Novel instrument to measure water uptake, dissolution and hygroscopic growth of an individual levitated aerosol particle in an environment identical to the lung (relative humidity >99.5%)

References

• Aardahl, C. L., R. Vehring, E. J. Davis, G. Schweiger, and B. D. Swanson. 1997. Trapping two-particle arrays in a double-ring electrodynamic balance. J. Aerosol Sci. 28 (8):1491–505. doi: 10.1016/S0021-8502(97)00012-8.
   Web of Science ®Google Scholar
• Akhuemokhan, P., N. A. Green, A. Haddrell, D. Lewis, J. P. Reid, and B. Forbes. 2023. How to engineer aerosol particle properties and biopharmaceutical performance of propellant inhalers. Int. J. Pharm. 634:122676. doi: 10.1016/j.ijpharm.2023.122676.
   PubMedGoogle Scholar
• Cheng, Y. S. 2014. Mechanisms of pharmaceutical aerosol deposition in the respiratory tract. AAPS PharmSciTech 15 (3):630–40. doi: 10.1208/s12249-014-0092-0.
   PubMed Web of Science ®Google Scholar
• Chow, A. H., H. H. Tong, P. Chattopadhyay, and B. Y. Shekunov. 2007. Particle engineering for pulmonary drug delivery. Pharm. Res. 24 (3):411–37. doi: 10.1007/s11095-006-9174-3.
   PubMed Web of Science ®Google Scholar
• Davies, J. F., A. E. Haddrell, and J. P. Reid. 2012. Time-resolved measurements of the evaporation of volatile components from single aerosol droplets. Aerosol Sci Tech 46 (6):666–77. doi: 10.1080/02786826.2011.652750.
   Web of Science ®Google Scholar
• de Boer, A. H., P. Hagedoorn, M. Hoppentocht, F. Buttini, F. Grasmeijer, and H. W. Frijlink. 2017. Dry powder inhalation: Past, present and future. Expert Opin. Drug Deliv. 14 (4):499–512. doi: 10.1080/17425247.2016.1224846.
   PubMed Web of Science ®Google Scholar
• Eedara, B. B., R. Bastola, and S. C. Das. 2022. Dissolution and absorption of inhaled drug particles in the lungs. Pharmaceutics 14 (12):2667. doi: 10.3390/pharmaceutics14122667.
   PubMed Web of Science ®Google Scholar
• Fernandez, M. O., R. J. Thomas, H. Oswin, A. E. Haddrell, and J. P. Reid. 2020. Transformative approach to investigate the microphysical factors influencing airborne transmission of pathogens. Appl Environ Microb 86:e01543-20. doi: 10.1128/AEM.01543-20.
   PubMed Web of Science ®Google Scholar
• Gerde, P., M. Malmlöf, L. Havsborn, C. O. Sjöberg, P. Ewing, S. Eirefelt, and K. Ekelund. 2017. Dissolvit: An in vitro method for simulating the dissolution and absorption of inhaled dry powder drugs in the lungs. Assay Drug Dev. Technol. 15 (2):77–88. doi: 10.1089/adt.2017.779.
   PubMed Web of Science ®Google Scholar
• Gradon, L., and T. R. Sosnowski. 2014. Formation of particles for dry powder inhalers. Adv. Powder Technol. 25 (1):43–55. doi: 10.1016/j.apt.2013.09.012.
   Web of Science ®Google Scholar
• Haddrell, A., G. Rovelli, D. Lewis, T. Church, and J. Reid. 2019. Identifying time-dependent changes in the morphology of an individual aerosol particle from its light scattering pattern. Aerosol Sci Tech 53 (11):1334–51. doi: 10.1080/02786826.2019.1661351.
   Web of Science ®Google Scholar
• Haddrell, A. E., J. F. Davies, A. Yabushita, and J. P. Reid. 2012. Accounting for changes in particle charge, dry mass and composition occurring during studies of single levitated particles. J. Phys. Chem. A 116 (40):9941–53. doi: 10.1021/jp304920x.
   PubMed Web of Science ®Google Scholar
• Haddrell, A. E., D. Lewis, T. Church, R. Vehring, D. Murnane, and J. P. Reid. 2017. Pulmonary aerosol delivery and the importance of growth dynamics. Ther. Deliv. 8 (12):1051–61. doi: 10.4155/tde-2017-0093.
   PubMed Web of Science ®Google Scholar
• Janson, C., R. Henderson, M. Löfdahl, M. Hedberg, R. Sharma, and A. J. K. Wilkinson. 2020. Carbon footprint impact of the choice of inhalers for asthma and COPD. Thorax 75 (1):82–4. doi: 10.1136/thoraxjnl-2019-213744.
   PubMed Web of Science ®Google Scholar
• Kaialy, W., and A. Nokhodchi. 2015. Particle engineering for improved pulmonary drug delivery through dry powder inhalers. In Pulmonary drug delivery, 171–98. West Sussex: John Wiley & Sons, Ltd.
   Google Scholar
• Kulmala, M., T. Vesala, and P. E. Wagner. 1993. An analytical expression for the rate of binary condensational particle growth. Proceedings of the Royal Society of London. Series A: Mathematical and Physical Sciences 441:589–605. doi: 10.1098/rspa.1993.0081.
   Google Scholar
• Lechanteur, A., and B. Evrard. 2020. Influence of composition and spray-drying process parameters on carrier-free dpi properties and behaviors in the lung: A review. Pharmaceutics 12 (1):55. doi: 10.3390/pharmaceutics12010055.
   PubMed Web of Science ®Google Scholar
• Longest, P. W., and M. Hindle. 2012. Condensational growth of combination drug-excipient submicrometer particles for targeted high efficiency pulmonary delivery: Comparison of cfd predictions with experimental results. Pharm. Res. 29 (3):707–21. doi: 10.1007/s11095-011-0596-1.
