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Aerosol Science and Technology Volume 47, 2013 - Issue 5
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Original Articles

Influence of Morphometry and Airway Patency on Response to Inhaled Methacholine

Michael J. Oldham Department of Community and Environmental Medicine, University of California, Irvine, California, USA; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USA; Altria Client Services, Richmond, Virginia, USA
,
Rodney E. Clinkenbeard Institute for Environmental Management, Health Sciences Center, University of Oklahoma, Oklahoma City, Oklahoma, USA
&
Owen R. Moss POK Research, Apex, North Carolina, USA
Pages 574-579 | Received 18 Sep 2012, Accepted 07 Jan 2013, Published online: 26 Feb 2013

REFERENCES

  • American Association for Respiratory Care. 2001 . AARC Clinical Practice Guideline—Methacholine Challenge Testing: 2001 Revision & Update . Respir. Care , 46 ( 5 ) : 523 – 530 .
  • American Thoracic Society. 2000 . Guidelines for Methacholine and Exercise Challenge Testing—1999 . Am. J. Respir. Crit. Care Med. , 161 ( 1 ) : 309 – 329 .
  • Brown , R. H. , Croisille , P. , Mudge , B. , Diemer , F. B. , Permutt , S. and Togias , A. 2000 . Airway Narrowing in Healthy Humans Inhaling Methacholine Without Deep Inspirations Demonstrated by HRCT . Am J. Respir. Crit. Care Med. , 161 : 1256 – 1263 .
  • Clinkenbeard , R. E. , Johnson , D. L. , Parthasarathy , R. , Altan , C. , Tan , K. H. Crawford , R. H. 2002 . Replication of Human Tracheobronchial Hollow Airway Models Using a Selective Laser Sintering Rapid Prototyping Technique . Am. Ind. Hyg. J. , 63 : 141 – 150 .
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  • DeLorme , M. P. and Moss , O. R. 2002 . Pulmonary Function Assessment by Whole-Body Plethysmography in Restrained Versus Unrestrained Mice . J. Pharmacol. Toxicol. Methods , 47 ( 1 ) : 1 – 10 .
  • Druz , W. S. and Sharp , J. T. 1981 . Activity of Respiratory Muscles in Upright and Recumbent Humans . J. Appl. Physiol. , 51 : 1552 – 1561 .
  • Ibanez , J. and Raurich , J. M. 1982 . Normal Values of Functional Residual Capacity in the Sitting and Supine Positions . Intensive Care Med. , 8 : 173 – 177 .
  • Moss , O. R. and Oldham , M. J. 2006 . Dosimetry Counts: Molecular Hypersensitivity May Not Drive Pulmonary Hyperresponsiveness . J. Aerosol Med. , 19 ( 4 ) : 555 – 564 .
  • Moss , O. R. and Oldham , M. J. 2011 . Predicting Balb/c and B6C3F1 Mouse Sensitivity to Inhaled Methacholine: Impact of Calculating Lung-Airway Dimension and Airflow Distribution . Aerosol Sci. Technol. , 45 ( 7 ) : 821 – 826 .
  • O’Riordan , T. G. , Walser , L. and Smaldone , G. C. 1993 . Changing Patterns of Aerosol Deposition During Methacholine Bronchoprovocation . Chest , 103 : 1385 – 1389 .
  • Phalen , R. F. , Yeh , H. C. , Schum , G. M. and Raabe , O. G. 1978 . Application of an Idealized Model to Morphometry of the Mammalian Tracheobronchial Tree . Anat. Record , 190 : 167 – 176 .
  • Tsai , L. L. , Mair , R. W. , Li , C.-H. , Rosen , M. S. , Patz , S. and Waisworth , R. L. 2008 . Posture-Dependent Human 3He Lung Imaging in an Open Access MRI System: Initial Results . Acad. Radiol. , 15 : 728 – 739 .
  • Weibel , E. R. 1963 . Morphometry of the Human Lung , 136 – 140 . Berlin : Springer-Verlag .

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