Over-prescription of short-acting β₂-agonists is associated with poor asthma outcomes: results from the Latin American cohort of the SABINA III study

References

• Global Asthma Network (GAN). The Global Asthma Report. Available from: http://www.globalasthmareport.org [accessed 22 March 2021]; 2018.
   Google Scholar
• Solé D, Aranda CS, Wandalsen GF. Asthma: epidemiology of disease control in Latin America - short review. Asthma Res Pract 2017;3(4):4.
   PubMedGoogle Scholar
• Nannini LJ, Luhning S, Rojas RA, Antunez JM, Miguel Reyes JL, Cano Salas C, Stelmach R. Position statement: asthma in Latin America. IS short-acting beta-2 agonist helping or compromising asthma management? J Asthma 2021;58(8):991–994. doi:10.1080/02770903.2020.1777563.
   PubMed Web of Science ®Google Scholar
• Cooper PJ, Rodrigues LC, Cruz AA, Barreto ML. Asthma in Latin America: a public heath challenge and research opportunity. Allergy 2009;64(1):5–17. doi:10.1111/j.1398-9995.2008.01902.x.
   PubMed Web of Science ®Google Scholar
• Mallol J, Solé, D, Asher I, Clayton T, Stein R, Soto-Quiroz M. Prevalence of asthma symptoms in Latin America: the International Study of Asthma and Allergies in Childhood (ISAAC). Pediatr Pulmonol 2000;30(6):439–444. doi:10.1002/1099-0496(200012)30:6<439::AID-PPUL1>3.0.CO;2-E.
   PubMed Web of Science ®Google Scholar
• da Cunha SS, Pujades-Rodriguez M, Barreto ML, Genser B, Rodrigues LC. Ecological study of socio-economic indicators and prevalence of asthma in schoolchildren in urban Brazil. BMC Public Health 2007;7:205. doi:10.1186/1471-2458-7-205.
   PubMed Web of Science ®Google Scholar
• Endara P, Vaca M, Platts‐Mills TAE, Workman L, Chico ME, Barreto ML, Rodrigues LC, Cooper PJ. Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis. Clin Exp Allergy 2015;45(2):438–447. doi:10.1111/cea.12399.
   PubMed Web of Science ®Google Scholar
• Noal RB, Menezes AMB, Macedo SEC, Dumith SC, Perez-Padilla R, Araújo CLP, Hallal PC. Is obesity a risk factor for wheezing among adolescents? A prospective study in southern Brazil. J Adolesc Health 2012;51(Suppl 6):S38–S45. doi:10.1016/j.jadohealth.2012.08.016.
   PubMedGoogle Scholar
• Global Initiative for Asthma. Global strategy for asthma management and prevention. Available from: http://ginasthma.org/ [accessed 22 May 2022]; 2022.
   Google Scholar
• Gold LS, Montealegre F, Allen-Ramey FC, Jardim J, Sansores R, Sullivan SD. Asthma control and cost in Latin America. Value Health Reg Issues 2014;5:25–28. doi:10.1016/j.vhri.2014.06.007.
   PubMedGoogle Scholar
• Neffen H, Gonzalez SN, Fritscher CC, Dovali C, Williams AE. The burden of unscheduled health care for asthma in Latin America. J Investig Allergol Clin Immunol 2010;20(7):596–601.
   PubMed Web of Science ®Google Scholar
• Hulett AC, Yibirin MG, Brandt RB, Garcia A, Hurtado D, Puigbo AP. Home/social environment and asthma profiles in a vulnerable community from Caracas: lessons for urban Venezuela? J Asthma 2013;50(1):14–24. doi:10.3109/02770903.2012.747205.
   PubMed Web of Science ®Google Scholar
• Neffen H, Fritscher C, Schacht FC, Levy G, Chiarella P, Soriano JB, Mechali D, AIRLA Survey Group. Asthma control in Latin America: the Asthma Insights and Reality in Latin America (AIRLA) survey. Rev Panam Salud Publica 2005;17(3):191–197. doi:10.1590/s1020-49892005000300007.
   PubMed Web of Science ®Google Scholar
• Maspero JF, Jardim JR, Aranda A, Tassinari C P, Gonzalez-Diaz SN, Sansores RH, Moreno-Cantu JJ, Fish JE. Insights, attitudes, and perceptions about asthma and its treatment: findings from a multinational survey of patients from Latin America. World Allergy Organ J 2013;6(1):19. doi:10.1186/1939-4551-6-19.
   PubMedGoogle Scholar
• Plaza V, Blanco M, Garcia G, Korta J, Molina J, Quirce S, en representación del Comité Ejecutivo de GEMA. Highlights of the Spanish Asthma Guidelines (GEMA), version 5.0. Arch Bronconeumol (Engl Ed) 2021;57(1):11–12. doi:10.1016/j.arbr.2020.10.010.
