Food Addiction and Obesity: Evidence from Bench to Bedside

REFERENCES

• Arana , F. S. , Parkinson , J. A. , Hinton , E. , Holland , A. J. , Owen , A. M. and Roberts , A. C. 2003 . Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection . Journal of Neuroscience , 23 ( 29 ) : 9632 – 38 .
   PubMed Web of Science ®Google Scholar
• Arias , F. , Ampuero , I. , Sagredo , O. , Almodovar , F. , Sanchez , S. , Gorgojo , J. J. and Ramos , J. A. 2009 . Lack of association between polymorphisms in cannabinoid receptor gene (CNR1) and fatty acid amide hydroxylase gene (FAAH) and eating disorders in a preliminary study . Psychiatric Genetics , 19 ( 6 ) : 336
   PubMed Web of Science ®Google Scholar
• Avena , N. M. , Rada , P. and Hoebel , B. G. 2008 . Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake . Neuroscience and Biobehavioral Revues , 32 ( 1 ) : 20 – 39 .
   PubMed Web of Science ®Google Scholar
• Avena , N. M. , Long , K. A. and Hoebel , B. G. 2005 . Sugar-dependent rats show enhanced responding for sugar after abstinence: Evidence of a sugar deprivation effect . Physiology and Behavior , 84 ( 3 ) : 359 – 62 .
   PubMed Web of Science ®Google Scholar
• Avena , N. M. , Carrillo , C. A. , Needham , L. , Leibowitz , S. F. and Hoebei , B. G. 2004 . Sugar-dependent rats show enhanced intake of unsweetened ethanol . Alcohol , 34 ( 2–3 ) : 203 – 9 .
   PubMed Web of Science ®Google Scholar
• Baker , J. H. , Maes , H. H. , Lissner , L. , Aggen , S. H. , Lichtenstein , P. and Kendler , K. S. 2009 . Genetic risk factors for disordered eating in adolescent males and females . Journal of Abnormal Psychology , 118 ( 3 ) : 576 – 86 .
   PubMed Web of Science ®Google Scholar
• Baskin , D. G. , Figlewicz Lattemann , D. , Seeley , R. J. , Woods , S. C. , Porte , D. Jr. and Schwartz , M. W. 1999 . Insulin and leptin: Dual adiposity signals to the brain for the regulation of food intake and body weight . Brain Research , 848 ( 1–2 ) : 114 – 23 .
   PubMed Web of Science ®Google Scholar
• Bassareo , V. and Di Chiara , G. 1999 . Modulation of feeding-induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state . European Journal of Neuroscience , 11 ( 12 ) : 4389 – 97 .
   PubMed Web of Science ®Google Scholar
• Bayol , S. A. , Farrington , S. J. and Stickland , N. C. 2007 . A maternal ‘junk food’ diet in pregnancy and lactation promotes an exacerbated taste for ‘junk food’ and a greater propensity for obesity in rat offspring . British Journal of Nutrition , 98 ( 4 ) : 843 – 51 .
   PubMed Web of Science ®Google Scholar
• Becker , A. E. , Keel , P. , Anderson-Fye , E. P. and Thomas , J. J. 2004 . Genes and/or jeans?: Genetic and socio-cultural contributions to risk for eating disorders . Journal of Addictive Diseases , 23 ( 3 ) : 81 – 103 .
   PubMed Web of Science ®Google Scholar
• Benarroch , F. , Hirsch , H. J. , Genstil , L. , Landau , Y. E. and Gross-Tsur , V. 2007 . Prader-Willi syndrome: Medical prevention and behavioral challenges . Child and Adolescent Psychiatric Clinics of North America , 16 ( 3 ) : 695 – 708 .
   PubMed Web of Science ®Google Scholar
• Berry , E. M. and Mechoulam , R. 2002 . Tetrahydrocannabinol and endocannabinoids in feeding and appetite . Pharmacology and Therapeutics , 95 ( 2 ) : 185 – 90 .
   PubMed Web of Science ®Google Scholar
• Berthoud , H. R. 2002 . Multiple neural systems controlling food intake and body weight . Neuroscience and Biobehavioral Revues , 26 ( 4 ) : 393 – 428 .
