2011;100(2):248–252. doi:https://doi.org/10.1111/j.1651-2227.2010.02024.x.
- Rodriguez-Martinez CE, Sossa-Briceño MP, Castro-Rodriguez JA. Cost-utility analysis of once-daily versus twice-daily inhaled corticosteroid dosing for maintenance treatment of asthma in pediatric patients. J Asthma. 2016;53(5):538–545. doi:https://doi.org/10.3109/02770903.2015.1116087.
- Reznik M, Silver EJ, Cao Y. Evaluation of MDI-spacer utilization and technique in caregivers of urban minority children with persistent asthma. J Asthma. 2014;51(2):149–154. doi:https://doi.org/10.3109/02770903.2013.854379.
- Giraud V, Roche N. Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability. Eur Respir J. 2002;19(2):246–251. doi:https://doi.org/10.1183/09031936.02.00218402.
- Lindgren S, Bake B, Larsson S. Clinical consequences of inadequate inhalation technique in asthma therapy. Eur J Respir Dis. 1987;70(2):93–98.
- Newman SP, Weisz AW, Talaee N, Clarke SW. Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique. Thorax. 1991;46(10):712–716. doi:https://doi.org/10.1136/thx.46.10.712.
- Laube BL, Janssens HM, de Jongh FHC, Devadason SG, Dhand R, Diot P, Everard ML, Horvath I, Navalesi P, Voshaar T, et al. What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J. 2011;37(6):1308–1331. doi:https://doi.org/10.1183/09031936.00166410.
- Rodríguez-Martínez CE, Sossa-Briceño MP, Nino G. A systematic review of instruments aimed at evaluating metered-dose inhaler administration technique in children. J Asthma. 2017;54(2):173–185. doi:https://doi.org/10.1080/02770903.2016.1198373.
- Kshatriya RM, Khara NV, Paliwal RP, Patel SN. Evaluation of proficiency in using different inhaler devices among intern doctors. J Family Med Prim Care. 2016;5(2):362–366. doi:https://doi.org/10.4103/2249-4863.192375.
- Elgendy MO, Hassan AH, Saeed H, Abdelrahim ME, Eldin RS. Asthmatic children and MDI verbal inhalation technique counseling. Pulm Pharmacol Ther. 2020;61:101900. doi:https://doi.org/10.1016/j.pupt.2020.101900.
- Fu Z, Xu Y, Cai C. Efficacy and safety of omalizumab in children with moderate-to-severe asthma: a meta-analysis. J Asthma. 2020:1–9. doi:https://doi.org/10.1080/02770903.2020.1789875.
- Corren J, Panettieri RA, Jr. How important is adherence to inhaled medications before starting a biologic therapy for asthma?J Allergy Clin Immunol Pract. 2018;6(5):1578–1579. doi:https://doi.org/10.1016/j.jaip.2018.07.007.
- Rosenthal M. Never mind the biologics, just take the inhalers. Breathe (Sheff). 2018;14(3):176–179. doi:https://doi.org/10.1183/20734735.021118.
- Institute for Clinical and Economic Review. Biologic therapies for treatment of asthma associated with type 2 inflamation: effectiveness, value, and value-based price benchmarks: Final evidence report. Boston, MA: Institute for Clinical and Economic Review; December 20, 2018. Available at: https://icer-review.org/material/asthma-nal-evidence-report/ [last accessed February 11, 2021].
- Zhou H, Lu Y, Wu B, Che D. Cost-effectiveness of omalizumab for the treatment of inadequately controlled severe allergic asthma in Chinese children. J Asthma. 2020;57(1):87–94. doi:https://doi.org/10.1080/02770903.2018.1544642.
- Lovinsky-Desir S. The use of biologic therapies for the management of pediatric asthma. Pediatr Pulmonol. 2020;55(3):803–808. doi:https://doi.org/10.1002/ppul.24613.
- Mills A. Reflections on the development of health economics in low- and middle-income countries. Proc Biol Sci. 2014;281(1789):20140451. doi:https://doi.org/10.1098/rspb.2014.0451.
- Schieber G, Maeda A. Health care financing and delivery in developing countries. Health Aff (Millwood). 1999;18(3):193–205. doi:https://doi.org/10.1377/hlthaff.18.3.193.
- Stewart MA. Effective physician-patient communication and health outcomes: a review. CMAJ: Can Med Assoc J = J L’Assoc Med Canadienne. 1995;152(9):1423–1433.