   PubMed Web of Science ®Google Scholar
• Alith MB, Gazzotti MR, Nascimento OA, Jardim JR. Impact of asthma control on different age groups in five Latin American countries. World Allergy Organ J 2020;13(4):100113. doi:10.1016/j.waojou.2020.100113.
   PubMed Web of Science ®Google Scholar
• Lai CC, Chen CH, Wang Y-H, Wang C-Y, Wang HC. The impact of the overuse of short-acting β2-agonists on the risk of sepsis and septic shock. J Allergy Clin Immunol 2022. doi:10.1016/j.jaci.2021.11.029.
   PubMed Web of Science ®Google Scholar
• Muñoz X, Romero-Mesones C, Cruz MJ. β2-Agonists in Asthma: the strange case of Dr. Jekyll and Mr. Hyde. Arch Bronconeumol (Engl Ed) 2020;56(4):204–205. doi:10.1016/j.arbr.2019.07.010.
   PubMed Web of Science ®Google Scholar
• Tanaka H, Nakatani E, Fukutomi Y, Sekiya K, Kaneda H, Iikura M, Yoshida M, Takahashi K, Tomii K, Nishikawa M, et al. Identification of patterns of factors preceding severe or life-threatening asthma exacerbations in a nationwide study. Allergy 2018;73(5):1110–1118. doi:10.1111/all.13374.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Barcala F-J, Calvo-Alvarez U, Garcia-Sanz M-T, Bourdin A, Pose-Reino A, Carreira J-M, Moure-Gonzalez J-D, Garcia-Couceiro N, Valdes-Cuadrado L, Muñoz X, et al. Characteristics and prognosis of near-fatal asthma exacerbations. Am J Med Sci 2015;350(2):98–102. doi:10.1097/MAJ.0000000000000518.
   PubMed Web of Science ®Google Scholar
• Blakey JD, Gayle A, Slater MG, Jones GH, Baldwin M. Observational cohort study to investigate the unmet need and time waiting for referral for specialist opinion in adult asthma in England (UNTWIST asthma). BMJ Open 2019;9(11):e031740. doi:10.1136/bmjopen-2019-031740.
   PubMed Web of Science ®Google Scholar
• Price D, Bjermer L, Bergin DA, Martinez R. Asthma referrals: a key component of asthma management that needs to be addressed. J Asthma Allergy 2017;10:209–223. doi:10.2147/JAA.S134300.
   PubMed Web of Science ®Google Scholar
• Most JF, Ambrose CS, Chung Y, Kreindler JL, Near A, Brunton S, Cao Y, Huang H, Zhao X. Real-world assessment of asthma specialist visits among U.S. patients with severe asthma. J Allergy Clin Immunol Pract 2021;9(10):3662–3671 e1. doi:10.1016/j.jaip.2021.05.003.
   PubMed Web of Science ®Google Scholar
• Gonzalez Barcala FJ, de la Fuente-Cid R, Alvarez-Gil R, Tafalla M, Nuevo J, Caamano-Isorna F. Factors associated with asthma control in primary care patients: the CHAS study. Arch Bronconeumol 2010;46(7):358–363. doi:10.1016/j.arbres.2010.01.007.
   PubMed Web of Science ®Google Scholar
• Bateman ED, Price DB, Wang H-C, Khattab A, Schonffeldt P, Catanzariti A, van der Valk RJ, Beekman MJ. Short-acting β2-agonist prescriptions are associated with poor clinical outcomes of asthma: the multi-country, cross-sectional SABINA III study. Eur Respir J 2022;59(5):2101402.
   PubMed Web of Science ®Google Scholar
• Motheral B, Brooks J, Clark MA, Crown WH, Davey P, Hutchins D, Martin BC, Stang P. A checklist for retrospective database studies-report of the ISPOR Task Force on Retrospective Databases. Value Health 2003;6(2):90–97. doi:10.1046/j.1524-4733.2003.00242.x.
   PubMed Web of Science ®Google Scholar
• Public Policy Committee ISoP. Guidelines for good pharmacoepidemiology practice (GPP). Pharmacoepidemiol Drug Saf 2016;25(1):2–10.
   PubMed Web of Science ®Google Scholar
• Cabrera CS, Nan C, Lindarck N, Beekman MJHI, Arnetorp S, van der Valk RJP. SABINA: global programme to evaluate prescriptions and clinical outcomes related to short-acting beta2-agonist use in asthma. Eur Respir J 2020;55(2):1901858. doi:10.1183/13993003.01858-2019.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma. Global strategy for asthma management and prevention. Available from: http://ginasthma.org/ [accessed 22 March 2021]; 2017.
