SNPs, adipokynes and adiposity in children with asthma

References

• Melén E, Granell R, Kogevinas M, Strachan D, Gonzalez JR, Wjst M, Jarvis D, Ege M, Braun-Fahrländer C, Genuneit J, et al. Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clin Exp Allergy. 2013;43(4):463–474. doi:10.1111/cea.12054.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Hasegawa K, Camargo CA, Liang L. Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis. J Allergy Clin Immunol. 2021;147(3):796–807. doi:10.1016/j.jaci.2020.07.004.
   Web of Science ®Google Scholar
• Su MW, Tung KY, Liang PH, Tsai CH, Kuo NW, Lee YL. Gene-gene and gene-environmental interactions of childhood asthma: A multifactor dimension reduction approach. PLoS One. 2012;7(2):e30694. doi:10.1371/journal.pone.0030694.
   PubMed Web of Science ®Google Scholar
• Vilella M, Nunes de Oliveira Costa G, Lima Barreto M, Alexandrina Figueredo C, Maria Alcantara-Neves N, Cunha Rodrigues L, Maria Alvim de Matos S, Leovigildo Fiaccone R, Oliveira P, Rocha A, et al. Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: The Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study. Br J Nutr. 2017;117(11):1503–1510. doi:10.1017/S0007114517001386.
   PubMed Web of Science ®Google Scholar
• Murphy A, Tantisira KG, Soto-Quirós ME, Avila L, Klanderman BJ, Lake S, Weiss ST, Celedón JC. PRKCA: a positional candidate gene for body mass index and asthma. Am J Hum Genet. 2009;85(1):87–96. doi:10.1016/j.ajhg.2009.06.011.
   PubMed Web of Science ®Google Scholar
• Chwalba A, Machura E, Ziora K, Ziora D. The role of adipokines in the pathogenesis and course of selected respiratory diseases. Endokrynol Pol. 2019;70(6):504–510. doi:10.5603/EP.a2019.0051.
   PubMed Web of Science ®Google Scholar
• Mikalsen IB, Byberg K, Forman MR, Øymar K. Adipokines in adolescence; the associations with lung function and atopy – a cross-sectional study. Respir Med. 2020;170:106063. doi:10.1016/J.RMED.2020.106063.
   PubMed Web of Science ®Google Scholar
• Miethe S, Guarino M, Alhamdan F, Simon H-U, Renz H, Dufour J-F, Potaczek DP, Garn H. Effects of obesity on asthma: immunometabolic links. Pol Arch Intern Med. 2018;128(7-8):469–477. doi:10.20452/pamw.4304.
   PubMedGoogle Scholar
• Bodini A, Tenero L, Sandri M, Maffeis C, Piazza M, Zanoni L, Peroni D, Boner A, Piacentini G. Serum and exhaled breath condensate Leptin levels in asthmatic and obesity children: a pilot study. J Breath Res. 2017;11(4):046005. doi:10.1088/1752-7163/aa61c5.
   PubMed Web of Science ®Google Scholar
• Ma C, Wang Y, Xue M. Correlations of severity of asthma in children with body mass index, adiponectin and Leptin. J Clin Lab Anal. 2019;33(6):e22915. doi:10.1002/jcla.22915.
   Web of Science ®Google Scholar
• Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, Sylvia JS, Lasky-Su J. Analyses of shared genetic factors between asthma and obesity in children. J Allergy Clin Immunol. 2010;126(3):631–637.e8. doi:10.1016/j.jaci.2010.06.030.
   PubMed Web of Science ®Google Scholar
• Kuo NW, Tung KY, Tsai CH, Chen YC, Lee YL. β3-Adrenergic receptor gene modifies the association between childhood obesity and asthma. J Allergy Clin Immunol. 2014;134(3):731–733.e3. doi:10.1016/j.jaci.2014.03.018.
   PubMed Web of Science ®Google Scholar
• White MJ, Risse-Adams O, Goddard P, Contreras MG, Adams J, Hu D, Eng C, Oh SS, Davis A, Meade K, et al. Novel genetic risk factors for asthma in African American children: Precision medicine and the SAGE II study. Immunogenetics. 2016;68(6-7):391–400. doi:10.1007/s00251-016-0914-1.
   PubMed Web of Science ®Google Scholar
• Sherenian MG, Cho SH, Levin A, Min J-Y, Oh SS, Hu D, Galanter J, Sen S, Huntsman S, Eng C, et al. PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort. Clin Exp Allergy. 2017;47(9):1150–1158. doi:10.1111/cea.12958.
   PubMed Web of Science ®Google Scholar
• Butsch Kovacic M, Martin LJ, Biagini Myers JM, He H, Lindsey M, Mersha TB, Khurana Hershey GK. Genetic approach identifies distinct asthma pathways in overweight vs normal weight children. Allergy Eur J Allergy Clin Immunol. 2015;70(8):1028–1032. doi:10.1111/all.12656.
   Web of Science ®Google Scholar
• Al-Ayed M, Alshaybari K, Alshehri D, Jamaan A, Nasser I, Alaamri H, Alaseeri W, Mahfouz AA, Ali Alsareli S, Asaad AM, et al. Obesity and childhood asthma in male schoolchildren in Saudi Arabia: is there a role for Leptin, interleukin-4, interleukin-5, and interleukin-21? Ann Saudi Med. 2019;39(5):295–301. doi:10.5144/0256-4947.2019.295.
   PubMed Web of Science ®Google Scholar
• de Oliveira Madeira LN, Bordallo MAN, Borges MA, Lopes AJ, Madeira IR, Kuschnir FC. Relations between asthma and obesity: an analysis of multiple factors. Rev Paul Pediatr. 2020;39:e2019405. doi:10.1590/1984-0462/2021/39/2019405.
   Google Scholar
• Best LG, Azure C, Segarra A, Enright KJ, Hamley S, Jerome D, O’Leary MA, O’Leary RA, Parisien A, Trottier K, et al. Genetic variants and risk of asthma in an American Indian population. Ann Allergy Asthma Immunol. 2017;119(1):31–36.e1. doi:10.1016/j.anai.2017.05.015.
   PubMed Web of Science ®Google Scholar
• da Silva CF, Zandoná MR, Vitolo MR, Campagnolo PDB, Rotta LN, Almeida S, Mattevi VS. Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children. BMC Med Genet. 2013;14(1):34. doi:10.1186/1471-2350-14-34.
   PubMed Web of Science ®Google Scholar
• Lourenço BH, Qi L, Willett WC, Cardoso MA, for the ACTION Study Team. FTO genotype, vitamin D status, and weight gain during childhood. Diabetes. 2014;63(2):808–814. doi:10.2337/db13-1290.
   PubMed Web of Science ®Google Scholar
• L Z, Y Y, H Z, W Z, J Z. Association of asthma diagnosis with Leptin and Adiponectin: a systematic review and meta-analysis. J Investig Med. 2017;65(1):57–64. doi:10.1136/JIM-2016-000127.
   PubMed Web of Science ®Google Scholar
• Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Struan F A Grant for the Early Growth Genetics Consortium, et al. A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Hum Mol Genet. 2019;28(19):3327–3338. doi:10.1093/hmg/ddz161.
   PubMed Web of Science ®Google Scholar