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Original Articles

Estimating the reduction in SARS-CoV-2 viral load by common face masks with a simple leak model

ORCID Icon, ORCID Icon &
Pages 573-591 | Received 01 May 2021, Accepted 22 Feb 2022, Published online: 19 May 2022

References

  • Almstrand, A.-C., B. Bake, E. Ljungström, P. Larsson, A. Bredberg, E. Mirgorodskaya, and A.-C. Olin. 2010. Effect of airway opening on production of exhaled particles. Journal of Applied Physiology 108 (3):584–8. doi:10.1152/japplphysiol.00873.2009.
  • Asadi, S., C. D. Cappa, S. Barreda, A. S. Wexler, N. M. Bouvier, and W. D. Ristenpart. 2020. Efficacy of masks and face coverings in controlling outward aerosol particle emission from expiratory activities. Sci. Rep. 10 (1):1–13. doi:10.1038/s41598-020-72798-7.
  • Asadi, S., A. S. Wexler, C. D. Cappa, S. Barreda, N. M. Bouvier, and W. D. Ristenpart. 2019. Aerosol emission and superemission during human speech increase with voice loudness. Sci. Rep. 9 (1):2348. doi:10.1038/s41598-019-38808-z.
  • Bazant, M. Z, and J. W. M. Bush. 2021. A guideline to limit indoor airborne transmission of COVID-19. Proc. Natl. Acad. Sci. U.S.A. 118 (17):e2018995118. doi:10.1073/pnas.2018995118.
  • Bird, R. B., W. E. Stewart, and E. N. Lightfoot. 2022. Transport phenomena. 2nd ed. New York: Wiley. doi:10.1115/1.1424298.
  • Brooks, J. T., D. H. Beezhold, J. D. Noti, J. P. Coyle, R. C. Derk, F. M. Blachere, and W. G. Lindsley. 2021. Maximizing fit for cloth and medical procedure masks to improve performance and reduce SARS-CoV-2 transmission and exposure, 2021. MMWR Morb. Mortal. Wkly. Rep. 70 (7):254–7. doi:10.15585/mmwr.mm7007e1.
  • Cascella, M. M. Rajnik, A. Cuomo, S. C. Dulebohn, and R. Di Napoli. 2020. Features, evaluation and treatment coronavirus [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK554776/.
  • Chan, J. F.-W., S. Yuan, A. J. Zhang, V. K.-M. Poon, C. C.-S. Chan, A. C.-Y. Lee, Z. Fan, C. Li, R. Liang, J. Cao, et al. 2020. Surgical mask partition reduces the risk of noncontact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19). Clin. Infect. Dis. 71 (16):2139–49. doi:10.1093/cid/ciaa644.
  • Chao, C., M. Wan, L. Morawska, G. Johnson, Z. Ristovski, M. Hargreaves, K. Mengersen, S. Corbett, Y. Li, X. Xie, et al. 2009. Characterization of expiration air jets and droplet size distributions immediately at the mouth opening. J. Aerosol Sci. 40 (2):122–33. doi:10.1016/j.jaerosci.2008.10.003.
  • Chen, H., Z. Zhang, Z. Zhang, F. Jiang, and R. Du. 2018. Enhancement of filtration efficiency by electrical charges on nebulized particles. Particuology 37:81–90. doi:10.1016/j.partic.2017.07.008.
  • Chu, D. K., E. A. Akl, S. Duda, K. Solo, S. Yaacoub, H. J. Schünemann, A. El-harakeh, A. Bognanni, T. Lotfi, M. Loeb, et al. 2020. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: A systematic review and meta-analysis. The Lancet 395 (10242):1973–87. doi:10.1016/S0140-6736(20)31142-9.
  • Cohen, M. D., R. C. Flagan, and J. H. Seinfeld. 1987. Studies of concentrated electrolyte solutions using the electrodynamic balance. 1. Water activities for single-electrolyte solutions. J. Phys. Chem. 91 (17):4563–74. doi:10.1021/j100301a029.
  • Cooper, D. W., W. C. Hinds, and J. M. Price. 1983. Emergency respiratory protection with common materials. Am. Ind. Hyg. Assoc. J. 44 (1):1–6. doi:10.1080/15298668391404275.