   PubMed Web of Science ®Google Scholar
• Blum , K. , Braverman , E. R. , Holder , J. M. , Lobar , J. F. , Monastra , V. J. , Miller , D. , Lobar , J. O. , Chen , T. J. and Comings , D. E. 2000 . Reward deficiency syndrome: A biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors . Journal of Psychoactive Drugs , 32 ( Suppl:i-iv ) : 1 – 112 .
   Google Scholar
• Blundell , J. E. and Cooling , J. 1999 . High-fat and low-fat (behavioural) phenotypes: Biology or environment? . Proceedings of the Nutrition Society , 58 ( 4 ) : 773 – 77 .
   PubMed Web of Science ®Google Scholar
• Blundell , J. E. , Lawton , C. L. and Halford , J. C. 1995 . Serotonin, eating behavior, and fat intake . Obesity Research , 3 ( Suppl 4 ) : 471S – 476S .
   PubMedGoogle Scholar
• Buda-Levin , A. , Wojnicki , F. H. and Corwin , R. L. 2005 . Baclofen reduces fat intake under binge-type conditions . Physiology and Behavior , 86 ( 1–2 ) : 176 – 84 .
   PubMed Web of Science ®Google Scholar
• Bulik , C. M. , Sullivan , P. F. and Kendler , K. S. 1998 . Heritability of binge-eating and broadly defined bulimia nervosa . Biological Psychiatry , 44 ( 12 ) : 1210 – 8 .
   PubMed Web of Science ®Google Scholar
• Bulik , C. M. , Slof-Op't Landt , M. C. , van Furth , E. F. and Sullivan , P. F. 2007 . The genetics of anorexia nervosa . Annual Review of Nutrition , 27 : 263 – 75 .
   PubMed Web of Science ®Google Scholar
• Bulik , C. M. , Sullivan , P. F. , Tozzi , F. , Furberg , H. , Lichtenstein , P. and Pedersen , N. L. 2006 . Prevalence, heritability, and prospective risk factors for anorexia nervosa . Archives of General Psychiatry , 63 ( 3 ) : 305 – 12 .
   PubMed Web of Science ®Google Scholar
• Bulik , C. M. , Sullivan , P. F. , Wade , T. D. and Kendler , K. S. 2000 . Twin studies of eating disorders: A review . lnternational Journal of Eating Disorders , 27 ( 1 ) : 1 – 20 .
   PubMed Web of Science ®Google Scholar
• Burns , L. H. , Annett , L. , Kelly , A. E. , Everitt , B. J. and Robbins , T. W. 1996 . Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implications for limbic—striatal interactions . Behavioral Neuroscience , 110 : 60 – 73 .
   PubMed Web of Science ®Google Scholar
• Cardinal , R. N. and Everitt , B. J. 2004 . Neural and psychological mechanisms underlying appetitive learning: links to drug addiction . Current Opinion in Neurobiology , 14 ( 2 ) : 156 – 62 .
   PubMed Web of Science ®Google Scholar
• Cassidy , S. B. 1997 . Prader-Willi syndrome . Journal of Medical Genetics , 34 ( 11 ) : 917 – 23 .
   PubMed Web of Science ®Google Scholar
• Colantuoni , C. , Rada , P. , McCarthy , J. , Patten , C. , Avena , N. M. , Chadeayne , A. and Hoebel , B. G. 2002 . Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence . Obesity Research , 10 ( 6 ) : 478 – 88 .
   PubMedGoogle Scholar
• Colantuoni , C. , Schwenker , J. , McCarthy , J. , Rada , P. , Ladenheim , B. , Cadet , J. L. , Schwartz , G. J. , Moran , T. H. and Hoebel , B. G. 2001 . Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain . Neuroreport , 12 ( 16 ) : 3549 – 52 .
   PubMed Web of Science ®Google Scholar
• Cooling , J. and Blundeii , J. E. 2001 . High-fat and low-fat phenotypes: Habitual eating of high- and low-fat foods not related to taste preference for fat . European Journal of Clinical Nutrition , 55 ( 11 ) : 1016 – 21 .
