Microparticle Transport and Deposition in the Human Oral Airway: Toward the Smart Spacer

REFERENCES

• Asmus, M. J., Liang, J., Coowanitwong, I., Vafadari, R., and Hochhaus, G. (2002). In Vitro Deposition of Fluticasone Aerosol from a Metered-Dose Inhaler with and Without Two Common Valved Holding Chambers. Ann. Allerg. Asthma. Immunol., 88:204–208.
   PubMed Web of Science ®Google Scholar
• Bisgaard, H., Anhoj, J., and Wildhaber, J. H. (2001). Spacer Devices, in Drug Delivery to the Lung. Marcel Dekker, New York, pp. 389–420.
   Google Scholar
• Brocklebank, D., Ram, F., Wright, J., Barry, P., Cates, C., Davies, L., Douglas, G., Muers, M., Smith, D., and White, J. (2001). Comparison of the Effectiveness of Inhaler Devices in Asthma and Chronic Obstructive Airways Disease: A Systematic Review of the Literature. Health Technol. Assess., 5:1–149.
   PubMedGoogle Scholar
• Chan, D. S., Callahan, C. W., Hatch-Pigott, V. B., Lawless, A., Proffitt, H. L., Manning, N. E., and Schweikert, M. P. (2006). Concurrent Use of Metered-Dose and Dry Powder Inhalers by Children with Persistent Asthma Does Not Adversely Affect Spacer/Inhaler Technique. Ann. Pharmacother., 40:1743–1746.
   PubMed Web of Science ®Google Scholar
• Cheng, K. H., Cheng, Y. S., Yeh, H. C., and Swift, D. L. (1997). Measurements of Airway Dimensions and Calculation of Mass Transfer Characteristics of the Human Oral Passage. J. Biomech. Eng., 119:476–482.
   PubMed Web of Science ®Google Scholar
• Cheng, Y.-S., Zhou, Y., and Chen, B. T. (1999). Particle Deposition in a Cast of Human Oral Airways. Aerosol Sci. Technol., 31:286–300.
   Web of Science ®Google Scholar
• Cheng, Y. S., Fu, C. S., Yazzie, D., and Zhou, Y. (2001). Respiratory Deposition Patterns of Salbutamol pMDI with CFC and HFA-134a Formulations in a Human Airway Replica. J. Aerosol Med., 14:255–266.
   PubMedGoogle Scholar
• Coates, M. S., Fletcher, D. F., Chan, H. K., and Raper, J. A. (2004). Effect of Design on the Performance of a Dry Powder Inhaler Using Computational Fluid Dynamics. Part 1: Grid Structure and Mouthpiece Length. J. Pharm. Sci., 93:2863–2876.
   PubMed Web of Science ®Google Scholar
• Cochrane, M. G., Bala, M. V., Downs, K. E., Mauskopf, J., and Ben-Joseph, R. H. (2000). Inhaled Corticosteroids for Asthma Therapy: Patient Compliance, Devices, and Inhalation Technique. Chest, 117:542–550.
   PubMed Web of Science ®Google Scholar
• Dolovich, M. (1995). Characterization of Medical Aerosols: Physical and Clinical Requirements for New Inhalers. Aerosol Sci. Technol., 22:392–399.
   Web of Science ®Google Scholar
• Golshahi, L., Tian, G., Azimi, M., Son, Y.-J., Walenga, R., Longest, P. W., and Hindle, M. (2013). The Use of Condensational Growth Methods for Efficient Drug Delivery to the Lungs during Noninvasive Ventilation High Flow Therapy. Pharm. Res., 30:2917–2930.
   PubMed Web of Science ®Google Scholar
• Han, R., Papadopoulos, G., and Greenspan, B. J. (2002). Flow Field Measurement Inside the Mouthpiece of the Spiros Inhaler Using Particle Image Velocimetry. Aerosol Sci. Technol., 36:329–341.
   Web of Science ®Google Scholar
• Haughney, J., Price, D., Barnes, N. C., Virchow, J. C., Roche, N., and Chrystyn, H. (2010). Choosing Inhaler Devices for People with Asthma: Current Knowledge and Outstanding Research Needs. Respir. Med., 104:1237–1245.
   PubMed Web of Science ®Google Scholar
• Hindle, M., and Longest, P. W. (2010). Evaluation of Enhanced Condensational Growth (ECG) for Controlled Respiratory Drug Delivery in a Mouth–Throat and Upper Tracheobronchial Model. Pharm. Res., 27:1800–1811.
   PubMed Web of Science ®Google Scholar
• Inthavong, K., Choi, L. T., Tu, J. Y., Ding, S., and Thien, F. (2010a). Micron Particle Deposition in a Tracheobronchial Airway Model Under Different Breathing Conditions. Med. Eng. Phys., 32:1198–1212.
