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Original Articles

Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data

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Pages 952-973 | Received 21 Feb 2007, Accepted 01 Aug 2007, Published online: 10 Sep 2007

REFERENCES

  • Allen , M. D. and Raabe , O. G. 1985 . Slip Correction Measurements of Spherical Solid Aerosol Particles in an Improved Millikan Apparatus . Aerosol Science and Technology , 4 : 269 – 286 .
  • Andersson , N. , Eriksson , L. and Davidson , L. 2005 . Investigation of an Isothermal Mach 0.75 Jet and its Radiated Sound using Large-Eddy Simulation and Kirchhoff Surface Integration . International Journal of Heat and Fluid Flow , 26 : 393 – 410 .
  • Becker , H. A. and Massaro , T. A. 1968 . Vortex Evolution in a Round Jet . Journal of Fluid Mechanics , 31 : 435 – 448 .
  • Bird , R. B. , Steward , W. E. and Lightfoot , E. N. 1960 . Transport Phenomina , New York : John Wiley & Sons .
  • Breuer , M. , Baytekin , H. T. and Matida , E. A. 2006 . Prediction of Aerosol Deposition in 90° Bends using LES and an Efficient Lagrangian Tracking Method . Journal of Aerosol Science , 37 : 1407 – 1428 .
  • Broday , D. M. and Georgopoulous , G. 2001 . Growth and Deposition of Hygroscopic Particulate Matter in the Human Lung . Aerosol Science and Technology , 34 : 144 – 159 .
  • Cinkotai , F. F. 1971 . The Behavior of Sodium Chloride Particles in Moist Air . Journal of Aerosol Science , 2 : 325 – 329 .
  • Copley , M. , Smurthwaite , M. , Roberts , D. L. and Mitchell , J. P. 2005 . Revised Internal Volumes of Cascade Impactors for those Provided by Mitchell and Nagel . Journal of Aerosol Medicine , 18 ( 3 ) : 364 – 366 .
  • Crow , S. C. and Champagne , F. H. 1971 . Orderly Structure in Jet Turbulence . Journal of Fluid Mechanics , 43 : 547 – 591 .
  • Crowe , C. , Sommerfeld , M. and Tsuji , Y. 1998 . Multiphase Flows with Drops and Bubbles , Boca Raton : CRC Press .
  • Crowe , C. T. , Troutt , T. R. and Chung , J. N. 1996 . Numerical Models for Two-Phase Turbulent Flows . Annual Review of Fluid Mechanics , 28 : 11 – 43 .
  • Danaila , I. , Dusek , J. and Anselmet , F. 1997 . Coherent Structures in a Round, Spatially Evolving, Unforced, Homogeneous Jet a Low Reynolds Number . Physics of Fluids , 9 ( 11 ) : 3323 – 3342 .
  • Ferron , G. A. , Kreyling , W. G. and Haider , B. 1988 . Inhalation of Salt Aerosol Particles—II. Growth and Deposition in the Human Respiratory Tract . Journal of Aerosol Science , 19 ( 5 ) : 611 – 631 .
  • Finlay , W. H. 2001 . The Mechanics of Inhaled Pharmaceutical Aerosols , San Diego : Academic Press .
  • Finlay , W. H. and Stapleton , K. W. 1995 . The Effect on Regional Lung Deposition of Coupled Heat and Mass-Transfer between Hygroscopic Droplets and their Surrounding Phase . Journal of Aerosol Science , 26 ( 4 ) : 655 – 670 .
  • Friedlander , S. K. , Windeler , R. S. and Weber , A. P. 1994 . Ultrafine Particle Formation by Aerosol Processes in Turbulent Jets: Mechanisms and Scale-Up . NanoStruct. Mat. , 4 : 521 – 528 .
  • Gemci , T. , Corcoran , T. E. and Chigier , N. 2002 . A Numerical and Experimental Study of Spray Dynamics in a Simple Throat Model . Aerosol Science and Technology , 36 : 18 – 38 .
  • Ghalichi , F. , Deng , X. , Champlain , A. D. , Douville , Y. , King , M. and Guidoin , R. 1998 . Low Reynolds Number Turbulence Modeling of Blood Flow in Arterial Stenoses . Biorheology , 35 ( 4&5 ) : 281 – 294 .
  • Gosman , A. D. and Ioannides , E. 1981 . Aspects of Computer Simulation of Liquid-Fueled Combustors . Journal of Energy , 7 : 482 – 490 .