   PubMed Web of Science ®Google Scholar
• Cooper , S. J. 2004 . Endocannabinoids and food consumption: comparisons with benzodiazepine and opioid palatability-dependent appetite . European Journal of Pharmacology , 500 ( 1–3 ) : 37 – 49 .
   PubMed Web of Science ®Google Scholar
• Cowley , M. A. , Smart , J. L. , Rubinstein , M. , Cerdan , M. G. , Diano , S. , Horvath , T. L. , Cone , R. D. and Low , M. J. 2001 . Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus . Nature , 411 ( 6836 ) : 480 – 84 .
   PubMed Web of Science ®Google Scholar
• Crombag , H. S. and Shaham , Y. 2002 . Renewal of drug seeking by contextual cues after prolonged extinction in rats . Behavioral Neuroscience , 116 ( 1 ) : 169 – 73 .
   PubMed Web of Science ®Google Scholar
• Cummings , D. E. , Clement , K. , Purnell , J. Q. , Vaisse , C. , Foster , K. E. , Frayo , R. S. , Schwartz , M. W. , Basdevant , A. and Weigle , D. S. 2002 . Elevated plasma ghrelin levels in Prader Willi syndrome . Nature Medicine , 8 ( 7 ) : 643 – 44 .
   PubMed Web of Science ®Google Scholar
• De Castro , J. M. 1997 . How can energy balance be achieved by free-living human subjects? . Proceedings of the Nutrition Society , 56 ( 1A ) : 1 – 14 .
   PubMed Web of Science ®Google Scholar
• de Krom , M. , Bauer , F. , Collier , D. , Adan , R. A. and la Fleur , S. E. 2009 . Genetic variation and effects on human eating behavior . Annual Revue of Nutrition , 29 : 283 – 304 .
   PubMed Web of Science ®Google Scholar
• Di Chiara , G. 2002 . Nucleus accumbens shell and core dopamine: Differential role in behavior and addiction . Behavioral Brain Research , 137 ( 1–2 ) : 75 – 114 .
   PubMed Web of Science ®Google Scholar
• Dimitropoulos , A. , Feurer , I. D. , Roof , E. , Stone , W. , Butler , M. G. , Sutcliffe , J. and Thompson , T. 2000 . Appetitive behavior, compulsivity, and neurochemistry in Prader-Willi syndrome . Mental Retardation and Developmental Disabilities Research Revue , 6 ( 2 ) : 125 – 30 .
   PubMedGoogle Scholar
• Elliott , R. , Friston , K. J. and Dolan , R. J. 2000 . Dissociable neural responses in human reward systems . Journal of Neuroscience , 20 ( 16 ) : 6159 – 65 .
   PubMed Web of Science ®Google Scholar
• Elmquist , J. K. , Elias , C. F. and Saper , C. B. 1999 . From lesions to leptin: Hypothalamic control of food intake and body weight . Neuron , 22 ( 2 ) : 221 – 32 .
   PubMed Web of Science ®Google Scholar
• Farooqi , I. S. and O'Rahilly , S. 2000 . Recent advances in the genetics of severe childhood obesity . Archives of Disease in Childhood , 83 ( 1 ) : 31 – 34 .
   PubMed Web of Science ®Google Scholar
• Fedoroff , I. , Polivy , J. and Herman , C. P. 2003 . The specificity of restrained versus unrestrained eaters’ responses to food cues: general desire to eat, or craving for the cued food? . Appetite , 41 ( 1 ) : 7 – 13 .
   PubMed Web of Science ®Google Scholar
• File , S. E. , Lippa , A. S. , Beer , B. and Lippa , M. T. 2004 . Animal tests of anxiety . Current Protocols in Neuroscience , Chapter 8: Unit 8 3
   PubMedGoogle Scholar
• Foster , G. D. , Brownell , K. D. and Fairbur , C. G. 2001 . Non-Dieting Approaches, Eating Disorders And Obesity: A Comprehensive Handbook. New York : Guilford. .
   Google Scholar
• Glenn , C. C. , Driscoll , D. J. , Yang , T. P. and Nicholls , R. D. 1997 . Genomic imprinting: Potential function and mechanisms revealed by the Prader-Willi and Angelman syndromes . Molecular Human Reproduction , 3 ( 4 ) : 321 – 32 .
