Deoxynivalenol impairs proliferation and induces apoptosis in primary murine osteoblasts

References

• Akl, H., T. Vervloessem, S. Kiviluoto, M. Bittremieux, J. B. Parys, H. De Smedt, and G. Bultynck. 2014. “A Dual Role for the Anti-Apoptotic Bcl-2 Protein in Cancer: Mitochondria Versus Endoplasmic Reticulum.” Biochimica et Biophysica Acta-Molecular Cell Research 1843 (10): 2240–2252. doi:10.1016/j.bbamcr.2014.04.017.
   PubMed Web of Science ®Google Scholar
• Alford, A. I., S. P. Terkhorn, A. B. Reddy, and K. D. Hankenson. 2010. “Thrombospondin-2 Regulates Matrix Mineralization in MC3T3-E1 Pre-osteoblasts.” Bone 46 (2): 464–471. doi:10.1016/j.bone.2009.08.058.
   PubMed Web of Science ®Google Scholar
• Bergsjo, B., O. Herstad, and I. Nafstad. 1993. “Effects of Feeding Deoxynivalenol-contaminated Oats on Reproduction Performance in White Leghorn Hens.” British Poultry Science 34 (1): 147–159. doi:10.1080/00071669308417570.
   PubMed Web of Science ®Google Scholar
• Bony, S., M. Carcelen, L. Olivier, and A. Devaux. 2006. “Genotoxicity Assessment of Deoxynivalenol in the Caco-2 Cell Line Model Using the Comet Assay.” Toxicology Letters 166 (1): 67–76. doi:10.1016/j.toxlet.2006.04.010.
   PubMed Web of Science ®Google Scholar
• Cano, P. M., J. Seeboth, F. Meurens, J. Cognie, R. Abrami, I. P. Oswald, and L. Guzylack-Piriou. 2013. “Deoxynivalenol as a New Factor in the Persistence of Intestinal Inflammatory Diseases: An Emerging Hypothesis Through Possible Modulation of Th17-mediated Response.” PLoS One 8 (1): e53647. doi:10.1371/journal.pone.0053647.
   PubMed Web of Science ®Google Scholar
• Cetin, Y., and L. B. Bullerman. 2005. “Cytotoxicity of Fusarium Mycotoxins to Mammalian Cell Cultures as Determined by the MTT Bioassay.” Food and Chemical Toxicology 43 (5): 755–764. doi:10.1016/j.fct.2005.01.016.
   PubMed Web of Science ®Google Scholar
• Collins, T. F., R. L. Sprando, T. N. Black, N. Olejnik, R. M. Eppley, H. Z. Alam, J. Rorie, and D. I. Ruggles. 2006. “Effects of Zearalenone on In Utero Development in Rats.” Food and Chemical Toxicology 44 (9): 1455–1465. doi:10.1016/j.fct.2006.04.015.
   PubMed Web of Science ®Google Scholar
• Cosentino, K., and A. J. Garcia-Saez. 2017. “Bax and Bak Pores: Are We Closing the Circle?” Trends in Cell Biology 27 (4): 266–275. doi:10.1016/j.tcb.2016.11.004.
   PubMed Web of Science ®Google Scholar
• Cutarelli, A., M. Marini, V. Tancredi, G. D'Arcangelo, M. Murdocca, C. Frank, and U. Tarantino. 2016. “Adenosine Triphosphate Stimulates Differentiation and Mineralization in Human Osteoblast-like Saos-2 Cells.” Development Growth & Differentiation 58 (4): 400–408. doi:10.1111/dgd.12288.
   PubMed Web of Science ®Google Scholar
• Debouck, C., E. Haubruge, P. Bollaerts, D. van Bignoot, Y. Brostaux, A. Werry, and M. Rooze. 2001. “Skeletal Deformities Induced by the Intraperitoneal Administration of Deoxynivalenol (Vomitoxin) in Mice.” International Orthopaedics 25 (3): 194–198. doi:10.1007/s002640100235.
   PubMed Web of Science ®Google Scholar
• Demaegdt, H., B. Daminet, A. Evrard, M. L. Scippo, M. Muller, L. Pussemier, A. Callebaut, and K. Vandermeiren. 2016. “Endocrine Activity of Mycotoxins and Mycotoxin Mixtures.” Food and Chemical Toxicology 96: 107–116. doi:10.1016/j.fct.2016.07.033.