  • Drewnick, F., J. Pikmann, F. Fachinger, L. Moormann, F. Sprang, and S. Borrmann. 2021. Aerosol filtration efficiency of household materials for homemade face masks: Influence of material properties, particle size, particle electrical charge, face velocity, and leaks. Aerosol Sci. Technol. 55 (1):63–79. doi:10.1080/02786826.2020.1817846.
  • Edwards, D. A., D. Ausiello, J. Salzman, T. Devlin, R. Langer, B. J. Beddingfield, A. C. Fears, L. A. Doyle-Meyers, R. K. Redmann, S. Z. Killeen, et al. 2021. Exhaled aerosol increases with COVID-19 infection, age, and obesity. Proc. Natl. Acad. Sci. U.S.A. 118 (8):e2021830118. doi:10.1073/pnas.2021830118.
  • Fabian, P., J. J. McDevitt, W. H. DeHaan, R. O. P. Fung, B. J. Cowling, K. H. Chan, G. M. Leung, and D. K. Milton. 2008. Influenza virus in human exhaled breath: An observational study. PLoS One. 3 (7):e2691–6. doi:10.1371/journal.pone.0002691.
  • Fischer, E. P., M. C. Fischer, D. Grass, I. Henrion, W. S. Warren, and E. Westman. 2020. Low-cost measurement of facemask efficacy for filtering expelled droplets during speech. Sci. Adv. 6 (36): eabd3083, doi:10.1126/sciadv.abd3083.
  • Gao, S., J. Kim, M. Yermakov, Y. Elmashae, X. He, T. Reponen, Z. Zhuang, S. Rengasamy, and S. A. Grinshpun. 2016. Performance of N95 FFRs against combustion and NaCl aerosols in dry and moderately humid air: Manikin-based study. ANNHYG. 60 (6):748–60. doi:10.1093/annhyg/mew019.
  • George, R., S. S. Vedam, T. D. Chung, V. Ramakrishnan, and P. J. Keall. 2005. The application of the sinusoidal model to lung cancer patient respiratory motion. Med. Phys. 32 (9):2850–61. doi:10.1118/1.2001220.
  • Gregson, F. K. A., S. Sheikh, J. Archer, H. E. Symons, J. S. Walker, A. E. Haddrell, C. M. Orton, F. W. Hamilton, J. M. Brown, B. R. Bzdek, et al. 2022. Analytical challenges when sampling and characterising exhaled aerosol. Aerosol Sci. Technol. 56 (2):160–75. doi:10.1080/02786826.2021.1990207.
  • Grinshpun, S. A., H. Haruta, R. M. Eninger, T. Reponen, R. T. McKay, and S.-A. Lee. 2009. Performance of an N95 filtering facepiece particulate respirator and a surgical mask during human breathing: Two pathways for particle penetration. Journal of Occupational and Environmental Hygiene 6 (10):593–603. doi:10.1080/15459620903120086.
  • Guallar, M. P., R. Meiriño, C. Donat-Vargas, O. Corral, N. Jouvé, and V. Soriano. 2020. Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity. Int. J. Infect. Dis. 97:290–2. doi:10.1016/j.ijid.2020.06.035.
  • Han, Z. Y., W. G. Weng, and Q. Y. Huang. 2013. Characterizations of particle size distribution of the droplets exhaled by sneeze. J. R. Soc. Interface 10 (88):20130560. doi:10.1098/rsif.2013.0560.
  • He, X., T. Reponen, R. T. McKay, and S. A. Grinshpun. 2013. Effect of particle size on the performance of an N95 filtering facepiece respirator and a surgical mask at various breathing conditions. Aerosol Sci. Technol. 47 (11):1180–7. doi:10.1080/02786826.2013.829209.
  • Heyder, J., J. Gebhart, G. Rudolf, C. Schiller, and W. Stahlhofen. 1986. Deposition of particles in the human respiratory tract in the size range 0.005–15 μm. J. Aerosol Sci. 17 (5):811–25. doi:10.1016/0021-8502(86)90035-2.
  • Holmgren, H., B. Bake, A.-C. Olin, and E. Ljungström. 2011. Relation between humidity and size of exhaled particles. J. Aerosol. Med. Pulm. Drug Deliv. 24 (5):253–60. doi:10.1089/jamp.2011.0880.
  • Holmgren, H., E. Ljungström, A.-C. Almstrand, B. Bake, and A.-C. Olin. 2010. Size distribution of exhaled particles in the range from 0.01 to 2.0μm. J. Aerosol Sci. 41 (5):439–46. doi:10.1016/j.jaerosci.2010.02.011.