   PubMed Web of Science ®Google Scholar
• Gold , M. S. 1999 . Etiology and management of obesity . Directions in Psychiatry , 19 ( 20 ) : 419 – 39 .
   Google Scholar
• Gold , M. S. and Sternbach , H. A. 1984 . Endorphins in obesity and in the regulation of appetite and weight . Integrative Psychiatry , 2 ( 6 ) : 203 – 10 .
   Google Scholar
• Gold , M. S. , Graham , N. A. , Cocores , J. A. and Nixon , S. J. 2009 . Food addiction? . Journal of Addiction Medicine , 3 ( 1 ) : 42 – 45 .
   PubMed Web of Science ®Google Scholar
• Gold , M. S. , Frost-Pineda , K and Jacobs , W. S. 2003 . Overeating, binge eating, and eating disorders as addictions . Psychiatric Annals , 33 ( 2 ) : 117 – 22 .
   Web of Science ®Google Scholar
• Goldstone , A. P. 2004 . Prader-Willi syndrome: Advances in genetics. pathophysiology and treatment . Trends in Endocrinology and Metabolism , 15 ( 1 ) : 12 – 20 .
   PubMed Web of Science ®Google Scholar
• Goldstone , A. P. , Patterson , M. , Kalingag , N. , Ghatei , M. A. , Brynes , A. E. , Bloom , S. R. , Grossman , A. B. and Korbonits , M. 2005 . Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3–36 deficiency or seen in hypothalamic obesity due to craniopharyngioma . Journal of Clinical Endocrinology and Metabolism , 90 ( 5 ) : 2681 – 90 .
   PubMed Web of Science ®Google Scholar
• Goldstone , A. P. , Brynes , A. E. , Thomas , E. L. , Bell , J. D. , Frost , G. , Holland , A. , Ghatei , M. A. and Bloom , S. R. 2002 . Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome . American Journal of Clinical Nutrition , 75 ( 3 ) : 468 – 75 .
   PubMed Web of Science ®Google Scholar
• Goldstone , A. P. , Thomas , E. L. , Brynes , A. E. , Bell , J. D. , Frost , G. , Saeed , N. , Hajnal , J. V. , Howard , J. K. , Holland , A. and Bloom , S. R. 2001 . Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution . Journal of Clinical Endocrinology and Metabolism , 86 ( 9 ) : 4330 – 38 .
   PubMed Web of Science ®Google Scholar
• Gonzalez , S. , Manzanares , J. , Berrendero , F. , Wenger , T. , Corchero , J. , Bisogno , T. , Romero , J. , Fuentes , J. A. , Di Marzo , V. , Ramos , J A. and Fernandez-Ruiz , J. 1999 . Identification of endocannabinoids and cannabinoid CB(1) receptor mRNA in the pituitary gland . Neuroendocrinology , 70 ( 2 ) : 137 – 45 .
   PubMed Web of Science ®Google Scholar
• Gottfried , J. A. , O'Doherty , J. and Dolan , R. J. 2003 . Encoding predictive reward value in human amygdala and orbitofrontal cortex . Science , 301 ( 5636 ) : 1104 – 07 .
   PubMed Web of Science ®Google Scholar
• Garwood , P. , Kipman , A. and Foulon , C. 2003 . The human genetics of anorexia nervosa . European Journal of Pharmacology , 480 ( 1–3 ) : 163 – 70 .
   PubMed Web of Science ®Google Scholar
• Haddock , C. K. and Dill , P. L. 2000 . “ The effects of food on mood and behavior: Implications for the addictions model of obesity and eating disorders. ” . In Food as a Drug. Edited by: Poston , W. S.C. and Haddock , C. K. New York : Haworth Press, Inc. .
   Google Scholar
• Halford , J. C. and Blundell , J. E. 2000 . Separate systems for serotonin and Jeptin in appetite control . Annals of Medicine , 32 ( 3 ) : 222 – 32 .
   PubMed Web of Science ®Google Scholar
• Hammer , C. , Kapeller , J. , Endele , M. , Fischer , C. , Hebebrand , J. , Hinney , A. , