Possible role of HE4 level elevation in the pathogenesis of TH2-high asthma

References

• Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG. A qPCR-based metric of Th2 airway inflammation in asthma. Clin Transl Allergy. 2013;3(1):24. doi:10.1186/2045-7022-3-24.
   PubMedGoogle Scholar
• Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014;133(2):388–394. doi:10.1016/j.jaci.2013.07.036.
   PubMed Web of Science ®Google Scholar
• Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007;104(40):15858–15863. doi:10.1073/pnas.0707413104.
   PubMed Web of Science ®Google Scholar
• Mo Y, Zhang K, Feng Y, Yi L, Liang Y, Wu W, Zhao J, Zhang Z, Xu Y, Hu Q, et al. Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2019;316(1):L245–L254. doi:10.1152/ajplung.00362.2017.
   PubMed Web of Science ®Google Scholar
• Poole A, Urbanek C, Eng C, Schageman J, Jacobson S, O’Connor BP, Galanter JM, Gignoux CR, Roth LA, Kumar R, et al. Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. J Allergy Clin Immunol. 2014;133(3):670–678.e12. doi:10.1016/j.jaci.2013.11.025.
   PubMed Web of Science ®Google Scholar
• Cheng D, Xue Z, Yi L, Shi H, Zhang K, Huo X, Bonser LR, Zhao J, Xu Y, Erle DJ, et al. Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma. Am J Respir Crit Care Med. 2014;190(6):639–648. doi:10.1164/rccm.201403-0505OC.
   PubMed Web of Science ®Google Scholar
• Chiu CJ, Huang MT. Asthma in the precision medicine era: biologics and probiotics. Int J Mol Sci. 2021;22(9):5428. doi:10.3390/ijms22094528.
   PubMed Web of Science ®Google Scholar
• Nelson RK, Bush A, Stokes J, Nair P, Akuthota P. Eosinophilic asthma. J Allergy Clin Immunol Pract. 2020;8(2):465–473. doi:10.1016/j.jaip.2019.11.024.
   PubMed Web of Science ®Google Scholar
• Akdis CA, Arkwright PD, Bruggen MC, Busse W, Gadina M, Guttman-Yassky E, Kabashima K, Mitamura Y, Vian L, Wu J, et al. Type 2 immunity in the skin and lungs. Allergy. 2020;75(7):1582–1605. doi:10.1111/all.14318.
   PubMed Web of Science ®Google Scholar
• Khalfaoui L, Symon FA, Couillard S, Hargadon B, Chaudhuri R, Bicknell S, Mansur AH, Shrimanker R, Hinks T, Pavord ID, et al. Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma. Allergy. 2022;77(10):2974–2986. doi:10.1111/all.15376.
   PubMed Web of Science ®Google Scholar
• Zhang K, Feng Y, Liang Y, Wu W, Chang C, Chen D, Chen S, Gao J, Chen G, Yi L, et al. Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2-high asthma. JCI Insight. 2021;6(11):e148103. doi:10.1172/jci.insight.148103.
   PubMed Web of Science ®Google Scholar
• Zhang K, Liang Y, Feng Y, Wu W, Zhang H, He J, Hu Q, Zhao J, Xu Y, Liu Z, et al. Decreased epithelial and sputum miR-221-3p associates with airway eosinophilic inflammation and CXCL17 expression in asthma. Am J Physiol Lung Cell Mol Physiol. 2018;315(2):L253–L264. doi:10.1152/ajplung.00567.2017.
   PubMed Web of Science ®Google Scholar
• Hashemi SF, Khorramdelazad H. The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence. J Cell Commun Signal. 2023;17(3):409–422. doi:10.1007/s12079-022-00699-7.
   PubMed Web of Science ®Google Scholar
• Huhtinen K, Suvitie P, Hiissa J, Junnila J, Huvila J, Kujari H, Setala M, Harkki P, Jalkanen J, Fraser J, et al. Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts. Br J Cancer. 2009;100(8):1315–1319. doi:10.1038/sj.bjc.6605011.
   PubMed Web of Science ®Google Scholar
• Hellstrom I, Raycraft J, Hayden-Ledbetter M, Ledbetter JA, Schummer M, McIntosh M, Drescher C, Urban N, Hellstrom KE. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Cancer Res. 2003;13(63):3695–3700.
   Google Scholar
• Rowswell-Turner RB, Singh RK, Urh A, Yano N, Kim KK, Khazan N, Pandita R, Sivagnanalingam U, Hovanesian V, James NE, et al. HE4 overexpression by ovarian cancer promotes a suppressive tumor immune microenvironment and enhanced tumor and macrophage PD-L1 expression. J Immunol. 2021;206(10):2478–2488. doi:10.4049/jimmunol.2000281.