   PubMed Web of Science ®Google Scholar
• Frankic, T., T. Pajk, V. Rezar, A. Levart, and J. Salobir. 2006. “The Role of Dietary Nucleotides in Reduction of DNA Damage Induced by T-2 Toxin and Deoxynivalenol in Chicken Leukocytes.” Food and Chemical Toxicology 44 (11): 1838–1844. doi:10.1016/j.fct.2006.06.002.
   PubMed Web of Science ®Google Scholar
• Gerez, J. R., P. Pinton, P. Callu, F. Grosjean, I. P. Oswald, and A. P. Bracarense. 2015. “Deoxynivalenol Alone or in Combination with Nivalenol and Zearalenone Induce Systemic Histological Changes in Pigs.” Experimental and Toxicologic Pathology 67 (2): 89–98. doi:10.1016/j.etp.2014.10.001.
   PubMed Web of Science ®Google Scholar
• Ghareeb, K., W. A. Awad, J. Bohm, and Q. Zebeli. 2015. “Impacts of the Feed Contaminant Deoxynivalenol on the Intestine of Monogastric Animals: Poultry and Swine.” Journal of Applied Toxicology 35 (4): 327–337. doi:10.1002/jat.3083.
   PubMed Web of Science ®Google Scholar
• Girardet, C., M. S. Bonnet, R. Jdir, M. Sadoud, S. Thirion, C. Tardivel, J. Roux, et al. 2011. “Central Inflammation and Sickness-Like Behavior Induced by the Food Contaminant Deoxynivalenol: A PGE2-Independent Mechanism.” Toxicological Sciences 124 (1): 179–191. doi:10.1093/toxsci/kfr219.
   PubMed Web of Science ®Google Scholar
• Girish, C. K., T. K. Smith, H. J. Boermans, P. Anil Kumar, and G. N. Girgis. 2010. “Effects of Dietary Fusarium Mycotoxins on Intestinal Lymphocyte Subset Populations, Cell Proliferation and Histological Changes in Avian Lymphoid Organs.” Food and Chemical Toxicology 48 (10): 3000–3007. doi:10.1016/j.fct.2010.07.040.
   PubMed Web of Science ®Google Scholar
• Huang, S., P. P. Eleniste, K. Wayakanon, P. Mandela, B. A. Eipper, R. E. Mains, M. R. Allen, and A. Bruzzaniti. 2014. “The Rho-GEF Kalirin Regulates Bone Mass and the Function of Osteoblasts and Osteoclasts.” Bone 60: 235–245. doi:10.1016/j.bone.2013.12.023.
   PubMed Web of Science ®Google Scholar
• Ikeda, K., T. Tsukui, D. Tanaka, Y. Maruyama, K. Horie-Inoue, and S. Inoue. 2012. “Conditional Expression of Human Bone Gla Protein in Osteoblasts Causes Skeletal Abnormality in Mice.” Biochemical and Biophysical Research Communications 424 (1): 164–169. doi:10.1016/j.bbrc.2012.06.098.
   PubMed Web of Science ®Google Scholar
• Kim, H., H. C. Tu, D. Ren, O. Takeuchi, J. R. Jeffers, G. P. Zambetti, J. J. Hsieh, and E. H. Cheng. 2009. “Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis.” Molecular Cell 36 (3): 487–499. doi:10.1016/j.molcel.2009.09.030.
   PubMed Web of Science ®Google Scholar
• Lei, R., N. Jiang, Q. Zhang, S. Hu, B. S. Dennis, S. He, and X. Guo. 2016. “Prevalence of Selenium, T-2 Toxin, and Deoxynivalenol in Kashin-Beck Disease Areas in Qinghai Province, Northwest China.” Biological Trace Element Research 171 (1): 34–40. doi:10.1007/s12011-015-0495-0.
   PubMed Web of Science ®Google Scholar
• Liu, J., X. Xing, L. Xing, and B. Zhou. 2009. “Effects of Deoxynivalenol on Apoptosis of Human Gastric Carcinoma Cell Line SGC-7901, BGC-823 In Vitro.” Wei Sheng Yan Jiu 38 (4): 408–412.
   PubMedGoogle Scholar
• Maresca, M., and J. Fantini. 2010. “Some Food-Associated Mycotoxins as Potential Risk Factors in Humans Predisposed to Chronic Intestinal Inflammatory Diseases.” Toxicon 56 (3): 282–294. doi:10.1016/j.toxicon.2010.04.016.
