Potential hepatoprotective effects of vitamin E and Nigella sativa oil on hepatotoxicity induced by chronic exposure to malathion in human and male albino rats

References

• Abdel-Fatah , AM , Matsumoto , K and Watanabe , H . 2000 . Anticonceptive effects of Nigella sativa and major component thymoquinone in mice . European Journal of Pharmacology , 400 : 89
   PubMed Web of Science ®Google Scholar
• Abdollahi , M , Mostafalou , S , Pournourmohammadi , S and Shadnia , S . 2004 . Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following sub-chronic exposure to malathion . Comparative Biochemistry and Physiology C: Toxicol & Pharmacology , 137 : 29
   PubMed Web of Science ®Google Scholar
• Abdollhi , M , Ranjbar , A , Shadnia , S , Nikfar , S and Rezale , A . 2004 . Pesticides and oxidative stress: A review . Medical Science Monitor , 10 : RA141
   PubMed Web of Science ®Google Scholar
• Aebi , H . 1984 . Catalase in vitro . Methods in Enzymology , 105 : 121
   PubMed Web of Science ®Google Scholar
• Agency for Toxic Substances and Disease Registry (ATSDR) 2003. US department of health and human services, Public Health Service. Toxicological profile for Malathion. http://www.atsdr.cdc.gov/toxprofiles/tp154.pdf (accessed September, 2003)
   Google Scholar
• Ahmed , RS , Seth , V , Pasha , T and Banerjee , BD . 2000 . Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats . Food and Chemical Toxicology , 38 : 443
   PubMed Web of Science ®Google Scholar
• Akhgari , M , Abdollahi , M , Kebryaeezadeh , A , Hosseini , R and Sabzevari , O . 2003 . Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats . Human & Experimental Toxicology , 22 : 205
   PubMed Web of Science ®Google Scholar
• Aldana , L , De Mejia , EG , Craigmill , A , Tsutsumi , V , Armendariz-Borunda , J , Panduro , A and Rincon , AR . 1998 . Cypermethrin increases apo A-1 and apo B mRNA but not hyperlipidemia in rats . Toxicology Letters , 95 : 31
   PubMed Web of Science ®Google Scholar
• Altuntas , I and Delibas , N . 2002 . Effects of organophosphate insecticide fenthion on lipid peroxidation and antioxidant enzymes in rat erythrocytes; the role of vitamin E and C . Biomedical Research , 13 : 43
   Google Scholar
• Altuntas , I , Delibas , N , Dermirci , M , Kiline , I and Tamer , N . 2002 . The effects of methidathion on lipid peroxidation and some liver enzymes; role of vitamin E and C . Archives of Toxicology , 76 : 470
   PubMed Web of Science ®Google Scholar
• Banerjee , BD , Pasha , ST , Hussain , Z , Koner , BC and Ray , A . 1998 . A comparative evaluation of immunotoxicity of malathion after subchronic exposure in experimental animals . Indian Journal of Experimental Biology , 36 : 273
   PubMedGoogle Scholar
• Banerjee , BD , Seth , V and Ahmed , RS . 2001 . Pesticide induced oxidative stress-perspectives and trends . Reviews on Environmental Health , 16 : 1
   PubMedGoogle Scholar
• Banerjee , BD , Seth , V , Bhattacharya , A , Pasha , ST and Chakraboty , AK . 1999 . Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers . Toxicology Letters , 107 : 33
   PubMed Web of Science ®Google Scholar
• Beauchamp , C and Fridovich , I . 1971 . Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels . Analytical Biochemistry , 44 : 276
   PubMed Web of Science ®Google Scholar
• Bermond , P . 1990 . “ Biological effects of food antioxidants ” . In Food antioxidants , Edited by: Hudson , BJF . 193 – 253 . London, NY, , USA : Elsevier Applied Science .
