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A Numerical Study of Spray Particle Deposition in a Human Nasal Cavity

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Pages 1034-1045 | Received 23 May 2006, Accepted 26 Jun 2006, Published online: 01 Feb 2007

REFERENCES

  • Cheng , Y. S. , Holmes , T. D. , Gao , J. , Guilmette , R. A. , Li , S. , Surakitbanharn , Y. and Rowlings , C. 2001 . Characterization of Nasal Spray Pumps and Deposition Pattern in a Replica of the Human Nasal Airway . J. Aerosol Med. , 14 ( 2 ) : 267 – 280 . [INFOTRIEVE] [CSA]
  • Cheng , Y. S. , Yeh , H. C. , Guilmette , R. A. , Simpson , S. Q. , Cheng , K. H. and Swift , D. L. 1996 . Nasal Deposition of Ultrafine Particles in Human Volunteers and its Relationship to Airway Geometry . Aerosol Sci. Technol. , 25 : 274 – 291 . [CSA]
  • Crowe , C. , Sommerfeld , M. and Tsuji , Y. 1998 . Multiphase Flows with Droplets and Particles , 25 CRC Press LLC .
  • Dayal , P. , Shaik , M. S. and Singh , M. 2004 . Evaluation of Different Parameters that Affect Droplet-Size Distribution from Nasal Sprays Using Malvern Spraytec . J. Phar. Sci. , 93 : 1725 – 1742 . [CROSSREF] [CSA]
  • Djupesland , P. G. , Sketting , A. , Winderen , M. and Holand , T. 2003 . Bi-Directional Nasal Delivery of Aerosols Can Prevent Lung Deposition . J. Aerosol Med. , 17 : 249 – 259 . [CROSSREF] [CSA]
  • Eck , C. R. , McGrath , T. F. and Perlwitz , A. G. 2000 . Droplet Size Distributions in a Solution Nasal Spray . Respir. Drug Deliv. , 7 : 475 – 478 . [CSA]
  • Gonda , I. and Gipps , E. 1990 . Model of Disposition of Drugs Administered into the Human Nasal Cavity . Pharm. Res. , 7 : 69 – 75 . [INFOTRIEVE] [CROSSREF] [CSA]
  • Häußerman , S. , Bailey , A. G. , Bailey , M. R. , Etherington , G. and Youngman , M. 2002 . The influence of breathing patterns on particle deposition in a nasal replicate cast . J. Aerosol Sci. , 33 : 923 – 933 . [CROSSREF] [CSA]
  • Hinchcliffe , M. and Illum , L. 1999 . Intranasal Insulin Delivery and Therapy . Adv. Drug Delivery Rev. , 35 : 199 – 234 . [CROSSREF] [CSA]
  • Hörschler , I. , Meinke , M. and Schröder , W. 2003 . Numerical Simulation of the Flow Field in a Model of the Nasal Cavity . Comput. Fluids. , 32 : 39 – 45 . [CROSSREF] [CSA]
  • Kelly , J. T. , Prasad , A. K. and Wexler , A. S. 2000 . Detailed flow patterns in the nasal cavity . J Appl. Physiol. , 89 : 323 – 337 . [INFOTRIEVE] [CSA]
  • Kelly , J. T. , Asgharian , B. , Kimbell , J. S. and Wong , B. A. 2004 . Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part 1: Inertial Regime Particles . Aerosol Sci. Technol. , 38 : 1063 – 1071 . [CSA]
  • Keyhani , K. , Scherer , P. W. and Mozell , M. M. 1995 . Numerical Simulation of Airflow in the Human Nasal Cavity . J. Biomech. Eng. , 117 : 429 – 441 . [INFOTRIEVE] [CSA]
  • Kublik , H. and Vidgren , M. T. 1998 . Nasal Delivery Systems and Their Effect on Deposition and Absorption . Adv. Drug Delivery Rev. , 29 : 157 – 177 . [CROSSREF] [CSA]
  • Lippman , M. , Yeates , D. B. and Albert , R. E. 1993 . Deposition, Retention and Clearance of Inhaled Particles . Br. J. Ind. Med. , 37 : 337 – 362 . [CSA]
  • Maccinnes , J. M. and Bracco , F. V. 1992 . Stochastic particle dispersion modelling and the tracer-particle limit . Phys Fluids , 4 ( 12 ) : 2809 – 2824 . [CROSSREF] [CSA]
  • Morsi , S. A. and Alexander , A. J. 1972 . An Investigation of Particle Trajectories in Two-Phase Flow Systems . J. Fluid Mech. , 55 ( 2 ) : 193 – 208 . [CROSSREF] [CSA]
  • Newman , S. P. , Moren , F. and Clarke , S. W. 1998 . Deposition Pattern of Nasal Sprays in Man . Rhinology , 26 : 111 – 120 . [CSA]
  • Shih , T.-H. , Liou , W. W. , Shabbir , A. , Yang , Z. and Zhu , J. 1995 . A New k-ϵ Eddy Viscosity Model for High Reynolds Number Turbulent Flows . Comput. Fluids , 24 : 227 – 238 . [CROSSREF] [CSA]
  • Suman , J. D. , Laube , B. L. , Lin , T. C. , Brouet , G. and Dalby , R. 2002 . Validity of In Vitro Tests on Aqueous Spray Pumps as Surrogates for Nasal Deposition . Pharma Res. , 19 : 1 – 6 . [CROSSREF] [CSA]
  • Swift , D. L. 1991 . Inspiratory Inertial Deposition of Aerosols in Human Nasal Airway Replicate Casts: Implication for the Proposed NCRP Lung Model . Rad. Prot. Dosimetry , 18 ( 1/3 ) : 29 – 34 . [CSA]
  • Tu , J. Y. 2000 . Numerical Investigation of Particle Flow Behavior in Particle-Wall Function . Aerosol Sci. Technol. , 32 : 509 – 526 . [CROSSREF] [CSA]
  • Tu , J. Y. , Abu-Hijleh , B. , Xue , C. and Li , C. G. CFD Simulation of Air/Particle Flow in the Human Nasal Cavity . Proceedings of 5th International Conference on Multiphase Flow . Yokohama, Japan. Paper 209
  • Wang , Y. and James , P. W. 1999 . On the Effect of Anisotropy on the Turbulent Dispersion and Deposition of Small Particles . Int. J. of Multiphase Flows , 25 : 551 – 558 . [CROSSREF] [CSA]
  • Yan , J. , Karanjkar , A. and Branagan , M. 2004 . Dynamic Modelling and Simulation for Nasal Drug Delivery . PMPS-Drug Delivery , : 68 – 71 . August 2004[CSA]
  • Yu , G. , Xhang , Z. and Lessmann , R. 1998 . Fluid Flow and Particle Diffusion in the Human Upper Respiratory System . Aerosol Sci. Technol. , 28 : 146 – 158 . [CSA]
  • Zhang , Y. , Finlay , W. H. and Matida , E. A. 2004 . Particle Deposition Measurements and Numerical Simulation in a Highly Idealized Mouth-Throat . J. Aerosol Sci. , 35 : 789 – 803 . [CROSSREF] [CSA]
  • Zwartz , G. J. and Guilmette , R. A. 2001 . Effect of Flow Rate on Particle Deposition in a Replica of a Human Nasal Airway . Inha. Toxicol. , 13 : 109 – 127 . [CROSSREF] [CSA]

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