   Google Scholar
• Reddel HK, Taylor DR, Bateman ED, Boulet L-P, Boushey HA, Busse WW, Casale TB, Chanez P, Enright PL, Gibson PG, et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009;180(1):59–99. doi:10.1164/rccm.200801-060ST.
   PubMed Web of Science ®Google Scholar
• Pan American Health Organization. Recommendations for Implementing Antimicrobial Stewardship Programs in Latin America and the Caribbean: Manual for Public Health Decision-Makers. Available from: https://iris.paho.org/handle/10665.2/49645 [accessed 22 March 2021].
   Google Scholar
• Cassol VE, Rizzato TM, Teche SP, Basso DF, Centenaro DF, Maldonado M, Moraes EZC, Hirakata VN, Solé D, Menna-Barreto SS, et al. Obesity and its relationship with asthma prevalence and severity in adolescents from southern Brazil. J Asthma 2006;43(1):57–60. doi:10.1080/02770900500448597.
   PubMed Web of Science ®Google Scholar
• Novosad S, Khan S, Wolfe B, Khan A. Role of obesity in asthma control, the obesity-asthma phenotype. J Allergy (Cairo) 2013;2013:538642. doi:10.1155/2013/538642.
   PubMedGoogle Scholar
• Vortmann M, Eisner MD. BMI and health status among adults with asthma. Obesity (Silver Spring) 2008;16(1):146–152. doi:10.1038/oby.2007.7.
   PubMed Web of Science ®Google Scholar
• Ahmadizar F, Vijverberg SJH, Arets HGM, de Boer A, Lang JE, Kattan M, Palmer CNA, Mukhopadhyay S, Turner S, Maitland-van der Zee AH, et al. Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis. Eur Respir J 2016;48(4):1063–1073. doi:10.1183/13993003.00766-2016.
   PubMed Web of Science ®Google Scholar
• Zein JG, Erzurum SC. Asthma is different in women. Curr Allergy Asthma Rep 2015;15(6):28. doi:10.1007/s11882-015-0528-y.
   PubMed Web of Science ®Google Scholar
• Yawn BP, Wechsler ME. Severe asthma and the primary care provider: identifying patients and coordinating multidisciplinary care. Am J Med 2017;130(12):1479. doi:10.1016/j.amjmed.2017.10.001.
   PubMed Web of Science ®Google Scholar
• Ding B, Small M. Disease burden of mild asthma: findings from a cross-sectional real-world survey. Adv Ther 2017;34(5):1109–1127. doi:10.1007/s12325-017-0520-0.
   PubMed Web of Science ®Google Scholar
• Baddar S, Jayakrishnan B, Al-Rawas O, George J, Al-Zeedy K. Is clinical judgment of asthma control adequate?: a prospective survey in a tertiary hospital pulmonary clinic. SQUMJ 2013;13(1):63–68. doi:10.12816/0003197.
   Google Scholar
• Boulet LP, Phillips R, O’Byrne P, Becker A. Evaluation of asthma control by physicians and patients: comparison with current guidelines. Can Respir J 2002;9(6):417–423. doi:10.1155/2002/731804.
   PubMedGoogle Scholar
• Chapman KR, Boulet LP, Rea RM, Franssen E. Suboptimal asthma control: prevalence, detection and consequences in general practice. Eur Respir J 2008;31(2):320–325. doi:10.1183/09031936.00039707.
   PubMed Web of Science ®Google Scholar
• Price D, Fletcher M, van der Molen T. Asthma control and management in 8,000 European patients: the REcognise Asthma and LInk to Symptoms and Experience (REALISE) survey. NPJ Prim Care Respir Med 2014;24(14009):14009.
   PubMed Web of Science ®Google Scholar
• Price D, David-Wang A, Cho S-H, Ho JC-M, Jeong J-W, Liam C-K, Lin J, Muttalif AR, Perng D-W, Tan T-L, et al. Time for a new language for asthma control: results from REALISE Asia. J Asthma Allergy 2015;8:93–103.
   PubMed Web of Science ®Google Scholar
• Arias SJ, Neffen H, Bossio JC, Calabrese CA, Videla AJ, Armando GA, Antó JM. Prevalence and features of asthma in young adults in urban areas of Argentina. Arch Bronconeumol (Engl Ed) 2018;54(3):134–139. doi:10.1016/j.arbres.2017.08.021.
   PubMed Web of Science ®Google Scholar
• Ferris TG, Blumenthal D, Woodruff PG, Clark S, Camargo CA, MARC Investigators. Insurance and quality of care for adults with acute asthma. J Gen Intern Med 2002;17(12):905–913. doi:10.1046/j.1525-1497.2002.20230.x.