   PubMed Web of Science ®Google Scholar
• Inthavong, K., Tian, Z. F., Li, H. F., Tu, J. Y., Yang, W., Xue, C. L., and Li, C. G. (2006). A Numerical Study of Spray Particle Deposition in a Human Nasal Cavity. Aerosol Sci. Technol., 40:1034–U1033.
   Web of Science ®Google Scholar
• Inthavong, K., Tu, J., and Heschl, C. (2011). Micron Particle Deposition in the Nasal Cavity using the v2–f Model. Comput. Fluids, 51:184–188.
   Web of Science ®Google Scholar
• Inthavong, K., Tu, J. Y., Ye, Y., Ding, S., Subic, A., and Thien, F. (2010b). Effects of Airway Obstruction Induced by Asthma Attack on Particle Deposition. J. Aerosol Sci., 41:587–601.
   Web of Science ®Google Scholar
• Inthavong, K., Zhang, K., and Tu, J. Y. (2009). Modelling Submicron and Micron Particle Deposition in a Human Nasal Cavity, in Seventh International Conference on Computational Fluid Dynamics in the Minerals and Process Industries, P. Schwarz and P. Witt, Eds., CSIRO Minerals, Australia, Melbourne, Australia.
   Google Scholar
• Jin, H. H., Fan, J. R., Zeng, M. J., and Cen, K. F. (2007). Large Eddy Simulation of Inhaled Particle Deposition Within the Human Upper Respiratory Tract. J. Aerosol Sci., 38:257–268.
   Web of Science ®Google Scholar
• Johnstone, A., Uddin, M., Pollard, A., Heenan, A., and Finlay, W. H. (2004). The Flow Inside an Idealised Form of the Human Extra-Thoracic Airway. Exp. Fluids, 37:673–689.
   Web of Science ®Google Scholar
• Kallio, G. A., and Reeks, M. W. (1989). A Numerical Simulation of Particle Deposition in Turbulent Boundary Layers. Int. J. Multiphas. Flow, 15:433–446.
   Web of Science ®Google Scholar
• Keeley, D. (1992). Large Volume Plastic Spacers in Asthma. BMJ (Clin. Res. ed.), 305:598–599.
   PubMed Web of Science ®Google Scholar
• Kleinstreuer, C., Shi, H., and Zhang, Z. (2007). Computational Analyses of a Pressurized Metered Dose Inhaler and a New Drug-Aerosol Targeting Methodology. J. Aerosol Med., 20:294–309.
   PubMedGoogle Scholar
• Kleinstreuer, C., and Zhang, Z. (2003). Laminar-to-Turbulent Fluid-Particle Flows in a Human Airway Model. Int. J. Multiphas Flow, 29:271–289.
   Web of Science ®Google Scholar
• Kleinstreuer, C., Zhang, Z., and Li, Z. (2008a). Modeling Airflow and Particle Transport/Deposition in Pulmonary Airways. Respir. Physiol. Neurobiol., 163:128–138.
   PubMed Web of Science ®Google Scholar
• Kleinstreuer, C., Zhang, Z., Li, Z., Roberts, W. L., and Rojas, C. (2008b). A New Methodology for Targeting Drug-Aerosols in the Human Respiratory System. Int. J. Heat Mass Transfer, 51:5578–5589.
   Web of Science ®Google Scholar
• Kofman, C., Berlinski, A., Zaragoza, S., and Teper, A. (2004). Aerosol Therapy for Pediatric Outpatients. RT: J. Respir. Care Practitioners, 117:26–28.
   Google Scholar
• Kral, L. D. (1998). Recent Experience with Different Turbulence Models Applied to the Calculation of Flow Over Aircraft Components. Prog. Aerosp. Sci., 34:481–541.
   Web of Science ®Google Scholar
• Kwok, P. C., Glover, W., and Chan, H. K. (2005). Electrostatic Charge Characteristics of Aerosols Produced From Metered Dose Inhalers. J. Pharm. Sci., 94:2789–2799.
   PubMed Web of Science ®Google Scholar
• Li, Z., Kleinstreuer, C., and Zhang, Z. (2007). Particle deposition in the Human Tracheobronchial Airways Due to Transient Inspiratory Flow Patterns. J. Aerosol Sci., 38:625–644.
   Web of Science ®Google Scholar
• Lin, C.-L., Tawhai, M. H., McLennan, G., and Hoffman, E. A. (2007). Characteristics of the Turbulent Laryngeal Jet and Its Effect on Airflow in the Human Intra-Thoracic Airways. Respir. Physiol. Neurobiol., 157:295–309.
