Predictors of methacholine challenge testing results in subjects without airflow obstruction

References

• Global Initiative for Asthma. Global strategy for asthma management and prevention; 2020. (report). [accessed 2021 Jan 22]. www.ginasthma.org.
   Google Scholar
• Lougheed M, Lemiere C, Ducharme F, Licskai C, Dell S, Rowe B, Fitzgerald JM, Leigh R, Watson W, Boulet L-P, Canadian Thoracic Society Asthma Clinical Assembly. Canadian Thoracic Society 2012 guideline update: Diagnosis and management of asthma in preschoolers, children and adults. Can Respir J. 2012;19(2):127–164. doi:10.1155/2012/635624.
   PubMed Web of Science ®Google Scholar
• British Thoracic Society. British guideline on the management of asthma; 2019. (report). [accessed 2021 Jan 22]. www.brit-thoracic.org.uk.
   Google Scholar
• Cockcroft DW, Murdock KY, Berscheid BA, Gore BP. Sensitivity and specificity of histamine PC20 determination in a random selection of young college students. J Allergy Clin Immunol. 1992;89(1):23–30. doi:10.1016/S0091-6749(05)80037-5.
   PubMed Web of Science ®Google Scholar
• Nieminen MM. Unimodal distribution of bronchial hyperresponsiveness to methacholine in asthmatic patients. Chest. 1992;102(5):1537–1543. doi:10.1378/chest.102.5.1537.
   PubMed Web of Science ®Google Scholar
• Thériault R, Raz A. Patterns of bronchial challenge testing in Canada. CJRT. 2018;54(2):41–47. doi:10.29390/cjrt-2018-006.
   Google Scholar
• Crapo R, Casaburi R, Coates A, Enright P, Hankinson J, Irvin C, MacIntyre N, McKay R, Wanger J, Anderson S, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med. 2000;161(1):309–329. doi:10.1164/ajrccm.161.1.ats11-99.
   PubMed Web of Science ®Google Scholar
• Coates A, Wanger J, Cockcroft DW, Culver B, Diamant Z, Gauvreau G, Hall G, Hallstrand T, Horvath I, de Jongh F, the Bronchoprovocation Testing Task Force, et al. ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. Eur Respir J. 2017;49(5):1601526. doi:10.1183/13993003.01526-2016.
   PubMed Web of Science ®Google Scholar
• Quanjer P, Stanojevic S, Cole T, Baur X, Hall G, Culver B, Enright P, Hankinson J, Ip M, Zheng J, ERS Global Lung Function Initiative, et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations . Eur Respir J. 2012;40(6):1324–1343. doi:10.1183/09031936.00080312.
   PubMed Web of Science ®Google Scholar
• Miller M, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, van der Grinten C, Gustafsson P, ATS/ERS Task Force, et al. General considerations for lung function testing. Eur Respir J. 2005;26(1):153–161. doi:10.1183/09031936.05.00034505.
   PubMed Web of Science ®Google Scholar
• Pellegrino R, Viegi G, Jensen R, Johnson D, MacIntyre N, McKay R, Miller M, Navajas D, Pedersen O, Wanger J, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–968. doi:10.1183/09031936.05.00035205.
   PubMed Web of Science ®Google Scholar
• Wanger J, Clausen J, Coates A, Pedersen O, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten C, et al. Standardisation of the measurement of lung volumes. Eur Respir J. 2005;26(3):511–522. doi:10.1183/09031936.05.00035005.
   PubMed Web of Science ®Google Scholar
• Morgado R, Oliveira C, Campanha R, Moreira S, Staats R, Escaleira D, Valença J, Bárbara C. Predictive factors of a positive methacholine challenge response based on data from a baseline respiratory function test. Eur Respir J. 2015;46(suppl):PA609. [abstract]. doi:10.1183/13993003.congress-2015.PA609.
   Web of Science ®Google Scholar
• Hardaker K, Downie S, Kermode J, Farah C, Brown N, Berend N, King G, Salome C. Predictors of airway hyperresponsiveness differ between old and young patients with asthma. Chest. 2011;139(6):1395–1401. doi:10.1378/chest.10-1839.