  • Howell, S. G., S. Freitag, A. Dobracki, N. Smirnow, I. I. I. Sedlacek, and A. J. 2020. Undersizing of aged African biomass burning aerosol by an ultra high sensitivity aerosol spectrometer. Atmos. Meas. Tech. Discuss. 2020:1–28. doi:10.5194/amt-2020-416.
  • Huang, S.-H., C.-W. Chen, Y.-M. Kuo, C.-Y. Lai, R. McKay, and C.-C. Chen. 2013. Factors affecting filter penetration and quality factor of particulate respirators. Aerosol Air Qual. Res. 13 (1):162–71. doi:10.4209/aaqr.2012.07.0179.
  • Johnson, G. R., and L. Morawska. 2009. The mechanism of breath aerosol formation. J. Aerosol Med. Pulm. Drug Deliv. 22 (3):229–37. doi:10.1089/jamp.2008.0720.
  • Johnson, G., L. Morawska, Z. Ristovski, M. Hargreaves, K. Mengersen, C. Y. H. Chao, M. Wan, Y. Li, X. Xie, D. Katoshevski, et al. 2011. Modality of human expired aerosol size distributions. J. Aerosol Sci. 42 (12):839–51. doi:10.1016/j.jaerosci.2011.07.009.
  • Joo, T., M. Takeuchi, F. Liu, M. P. Rivera, J. Barr, E. S. Blum, E. Parker, J. H. Tipton, J. Varnedoe, B. Dutta, et al. 2021. Evaluation of particle filtration efficiency of commercially available materials for homemade face mask usage. Aerosol Sci. Technol. 55 (8):930–42. doi:10.1080/02786826.2021.1905149.
  • Jung, H., J. K. Kim, S. Lee, J. Lee, J. Kim, P. Tsai, and C. Yoon. 2014. Comparison of filtration efficiency and pressure drop in anti-yellow sand masks, quarantine masks, medical masks, general masks, and handkerchiefs. Aerosol Air Qual. Res. 14 (3):991–1002. doi:10.4209/aaqr.2013.06.0201.
  • Kanaoka, C., H. Emi, Y. Otani, and T. Iiyama. 1987. Effect of charging state of particles on electret filtration. Aerosol Sci. Technol. 7 (1):1–13. doi:10.1080/02786828708959142.
  • Konda, A., A. Prakash, G. A. Moss, M. Schmoldt, G. D. Grant, and S. Guha. 2020. Aerosol filtration efficiency of common fabrics used in respiratory cloth masks. ACS Nano 14 (5):6339–47. doi:10.1021/acsnano.0c03252.
  • Lam, T.-N., C.-H. Wu, S.-H. Huang, W.-C. Ko, Y.-L. Huang, C.-Y. Ma, C.-C. Wang, and E.-W. Huang. 2019. Multi-scale microstructure investigation for a PM2. 5 air-filter efficiency study of non-woven polypropylene. QuBS 3 (4):20. doi:10.3390/qubs3040020.
  • Larsson, P., B. Bake, A. Wallin, O. Hammar, A.-C. Almstrand, M. Lärstad, E. Ljungström, E. Mirgorodskaya, and A.-C. Olin. 2017. The effect of exhalation flow on endogenous particle emission and phospholipid composition. Respir. Physiol. Neurobiol. 243:39–46. doi:10.1016/j.resp.2017.05.003.
  • Lathrache, R., H. Fissan, and S. Neumann. 1986. Deposition of submicron particles on electrically charged fibers. J. Aerosol Sci. 17 (3):446–9. doi:10.1016/0021-8502(86)90127-8.
  • Lee, S.-A., S. A. Grinshpun, and T. Reponen. 2008. Respiratory performance offered by N95 respirators and surgical masks: Human subject evaluation with NaCl aerosol representing bacterial and viral particle size range. Annals of Occupational Hygiene 52 (3):177–85. doi:10.1093/annhyg/men005.
  • Leung, N. H. L., D. K. W. Chu, E. Y. C. Shiu, K.-H. Chan, J. J. McDevitt, B. J. P. Hau, H.-L. Yen, Y. Li, D. K. M. Ip, J. S. M. Peiris, et al. 2020. Respiratory virus shedding in exhaled breath and efficacy of face masks. Nat. Med. 26 (5):676–80. doi:10.1038/s41591-020-0843-2.
