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Articles

Transient flashing propellant flow models to predict internal flow characteristics, spray velocity, and aerosol droplet size of a pMDI

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Pages 564-575 | Received 28 Sep 2016, Accepted 27 Dec 2016, Published online: 31 Jan 2017

References

  • Abramovich, G. (1976). Applied Gasdynamics. 4th revised ed. Izdatel'stvo Nauka, Moscow.
  • Bailey, A. G., Balachandran, W., and Williams, T. J. (1983). The Rosin—Rammler Size Distribution for Liquid Droplet Ensembles. J. Aerosol Sci., 14(1):39–46.
  • Clark, A. R. (1991). Metered Atomisation for Respiratory Drug Delivery, Ph.D. Dissertation. Loughborough University Of Technology, Loughborough, UK.
  • Crosland, B. M., Johnson, M. R., and Matida, E. A. (2009). Characterization of the Spray Velocities from A Pressurized Metered-Dose Inhaler. J. Aerosol Med. Pulm. Drug Deliv., 22(2):85–98.
  • Dolovich, M. B., and Fink, J. B. (2001). Aerosols and Devices. Respir. Care Clin. N. Am., 7(2):131–174.
  • Dunbar, C. A. (1996). An Experimental And Theoretical Investigation Of The Spray Issued From A Pressurised Metered-Dose Inhaler, Ph.D. Dissertation. University of Manchester Institute of Science and Technology, Manchester, UK.
  • Dunbar, C. A., and Miller, J. F. (1997). Theoretical Investigation of the Spray from A Pressurized Metered-Dose Inhaler. Atom. Sprays, 7(4):417–436.
  • Dunbar, C. A., Watkins, A. P., and Miller, J. F. (1997). An Experimental Investigation of the Spray Issued From A pMDI Using Laser Diagnostic Techniques. J. Aerosol Med., 10(4):351–368.
  • Fauske, H. K. (1985). Flashing Flows or: Some Practical Guidelines for Emergency Releases. Plant/Operat. Prog., 4(3):132–134.
  • Finlay, W. H. (2001). The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. 6 ed. Academic Press, London.
  • Fletcher, G. E. (1975). Factors Affecting the Atomisation of Saturated Liquids, Ph.D. Dissertation. Loughborough University Of Technology, Loughborough, Uk.
  • Gavtash, B., Versteeg, H. K., Hargrave, G. K., Lewis, D., Church, T., and Brambilla, G. (2014). Linear Instability Sheet Atomisation (LISA) Model to Predict Droplet Size Issued from A pMDI, in Proceedings Of The Ilass – Europe 2014, 26th Annual Conference On Liquid Atomization And Spray Systems, Bremen, September 2014, pp. 283–285.
  • Hewitt, G. F., and Hall-Taylor, N. S. (1970). Annular Two-Phase Flow. Pergamon Press, Oxford, UK.
  • Huff, J. (1985). Multiphase Flashing Flow in Pressure Relief Systems. Plant/Operat. Prog., 4(4):191–199.
  • Ju, D., Shrimpton, J., and Hearn, A. (2010). The Effect of Reduction of Propellant Mass Fraction on the Injection Profile of Metered Dose Inhalers. Int. J. Pharm., 391(1):221–229.
  • Lefebvre, A. (1989). Atomization and Sprays. CRC Press, Taylor & Francis, Florida.
  • Moody, F. J. (1965). Maximum Flow Rate of a Single Component, Two-Phase Mixture. J. Heat Transfer, 87(1):134–141.
  • Myatt, B., Lewis, D., Church, T., Brambilla, G., Hargrave, G., Versteeg, H., Long, E., and Gavtash, B. (2015a). PDA Analysis of HFA/Ethanol pMDI Aerosols: An Improved Test Protocol And New Findings, in Proceedings of the Iclass 2015, 13th Triennial International Conference on Liquid Atomization And Spray Systems, Thailand, August 2015, p. 11.
  • Myatt, B., Newton, R., Lewis, D., Church, T., Brambilla, G., Hargrave, G., Versteeg, H., Gavtash, B., and Long, E. (2015b). PDA and High Speed Image Analysis Of HFA/Ethanol pMDI Aerosols: New Findings, in Ddl 26, Edinburgh, December 2015, pp. 73–77.
  • Sher, E., Bar-Kohany, T., and Rashkovan, A. (2008). Flash-Boiling Atomization. Progress Energy Combust. Sci., 34(4):417–439.
  • Starkman, E., Neusen, K., Maneely, D., and Schrock, V. (1964). Expansion of a Very Low Quality Two-Phase Fluid Through A Convergent-Divergent Nozzle. Trans ASME, J. Basic Eng., 86(2):247–254.
  • Versteeg, H., Hargrave, G., and Kirby, M. (2006). Internal Flow And Near-Orifice Spray Visualisations Of A Model Pharmaceutical Pressurised Metered Dose Inhaler. J. Phys.: Conf. Ser., 45:207–217.
  • Wigley, G., Versteeg, H. K., and Hodson, D., ILASS-Europe. (2002). Near-Orifice PDA Measurements And Atomisation Mechanism Of A Pharmaceutical Pressurised Metered Dose Inhaler, in Proceedings Of The 18th Annual Conference On Liquid Atomization & Spray Systems, Zaragoza, Spain, September 2002, pp. 165–170.

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