Urinary metabolomic profiles uncover metabolic pathways in children with asthma

References

• Shipp CL, Gergen PJ, Gern JE, Matsui EC, Guilbert TW. Asthma management in children. J Allergy Clin Immunol Pract. 2023;11(1):9–18. doi:10.1016/j.jaip.2022.10.031.
   PubMed Web of Science ®Google Scholar
• Sun T, Yu HY, Yang M, Song YF, Fu JH. Risk of asthma in preterm infants with bronchopulmonary dysplasia: a systematic review and meta-analysis. World J Pediatr. 2023;19(6):549–556. doi:10.1007/s12519-023-00701-1.
   PubMed Web of Science ®Google Scholar
• Lisik D, Ermis S, Ioannidou A, Milani GP, Nyassi S, Spolidoro GCI, Kankaanranta H, Goksör E, Wennergren G, Nwaru BI. Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis. World J Pediatr. 2023;19(12):1127–1138. doi:10.1007/s12519-023-00706-w.
   PubMed Web of Science ®Google Scholar
• Naja AS, Permaul P, Phipatanakul W. Taming asthma in school-aged children: a comprehensive review. J Allergy Clin Immunol Pract. 2018;6(3):726–735. doi:10.1016/j.jaip.2018.01.023.
   PubMed Web of Science ®Google Scholar
• Kuruvilla ME, Vanijcharoenkarn K, Shih JA, Lee FE. Epidemiology and risk factors for asthma. Respir Med. 2019;149:16–22. doi:10.1016/j.rmed.2019.01.014.
   PubMed Web of Science ®Google Scholar
• Guo X, Li Z, Ling W, Long J, Su C, Li J, Liang S, Su L. Epidemiology of childhood asthma in mainland China (1988-2014): a meta-analysis. Allergy Asthma Proc. 2018;39(3):15–29. doi:10.2500/aap.2018.39.4131.
   PubMed Web of Science ®Google Scholar
• National Cooperative Group on Childhood Asthma; Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention; Chinese Center for Disease Control and Prevention. [Third nationwide survey of childhood asthma in urban areas of China]. Zhonghua Er Ke Za Zhi. 2013;51:729–735.
   PubMedGoogle Scholar
• Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391(10122):783–800. doi:10.1016/s0140-6736(17)33311-1.
   PubMed Web of Science ®Google Scholar
• Mims JW. Asthma: definitions and pathophysiology. Int Forum Allergy Rhinol. 2015;5(Suppl 1):S2–S6. doi:10.1002/alr.21609.
   PubMed Web of Science ®Google Scholar
• Li S, Liu J, Zhou J, Wang Y, Jin F, Chen X, Yang J, Chen Z. Urinary metabolomic profiling reveals biological pathways and predictive signatures associated with childhood asthma. J Asthma Allergy. 2020;13:713–724. doi:10.2147/jaa.S281198.
   PubMed Web of Science ®Google Scholar
• Li H, Duan C, Zhou L, Wang M. [Application progress of metabonomics evaluation methods in bronchial asthma]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021;33(8):1021–1024. doi:10.3760/cma.j.cn121430-20210128-00157.
   PubMedGoogle Scholar
• Wishart DS. Metabolomics for investigating physiological and pathophysiological processes. Physiol Rev. 2019;99(4):1819–1875. doi:10.1152/physrev.00035.2018.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Camargo CAJr., Raita Y, Fujiogi M, Liang L, Rhee EP, Woodruff PG, Hasegawa K. Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma. J Allergy Clin Immunol. 2022;149(1):102–112. doi:10.1016/j.jaci.2021.05.036.
   PubMed Web of Science ®Google Scholar
• Sordillo JE, Rifas-Shiman SL, Switkowski K, Coull B, Gibson H, Rice M, Platts-Mills TAE, Kloog I, Litonjua AA, Gold DR, et al. Prenatal oxidative balance and risk of asthma and allergic disease in adolescence. J Allergy Clin Immunol. 2019;144(6):1534–1541.e5. doi:10.1016/j.jaci.2019.07.044.
   PubMed Web of Science ®Google Scholar
• Xu S, Panettieri RAJr, Jude J. Metabolomics in asthma: a platform for discovery. Mol Aspects Med. 2022;85:100990. doi:10.1016/j.mam.2021.100990.
   PubMed Web of Science ®Google Scholar
• Saude EJ, Skappak CD, Regush S, Cook K, Ben-Zvi A, Becker A, Moqbel R, Sykes BD, Rowe BH, Adamko DJ. Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy. J Allergy Clin Immunol. 2011;127(3):757–764.e6. doi:10.1016/j.jaci.2010.12.1077.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang T, Shen X, Liu J, Zhao D, Sun Y, Wang L, Liu Y, Gong X, Liu Y, et al. Serum metabolomics for early diagnosis of esophageal squamous cell carcinoma by UHPLC-QTOF/MS. Metabolomics. 2016;12(7):116. doi:10.1007/s11306-016-1050-5.
   Web of Science ®Google Scholar
• Smith CA, Want EJ, O’Maille G, Abagyan R, Siuzdak G. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem. 2006;78(3):779–787. doi:10.1021/ac051437y.
   PubMed Web of Science ®Google Scholar
• Trygg J, Wold S. Orthogonal projections to latent structures (O-PLS). J Chemom. 2002;16(3):119–128. doi:10.1002/cem.695.
   Web of Science ®Google Scholar
• Saccenti E, Hoefsloot HCJ, Smilde AK, Westerhuis JA, Hendriks MMWB. Reflections on univariate and multivariate analysis of metabolomics data. Metabolomics. 2014;10(3):361–374. doi:10.1007/s11306-013-0598-6.
   Web of Science ®Google Scholar
• Kanehisa M, Goto S. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 2000;28(1):27–30. doi:10.1093/nar/28.1.27.
   PubMed Web of Science ®Google Scholar
• Kanehisa M, Sato Y, Kawashima M, Furumichi M, Tanabe M. KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 2016;44(D1):D457–D462. doi:10.1093/nar/gkv1070.
   PubMed Web of Science ®Google Scholar
• Asher I, Pearce N. Global burden of asthma among children. Int J Tuberc Lung Dis. 2014;18(11):1269–1278. doi:10.5588/ijtld.14.0170.
   PubMed Web of Science ®Google Scholar
• Papamichael MM, Katsardis C, Sarandi E, Georgaki S, Frima ES, Varvarigou A, Tsoukalas D. Application of metabolomics in pediatric asthma: prediction, diagnosis and personalized treatment. Metabolites. 2021;11(4):251. doi:10.3390/metabo11040251.
   PubMed Web of Science ®Google Scholar
• Zhu L, Xu F, Wan W, Yu B, Tang L, Yang Y, Du Y, Chen Z, Xu H. Gut microbial characteristics of adult patients with allergy rhinitis. Microb Cell Fact. 2020;19(1):171. doi:10.1186/s12934-020-01430-0.
   PubMed Web of Science ®Google Scholar
• Rohmann N, Munthe L, Schlicht K, Geisler C, Demetrowitsch TJ, Bang C, Jensen-Kroll J, Türk K, Bacher P, Franke A, et al. Differential effects of obesity, hyperlipidaemia, dietary intake and physical inactivity on type I versus type IV allergies. Nutrients. 2022;14(11):2351. doi:10.3390/nu14112351.
   PubMed Web of Science ®Google Scholar
• Rodriguez Del Rio P, Liu AH, Borres MP, Södergren E, Iachetti F, Casale TB. Asthma and allergy: unravelling a tangled relationship with a focus on new biomarkers and treatment. Int J Mol Sci. 2022;23(7):3881. doi:10.3390/ijms23073881.
   PubMed Web of Science ®Google Scholar
• Wendell SG, Baffi C, Holguin F. Fatty acids, inflammation, and asthma. J Allergy Clin Immunol. 2014;133(5):1255–1264. doi:10.1016/j.jaci.2013.12.1087.
   PubMed Web of Science ®Google Scholar
• Yuan Q, Xie F, Huang W, Hu M, Yan Q, Chen Z, Zheng Y, Liu L. The review of alpha-linolenic acid: sources, metabolism, and pharmacology. Phytother Res. 2022;36(1):164–188. doi:10.1002/ptr.7295.
   PubMed Web of Science ®Google Scholar
• Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, et al. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids Health Dis. 2013;12(1):141. doi:10.1186/1476-511x-12-141.
   PubMedGoogle Scholar
• Ekström S, Sdona E, Klevebro S, Hallberg J, Georgelis A, Kull I, Melén E, Risérus U, Bergström A. Dietary intake and plasma concentrations of PUFAs in childhood and adolescence in relation to asthma and lung function up to adulthood. Am J Clin Nutr. 2022;115(3):886–896. doi:10.1093/ajcn/nqab427.
   PubMed Web of Science ®Google Scholar