   Google Scholar
• Bessey , OA , Lowry , OH and Borck , MJ . 1946 . A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum . The Journal of Biological Chemistry , 164 : 321
   PubMed Web of Science ®Google Scholar
• Blasiak , J and Kowalik , J . 1999 . Protective action of sodium ascorbate against the DNA damaging effect of malaoxon . Pesticide Biochemistry and Physiology , 65 : 110
   Web of Science ®Google Scholar
• Burits , M and Bucar , F . 2000 . Antioxidant activity of Nigella sativa essential oil . Phytotherapy Research , 14 : 323
   PubMed Web of Science ®Google Scholar
• Ceconi , C , Boraso , A , Cargoni , A and Ferrari , R . 2003 . Oxidative stress in cardiovascular disease . Archives of Biochemistry and Biophysics , 420 : 217
   PubMed Web of Science ®Google Scholar
• Chow , CK . 2004 . Biological functions and metabolic fate of vitamin E revisited . Journal of Biomedical Science , 11 : 295
   PubMed Web of Science ®Google Scholar
• Eitenmiller , RR . 1997 . Vitamin E content of fats and oils: Nutritional implications . Food Technology , 51 : 78
   Web of Science ®Google Scholar
• El-Dakhakhny , M , Mady , NI and Abdel-Halim , M . 2000 . Nigella sativa oil protects against induced hepatotoxicity and improves serum lipid profile in rats . Drug Research , 50 : 832
   PubMed Web of Science ®Google Scholar
• Fallon , MB , Abrams , GA , Abdel-Razzek , TT , Dai , J , Chen , SJ , Chen , YF , Luo , B , Oparil , S and Ku , DD . 1998 . Antioxidants prevent hypoxic pulmonary hypertension in rats . The American Journal of Physiology , 275 : 283
   PubMed Web of Science ®Google Scholar
• Farag R.S., Amr M.M., Radwan A.M. 1996 Biochemical studies on the effects of some pesticides on human. Thesis, Faculty of Agriculture, Cairo University, Egypt
   Google Scholar
• Flohe , L and Gunzler , WA . 1984 . Assays of glutathione peroxidase . Methods in Enzymology , 105 : 114
   PubMed Web of Science ®Google Scholar
• Fortunato , JJ , Agostinho , FR , Reus , GZ , Petronilho , FC , Dal-Pizzol , F and Quevedo , J . 2006b . Lipid peroxidative damage on malathion exposure in rats . Neurotoxicity Research , 9 : 23
   PubMed Web of Science ®Google Scholar
• Fortunato , JJ , Feier , G , Vitali , AM , Petronilho , FC , Dal-Pizzol , F and Quevedo , J . 2006a . Malathion-induced oxidative stress in rat brain regions . Neurochemical Research , 31 : 671 – 678 .
   PubMed Web of Science ®Google Scholar
• Fouchecourt , M and Riviere , J . 1995 . Acitivites of cytochrome P450-dependent monooxyganases and antioxidant enzymes in different organs of Norway rats (Rattus norvegicus) inhabiting reference and contaminated sites . Chemosphere , 31 : 4375
   PubMed Web of Science ®Google Scholar
• Giray , B , Gurbay , A and Hincal , F . 2001 . Cypermethrin-induced oxidative stress in rat brain and liver is prevented by vitamin E or allopurinol . Toxicology Letters , 118 : 139
   PubMed Web of Science ®Google Scholar
• Gomes , J , Dawodu , AH , Lloyd , O , Revitt , DM and Anilal , SV . 1999 . Hepatic injury and disturbed amino acid metabolism in mice following prolonged exposure to organophosphorus pesticides . Human & Experimental Toxicology , 18 : 33
   PubMed Web of Science ®Google Scholar
• Hazleton , LW and Holland , EG . 1983 . Toxicity of malathion. Summary of mammalian investigations . Archives of Industrial Hygiene and Occupational Medicine , 8 : 399
   Google Scholar
• Houghton , PJ , Zarka , R , Heras , B and Hoult , RS . 1995 . Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation . Planta Medica , 61 : 33
   PubMed Web of Science ®Google Scholar
• Ilhan N., and D. Seçkin. 2005. Protective effect of Nigella sativa seeds on CCL4-induced hepatotoxicity. F.Ü. Sagˇlik Bil. Dergisi, 19: 175–9
   Google Scholar
• John , S , Kale , M , Rathore , N and Bhatnagar , D . 2001 . Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes . The Journal of Nutritional Biochemistry , 12 : 500
   PubMed Web of Science ®Google Scholar
• Kalender , S , Kalender , Y , Ates , A , Yel , M , Olcay , E and Candan , S . 2002 . Protective role of antioxidant vitamin E and catechin on idarubicin-induced cardiotoxicity in rats . Brazilian Journal of Medical and Biological Research , 35 : 1379
   PubMed Web of Science ®Google Scholar
• Kalender , S , Kalender , Y , Ogutcu , A , Uzunhisarcikli , M , Durak , D and Acikgoz , F . 2004 . Endosulfan-induced cardiotoxicity and free radical metabolism in rats: The protective effect of vitamin E . Toxicology , 3 : 227
   Web of Science ®Google Scholar
• Kanter , M , Coskun , O and Budancamanak , M . 2005 . Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats . World Journal of Gastroenterology , 14 : 6684
   Web of Science ®Google Scholar
• Keadtisuke , S , Dheranetra , W , Nakatsugawa , T and Fukuto , TR . 1990 . Liver damage induced in rats by malathion impurities . Toxicology Letters , 52 : 35
   PubMed Web of Science ®Google Scholar
• Kim , XY and Mahan , DC . 2003 . Biological aspects of selenium in farm animals . Asian Australian Journal of Animal Science , 16 : 433
   Web of Science ®Google Scholar
• Kingsley , GR . 1942 . The direct biuret method for the determination of serum proteins as applied to photoelectric and visual colorimetry . The Journal of Laboratory and Clinical Medicine , 27 : 840
   Google Scholar
• Kirkman M.N., Gaetani, G.F. 1984. Catalase: A tetrameric enzyme with four tightly bound molecules of NADPH. Proceedings of the National Academy of Sciences of the United States of America 81: 4343
   Google Scholar
• Kono , Y and Fridovich , I . 1982 . Superoxide radicals inhibit catalase . The Journal of Biological Chemistry , 257 : 5751
   PubMed Web of Science ®Google Scholar
• Lee , A , East , J and Balgaug , P . 1991 . Interactions of insecticides with biological membranes . Pesticide Science , 32 : 317 – 27 .
   Google Scholar
• Lowry , OH , Rosebrough , NJ , Farr , AL and Randall , RJ . 1951 . Protein measurement with the folin phenol reagent . The Journal of Biological Chemistry , 193 : 265 – 75 .
   PubMed Web of Science ®Google Scholar
• Ma , TG , Song , RK and Liu , YG . 1985 . On malathion binding to tissue macromolecules in the rat . Acta Academiae Medicinae Wuhan , 5 : 97 – 102 .
   PubMedGoogle Scholar
• Mansour , MA , Nagi , MN , El-Khatib , AS and Al-Bekairi , AM . 2002 . Effect of thymoquinone on the antioxidant enzyme activites, lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action . Cell Biochemistry and Function , 20 : 143 – 51 .
   PubMed Web of Science ®Google Scholar
• Marczin , N , Elhabashi , N , Hoare , GS , Bundy , RE and Yacoub , M . 2003 . Antioxidants in myocardial ischemia reperfusion injury therapeutic potential and basic mechanisms . Archives of Biochemistry and Biophysics , 222 : 236
   Google Scholar
• Marubayashi , S , Dohi , K , Ochi , K and Kawasaki , T . 1986 . Role of free radicals in ischaemic rat liver cell injury: Prevention of damage by α-tocopherol administration . Surgery , 99 : 184
   PubMed Web of Science ®Google Scholar
• Meral , I , Yener , Z , Kahraman , T and Mert , N . 2001 . Effect of Nigella Sativa on glucose concentration, lipid peroxidation and antioxidant defense system and liver damage in experimentally-induced diabetic rabbits . Journal of Veterinary Medicine , 48 : 593
   Web of Science ®Google Scholar
• Michael , AG and Nicholas , JL . 1991 . “ Organophosphorus pesticides ” . In Handbook of Pesticides Toxicology'' , Edited by: Hayes , Wayland J Jr and Laws, Jr. , Edward R . 917 San Diego : Academic Press Inc .
   Google Scholar
• Morcos , NC . 1997 . Modulation of lipid profile by fish oil, and garlic combination . Journal of the National Medical Association , 89 : 673
   PubMed Web of Science ®Google Scholar
• Morowati , M . 1997 . Inhalation toxicity studies of thimet (phorate) in male swiss albino mouse, Mus musculus. I. Hepatotoxicity . Environmental Pollution , 96 : 283 – 8 .
   PubMed Web of Science ®Google Scholar
• Numan , IT , Hassan , MQ and Stohs , SJ . 1990 . Protective effects of antioxidants against endrin-induced lipid peroxidation, glutathione depletion, and lethality in rats . Archives of Environmental Contamination and Toxicology , 19 : 302 – 6 .
   PubMed Web of Science ®Google Scholar
• Ohkawa , H , Ohishi , N and Yagi , K . 1979 . Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction . Analytical Biochemistry , 95 : 351 – 8 .
   PubMed Web of Science ®Google Scholar
• Pahwa , R and Chatterje , VC . 1990 . Hepatic toxicity in rats . Veterinary & Human Toxicology , 32 : 561
   PubMedGoogle Scholar
• Pannell , M , Gilbert , JD , Gardiner , J and Byard , RW . 2001 . Death due to malathion poisoning . Journal of Clinical Forensic Medicine , 8 : 156
   PubMedGoogle Scholar
• Pigeolet , E , Corbisier , P , Houbion , A , Lambert , D , Michiels , DC , Raes , M , Zachary , MD and Remacle , J . 1990 . GPX, SOD, and catalase inactivation by peroxides and oxygen derived free radicals . Mechanism of Aging and Development , 51 : 283 – 97 .