   PubMed Web of Science ®Google Scholar
• James NE, Cantillo E, Oliver MT, Rowswell-Turner RB, Ribeiro JR, Kim KK, Chichester CR, DiSilvestro PA, Moore RG, Singh RK, et al. HE4 suppresses the expression of osteopontin in mononuclear cells and compromises their cytotoxicity against ovarian cancer cells. Clin Exp Immunol. 2018;193(3):327–340. doi:10.1111/cei.13153.
   PubMed Web of Science ®Google Scholar
• Chhikara N, Saraswat M, Tomar AK, Dey S, Singh S, Yadav S. Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor. PLOS One. 2012;7(11):e47672. doi:10.1371/journal.pone.0047672.
   PubMed Web of Science ®Google Scholar
• Jeong H, Lee B, Kim KH, Cho SY, Cho Y, Park J, Lee Y, Oh Y, Hwang BR, Jang AR, et al. WFDC2 promotes spasmolytic polypeptide-expressing metaplasia through the up-regulation of IL33 in response to injury. Gastroenterology. 2021;161(3):953.e15–967.e15. doi:10.1053/j.gastro.2021.05.058.
   Web of Science ®Google Scholar
• Lin T, Xu S, Wang Y, Nian X, Shan X, Jiang T, Qiu M. Human epididymis protein 4 as a new diagnostic biomarker for rheumatoid arthritis-associated interstitial lung disease. Clin Exp Rheumatol. 2022;40(11):2167–2174. doi:10.55563/clinexprheumatol/zy6hbf.
   PubMed Web of Science ®Google Scholar
• Liang L, Chen J, Di C, Zhan M, Bao H, Xia C, Fan C, Liu Y. Serum human epididymis protein 4 as a novel biomarker in identifying patients with interstitial lung disease in rheumatoid arthritis. Front Med. 2021;8(8):755268. doi:10.3389/fmed.2021.755268.
   Google Scholar
• Meng K, Tian M, Gui X, Xie M, Gao Y, Shi S, Zhao T, Xiao Y, Cai H, Ding J. Human epididymis protein 4 is associated with severity and poor prognosis of connective tissue disease-associated interstitial lung disease with usual interstitial pneumonia pattern. Int Immunopharmacol. 2022;108(108):108704. doi:10.1016/j.intimp.2022.108704.
   PubMedGoogle Scholar
• Nagy BJ, Nagy B, Fila L, Clarke LA, Gonczy F, Bede O, Nagy D, Ujhelyi R, Szabo A, Anghelyi A, et al. Human epididymis protein 4: a novel serum inflammatory biomarker in cystic fibrosis. Chest. 2016;150(3):661–672. doi:10.1016/j.chest.2016.04.006.
   PubMed Web of Science ®Google Scholar
• Bene Z, Fejes Z, Szanto TG, Fenyvesi F, Varadi J, Clarke LA, Panyi G, Macek MJ, Amaral MD, Balogh I, et al. Enhanced expression of human epididymis protein 4 (HE4) reflecting pro-inflammatory status is regulated by CFTR in cystic fibrosis bronchial epithelial cells. Front Pharmacol. 2021;12(12):592184. doi:10.3389/fphar.2021.592184.
   PubMedGoogle Scholar
• Visser E, Genet S, de Kock R, van den Borne B, Youssef-El SM, Belderbos H, Stege G, de Saegher M, van TW, Brunsveld L, et al. Liquid biopsy-based decision support algorithms for diagnosis and subtyping of lung cancer. Lung Cancer. 2023;178(178):28–36. doi:10.1016/j.lungcan.2023.01.014.
   PubMedGoogle Scholar
• Nagy B, Bhattoa HP, Steiber Z, Csobán M, Szilasi M, Méhes G, Müller M, Lázár J, Kappelmayer J, Antal-Szalmás P. Serum human epididymis protein 4 (HE4) as a tumor marker in men with lung cancer. Clin Chem Lab Med. 2014;52(11):1639–1648. doi:10.1515/cclm-2014-0041.
   PubMed Web of Science ®Google Scholar
• Zhan Y, Chen J, Wu J, Gu Y, Huang Q, Deng Z, Chen S, Wu X, Lv Y, Zeng Z, et al. Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease. Respir Res. 2022;23(1):120. doi:10.1186/s12931-022-02040-7.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Oxidative stress-based therapeutics in COPD. Redox Biol. 2020;33(33):101544. doi:10.1016/j.redox.2020.101544.
   PubMedGoogle Scholar
• Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138(1):16–27. doi:10.1016/j.jaci.2016.05.011.
   PubMed Web of Science ®Google Scholar
• Gauvreau GM, El-Gammal AI, O’Byrne PM. Allergen-induced airway responses. Eur Respir J. 2015;46(3):819–831. doi:10.1183/13993003.00536-2015.
   PubMed Web of Science ®Google Scholar
• Lambrecht BN, Hammad H, Fahy JV. The cytokines of asthma. Immunity. 2019;50(4):975–991. doi:10.1016/j.immuni.2019.03.018.
   PubMed Web of Science ®Google Scholar
• Varricchi G, Ferri S, Pepys J, Poto R, Spadaro G, Nappi E, Paoletti G, Virchow JC, Heffler E, Canonica WG. Biologics and airway remodeling in severe asthma. Allergy. 2022;77(12):3538–3552. doi:10.1111/all.15473.
   PubMed Web of Science ®Google Scholar
• Abdo M, Pedersen F, Kirsten AM, Veith V, Biller H, Trinkmann F, von Mutius E, Kopp M, Hansen G, Rabe KF, et al. Longitudinal impact of sputum inflammatory phenotypes on small airway dysfunction and disease outcomes in asthma. J Allergy Clin Immunol Pract. 2022;10(6):1545–1553.e2. doi:10.1016/j.jaip.2022.02.020.
   PubMed Web of Science ®Google Scholar
• Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med. 2010;363(23):2233–2247. doi:10.1056/NEJMra0910061.
   PubMed Web of Science ®Google Scholar
• Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med. 2012;18(5):684–692. doi:10.1038/nm.2737.
   PubMed Web of Science ®Google Scholar
• Venkatesan P. GOLD COPD report: 2023 update. Lancet Respir Med. 2023;11(1):18. doi:10.1016/S2213-2600(22)00494-5.
   PubMed Web of Science ®Google Scholar
• Ohlsson L, Hammarstrom ML, Lindmark G, Hammarstrom S, Sitohy B. Ectopic expression of the chemokine CXCL17 in colon cancer cells. Br J Cancer. 2016;114(6):697–703. doi:10.1038/bjc.2016.4.
   PubMed Web of Science ®Google Scholar
• Hiraoka N, Yamazaki-Itoh R, Ino Y, Mizuguchi Y, Yamada T, Hirohashi S, Kanai Y. CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis. Gastroenterology. 2011;140(1):310–321. doi:10.1053/j.gastro.2010.10.009.
   PubMed Web of Science ®Google Scholar
• Li Y, Liu A, Liu S, Yan L, Yuan Y, Xu Q. Involvement of CXCL17 and GPR35 in gastric cancer initiation and progression. Int J Mol Sci. 2022;24(1):615. doi:10.3390/ijms24010615.
   PubMed Web of Science ®Google Scholar
• Hsu YL, Yen MC, Chang WA, Tsai PH, Pan YC, Liao SH, Kuo PL. CXCL17-derived CD11b(+)Gr-1(+) myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB. Breast Cancer Res. 2019;21(1):23. doi:10.1186/s13058-019-1114-3.
   PubMedGoogle Scholar
• Burkhardt AM, Tai KP, Flores-Guiterrez JP, Vilches-Cisneros N, Kamdar K, Barbosa-Quintana O, Valle-Rios R, Hevezi PA, Zuniga J, Selman M, et al. CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity. J Immunol. 2012;188(12):6399–6406. doi:10.4049/jimmunol.1102903.
   PubMed Web of Science ®Google Scholar
• Centeio R, Ousingsawat J, Schreiber R, Kunzelmann K. CLCA1 regulates airway mucus production and ion secretion through TMEM16A. Int J Mol Sci. 2021;22(10) doi:10.3390/ijms22105133.
   Web of Science ®Google Scholar
• Tan HT, Hagner S, Ruchti F, Radzikowska U, Tan G, Altunbulakli C, Eljaszewicz A, Moniuszko M, Akdis M, Akdis CA, et al. Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice. Allergy. 2019;74(2):294–307. doi:10.1111/all.13619.
   PubMed Web of Science ®Google Scholar
• Keeler SP, Yantis J, Gerovac BJ, Youkilis SL, Podgorny S, Mao D, Zhang Y, Whitworth KM, Redel B, Samuel MS, et al. Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model. Am J Physiol Lung Cell Mol Physiol. 2022;322(6):L842–L852. doi:10.1152/ajplung.00443.2021.
   PubMed Web of Science ®Google Scholar
• Thai P, Chen Y, Dolganov G, Wu R. Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium. Am J Respir Cell Mol Biol. 2005;33(6):523–530. doi:10.1165/rcmb.2004-0220RC.
   PubMed Web of Science ®Google Scholar