Effects of MAL gene knockout on lung tissue morphology and on E-cad and α-SMA expression in asthma mouse models

References

• Miller RL, Grayson MH, Strothman K. Advances in asthma: new understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management. J Allergy Clin Immunol. 2021;148(6):1430–1441. doi:10.1016/j.jaci.2021.10.001.
   PubMed Web of Science ®Google Scholar
• Reddel HK, Bacharier LB, Bateman ED, Brightling CE, Brusselle GG, Buhl R, Cruz AA, Duijts L, Drazen JM, FitzGerald JM, et al. Global initiative for asthma strategy 2021: executive summary and rationale for key changes. Eur Respir J. 2022;59(1):2102730. doi:10.1183/13993003.02730-2021.
   PubMed Web of Science ®Google Scholar
• Aghapour M, Ubags ND, Bruder D, Hiemstra PS, Sidhaye V, Rezaee F, Heijink IH. Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD. Eur Respir Rev. 2022;31(163):210112. doi:10.1183/16000617.0112-2021.
   PubMed Web of Science ®Google Scholar
• Stern J, Pier J, Litonjua AA. Asthma epidemiology and risk factors. Semin Immunopathol. 2020;42(1):5–15. doi:10.1007/s00281-020-00785-1.
   PubMed Web of Science ®Google Scholar
• Huang K, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet. 2019;394(10196):407–418. doi:10.1016/s0140-6736(19)31147-x.
   PubMed Web of Science ®Google Scholar
• Levy ML, Bacharier LB, Bateman E, Boulet LP, Brightling C, Buhl R, Brusselle G, Cruz AA, Drazen JM, Duijts L, et al. Key recommendations for primary care from the 2022 global initiative for asthma (GINA) update. NPJ Prim Care Respir Med. 2023;33(1):7. doi:10.1038/s41533-023-00330-1.
   PubMed Web of Science ®Google Scholar
• Liu F, Shang YX. Sirtuin 6 attenuates epithelial–mesenchymal transition by suppressing the TGF-β1/Smad3 pathway and C-jun in asthma models. Int Immunopharmacol. 2020;82:106333. doi:10.1016/j.intimp.2020.106333.
   PubMed Web of Science ®Google Scholar
• Singh S, Dutta J, Ray A, Karmakar A, Mabalirajan U. Airway epithelium: a neglected but crucial cell type in asthma pathobiology. Diagnostics (Basel). 2023;13(4):808. doi:10.3390/diagnostics13040808.
   PubMedGoogle Scholar
• Fang L, Sun Q, Roth M. Immunologic and non-immunologic mechanisms leading to airway remodeling in asthma. Int J Mol Sci. 2020;21(3):757. doi:10.3390/ijms21030757.
   PubMed Web of Science ®Google Scholar
• McLellan K, Shields M, Power U, Turner S. Primary airway epithelial cell culture and asthma in children-lessons learnt and yet to come. Pediatr Pulmonol. 2015;50(12):1393–1405. doi:10.1002/ppul.23249.
   PubMed Web of Science ®Google Scholar
• Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, Qian Y, Wu C, Hu F, Huang M, et al. Epithelial-mesenchymal transition in asthma airway remodeling is regulated by the IL-33/CD146 axis. Front Immunol. 2020;11:1598. doi:10.3389/fimmu.2020.01598.
   PubMed Web of Science ®Google Scholar
• Davis JD, Wypych TP. Cellular and functional heterogeneity of the airway epithelium. Mucosal Immunol. 2021;14(5):978–990. doi:10.1038/s41385-020-00370-7.
   PubMed Web of Science ®Google Scholar
• Gon Y, Maruoka S, Kishi H, Kozu Y, Kuroda K, Mizumura K, Nomura Y, Oshima T, Hashimoto S. DsRNA disrupts airway epithelial barrier integrity through down-regulation of claudin members. Allergol Int. 2016;65 Suppl:S56–S58. doi:10.1016/j.alit.2016.04.006.
   PubMed Web of Science ®Google Scholar
• Lee HW, Park YM, Lee SJ, Cho HJ, Kim DH, Lee JI, Kang MS, Seol HJ, Shim YM, Nam DH, et al. Alpha-smooth muscle actin (ACTA2) is required for metastatic potential of human lung adenocarcinoma. Clin Cancer Res. 2013;19(21):5879–5889. doi:10.1158/1078-0432.Ccr-13-1181.
   PubMed Web of Science ®Google Scholar
• Mottais A, Riberi L, Falco A, Soccal S, Gohy S, De Rose V. Epithelial–mesenchymal transition mechanisms in chronic airway diseases: a common process to target? Int J Mol Sci. 2023;24(15):12412. doi:10.3390/ijms241512412.
   PubMed Web of Science ®Google Scholar
• Sisto M, Ribatti D, Lisi S. E-cadherin signaling in salivary gland development and autoimmunity. J Clin Med. 2022;11(8):2241. doi:10.3390/jcm11082241.
