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Research Article

Effects of menopause and fat mass in asthmatic inflammation

, MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD & , MD, PhD show all
Received 19 Jan 2024, Accepted 29 May 2024, Published online: 20 Jun 2024

References

  • Becklake MR, Kauffmann F. Gender differences in airway behaviour over the human life span. Thorax. 1999; 54(12):1119–1138. doi:10.1136/thx.54.12.1119.
  • de Marco R, Locatelli F, Sunyer J, Burney P. Differences in incidence of reported asthma related to age in men and women. A retrospective analysis of the data of the European Respiratory Health Survey. Am J Respir Crit Care Med. 2000;162(1):68–74. doi:10.1164/ajrccm.162.1.9907008.
  • Skobeloff EM, Spivey WH, St Clair SS, Schoffstall JM. The influence of age and sex on asthma admissions. JAMA. 1992;268(24):3437–3440. doi:10.1001/jama.268.24.3437.
  • Zein JG, Erzurum SC. Asthma is different in women. Curr Allergy Asthma Rep. 2015; 15(6):28. doi:10.1007/s11882-015-0528-y.
  • Zemp E, Schikowski T, Dratva J, Schindler C, Probst-Hensch N. Asthma and the menopause: a systematic review and meta-analysis. Maturitas. 2012; 73(3):212–217. doi:10.1016/j.maturitas.2012.08.010.
  • Malutan AM, Dan M, Nicolae C, Carmen M. Proinflammatory and anti-inflammatory cytokine changes related to menopause. Prz Menopauzalny. 2014; 13(3):162–168.
  • Balzano G, Fuschillo S, De Angelis E, Gaudiosi C, Mancini A, Caputi M. Persistent airway inflammation and high exacerbation rate in asthma that starts at menopause. Monaldi Arch Chest Dis. 2007; 67(3):135–141. doi:10.4081/monaldi.2007.484.
  • Sood A, Ford ES, Camargo CAJr. Association between leptin and asthma in adults. Thorax. 2006; 61(4):300–305. doi:10.1136/thx.2004.031468.
  • Vezir E, Civelek E, Dibek Misirlioglu E, Toyran M, Capanoglu M, Karakus E, Kahraman T, Ozguner M, Demirel F, Gursel I, et al. Effects of obesity on airway and systemic inflammation in asthmatic children. Int Arch Allergy Immunol. 2021;182(8):679–689. doi:10.1159/000513809.
  • Sharma V, Cowan DC. Obesity, inflammation, and severe asthma: an update. Curr Allergy Asthma Rep. 2021; 21(12):46. doi:10.1007/s11882-021-01024-9.
  • Després J-P, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006; 444(7121):881–887. doi:10.1038/nature05488.
  • Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, Stream AR, Fahy JV, Leung DYM, Asthma Clinical Research Network Cluster analysis of obesity and asthma phenotypes. PLoS One. 2012;7(5):e36631. doi:10.1371/journal.pone.0036631.
  • Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D’Agostino R, Castro M, Curran-Everett D, Fitzpatrick AM, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010; 181(4):315–323. doi:10.1164/rccm.200906-0896OC.
  • Bantulà M, Tubita V, Roca-Ferrer J, Mullol J, Valero A, Bobolea I, Pascal M, de Hollanda A, Vidal J, Picado C, et al. Differences in inflammatory cytokine profile in obesity-associated asthma: effects of weight loss. J Clin Med. 2022; 11(13):3782. doi:10.3390/jcm11133782.
  • Global Stragegy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2022.
  • Schmalenberger KM, Tauseef HA, Barone JC, Owens SA, Lieberman L, Jarczok MN, Girdler SS, Kiesner J, Ditzen B, Eisenlohr-Moul TA, et al. How to study the menstrual cycle: practical tools and recommendations. Psychoneuroendocrinology. 2021; 123:104895. doi:10.1016/j.psyneuen.2020.104895.
  • Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med. 1995; 152(3):1107–1136. doi:10.1164/ajrccm.152.3.7663792.
  • American Thoracic S, European Respiratory S. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005; 171(8):912–930. doi:10.1164/rccm.200406-710ST.
  • Ridolo E, Incorvaia C, Martignago I, Caminati M, Canonica GW, Senna G. Sex in respiratory and skin allergies. Clin Rev Allergy Immunol. 2019; 56(3):322–332.
  • Semik-Orzech A, Skoczyński S, Pierzchała W. Serum estradiol concentration, estradiol-to-progesterone ratio and sputum IL-5 and IL-8 concentrations are increased in luteal phase of the menstrual cycle in perimenstrual asthma patients. Eur Ann Allergy Clin Immunol. 2017; 49(4):161–170. doi:10.23822/eurannaci.1764-1489.09.