   PubMed Web of Science ®Google Scholar
• Matsumoto, M., W. Nakajima, M. Seike, A. Gemma, and N. Tanaka. 2016. “Cisplatin-Induced Apoptosis in Non-small-Cell Lung Cancer Cells is Dependent on Bax- and Bak-Induction Pathway and Synergistically Activated by BH3-Mimetic ABT-263 in p53 Wild-Type and Mutant Cells.” Biochemical and Biophysical Research Communications 473 (2): 490–496. doi:10.1016/j.bbrc.2016.03.053.
   PubMed Web of Science ®Google Scholar
• Mikami, O., S. Yamamoto, N. Yamanaka, and Y. Nakajima. 2004. “Porcine Hepatocyte Apoptosis and Reduction of Albumin Secretion Induced by Deoxynivalenol.” Toxicology 204 (2–3): 241–249. doi:10.1016/j.tox.2004.07.001.
   PubMed Web of Science ®Google Scholar
• Mishra, S., P. D. Dwivedi, H. P. Pandey, and M. Das. 2014. “Role of Oxidative Stress in Deoxynivalenol Induced Toxicity.” Food and Chemical Toxicology 72: 20–29. doi:10.1016/j.fct.2014.06.027.
   PubMed Web of Science ®Google Scholar
• Mortus, J. R., Y. Zhang, and D. P. Hughes. 2014. “Developmental Pathways Hijacked by Osteosarcoma.” Advances in Experimental Medicine and Biology 804: 93–118. doi:10.1007/978-3-319-04843-7_5.
   PubMed Web of Science ®Google Scholar
• Nicolaije, C., M. Koedam, and J. P. van Leeuwen. 2012. “Decreased Oxygen Tension Lowers Reactive Oxygen Species and Apoptosis and Inhibits Osteoblast Matrix Mineralization Through Changes in Early Osteoblast Differentiation.” Journal of Cellular Physiology 227 (4): 1309–1318. doi:10.1002/jcp.22841.
   PubMed Web of Science ®Google Scholar
• Parent-Massin, D. 2004. “Haematotoxicity of Trichothecenes.” Toxicology Letters 153 (1): 75–81. doi:10.1016/j.toxlet.2004.04.024.
   PubMed Web of Science ®Google Scholar
• Payros, D., I. Alassane-Kpembi, A. Pierron, N. Loiseau, P. Pinton, and I. P. Oswald. 2016. “Toxicology of Deoxynivalenol and Its Acetylated and Modified Forms.” Archives of Toxicology 90 (12): 2931–2957. doi:10.1007/s00204-016-1826-4.
   PubMed Web of Science ®Google Scholar
• Pestka, J. J. 2008. “Mechanisms of Deoxynivalenol-Induced Gene Expression and Apoptosis.” Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment 25 (9): 1128–1140. doi:10.1080/02652030802056626.
   PubMed Web of Science ®Google Scholar
• Pestka, J. J. 2010a. “Deoxynivalenol-Induced Proinflammatory Gene Expression: Mechanisms and Pathological Sequelae.” Toxins 2 (6): 1300–1317. doi:10.3390/toxins2061300.
   PubMed Web of Science ®Google Scholar
• Pestka, J. J. 2010b. “Deoxynivalenol: Mechanisms of Action, Human Exposure, and Toxicological Relevance.” Archives of Toxicology 84 (9): 663–679. doi:10.1007/s00204-010-0579-8.
   PubMed Web of Science ®Google Scholar
• Pestka, J. J., and A. T. Smolinski. 2005. “Deoxynivalenol: Toxicology and Potential Effects on Humans.” Journal of Toxicology and Environmental Health-Part B-Critical Reviews 8 (1): 39–69. doi:10.1080/10937400590889458.
   PubMed Web of Science ®Google Scholar
• Pierron, A., S. Mimoun, L. S. Murate, N. Loiseau, Y. Lippi, A. P. Bracarense, G. Schatzmayr, et al. 2016. “Microbial Biotransformation of DON: Molecular Basis for Reduced Toxicity.” Scientific Reports 6: 29105. doi:10.1038/srep29105.
