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Eco/Toxicology

Acrylamide disrupts the steroidogenic pathway in Leydig cells: possible mechanism of action

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Pages 235-246 | Received 05 May 2017, Accepted 22 Mar 2018, Published online: 20 Apr 2018

References

  • Abarikwu, S. O., E. O. Farombi, M. Kashyap, and A. B. Pant. 2011. “Atrazine Induces Transcriptional Change in Steroidogenesis Marker Genes in Primary Cultures of Rat Leydig Cells.” Toxicology in Vitro 25 (8): 1588–1595.
  • Adedara, I. A., M. K. Nanjappa, E. O. Farombi, and B. T. Akingbemi. 2014. “Aflatoxin B1 Disrupts the Androgen Biosynthetic Pathway in Rat Leydig Cells.” Food and Chemical Toxicology 65: 252–259.
  • Attoff, K., D. Kertika, J. Lundqvist, S. Oredsson, and A. Forsby. 2016. “Acrylamide Affects Proliferation and Differentiation of the Neural Progenitor Cell Line C17. 2 and The Neuroblastoma Cell Line SH-SY5Y.” Toxicology in Vitro 35: 100–111.
  • Camacho, L., J. R. Latendresse, L. Muskhelishvili, R. Patton, J. F. Bowyer, M. Thomas, and D. R. Doerge. 2012. “Effects of Acrylamide Exposure on Serum Hormones, Gene Expression, Cell Proliferation, and Histopathology in Male Reproductive Tissues of Fischer 344 Rats.” Toxicology Letters 211 (2): 135–143.
  • Chung, J. Y. 1., Y. J. Kim, J. Y. Kim, S. G. Lee, J. E. Park, W. R. Kim, Y. D. Yoon, K. S. Yoo, Y. H. Yoo, and J. M. Kim. 2011. “Benzo[a]pyrene Reduces Testosterone Production in Rat Leydig Cells via a Direct Disturbance of Testicular Steroidogenic Machinery.” Environmental Health Perspectives 119 (11): 1569–1574.
  • Dobrovolsky, V. N., M. M. Pacheco-Martinez, L. P. McDaniel, M. G. Pearce, and W. Ding. 2016. “In vivo Genotoxicity Assessment of Acrylamide and Glycidyl Methacrylate.” Food and Chemical Toxicology 87: 120–127.
  • Ehlers, A., D. Lenze, H. Broll, J. Zagon, M. Hummel, and A. Lampen. 2013. “Dose Dependent Molecular Effects of Acrylamide and Glycidamide in Human Cancer Cell Lines and Human Primary Hepatocytes.” Toxicology Letters 217 (2): 111–120.
  • Fennell, T. R., S. C. J. Sumner, R. W. Snyder, J. Burgess, R. Spicer, W. E. Bridson, and M. Friedman. 2005. “Metabolism and Hemoglobin Adduct Formation of Acrylamide in Humans.” Toxicological Science 85 (1): 447–459.
  • Friedman, M. 2003. “Chemistry, Biochemistry and Safety of Acrylamide. A Review.” Journal of Agricultural and Food Chemistry 51 (16): 4504–4526.
  • Hales, D. B. 2002. “Testicular Macrophage Modulation of Leydig Cell Steroidogenesis.” Journal of Reproductive Immunology 57 (1): 3–18.
  • Hamdy, S. M., H. M. Bakeer, E. F. Eskander, and O. N. Sayed. 2012. “Effect of Acrylamide on Some Hormones and Endocrine Tissues in Male Rats.” Human Experimental Toxicology 31 (5): 483–491.
  • Horstman, K. A., J. M. Naciff, G. J. Overmann, L. M. Foertsch, B. D. Richardson, and G. P. Daston. 2012. “Effects Of Transplacental 17-Ethinyl Estradiol or Bisphenol a on the Development Profile of Steroidogenic Acute Regulatory Protein in the Rat Testis.” Birth Defects Research Part B: Developmental and Reproductive Toxicology 95 (4): 318–325.
  • Hu, Y., C. Dong, M. Chen, Y. Chen, A. Gu, Y. Xia, H. Sun, Z. Li, and Y. Wang. 2015. “Effects of Monobutyl Phthalate on Steroidogenesis Through Steroidogenic Acute Regulatory Protein Regulated by Transcription Factors In Mouse Leydig Tumor Cells.” Journal of Endocrinology Investigation 38 (8): 875–884.