  • Green , D. W. 1997 . Perry's Chemical Engineers' Handbook , New York : McGraw-Hill .
  • Gupta , R. , Hindle , M. , Byron , P. R. , Cox , K. A. and McRae , D. D. 2003 . Investigation of a Novel Condensation Aerosol Generator: Solute and Solvent Effects . Aerosol Science and Technology , 37 ( 8 ) : 672 – 681 .
  • Hindle , A. , Gupta , R. and Cox , K. A. 2004 . Adding Pharmaceutical Flexibility to the Capillary Aerosol Generator. Respiratory Drug Delivery IX , Edited by: R. , N. Dalby , P. , R. Byron , J. , Peart , J. , D. Suman and S. , J. Farr . 247 – 254 . River Grove, IL : DHI Publishing .
  • Hindle , M. , Byron , P. R. , Jashnani , R. N. , Howell , T. M. and Cox , K. A. 1998 . High Efficiency Fine Particle Generation using Novel Condensation Technology. Proceedings of Respiratory Drug Delivery VI , Edited by: R. , N. Dalby , P. , R. Byron and S. , J. Farr . 97 – 102 . Buffalo Grove, IL : Interpharm Press, Inc. .
  • Hong , J. N. , Hindle , M. and Byron , P. R. 2002 . Control of Particle Size by Coagulation of Novel Condensation Aerosols in Reservoir Chambers . Journal of Aerosol Medicine , 15 ( 4 ) : 359 – 368 .
  • Howell , T. M. and Sweeney , W. R. 1998 . Aerosol and a Method and Apparatus for Generating an Aerosol . United States Patent , 5/743 : 251
  • Kamiya , A. , Sakagami , M. , Hindle , M. and Byron , P. R. 2004 . Aerodynamic Sizing of Metered Dose Inhalers: An Evaluation of the Andersen and Next Generation Pharmaceutical Impactors and Their USP Methods . Journal of Pharmaceutical Sciences , 93 ( 7 ) : 1828 – 1837 .
  • Kim , J. , Moin , P. and Moser , R. D. 1987 . Turbulence Statistics in Fully Developed Channel Flow at Low Reynolds Number . Journal of Fluid Mechanics , 177 : 133 – 166 .
  • Kundu , P. K. and Cohen , I. M. 2004 . Fluid Mechanics , San Diego : Elsevier Academic Press .
  • Lesniewski , T. K. and Friedlander , S. K. 1995 . The Effect of Turbulence on Rates of Particle Formation by Homogeneous Nucleation . Aerosol Science and Technology , 23 : 174 – 182 .
  • Lesniewski , T. K. and Friedlander , S. K. 1998 . Particle Nucleation and Growth in a Free Turbulent Jet . Proceedings of the Royal Society of London A , 454 : 2477 – 2504 .
  • Lesniewski , T. K. and Koch , W. 1998 . Production of Rounded Ti- and Al-Hydroxide Particles in a Turbulent Jet by Coagulation-Controlled Growth Followed by Rapid Coalescence . Journal of Aerosol Science , 29 : 81 – 89 .
  • Li , W.-I , Perzl , M. , Heyder , J. , Langer , R. , Brian , J. D. , Englmeier , K.-H , Niven , R. W. and Edwards , D. A. 1996 . Aerodynamics and Aerosol Particle Deaggregation Phenomena in Model Oral-Pharyngeal Cavities . Journal of Aerosol Science , 27 ( 8 ) : 1269 – 1286 .
  • Longest , P. W. and Kleinstreuer , C. 2004 . Interacting Effects of Uniform Flow, Plane Shear, and Near-Wall Proximity on the Heat and Mass Transfer of Respiratory Aerosols . International Journal of Heat and Mass Transfer , 47 : 4745 – 4759 .
  • Longest , P. W. and Kleinstreuer , C. 2005 . Computational Models for Simulating Multicomponent Aerosol Evaporation in the Upper Respiratory Airways . Aerosol Science and Technology , 39 : 124 – 138 .
  • Longest , P. W. , Kleinstreuer , C. and Buchanan , J. R. 2004 . Efficient Computation of Micro–Particle Dynamics Including Wall Effects . Computers & Fluids , 33 ( 4 ) : 577 – 601 .
  • Longest , P. W. and Vinchurkar , S. 2007a . Effects of Mesh Style and Grid Convergence on Particle Deposition in Bifurcating Airway Models with Comparisons to Experimental Data . Medical Engineering and Physics , 29 ( 3 ) : 350 – 366 .
  • Longest , P. W. and Vinchurkar , S. 2007b . Validating CFD Predictions of Respiratory Aerosol Deposition: Effects of Upstream Transition and Turbulence . Journal of Biomechanics , 40 : 305 – 316 .
  • Longest , P. W. and Xi , J. 2007 . Effectiveness of Direct Lagrangian Tracking Models for Simulating Nanoparticle Deposition in the Upper Airways . Aerosol Science and Technology , 41 : 380 – 397 .
  • Loth , E. 2000 . Numerical Approaches for Motion of Dispersed Particles Droplets and Bubbles . Progress in Energy and Combustion Science , 26 : 161 – 223 .
  • Martonen , T. B. 1982 . Analytical Model of Hygroscopic Particle Behavior in Human Airways . Bulletin of Mathematical Biology , 44 ( 3 ) : 425 – 442 .
  • Martonen , T. B. and Katz , I. 1996 . Thermodynamics of Inhaled Hydroscopic Drugs. Inhalation Aerosols , Edited by: A. , J. Hickey . 29 – 50 . New York : Marcel Dekker .
  • Matida , E. A. , Finlay , W. H. , Breuer , M. and Lange , C. F. 2006 . Improving Prediction of Aerosol Deposition in an Idealized Mouth using Large-Eddy Simulation . Journal of Aerosol Medicine , 19 ( 3 ) : 290 – 300 .
  • Matida , E. A. , Finlay , W. H. and Grgic , L. B. 2004 . Improved Numerical Simulation of Aerosol Deposition in an Idealized Mouth-Throat . Journal of Aerosol Science , 35 : 1 – 19 .
  • Matida , E. A. , Nishino , K. and Torii , K. 2000 . Statistical Simulation of Particle Deposition on the Wall from Turbulent Dispersed Pipe Flow . International Journal of Heat and Fluid Flow , 21 : 389 – 402 .
  • Morsi , S. A. and Alexander , A. J. 1972 . An Investigation of Particle Trajectories in Two-Phase Flow Systems . J. Fluid Mechanics , 55 ( 2 ) : 193 – 208 .
  • O'Neill , P. , Soria , J. and Honnery , D. 2004 . The Stability of Low Reynolds Number Round Jets . Experiments in Fluids , 36 : 473 – 483 .
  • Oldham , M. J. 2006 . Challenges in Validating CFD-Derived Inhaled Aerosol Deposition Predictions . Inhalation Toxicology , 18 : 781 – 786 .
  • Peng , C. , Chow , A. H. L. and Chan , C. K. 2000 . Study of the Hygroscopic Properties of Selected Pharmaceutical Aerosols using Single Particle Levitation . Pharmaceutical Research , 17 : 1104 – 1109 .
  • Pepper , D. W. and Heinrich , J. C. 1992 . The Finite Element Method: Basic Concepts and Applications , Bristol : Taylor and Francis .
  • Persons , D. D. , Hess , G. D. , Muller , W. J. and Scherer , P. W. 1987 . Airway Deposition of Hygroscopic Heterodispersed Aerosols—Results of a Computer Calculation . Journal of Applied Physiology , 63 ( 3 ) : 1195 – 1204 .
  • Robinson , R. and Yu , C. P. 1998 . Theoretical Analysis of Hygroscopic Growth Rate of Mainstream and Sidestream Cigarette Smoke Particles in the Human Respiratory Tract . Aerosol Science and Technology , 28 : 21 – 32 .
  • Sbrizzai , F. , Verzicco , R. , Pidria , M. F. and Soldati , A. 2004 . Mechanisms for Selective Radial Dispersion of Microparticles in the Transitional Region of a Confined Turbulent Round Jet . International Journal of Multiphase Flow , 30 : 1389 – 1417 .
  • Schroeter , J. D. , Musante , C. J. , Hwang , D. M. , Burton , R. , Guilmette , R. and Martonen , T. B. 2001 . Hygroscopic Growth and Deposition of Inhaled Secondary Cigarette Smoke in Human Nasal Pathways . Aerosol Science and Technology , 34 ( 1 ) : 137 – 143 .
  • Shen , X. , Hindle , A. and Byron , P. R. 2004 . Effect of Energy on Propylene Glycol Aerosols using the Capillary Aerosol Generator . International Journal of Pharmaceutics , 275 ( 1–2 ) : 249 – 258 .
  • Stapleton , K. W. , Guentsch , E. , Hoskinson , M. K. and Finlay , W. H. 2000 . On the Suitability of k-Epsilon Turbulence Modeling for Aerosol Deposition in the Mouth and Throat: A Comparison with Experiment . Journal of Aerosol Science , 31 ( 6 ) : 739 – 749 .
  • Stein , S. W. and Myrdal , P. B. 2006 . The Relative Influence of Atomization and Evaporation on Metered Dose Inhaler Drug Delivery Efficiency . Aerosol Science and Technology , 40 : 335 – 347 .
  • Sutugin , A. G. and Fuchs , N. A. 1968 . Formation of Condensation Aerosols at High Vapor Supersaturation . Journal of Colloid and Interface Science , 27 ( 2 ) : 216 – 228 .
  • USP . 2005 . Physical Tests and Determinations: Aerosols, Nasal Sprays, Metered—Dose Inhalers, and Dry Powder Inhalers. United States Pharmacopeia First Supplement, 28–NF, General Chapter (601). United States Pharmacopeial Convention, Rockville MD 3298-3316
  • Vargaftik , N. B. 1975 . Tables on Thermophysical Properties of Liquids and Gases , Washington, DC : Hemisphere .
  • Vincenti , W. G. and Kruger , C. H. 1996 . Physical Gas Dynamics , Malabar : Robert E. Krieger Publishing Company, Inc. .
  • Wang , Y. and James , P. W. 1999 . On the Effect of Anisotropy on the Turbulent Dispersion and Deposition of Small Particles . International Journal of Multiphase Flow , 22 : 551 – 558 .
  • Weisgraber , T. H. and Liepmann , D. 1998 . Turbulent Structure During Transition to Self-Similarity in a Round Jet . Experiments in Fluids , 24 : 210 – 224 .
  • Wen , H. Y. , Kasper , G. and Montgomery , D. 1988 . Nucleation of Trace Amounts of Condensable Vapors in an Expanding Gas Jet . Journal of Aerosol Science , 19 : 153 – 156 .
  • Wilcox , D. C. 1998 . Turbulence Modeling for CFD, 2nd Ed , California : DCW Industries, Inc. .
  • Xi , J. and Longest , P. W. 2007a . “ Effects of Oral Airway Geometry Characteristics on the Diffusional Deposition of Inhaled Nanoparticles ” . In ASME Journal of Biomechanical Engineering
  • Xi , J. and Longest , P. W. 2007b . Transport and Deposition of Micro-Aerosols in Realistic and Simplified Models of the Oral Airway . Annals of Biomedical Engineering , 35 ( 4 ) : 560 – 581 .
  • Zhang , Y. , Chia , T. L. and Finlay , W. H. 2006 . Experimental Measurement and Numerical Study of Particle Deposition in Highly Idealized Mouth–Throat Models . Aerosol Science and Technology , 40 : 361 – 372 .
  • Zhang , Z. and Kleinstreuer , C. 2003 . Low-Reynolds-Number Turbulent Flows in Locally Constricted Conduits: A Comparison Study . AIAA Journal , 41 ( 5 ) : 831 – 840 .
  • Zhang , Z. and Kleinstreuer , C. 2004 . Airflow Structures and Nano–Particle Deposition in a Human Upper Airway Model . Journal of Computational Physics , 198 ( 1 ) : 178 – 210 .
  • Zhang , Z. , Kleinstreuer , C. , Donohue , J. F. and Kim , C. S. 2005 . Comparison of Micro- and Nano-Size Particle Depositions in a Human Upper Airway Model . Journal of Aerosol Science , 36 ( 2 ) : 211 – 233 .
  • Zhang , Z. , Kleinstreuer , C. and Kim , C. S. 2006a . Isotonic and Hypertonic Saline Droplet Deposition in a Human Upper Airway Model . Journal of Aerosol Medicine , 19 ( 2 ) : 184 – 198 .
  • Zhang , Z. , Kleinstreuer , C. and Kim , C. S. 2006b . Water Vapor Transport and its Effects on the Deposition of Hygroscopic Droplets in a Human Upper Airway Model . Aerosol Science and Technology , 40 : 52 – 67 .

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