  • Marijsse GS, Seys SF, Schelpe A-S, Dilissen E, Goeminne P, Dupont LJ, Ceuppens JL, Bullens DMA. Obese individuals with asthma preferentially have a high IL-5/IL-17A/IL-25 sputum inflammatory pattern. Am J Respir Crit Care Med. 2014; 189(10):1284–1285. doi:10.1164/rccm.201311-2011LE.
  • Ohbayashi H, Shimokata K. Matrix metalloproteinase-9 and airway remodeling in asthma. Curr Drug Targets Inflamm Allergy. 2005; 4(2):177–181. doi:10.2174/1568010053586246.
  • Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007; 8(9):942–949. doi:10.1038/ni1496.
  • Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, et al. Role for NLRP3 inflammasome-mediated, IL-1beta-dependent responses in severe, steroid-resistant asthma. Am J Respir Crit Care Med. 2017; 196(3):283–297. doi:10.1164/rccm.201609-1830OC.
  • Cheng C, Wu H, Wang M, Wang L, Zou H, Li S, Liu R. Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice. Biosci Rep. 2019; 39(1). doi:10.1042/BSR20181117.
  • de Oliveira AP, Domingos HV, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho RM, Vargaftig BB, de Lima WT. Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol. Am J Physiol Cell Physiol. 2007; 293(3):C1120–C1128.
  • Sugita M, Kuribayashi K, Nakagomi T, Miyata S, Matsuyama T, Kitada O. Allergic bronchial asthma: airway inflammation and hyperresponsiveness. Intern Med. 2003; 42(8):636–643.
  • Tailor P, Tamura T, Ozato K. IRF family proteins and type I interferon induction in dendritic cells. Cell Res. 2006; 16(2):134–140. doi:10.1038/sj.cr.7310018.
  • Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick SM, Dutton RW, Huston G, et al. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev. 1991; 123:115–144.
  • Girón-González JA, Moral FJ, Elvira J, García-Gil D, Guerrero F, Gavilán I, Escobar L. Consistent production of a higher TH1: TH2 cytokine ratio by stimulated T cells in men compared with women. Eur J Endocrinol. 2000; 143(1):31–36. doi:10.1530/eje.0.1430031.
  • Wegienka G, Bobbitt KR, Woodcroft KJ, Havstad S. Regulatory T cells vary over bleeding segments in asthmatic and non-asthmatic women. J Reprod Immunol. 2011; 89(2):192–198. doi:10.1016/j.jri.2011.03.002.
  • Dimitropoulou C, Drakopanagiotakis F, Chatterjee A, Snead C, Catravas JD. Estrogen replacement therapy prevents airway dysfunction in a murine model of allergen-induced asthma. Lung. 2009; 187(2):116–127. doi:10.1007/s00408-008-9129-z.
  • Fuseini H, Newcomb DC. Mechanisms driving gender differences in asthma. Curr Allergy Asthma Rep. 2017; 17(3):19. doi:10.1007/s11882-017-0686-1.
  • Dejager L, Dendoncker K, Eggermont M, Souffriau J, Van Hauwermeiren F, Willart M, Van Wonterghem E, Naessens T, Ballegeer M, Vandevyver S, et al. Neutralizing TNFalpha restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation. Mucosal Immunol. 2015; 8(6):1212–1225.
  • Burger D, Dayer JM. Cytokines, acute-phase proteins, and hormones: IL-1 and TNF-alpha production in contact-mediated activation of monocytes by T lymphocytes. Ann N Y Acad Sci. 2002; 966:464–473.
  • Alexiou E, Hatziagelaki E, Pergialiotis V, Chrelias C, Kassanos D, Siristatidis C, Kyrkou G, Kreatsa M, Trakakis E. Hyperandrogenemia in women with polycystic ovary syndrome: prevalence, characteristics and association with body mass index. Horm Mol Biol Clin Investig. 2017; 29(3):105–111. doi:10.1515/hmbci-2016-0047.
  • Pacifici R, Brown C, Puscheck E, Friedrich E, Slatopolsky E, Maggio D, McCracken R, Avioli LV. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci U S A. 1991; 88(12):5134–5138.
  • Han A, Kim JY, Kwak-Kim J, Lee SK. Menopause is an inflection point of age-related immune changes in women. J Reprod Immunol. 2021; 146:103346. doi:10.1016/j.jri.2021.103346.
  • Maggio M, Ceda GP, Lauretani F, Bandinelli S, Corsi AM, Giallauria F, Guralnik JM, Zuliani G, Cattabiani C, Parrino S, et al. SHBG, sex hormones, and inflammatory markers in older women. J Clin Endocrinol Metab. 2011; 96(4):1053–1059. doi:10.1210/jc.2010-1902.
  • Hizawa N, Kawaguchi M, Huang S-K, Nishimura M. Role of interleukin-17F in chronic inflammatory and allergic lung disease. Clin Exp Allergy. 2006; 36(9):1109–1114.
  • Teijeiro A, Garrido A, Ferre A, Perna C, Djouder N. Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice. Nat Metab. 2021; 3(4):496–512. doi:10.1038/s42255-021-00371-1.