   PubMed Web of Science ®Google Scholar
• May, S., B. Jensen, M. Wolkenhauer, M. Schneider, and C. M. Lehr. 2012. Dissolution techniques for in vitro testing of dry powders for inhalation. Pharm. Res. 29 (8):2157–66. doi: 10.1007/s11095-012-0744-2.
   PubMed Web of Science ®Google Scholar
• Nandiyanto, A. B. D., and K. Okuyama. 2011. Progress in developing spray-drying methods for the production of controlled morphology particles: From the nanometer to submicrometer size ranges. Adv. Powder Technol. 22 (1):1–19. doi: 10.1016/j.apt.2010.09.011.
   Web of Science ®Google Scholar
• Nokhodchi, A., S. Chavan, and T. Ghafourian. 2023. In vitro dissolution and permeability testing of inhalation products: Challenges and advances. Pharmaceutics 15 (3):983. doi: 10.3390/pharmaceutics15030983.
   PubMed Web of Science ®Google Scholar
• Shetty, N., H. Park, D. Zemlyanov, S. Mangal, S. Bhujbal, and Q. T. Zhou. 2018. Influence of excipients on physical and aerosolization stability of spray dried high-dose powder formulations for inhalation. Int. J. Pharm. 544 (1):222–34. doi: 10.1016/j.ijpharm.2018.04.034.
   PubMedGoogle Scholar
• Sonvico, F., V. Chierici, G. Varacca, E. Quarta, D. D'Angelo, B. Forbes, and F. Buttini. 2021. Respicell(tm): An innovative dissolution apparatus for inhaled products. Pharmaceutics 13 (10):1541. doi: 10.3390/pharmaceutics13101541.
   PubMed Web of Science ®Google Scholar
• Stein, S. W., and C. G. Thiel. 2017. The history of therapeutic aerosols: A chronological review. J. Aerosol Med. Pulm. Drug Deliv. 30 (1):20–41. doi: 10.1089/jamp.2016.1297.
   PubMed Web of Science ®Google Scholar
• Svedsater, H., P. Dale, K. Garrill, R. Walker, and M. W. Woepse. 2013. Qualitative assessment of attributes and ease of use of the ellipta™ dry powder inhaler for delivery of maintenance therapy for asthma and copd. BMC Pulm. Med. 13 (1):72. doi: 10.1186/1471-2466-13-72.
   PubMed Web of Science ®Google Scholar
• Tarara, T. E., D. P. Miller, A. E. Weers, A. Muliadi, J. Tso, A. Eliahu, and J. G. Weers. 2022. Formulation of dry powders for inhalation comprising high doses of a poorly soluble hydrophobic drug. Front. Drug Deliv. 2:862336. doi: 10.3389/fddev.2022.862336.
   Google Scholar
• Tian, G., P. W. Longest, G. Su, and M. Hindle. 2011. Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways. Ann. Biomed. Eng. 39 (3):1136–53. doi: 10.1007/s10439-010-0223-z.
   PubMed Web of Science ®Google Scholar
• Valenzuela, A., F. Chu, A. E. Haddrell, M. I. Cotterell, J. S. Walker, A. J. Orr-Ewing, and J. P. Reid. 2021. Optical interrogation of single levitated droplets in a linear quadrupole trap by cavity ring-down spectroscopy. J. Phys. Chem. A 125 (1):394–405. doi: 10.1021/acs.jpca.0c09213.
   PubMed Web of Science ®Google Scholar
• Walker, J. S., J. Archer, F. K. A. Gregson, S. E. S. Michel, B. R. Bzdek, and J. P. Reid. 2021. Accurate representations of the microphysical processes occurring during the transport of exhaled aerosols and droplets (vol 7, pg 200, 2021). ACS Cent. Sci. 7 (3):507– doi: 10.1021/acscentsci.1c00220.
   PubMed Web of Science ®Google Scholar
• Wexler, A. S., and S. L. Clegg. 2002. Atmospheric aerosol models for systems including the ions H+, NH4+, NA+, SO42−, NO3−, CL−, BR−, and H2O. J. Geophys. Res. 107 (D14):ACH 14-11–14-14. doi: 10.1029/2001JD000451.
   Web of Science ®Google Scholar
• Wise, M. E., S. T. Martin, L. M. Russell, and P. R. Buseck. 2008. Water uptake by nacl particles prior to deliquescence and the phase rule. Aerosol Sci. Tech. 42 (4):281–94. doi: 10.1080/02786820802047115.
   Web of Science ®Google Scholar
• Worth Longest, P., and J. Xi. 2008. Condensational growth may contribute to the enhanced deposition of cigarette smoke particles in the upper respiratory tract. Aerosol Sci. Tech. 42 (8):579–602. doi: 10.1080/02786820802232964.
   Web of Science ®Google Scholar
• Yao, W., X. Yu, J. W. Lee, X. Yuan, and S. J. Schmidt. 2011. Measuring the deliquescence point of crystalline sucrose as a function of temperature using a new automatic isotherm generator. Int. J. Food Prop. 14 (4):882–93. doi: 10.1080/10942910903474393.
   Web of Science ®Google Scholar
• Yu, C., D. Pasternak, J. Lee, M. Yang, T. Bell, K. Bower, H. Wu, D. Liu, C. Reed, S. Bauguitte, et al. 2020. Characterizing the particle composition and cloud condensation nuclei from shipping emission in western europe. Environ. Sci. Technol. 54 (24):15604–12. doi: 10.1021/acs.est.0c04039.
   PubMed Web of Science ®Google Scholar