  • Hu, Y., C. Dong, M. Chen, J. Lu, X. Han, L. Qiu, Y. Chen, et al. 2013. “Low-Dose Monobutyl Phthalate Stimulates Steroidogenesis Through Steroidogenic Acute Regulatory Protein Regulated by SF-1, GATA-4 and C/EBP-Beta in Mouse Leydig Tumor Cells.” Reproductive Biolology and Endocrinology 11 (1): 72.
  • IARC (International Agency for Research on Cancer). 1994. “Acrylamide.” In Some Industrial Chemicals. Vol 60 of IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, 389–441. Lyon: World Health Organization.
  • Kermani-Alghoraishi, M., M. Anvari, A. R. Talebi, O. Amini-Rad, R. Ghahramani, and S. M. Miresmaili. 2010. “The Effects of Acrylamide on Sperm Parameters and Membrane Integrity of Epididymal Spermatozoa in Mice.” European Journal of Obstetrics Gynecology and Reproductive Biology 153 (1): 52–55.
  • Khalil, W. K. B., H. H. Ahmedb, H. F. Aly, and M. G. Eshaka. 2014. “Toxicological Effects of Acrylamide on Testicular Function and Immune Genes Expression Profile in Rats.” International Journal of Pharmaceutical Sciences and Research 24 (1): 143–151.
  • Kiiveri, S., J. Liu, M. Westerholm-Ormio, N. Narita, D. B. Wilson, R. Voutilainen, and M. Heikinheimo. 2002. “Differential Expression of GATA-4 and GATA-6 in Fetal and Adult Mouse and Human Adrenal Tissue.” Endocrinology 143 (8): 3136–3143.
  • Kumar, V., C. Balomajumder, and P. Roy. 2008. “Disruption of LH-Induced Testosterone Biosynthesis in Testicular Leydig Cells by Triclosan: Probable Mechanism of Action.” Toxicology 250 (2): 124–131.
  • Lakshmi, D., K. Gopinath, G. Jayanthy, S. Anjum, D. Prakash, and G. Sudhandiran. 2012. “Ameliorating Effect of Fish Oil on Acrylamide Induced Oxidative Stress and Neuronal Apoptosis in Cerebral Cortex.” Neurochemical Research 37 (9): 1859–1867.
  • Lee, J. G., Y. S. Wang, and C. C. Chou. 2014. “Acrylamide-Induced Apoptosis in Rat Primary Astrocytes and Human Astrocytoma Cell Lines.” Toxicology in Vitro 28 (4): 562–570.
  • Lin, L., and J. C. Achermann. 2008. “Steroidogenic factor-1 (SF-1, Ad4BP, NR5A1) and disorders of testis development.” Sexual Development 2 (4–5): 200–209.
  • Liu, Q., Y. Wang, J. Gu, Y. Yuan, X. Liu, W. Zheng, Q. Huang, Z. Liu, and J. Bian. 2014. “Zearalenone Inhibits Testosterone Biosynthesis in Mouse Leydig Cells via the Crosstalk of Estrogen Receptor Signaling and Orphan Nuclear Receptor Nur77 Expression.” Toxicology in Vitro 28 (4): 647–656.
  • Livak, K. J., and T. D. Schmittgen. 2001. “Analysis of Relative Gene Expression Data Using Real-Time Quantative PCR and The 2−ΔΔCt Method.” Methods 25 (4): 402–408.
  • Martin, L. J., N. Boucher, C. Brousseau, and J. J. Tremblay. 2008. “The Orphan Nuclear Receptor NUR77 Regulates Hormone-Induced Star Transcription in Leydig Cells through Cooperation with Ca2+/Calmodulin-Dependent Protein Kinase I.” Molecular Endocrinology 22 (9): 2021–2037.
  • Martin, L. J., and J. J. Tremblay. 2005. “The Human 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Type 2 Promoter is a Novel Target for the Immediate Early Orphan Nuclear Receptor Nur77 In Steroidogenic Cells.” Endocrinology 146 (2): 861–869.
  • Matzkin, M. E., S. Yamashita, and M. Ascoli. 2013. “The ERK1/2 Pathway Regulates Testosterone Synthesis by Coordinately Regulating the Expression of Steroidogenic Genes in Leydig Cells.” Molecular and Cellular Endocrinology 370 (1): 130–137.
  • Mottram, D. S., B. L. Wedzicha, and A. T. Dodson. 2002. “Food Chemistry: Acrylamide is Formed in the Maillard Reaction.” Nature 419: 448–49.
  • Parzefall, W. 2008. “Minireview on the Toxicity of Dietary Acrylamide.” Food and Chemical Toxicology 46 (4): 1360–1364.
  • Rao, R. M., Y. Jo, S. Leers-Sucheta, H. S. Bose, W. L. Miller, S. Azhar, and D. M. Stocco. 2003. “Differential Regulation of Steroid Hormone Biosynthesis in R2C and MA-10 Leydig Tumor Cells: Role of SR-B1-Mediated Selective Cholesteryl Ester Transport.” Biology of Reproduction 68 (1): 114–121.
  • Schettgen, T., T. Weiss, H. Drexler, and J. Angerer. 2003. “A First Approach To Estimate the Internal Exposure to Acrylamide in Smoking and Non-Smoking Adults From Germany.” International Journal of Hygiene and Environmental Health 206 (1): 9–14.
  • Schrade, A., A. Kyrönlahti, O. Akinrinade, M. Pihlajoki, M. Häkkinen, S. Fischer, T. P. Alastalo, et al. 2015. “GATA4 is a Key Regulator of Steroidogenesis and Glycolysis in Mouse Leydig Cells.” Endocrinology 156 (5): 1860–1872.
  • Sen, E., Y. Tunali, and M. Erkan. 2015. “Testicular Development of Male Mice Offsprings Exposed to Acrylamide and Alcohol During the Gestation and Lactation Period.” Human & Experimental Toxicology 34 (4): 401–414. doi:10.1177/0960327114542883.
  • Stadler, R. H., I. Blank, N. Varga, F. Robert, J. Hau, P. A. Guy, and S. Riediker. 2002. “Food Chemistry: Acrylamide From Maillard Reaction Products.” Nature 419 (6906): 449–450.
  • Tareke, E., P. Rydberg, P. Karlsson, S. Eriksson, and M. Törnqvist. 2002. “Analysis of Acrylamide, a Carcinogen Formed in Heated Foodstuffs.” ʺ Journal of Agricultural and Food Chemistry 50 (17): 4998–5006.
  • Wei, Q., J. Li, X. Li, L. Zhang, and F. Shi. 2014. “Reproductive Toxicity in Acrylamide-Treated Female Mice.” Reproductive Toxicology 46: 121–128.
  • Yang, H. J., S. H. Lee, Y. Jin, J. H. Choi, D. U. Han, C. Chae, M. H. Lee, and C. H. Han. 2005b. “Toxicological Effects of Acrylamide on Rat Testicular Gene Expression Profile.” Reproductive Toxicology 19 (4): 527–534.
  • Yang, H. J., S. H. Lee, Y. Jin, J. H. Choi, C. H. Han, and M. H. Lee. 2005a. “Genotoxicity and Toxicological Effects of Acrylamide on Reproductive System in Male Rats.” Journal of Veterinary Science 6 (2): 103–109.
  • Ye, L., Z. J. Su, and R. S. Ge. 2011. “Inhibitors of Testosterone Biosynthetic and Metabolic Activation Enzymes.” Molecules 16 (12): 9983–10001.
  • Yilmaz, B. O., N. Yildizbayrak, Y. Aydin, and M. Erkan. 2017. “Evidence of Acrylamide-and Glycidamide-Induced Oxidative Stress and Apoptosis in Leydig and Sertoli cells.” Human and Experimental Toxicology 36 (12): 1225–1235.
  • Zhang, Y., R. Ge, and M. P. Hardy. 2008. “Androgen-Forming Stem Leydig Cells: Identification, Function and Therapeutic Potential.” Disease Markers 24 (4–5): 277–286.
  • Zhang, Q., P. Zou, H. Zhan, M. Zhang, L. Zhang, R. S. Ge, and Y. Huang. 2011. “Dihydrolipoamide Dehydrogenase and cAMP are Associated With Cadmium-Mediated Leydig Cell Damage.” Toxicology Letters 205 (2): 183–189.

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