   PubMed Web of Science ®Google Scholar
• Longest, P. W., Tian, G., Delvadia, R., and Hindle, M. (2012a). Development of a Stochastic Individual Path (SIP) Model for Predicting the Deposition of Pharmaceutical Aerosols: Effects of Turbulence, Polydisperse Aerosol Size, and Evaluation of Multiple Lung Lobes. Aerosol Sci. Technol., 46:1271–1285.
   Web of Science ®Google Scholar
• Longest, P. W., Tian, G., Walenga, R. L., and Hindle, M. (2012b). Comparing MDI and DPI Aerosol Deposition using in vitro Experiments and a New Stochastic Individual Path (SIP) Model of the Conducting Airways. Pharm. Res., 29:1670–1688.
   PubMed Web of Science ®Google Scholar
• Longest, P. W., and Xi, J. (2007a). Computational Investigation of Particle Inertia Effects on Submicron Aerosol Deposition in the Respiratory Tract. J. Aerosol Sci., 38:111–130.
   Web of Science ®Google Scholar
• Longest, P. W., and Xi, J. (2007b). Effectiveness of Direct Lagrangian Tracking Models for Simulating Nanoparticle Deposition in the Upper Airways. Aerosol Sci. Technol., 41:380–397.
   Web of Science ®Google Scholar
• Longest, W. P., and Hindle, M. (2009). Evaluation of the Respimat Soft Mist Inhaler using a Concurrent CFD and In Vitro Approach. J. Aerosol Med. Pulmonar. Drug Deliv., 22:99–112.
   PubMed Web of Science ®Google Scholar
• Matida, E. A., DeHaan, W. H., Finlay, W. H., and Lange, C. F. (2003). Simulation of Particle Deposition in an Idealized Mouth with Different Small Diameter Inlets. Aerosol Sci. Technol., 37:924–932.
   Web of Science ®Google Scholar
• Matida, E. A., Finlay, W. H., Lange, C. F., and Grgic, B. (2004a). Improved Numerical Simulation for Aerosol Deposition in an Idealized Mouth–Throat. J. Aerosol Sci., 35:1–19.
   Web of Science ®Google Scholar
• Matida, E. A., Finlay, W. H., Rimkus, M., Grgic, B., and Lange, C. F. (2004b). A New Add-on Spacer Design Concept for Dry-Powder Inhalers. J. Aerosol Sci., 35:823–833.
   Web of Science ®Google Scholar
• Molimard, M., Raherison, C., Lignot, S., Depont, F., Abouelfath, A., and Moore, N. (2003). Assessment of Handling of Inhaler Devices in Real Life: An Observational Study in 3811 Patients in Primary Care. J. Aerosol Med., 16:249–254.
   PubMedGoogle Scholar
• Morén, F. (1981). Pressurized Aerosols for Oral Inhalation. Int. J. Pharmaceut., 8:1–10.
   Web of Science ®Google Scholar
• Morsi, S., and Alexander, A. (1972). An Investigation of Particle Trajectories in Two-Phase Flow Systems. J. Fluid Mech., 55:193–208.
   Web of Science ®Google Scholar
• Newman, S. P. (2004). Spacer Devices for Metered Dose Inhalers. Clin. Pharmacokinet, 43:349–360.
   PubMed Web of Science ®Google Scholar
• Oliveira, R. F., Teixeira, S., Marques, H. C., and Teixeira, J. C. (2014). Efficiency Evaluation of VHC: A CFD Comparison Study at Constant Flow, in International Conference on Mechanics, Fluid Mechanics, Heat and Mass Transfer.
   Google Scholar
• Oliveira, R. F., Teixeira, S., Silva, L. F., Teixeira, J. C., and Antunes, H. (2010). CFD Study of the Volumetric Spacer: A Realistic Approach, in Vth European Conference on Computational Fluid Dynamics, J. C. F. Pereira and A. Sequeira, eds., Lisbon, Portugal.
   Google Scholar
• Price, D., Roche, N., Christian Virchow, J., Burden, A., Ali, M., Chisholm, A., Lee, A. J., Hillyer, E. V., and von Ziegenweidt, J. (2011). Device Type and Real-World Effectiveness of Asthma Combination Therapy: An Observational Study. Respir. Med., 105:1457–1466.
   PubMed Web of Science ®Google Scholar
• Rebelo, R., Oliveira, R. F., Silva, L. F., Teixeira, S., Teixeira, J. C., and Antunes, H. (2009). Further Development on the CFD Flow Analysis Inside the Volmumetric Spacer, in XIII Congreso International de Ingenieria de Proyectos, Badajoz.