   PubMed Web of Science ®Google Scholar
• Schwartz J, Schindler C, Zemp E, Perruchoud AP, Zellweger J-P, Wüthrich B, Leuenberger P, Ackermann-Liebrich U. Predictors of methacholine responsiveness in a general population. Chest. 2002;122(3):812–820. doi:10.1378/chest.122.3.812.
   PubMed Web of Science ®Google Scholar
• Burgess JA, Matheson MC, Diao F, Johns DP, Erbas B, Lowe AJ, Gurrin LC, Lodge CJ, Thomas PS, Morrison S, et al. Bronchial hyperresponsiveness and obesity in middle age: insights from an Australian cohort. Eur Respir J. 2017;50(3):1602181. doi:10.1183/13993003.02181-2016.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Asthma data visualizations. 2020. [accessed 2021 Jan 22]. https://www.cdc.gov/asthma/data-visualizations/default.htm.
   Google Scholar
• Fuseini H, Newcomb DC. Mechanisms driving gender differences in asthma. Curr Allergy Asthma Rep. 2017;17(3):19. doi:10.1007/s11882-017-0686-1.
   PubMed Web of Science ®Google Scholar
• Zein JG, Erzurum SC. Asthma is different in women. Curr Allergy Asthma Rep. 2015;15(6):28. doi:10.1007/s11882-015-0528-y.
   PubMed Web of Science ®Google Scholar
• Shah N, Manek G, Stettmeier KD, Datta D. Demographic and spirometric characteristics of patients with positive and negative methacholine challenge test. Am J Respir Crit Care Med. 2020;201:A5643–A5643. [abstract]. doi:10.1164/ajrccm-conference.2020.201.1_MeetingAbstracts.A5643.
   Web of Science ®Google Scholar
• Vijayan K, Shrestha P, Bautista M, Goldstein L, Neupane B. Association of BMI with airways hyper-responsive to methacholine [abstract]. Chest. 2016;149(4):A13. doi:10.1016/j.chest.2016.02.015.
   Web of Science ®Google Scholar
• Neder JA, Berton DC, O’Donnell DE. Obesity: how pulmonary function tests may let us down. J Bras Pneumol. 2020;46(3):e20200116.
   PubMed Web of Science ®Google Scholar
• Saint-Pierre M, Ladha J, Berton DC, Reimao G, Castelli G, Marillier M, Bernard A-C, O’Donnell DE, Neder JA. Is the slow vital capacity clinically useful to uncover airflow limitation in subjects with preserved FEV1/FVC ratio? Chest. 2019;156(3):497–506. doi:10.1016/j.chest.2019.02.001.
   PubMed Web of Science ®Google Scholar
• D’urzo K, Chen A, D’Urzo A. Lung function among patients with and without airway hyperresponsiveness in primary care [abstract]. Chest. 2019;155(6):A381. doi:10.1016/j.chest.2019.04.082.
   Web of Science ®Google Scholar
• Litonjua AA, Sparrow D, Weiss ST. The FEF25-75/FVC ratio is associated with methacholine airway responsiveness: the Normative Aging Study. Am J Respir Crit Care Med. 1999;159(5):1574–1579. doi:10.1164/ajrccm.159.5.9803063.
   PubMed Web of Science ®Google Scholar
• Stanbrook MB, Chapman KR, Kesten S. Gas trapping as a predictor of positive methacholine challenge in patients with normal spirometry results. Chest. 1995;107(4):992–995. doi:10.1378/chest.107.4.992.
   PubMed Web of Science ®Google Scholar
• Collard P, Njinou B, Nejadnik B, Keyeux A, Frans A. Single breath diffusing capacity for carbon monoxide in stable asthma. Chest. 1994;105(5):1426–1429. doi:10.1378/chest.105.5.1426.
   PubMed Web of Science ®Google Scholar
• Neder JA, Berton DC, Muller PT, O’Donnell DE. Incorporating lung diffusing capacity for carbon monoxide in clinical decision making in chest medicine. Clin Chest Med. 2019;40(2):285–305. doi:10.1016/j.ccm.2019.02.005.