   PubMed Web of Science ®Google Scholar
• Türkeli A, Yilmaz Ö, Karaman M, Kanik ET, Firinci F, İnan S, Yüksel H. Anti-VEGF treatment suppresses remodeling factors and restores epithelial barrier function through the E-cadherin/β-catenin signaling axis in experimental asthma models. Exp Ther Med. 2021;22(1):689. doi:10.3892/etm.2021.10121.
   PubMed Web of Science ®Google Scholar
• Dong L, Wang Y, Zheng T, Pu Y, Ma Y, Qi X, Zhang W, Xue F, Shan Z, Liu J, et al. Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. Stem Cell Res Ther. 2021;12(1):4. doi:10.1186/s13287-020-02072-0.
   PubMed Web of Science ®Google Scholar
• Castello-Serrano I, Lorent JH, Ippolito R, Levental KR, Levental I. Myelin-associated MAL and PLP are unusual among multipass transmembrane proteins in preferring ordered membrane domains. J Phys Chem B. 2020;124(28):5930–5939. doi:10.1021/acs.jpcb.0c03028.
   PubMed Web of Science ®Google Scholar
• Zhang D, Liu X, Xiao L, Zhang S, Liu W, Yang S. To study the effect of Chaipu decoction on differentially expressed genes in asthmatic rats by gene chip. Med Sci J Cent South China. 2019;47:12.
   Google Scholar
• Casaro M, Souza VR, Oliveira FA, Ferreira CM. OVA-induced allergic airway inflammation mouse model. Methods Mol Biol. 2019;1916:297–301. doi:10.1007/978-1-4939-8994-2_28.
   PubMedGoogle Scholar
• Yu Y, Wang L, Dou J. Inhibitory effect on airway remodelling and airway epithelial mesenchymal transition in asthmatic mice. J Shanxi Med Univ. 2019;50:917.
   Google Scholar
• He H, Cao L, Wang Z, Wang Z, Miao J, Li XM, Miao M. Sinomenine relieves airway remodeling by inhibiting epithelial-mesenchymal transition through downregulating TGF-β1 and Smad3 expression in vitro and in vivo. Front Immunol. 2021;12:736479. doi:10.3389/fimmu.2021.736479.
   PubMed Web of Science ®Google Scholar
• Guan R, Wang J, Cai Z, Li Z, Wang L, Li Y, Xu J, Li D, Yao H, Liu W, et al. Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway. Redox Biol. 2020;28:101356. doi:10.1016/j.redox.2019.101356.
   PubMed Web of Science ®Google Scholar
• Fedele M, Sgarra R, Battista S, Cerchia L, Manfioletti G. The epithelial–mesenchymal transition at the crossroads between metabolism and tumor progression. Int J Mol Sci. 2022;23(2):800. doi:10.3390/ijms23020800.
   PubMed Web of Science ®Google Scholar
• Han L, Luo H, Huang W, Zhang J, Wu D, Wang J, Pi J, Liu C, Qu X, Liu H, et al. Modulation of the EMT/MET process by E-cadherin in airway epithelia stress injury. Biomolecules. 2021;11(5):669. doi:10.3390/biom11050669.
   PubMed Web of Science ®Google Scholar
• Cong LH, Li T, Wang H, Wu YN, Wang SP, Zhao YY, Zhang GQ, Duan J. IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy. J Cell Mol Med. 2020;24(15):8532–8544. doi:10.1111/jcmm.15475.
   PubMed Web of Science ®Google Scholar
• Li D, Shen C, Liu L, Hu J, Qin J, Dai L, Gao L, Cheng M, Wang D, Bao R, et al. PKM2 regulates cigarette smoke-induced airway inflammation and epithelial-to-mesenchymal transition via modulating PINK1/Parkin-mediated mitophagy. Toxicology. 2022;477:153251. doi:10.1016/j.tox.2022.153251.
   PubMed Web of Science ®Google Scholar
• Frey A, Lunding LP, Ehlers JC, Weckmann M, Zissler UM, Wegmann M. More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis. Front Immunol. 2020;11:761. doi:10.3389/fimmu.2020.00761.
   PubMed Web of Science ®Google Scholar
• Gon Y, Hashimoto S. Role of airway epithelial barrier dysfunction in pathogenesis of asthma. Allergol Int. 2018;67(1):12–17. doi:10.1016/j.alit.2017.08.011.
   PubMed Web of Science ®Google Scholar
• Wu Z, Nasab EM, Arora P, Athari SS. Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway. J Transl Med. 2022;20(1):130. doi:10.1186/s12967-022-03337-3.
   PubMed Web of Science ®Google Scholar
• Xu T, Wu Z, Yuan Q, Zhang X, Liu Y, Wu C, Song M, Wu J, Jiang J, Wang Z, et al. Proline is increased in allergic asthma and promotes airway remodeling. JCI Insight. 2023;8(16):e167395. doi:10.1172/jci.insight.167395.
   PubMed Web of Science ®Google Scholar