   PubMed Web of Science ®Google Scholar
• Pinnel , AE and Northam , BE . 1978 . New automated dye-binding method for serum albumin determination with bromocresol purple . Clinical Chemistry , 24 : 80
   PubMed Web of Science ®Google Scholar
• Piramanayagam , S and Manohar , BM . 2002 . Histological changes induced by malathion in rats . Indian Veterinary Journal , 79 : 114 – 17 .
   Google Scholar
• Piramanayagam , S , Manohar , BM and Sundararaj , A . 1996 . Pathology of malathion toxicity in rats . Indian Veterinary Journal , 73 : 734 – 7 .
   Google Scholar
• Ranjbar , A , Solhi , H , Mashayekhi , FJ , Susanabdi , A , Rezaie , A and Abdollahi , M . 2005 . Oxidative stress in acute human poisoning with organophosphorus insecticides: A case control study . Environmental Toxicology and Pharmacology , 20 : 88 – 91 .
   PubMed Web of Science ®Google Scholar
• Reitman , S and Frankel , SA . 1957 . Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases . American Journal of Clinical Pathology , 28 : 53
   Web of Science ®Google Scholar
• Salonen , ST , Nyssonen , K and Salonen , R . 2000 . Antioxidant supplementation. A randomized study of the effects of vitamin E and C on 3 year progression . Journal of Internal Medicine , 248 : 377
   PubMed Web of Science ®Google Scholar
• Scott , ML . 1969 . “ Studies on vitamin E and related factors in nutrition and metabolism ” . In The Fat Soluble Vitamins , Edited by: Deluca , HF and Suttie , JW . 355 – 368 . Madison, WI : University of Wisconsin Press .
   Google Scholar
• Slauter , R . 1994. 18-Month oral (dietary) oncogenicity study in mice: Malathion. Lab project No. 668-001. Unpublished study prepared by International Research and Development Corp. MRID 43407201 (As cited in EPA 2000a, 2000b)
   Google Scholar
• Sodhi , S , Sharma , A , Brar , APS and Brar , RS . 2007 . Effect of α tocopherol and selenium on antioxidant status, lipid peroxidation and hepatopathy induced by malathion in chicks . Pesticide Biochemistry and Physiology , 90 : 82
   Web of Science ®Google Scholar
• Srivastava , MK and Raizada , RB . 1999 . Assessment of the noobserved- effect level (NOEL) of quinalphos in pregnant rats . Food and Chemical Toxicology , 37 : 649 – 53 .
   PubMed Web of Science ®Google Scholar
• Tos-Luty , S , Obuchowska-Przebirowska , D , Latuszynska , J , Tokarska-Rodak , M and Haratym-Maj , A . 2003 . Dermal and oral toxicity of malathion in rats . Annals of Agricultural and Environmental Medicine , 10 : 101 – 6 .
   PubMed Web of Science ®Google Scholar
• US Environmental Protection agency (USEPA) . Office of Pesticide Program, Washington, DC. Label Review Manual. http://www.epa.gov/oppfod0l/labeling/lrm/chap-08.htm (accessed November 2000)
   Google Scholar
• Worthen , DR , Ghoshch , OA and Crooks , PA . 1998 . The in vitro antitumor activity of some crude and purified components of black seed (Nigella sativa) . Anticancer Research , 18 : 1527
   PubMed Web of Science ®Google Scholar
• Wormser , U , Zakine , SB , Stivelband , E , Eizen , O and Nyska , A . 1990 . The liver slice system: A rapid in vitro acute toxicity test for primary screening of hepatotoxic agents . Toxicology In Vitro , 4 : 783 – 9 .
   PubMed Web of Science ®Google Scholar
• Yarsan , E , Tanyuksel , M , Celik , S and Aydin , A . 1999 . Effects of aldicarb and malathion on lipid peroxidation . Bulletin of Environmental Contamination and Toxicology , 63 : 575 – 81 .
   PubMed Web of Science ®Google Scholar
• Zimmerman , HJ , Kodera , Y and West , M . 1965 . Rate of increase in plasma levels of cytoplasmic and mitochondrial enzymes in experimental carbon tetrachloride hepatotoxicity . The Journal of Laboratory and Clinical Medicine , 66 : 315 – 23 .
   PubMed Web of Science ®Google Scholar