  • Liu, L., J. Wei, Y. Li, and A. Ooi. 2017. Evaporation and dispersion of respiratory droplets from coughing. Indoor Air. 27 (1):179–90. doi:10.1111/ina.12297.
  • Liu, Y., Z. Ning, Y. Chen, M. Guo, Y. Liu, N. K. Gali, L. Sun, Y. Duan, J. Cai, D. Westerdahl, et al. 2020. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature 582 (7813):557–6. doi:10.1038/s41586-020-2271-3.
  • Lyu, W., and G. L. Wehby. 2020. Community use of face masks and COVID-19: Evidence from a natural experiment of state mandates in the US: Study examines impact on COVID-19 growth rates associated with state government mandates requiring face mask use in public. Health Aff. (Millwood) 39 (8):1419–25. doi:10.1377/hlthaff.2020.00818.
  • Malashenko, A., A. Tsuda, and S. Haber. 2009. Propagation and breakup of liquid menisci and aerosol generation in small airways. J. Aerosol Med. Pulm. Drug. Deliv. 22 (4):341–53. doi:10.1089/jamp.2008.0696.
  • Mitze, T., R. Kosfeld, J. Rode, and K. Wälde. 2020. Face masks considerably reduce COVID-19 cases in Germany. Proc. Natl. Acad. Sci. U.S.A. 117 (51):32293–301. doi:10.1073/pnas.2015954117.
  • Morais, F. G., V. K. Sakano, L. N. de Lima, M. A. Franco, D. C. Reis, L. M. Zanchetta, F. Jorge, E. Landulfo, L. H. Catalani, H. M. J. Barbosa, et al. 2021. Filtration efficiency of a large set of COVID-19 face masks commonly used in Brazil. Aerosol Sci. Technol. 55 (9):1028–41. doi:10.1080/02786826.2021.1915466.
  • Morawska, L., G. Johnson, Z. Ristovski, M. Hargreaves, K. Mengersen, S. Corbett, C. Y. H. Chao, Y. Li, and D. Katoshevski. 2009. Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities. J. Aerosol Sci. 40 (3):256–69. doi:10.1016/j.jaerosci.2008.11.002.
  • Mostofi, R., A. Bahloul, J. Lara, B. Wang, Y. Cloutier, and F. Haghighat. 2011. Investigation of potential affecting factors on performance of N95 respirator. Journal of the International Society for Respiratory Protection 28:26–39.
  • Munster, V. J., F. Feldmann, B. N. Williamson, N. Van Doremalen, L. Pérez-Pérez, J. Schulz, K. Meade-White, A. Okumura, J. Callison, B. Brumbaugh, et al. 2020. Respiratory disease in rhesus macaques inoculated with SARS-CoV-2. Nature 585 (7824):268–72. doi:10.1038/s41586-020-2324-7.
  • Ou, Q., C. Pei, S. C. Kim, E. Abell, and D. Y. Pui. 2020. Evaluation of decontamination methods for commercial and alternative respirator and mask materials - View from filtration aspect. J. Aerosol Sci. 150:105609. doi:10.1016/j.jaerosci.2020.105609.
  • Pan, Y., D. Zhang, P. Yang, L. L. Poon, and Q. Wang. 2020. Viral load of SARS-CoV-2 in clinical samples. Lancet. Infect. Dis. 20 (4):411–2. doi:10.1016/S1473-3099(20)30113-4.
  • Papineni, R. S., and F. S. Rosenthal. 1997. The size distribution of droplets in the exhaled breath of healthy human subjects. J. Aerosol Med. 10 (2):105–16. doi:10.1089/jam.1997.10.105.
  • Paulo, A. C., M. Correia-Neves, T. Domingos, A. G. Murta, and J. Pedrosa. 2010. Influenza infectious dose may explain the high mortality of the second and third wave of 1918–1919 influenza pandemic. PLoS One. 5 (7):e11655. doi:10.1371/journal.pone.0011655.
  • Rengasamy, S., B. C. Eimer, and R. E. Shaffer. 2009. Comparison of nanoparticle filtration performance of NIOSH-approved and CE-marked particulate filtering facepiece respirators. Ann. Occup. Hyg. 53 (2):117–28. doi:10.1093/annhyg/men086.