   PubMed Web of Science ®Google Scholar
• Pinton, P., and I. P. Oswald. 2014. “Effect of Deoxynivalenol and Other Type B Trichothecenes on the Intestine: A Review.” Toxins 6 (5): 1615–1643. doi:10.3390/toxins6051615.
   PubMed Web of Science ®Google Scholar
• Pizzo, F., F. Caloni, N. B. Schreiber, C. Cortinovis, and L. J. Spicer. 2016. “In Vitro Effects of Deoxynivalenol and Zearalenone Major Metabolites Alone and Combined, on Cell Proliferation, Steroid Production and Gene Expression in Bovine Small-Follicle Granulosa Cells.” Toxicon 109: 70–83. doi:10.1016/j.toxicon.2015.11.018.
   PubMed Web of Science ®Google Scholar
• Sergeev, I. N., L. V. Kravchenko, N. M. Piliia, A. B. Batukhanov, V. S. Sobolev, E. E. Kuz'mina, L. M. Iakushina, V. B. Spirichev, and V. A. Tutel'ian. 1990. “The Effect of the Trichothecene Mycotoxin Deoxynivalenol (Vomitoxin) on Calcium Homeostasis, Vitamin D Metabolism and Receptors in Rats.” Voprosy Meditsinskoi Khimii 36 (5): 26–29.
   PubMedGoogle Scholar
• Walsh, S., G. R. Jordan, C. Jefferiss, K. Stewart, and J. N. Beresford. 2001. “High Concentrations of Dexamethasone Suppress the Proliferation but Not the Differentiation or Further Maturation of Human Osteoblast Precursors In Vitro: Relevance to Glucocorticoid-Induced Osteoporosis.” Rheumatology 40 (1): 74–83. doi:10.1093/rheumatology/40.1.74.
   PubMed Web of Science ®Google Scholar
• Wang, X., and N. Welsh. 2014. “Bcl-2 Maintains the Mitochondrial Membrane Potential, but Fails to Affect Production of Reactive Oxygen Species and Endoplasmic Reticulum Stress, in Sodium Palmitate-Induced Beta-Cell Death.” Upsala Journal of Medical Sciences 119 (4): 306–315. doi:10.3109/03009734.2014.962714.
   PubMed Web of Science ®Google Scholar
• Weaver, A. C., M. T. See, J. A. Hansen, Y. B. Kim, A. L. De Souza, T. F. Middleton, and S. W. Kim. 2013. “The Use of Feed Additives to Reduce the Effects of Aflatoxin and Deoxynivalenol on Pig Growth, Organ Health and Immune Status During Chronic Exposure.” Toxins 5 (7): 1261–1281. doi:10.3390/toxins5071261.
   PubMed Web of Science ®Google Scholar
• Wu, C., A. J. Giaccia, and E. B. Rankin. 2014. “Osteoblasts: A Novel Source of Erythropoietin.” Current Osteoporosis Reports 12 (4): 428–432. doi:10.1007/s11914-014-0236-x.
   PubMed Web of Science ®Google Scholar
• Wu, M., H. Xiao, W. Ren, J. Yin, B. Tan, G. Liu, L. Li, C. M. Nyachoti, X. Xiong, and G. Wu. 2014. “Therapeutic Effects of Glutamic Acid in Piglets Challenged with Deoxynivalenol.” PLoS One 9 (7): e100591. doi:10.1371/journal.pone.0100591.
   PubMed Web of Science ®Google Scholar
• Yazar, S., and G. Z. Omurtag. 2008. “Fumonisins, Trichothecenes and Zearalenone in Cereals.” International Journal of Molecular Sciences 9 (11): 2062–2090. doi:10.3390/ijms9112062.
   PubMed Web of Science ®Google Scholar
• Yu, F. F., J. Han, X. Wang, H. Fang, H. Liu, and X. Guo. 2016. “Salt-Rich Selenium for Prevention and Control Children with Kashin-Beck Disease: A Meta-Analysis of Community-Based Trial.” Biological Trace Element Research 170 (1): 25–32. doi:10.1007/s12011-015-0437-x.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., X. Zhu, H. Wu, D. Zhuang, G. Yu, X. Li, F. Li, and A. Yu. 2012. “Evaluation of Fetal Skeletal Malformations in Deoxynivalenol-Treated Mice Using Microarray Analysis.” Archives of Environmental Contamination and Toxicology 63 (3): 445–452. doi:10.1007/s00244-012-9781-4.
   PubMed Web of Science ®Google Scholar