   PubMed Web of Science ®Google Scholar
• FitzGerald JM, Lemiere C, Lougheed MD, Ducharme FM, Dell SD, Ramsey C, Yang MCL, Côté A, Watson W, Olivenstein R, et al. Recognition and management of severe asthma: A Canadian Thoracic Society position statement. Can J Respir Crit Care Sleep Med. 2017;1(4):199–221. doi:10.1080/24745332.2017.1395250.
   Web of Science ®Google Scholar
• Bourbeau J, Bhutani M, Hernandez P, Aaron SD, Balter M, Beauchesne M-F, D’Urzo A, Goldstein R, Kaplan A, Maltais F, et al. Canadian Thoracic Society Clinical Practice Guideline on pharmacotherapy in patients with COPD – 2019 update of evidence. Can J Respir Crit Care Sleep Med. 2019;3(4):210–232. doi:10.1080/24745332.2019.1668652.
   Web of Science ®Google Scholar
• Kovalszki A, Weller PF. Eosinophilia. Prim Care. 2016;43(4):607–617. doi:10.1016/j.pop.2016.07.010.
   PubMed Web of Science ®Google Scholar
• Annema JT, Sparrow D, O’Connor GT, Rijcken B, Koëter GH, Postma DS, Weiss ST. Chronic respiratory symptoms and airway responsiveness to methacholine are associated with eosinophilia in older men: The Normative Aging Study. Eur Respir J. 1995;8(1):62–69. doi:10.1183/09031936.95.08010062.
   PubMed Web of Science ®Google Scholar
• Schwartz N, Grossman A, Levy Y, Schwarz Y. Correlation between eosinophil count and methacholine challenge test in asymptomatic subjects. J Asthma. 2012;49(4):336–341. doi:10.3109/02770903.2012.672613.
   PubMed Web of Science ®Google Scholar
• Cockcroft DW. Methacholine challenge. Clin Pulm Med. 2007;14(1):1–6. doi:10.1097/01.cpm.0000252840.59547.29.
   Google Scholar
• Sumino K, Sugar EA, Irvin CG, Kaminsky DA, Shade D, Wei CY, Holbrook JT, Wise RA, Castro M, American Lung Association Asthma Clinical Research Centers. Methacholine challenge test: Diagnostic characteristics in asthmatic patients receiving controller medications. J Allergy Clin Immunol. 2012;130(1):69–75. doi:10.1016/j.jaci.2012.02.025.
   PubMed Web of Science ®Google Scholar
• Cockcroft DW. Methacholine challenge testing in the diagnosis of asthma. Chest. 2020;158(2):433–434. doi:10.1016/j.chest.2020.04.034.
   PubMed Web of Science ®Google Scholar
• McGrath KW, Fahy JV. Negative methacholine challenge tests in subjects who report physician-diagnosed asthma. Clin Exp Allergy. 2011;41(1):46–51. doi:10.1111/j.1365-2222.2010.03627.x.
   PubMed Web of Science ®Google Scholar
• Cockcroft DW, Davis B. Direct and indirect challenges in the clinical assessment of asthma. Ann Allergy Asthma Immunol. 2009;103(5):363–369. doi:10.1016/S1081-1206(10)60353-5.
   PubMed Web of Science ®Google Scholar
• Aaron SD, Vandemheen KL, Boulet L-P, McIvor RA, Fitzgerald JM, Hernandez P, Lemiere C, Sharma S, Field SK, Alvarez GG, Canadian Respiratory Clinical Research Consortium, et al. Overdiagnosis of asthma in obese and nonobese adults. CMAJ. 2008;179(11):1121–1131. doi:10.1503/cmaj.081332.
   PubMed Web of Science ®Google Scholar
• Aaron SD, Vandemheen KL, FitzGerald JM, Ainslie M, Gupta S, Lemière C, Field SK, McIvor RA, Hernandez P, Mayers I, Canadian Respiratory Research Network, et al. Reevaluation of diagnosis in adults with physician-diagnosed asthma. JAMA. 2017;317(3):269–279. doi:10.1001/jama.2016.19627.
   PubMed Web of Science ®Google Scholar