   PubMed Web of Science ®Google Scholar
• Comaru T, Pitrez PM, Friedrich FO, Silveira VD, Pinto LA. Free asthma medications reduces hospital admissions in Brazil (Free asthma drugs reduces hospitalizations in Brazil). Respir Med 2016;121:21–25. doi:10.1016/j.rmed.2016.10.008.
   PubMed Web of Science ®Google Scholar
• Henry DA, Sutherland D, Francis L. The use of non-prescription salbutamol inhalers by asthmatic patients in the Hunter Valley, New South Wales. Newcastle Retail Pharmacy Research Group. Med J Aust 1989;150(8):445–449.
   PubMed Web of Science ®Google Scholar
• Rodrigo GJ, Plaza V, Bellido-Casado J, Neffen H, Bazús MT, Levy G, Armengol J. The study of severe asthma in Latin America and Spain (1994-2004): characteristics of patients hospitalized with acute severe asthma. J Bras Pneumol 2009;35(7):635–644. doi:10.1590/s1806-37132009000700004.
   PubMed Web of Science ®Google Scholar
• Neffen H, Moraes F, Viana K, Di Boscio V, Levy G, Vieira C, Abreu G, Soares C. Asthma severity in four countries of Latin America. BMC Pulm Med 2019;19(1):123. doi:10.1186/s12890-019-0871-1.
   PubMed Web of Science ®Google Scholar
• Bloom CI, Cabrera C, Arnetorp S, Coulton K, Nan C, van der Valk RJP, Quint JK. Asthma-related health outcomes associated with short-acting β2-agonist inhaler use: an observational UK study as part of the SABINA global program. Adv Ther 2020;37(10):4190–4208. doi:10.1007/s12325-020-01444-5.
   PubMed Web of Science ®Google Scholar
• Di Marco F, D’Amato M, Lombardo FP, Micheletto C, Heiman F, Pegoraro V, Boarino S, Manna G, Mastromauro F, Spennato S, et al. The burden of short-acting β2-agonist use in asthma: is there an Italian case? An update from SABINA program. Adv Ther 2021;38(7):3816–3830. doi:10.1007/s12325-021-01772-0.
   PubMed Web of Science ®Google Scholar
• Worth H, Criée C-P, Vogelmeier CF, Kardos P, Becker E-M, Kostev K, Mokros I, Schneider A. Prevalence of overuse of short-acting beta-2 agonists (SABA) and associated factors among patients with asthma in Germany. Respir Res 2021;22(1):108. doi:10.1186/s12931-021-01701-3.
   PubMed Web of Science ®Google Scholar
• Janson C, Menzies-Gow A, Nan C, Nuevo J, Papi A, Quint JK, Quirce S, Vogelmeier CF. SABINA: an overview of short-acting β2-agonist use in asthma in European countries. Adv Ther 2020;37(3):1124–1135. doi:10.1007/s12325-020-01233-0.
   PubMed Web of Science ®Google Scholar
• Quint JK, Arnetorp S, Kocks JWH, Kupczyk M, Nuevo J, Plaza V, Cabrera C, Raherison-Semjen C, Walker B, Penz E, et al. Short-acting β2-agonist exposure and severe asthma exacerbations: SABINA findings from Europe and North America. J Allergy Clin Immunol Pract 2022;S2213-2198(22)00285-9. doi:10.1016/j.jaip.2022.02.047.
   Web of Science ®Google Scholar
• Lasmar L, Fontes MJ, Mohallen MT, Fonseca AC, Camargos P. Wheezy child program: the experience of the belo horizonte pediatric asthma management program. World Allergy Organ J 2009;2(12):289–295. doi:10.1097/WOX.0b013e3181c6c8cb.
   PubMedGoogle Scholar
• de Oliveira MA, Faresin SM, Bruno VF, de Bittencourt AR, Fernandes AL. Evaluation of an educational programme for socially deprived asthma patients. Eur Respir J 1999;14(4):908–914. doi:10.1034/j.1399-3003.1999.14d30.x.
   PubMed Web of Science ®Google Scholar
• Neffen H, Baena-Cagnani C, Passalacqua G, Canonica GW, Rocco D. Asthma mortality, inhaled steroids, and changing asthma therapy in Argentina (1990-1999). Respir Med 2006;100(8):1431–1435. doi:10.1016/j.rmed.2005.11.004.
   PubMed Web of Science ®Google Scholar
• Roche N, Reddel H, Martin R, Brusselle G, Papi A, Thomas M, Postma D, Thomas V, Rand C, Chisholm A, et al. Quality standards for real-world research. Focus on observational database studies of comparative effectiveness. Ann Am Thorac Soc 2014;11(Suppl 2):S99–S104. doi:10.1513/AnnalsATS.201309-300RM.
   PubMedGoogle Scholar