Dissecting the performance of a jet nebulizer: The effect of changing design parameters and operating conditions

References

• Amirav, I, et al. 2002. B-agonist aerosol distribution in respiratory syncytial virus bronchiolitis in infants. J. Nuclear Med. 43 (4):487.
   PubMed Web of Science ®Google Scholar
• Ari, A., A. D. de Andrade, M. Sheard, B. AlHamad, and J. B. Fink. 2015. Performance comparisons of jet and mesh nebulizers using different interfaces in simulated spontaneously breathing adults and children. J. Aerosol Med. Pulm. Drug Deliv. 28 (4):281–9. doi:10.1089/jamp.2014.1149.
   PubMed Web of Science ®Google Scholar
• Awad, S., D. Williams, and A. Berlinski. 2014. Longitudinal evaluation of compressor/nebulizer performance. Respir. Care. 59 (7):1053–61. doi:10.4187/respcare.02776.
   PubMed Web of Science ®Google Scholar
• Brennan, C. E. 2014. Introduction to jet pumps - An internet book on fluid dynamics. Accessed March 16, 2023. http://www.brennen.caltech.edu/fluidbook/Fluidmachinery/Pumps/jetpumps.pdf.
   Google Scholar
• Clark, A. R. 1995. The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers. Int. J. Pharm. 115 (1):69–78. doi:10.1016/0378-5173(94)00255-4.
   Google Scholar
• Finlay, W. H., and C. Darquenne. 2020. Particle size distributions. J. Aerosol Med. Pulm. Drug Deliv. 33 (4):178–80. doi:10.1089/jamp.2020.29028.whf.
   PubMed Web of Science ®Google Scholar
• Goralski, J., and S. D. Davis. 2014. Breathing easier: Addressing the challenges of aerosolizing medications to infants and preschoolers. Respir. Med. 108 (8):1069–74. doi:10.1016/j.rmed.2014.06.004.
   PubMed Web of Science ®Google Scholar
• Hardaker, L., S. Byrne, and R. Hatley. 2013. Variability in particle size of currently commercially available nebulizers. DDL Conference, Edinburgh, December 11–13.
   Google Scholar
• Hess, D., D. Fisher, P. Williams, S. Pooler, and R. Kacmarek. 1996. Medication nebulizer performance: Effects of diluent volume, nebulizer flow, and nebulizer brand. Chest 110 (2):498–505. doi:10.1378/chest.110.2.498.
   PubMed Web of Science ®Google Scholar
• Hinds, W. C. 1999. Aerosol technology: Properties, behavior, and measurement of airborne particles. 2nd ed. Hoboken, NJ: John Wiley & Sons, Inc.
   Google Scholar
• Kayser, J., and R. Shambaugh. 1991. Discharge coefficients for compressible flow through small-diameter orifices and convergent nozzles. Chem. Eng. Sci. 46 (7):1697–711. doi:10.1016/0009-2509(91)87017-7.
   Web of Science ®Google Scholar
• Koullapis, P. G., S. C. Kassinos, M. P. Bivolarova, and A. K. Melikov. 2016. Particle deposition in a realistic geometry of the human conducting airways: Effects of inlet velocity profile, inhalation flowrate and electrostatic charge. J. Biomech. 49 (11):2201–12. doi:10.1016/j.jbiomech.2015.11.029.
   PubMed Web of Science ®Google Scholar
• MacLoughlin, R. J., B. D. Higgins, J. G. Laffey, and T. O'Brien. 2009. Optimized aerosol delivery to a mechanically ventilated rodent. J. Aerosol Med. Pulm. Drug Deliv. 22 (4):323–32. doi:10.1089/jamp.2008.0717.
   PubMed Web of Science ®Google Scholar
• Martin, A., and W. Finlay. 2015. Nebulizers for drug delivery to the lungs. Expert Opin. Drug Deliv. 12 (6):889–900. doi:10.1517/17425247.2015.995087.
   PubMed Web of Science ®Google Scholar
• Morawska, L., and G. Buonanno. 2021. The physics of particle formation and deposition during breathing. Nat. Rev. Phys. 3 (5):300–1. doi:10.1038/s42254-021-00307-4.
   PubMedGoogle Scholar
• Mott, R. L. 2006. Applied fluid mechanics. Upper Saddle River, NJ: Pearson Education, Inc.
   Google Scholar
• Nerbrink, O., M. Dahlbäck, and C.-H. Hansson. 1992. The nebulizer function; Primary and secondary generation. J. Aerosol Sci. 23 (Suppl. I):217–20. doi:10.1016/0021-8502(92)90388-C.
   Google Scholar
• Niven, R. W., and J. D. Brain. 1994. Some functional aspects of air-jet nebulizers. Int. J. Pharm. 104 (1):73–85. doi:10.1016/0378-5173(94)90338-7.
   Google Scholar
• O'Neil, J. A., and L. A. Villasmil-Urdaneta. 2023. Path forward in the development of new aerosol drug delivery devices for pediatrics. Respir. Med. 211:107210. doi:10.1016/j.rmed.2023.107210.
   PubMed Web of Science ®Google Scholar
• Ramlan, B., and N. B. Darlis. 2020. Comparison between SolidWorks and Ansys flow simulation on aerodynamic studies. J. Industry, Engineering, and Innovation 2 (1):1–9.
   Google Scholar
• Schueepp, K., S. Devadason, C. Roller, S. Minocchieri, A. Moeller, J. Hamacher, and J. Wildhaber. 2009. Aerosol delivery of nebulized budesonide in young children with asthma. Respir. Med. 103 (11):1738–45. doi:10.1016/j.rmed.2009.04.029.
   PubMed Web of Science ®Google Scholar
• Sheth, P., S. W. Stein, and P. B. Myrdal. 2013. The influence of initial atomized droplet size on residual particle size from pressurized metered dose inhalers. Int. J. Pharm. 455 (1-2):57–65. doi:10.1016/j.ijpharm.2013.07.061.
   PubMed Web of Science ®Google Scholar
• Smith, E. C., J. Denyer, and A. H. Kendrick. 1995. Comparison of twenty-three nebulizer/compressor combinations for domiciliary use. Eur. Respir. J. 8 (7):1214–21. doi:10.1183/09031936.95.08071214.
   PubMed Web of Science ®Google Scholar
• Sobachkin, A., and G. Dumnov. 2014. Numerical basis of CAD-embedded CFD white paper. Upper Saddle River, NJ: Prentice Hall.
   Google Scholar