   Google Scholar
• Shi, H., Kleinstreuer, C., and Zhang, Z. (2007). Modeling of Inertial Particle Transport and Deposition in Human Nasal Cavities with Wall Roughness. J. Aerosol Sci., 38:398–419.
   Web of Science ®Google Scholar
• Stapleton, K.-W., Guentsch, E., Hoskinson, M., and Finlay, W. (2000). On the Suitability of k–ϵ Turbulence Modeling for Aerosol Deposition in the Mouth and Throat: A Comparison with Experiment. J. Aerosol Sci., 31:739–749.
   Web of Science ®Google Scholar
• Tian, G., Hindle, M., and Longest, P. W. (2014). Targeted Lung Delivery of Nasally Administered Aerosols. Aerosol Sci. Technol. 48:434–449.
   PubMed Web of Science ®Google Scholar
• Tian, G., Longest, P. W., Su, G., Walenga, R. L., and Hindle, M. (2011). Development of a Stochastic Individual Path (SIP) Model for Predicting the Tracheobronchial Deposition of Pharmaceutical Aerosols: Effects of Transient Inhalation and Sampling the Airways. J. Aerosol Sci., 42:781–799.
   Web of Science ®Google Scholar
• Van Oort, M. (1995). In Vitro Testing of Dry Powder Inhalers. Aerosol Sci. Technol., 22:364–373.
   Web of Science ®Google Scholar
• Versteeg, H. K., Hargrave, G., Harrington, L., Shrubb, I., and Hodson, D. (2000). The Use of Computational Fluid Dynamics (CFD) to Predict pMD Air Flows and Aerosol Plume Formation, in Respiratory Drug Delivery VII, Raleigh Serentec Press, Inc., 257–264.
   Google Scholar
• Wang, Y., and James, P. W. (1999). On the Effect of Anisotropy on the Turbulent Dispersion and Deposition of Small Particles. Int. J. Multiphase Flows, 25:551–558.
   Web of Science ®Google Scholar
• Wilcox, D. C. (1998). Turbulence Modeling for CFD. DCW Industries, Inc.
   Google Scholar
• Worth Longest, P., and Vinchurkar, S. (2007). Validating CFD Predictions of Respiratory Aerosol Deposition: Effects of Upstream Transition and Turbulence. J. Biomech., 40:305–316.
   PubMed Web of Science ®Google Scholar
• Yang, M. Y., Chan, J. G., and Chan, H. K. (2014). Pulmonary Drug Delivery by Powder Aerosols. J. Control. Release, 193c:228–240.
   Web of Science ®Google Scholar
• Yazdani, A., Normandie, M., Yousefi, M., Saidi, M. S., and Ahmadi, G. (2014). Transport and Deposition of Pharmaceutical Particles in Three Commercial Spacer–MDI Combinations. Comput. Biol. Med., 54:145–155.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Chia, T. L., and Finlay, W. H. (2006). Experimental Measurement and Numerical Study of Particle Deposition in Highly Idealized Mouth–Throat Models. Aerosol Sci. Technol., 40:361–372.
   Web of Science ®Google Scholar
• Zhang, Z., and Kleinstreuer, C. (2002). Transient Airflow Structures and Particle Transport in a Sequentially Branching Lung Airway Model. Phys. Fluid., 14:862–880.
   Web of Science ®Google Scholar
• Zhang, Z., and Kleinstreuer, C. (2004). Airflow Structures and Nano-Particle Deposition in a Human Upper Airway Model. J. Comput. Phys., 198:178–210.
   Web of Science ®Google Scholar
• Zhang, Z., Kleinstreuer, C., Donohue, J. F., and Kim, C. S. (2005). Comparison of Micro- and Nano-Size Particle Depositions in a Human Upper Airway Model. J. Aerosol Sci., 36:211–233.
   Web of Science ®Google Scholar
• Zhang, Z., Kleinstreuer, C., and Kim, C. S. (2002). Micro-Particle Transport and Deposition in a Human Oral Airway Model. J. Aerosol Sci., 33:1635–1652.
   Web of Science ®Google Scholar
• Zhou, Q. T., Tang, P., Leung, S. S., Chan, J. G., and Chan, H. K. (2014). Emerging Inhalation Aerosol Devices and Strategies: Where Are We Headed? Adv. Drug Deliv. Rev., 75:3–17.
   PubMed Web of Science ®Google Scholar
• Zhou, Y., Sun, J., and Cheng, Y. S. (2011). Comparison of Deposition in the USP and Physical Mouth-Throat Models with Solid and Liquid Particles. J. Aerosol Med. Pulmonar. Drug Deliv., 24:8.
   Web of Science ®Google Scholar