  • Rengasamy, S., B. Eimer, and R. E. Shaffer. 2010. Simple Respiratory protection-evaluation of the filtration performance of cloth masks and common fabric materials against 20–1000 nm size particles. Ann. Occup. Hyg. 54 (7):789–98. doi:10.1093/annhyg/meq044.
  • Rengasamy, S., B. C. Eimer, and J. Szalajda. 2014. A quantitative assessment of the total inward leakage of NaCl aerosol representing submicron-size bioaerosol through N95 filtering facepiece respirators and surgical masks. J. Occup. Environ. Hyg. 11 (6):388–96. doi:10.1080/15459624.2013.866715.
  • Roberge, R. J., E. Bayer, J. B. Powell, A. Coca, M. R. Roberge, and S. M. Benson. 2010. Effect of exhaled moisture on breathing resistance of N95 filtering facepiece respirators. Ann. Occup. Hyg. 54 (6):671–7. doi:10.1093/annhyg/meq042.
  • Rossman, J. S., and R. A. Lamb. 2011. Influenza virus assembly and budding. Virology 411 (2):229–36. doi:10.1016/j.virol.2010.12.003.
  • Schmitt, J., and J. Wang. 2021. Quantitative modeling of the impact of facemasks and associated leakage on the airborne transmission of SARS-CoV-2. Sci. Rep. 11 (1):19403. doi:10.1038/s41598-021-98895-9.
  • Schwarz, K., H. Biller, H. Windt, W. Koch, and J. M. Hohlfeld. 2010. Characterization of exhaled particles from the healthy human lung-a systematic analysis in relation to pulmonary function variables. J. Aerosol Med. Pulm. Drug Deliv. 23 (6):371–9. doi:10.1089/jamp.2009.0809.
  • Serfozo, N., J. Ondráček, N. Zíková, M. Lazaridis, and V. Ždímal. 2017. Size-resolved penetration of filtering materials from CE-marked filtering facepiece respirators. Aerosol Air Qual. Res. 17 (5):1305–15. doi:10.4209/aaqr.2016.09.0390.
  • Shakya, K. M., A. Noyes, R. Kallin, and R. E. Peltier. 2017. Evaluating the efficacy of cloth facemasks in reducing particulate matter exposure. J. Expo. Sci. Environ. Epidemiol. 27 (3):352–7. doi:10.1038/jes.2016.42.
  • To, K. K.-W., O. T.-Y. Tsang, W.-S. Leung, A. R. Tam, T.-C. Wu, D. C. Lung, C. C.-Y. Yip, J.-P. Cai, J. M.-C. Chan, T. S.-H. Chik, et al. 2020. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: An observational cohort study. Lancet Infect. Dis. 20 (5):565–74. doi:10.1016/S1473-3099(20)30196-1.
  • Univ. of Florida, Dept. of Anesthesiology. 2021. Mask alternative guide. https://anest.ufl.edu/clinical-divisions/mask-alternative/, https://anest.ufl.edu/clinical-divisions/mask-alternative/. Last accessed January 7, 2020.
  • Van Damme, W., R. Dahake, R. van de Pas, G. Vanham, and Y. Assefa. 2021. COVID-19: Does the infectious inoculum dose-response relationship contribute to understanding heterogeneity in disease severity and transmission dynamics? Med. Hypotheses 146:110431. doi:10.1016/j.mehy.2020.110431. https://www.sciencedirect.com/science/article/pii/S0306987720333223.
  • Wölfel, R., V. M. Corman, W. Guggemos, M. Seilmaier, S. Zange, M. A. Müller, D. Niemeyer, T. C. Jones, P. Vollmar, C. Rothe, et al. 2020. Virological assessment of hospitalized patients with COVID-2019. Nature 581 (7809):465–9. doi:10.1038/s41586-020-2196-x.
  • Zayas, G., M. C. Chiang, E. Wong, F. MacDonald, C. F. Lange, A. Senthilselvan, and M. King. 2012. Cough aerosol in healthy participants: Fundamental knowledge to optimize droplet-spread infectious respiratory disease management. BMC Pulm. Med. 12 (1):1–12. doi:10.1186/1471-2466-12-11.
  • Zuurbier, M., G. Hoek, P. Van den Hazel, and B. Brunekreef. 2009. Minute ventilation of cyclists, car and bus passengers: An experimental study. Environ. Health 8:48. doi:10.1186/1476-069X-8-48.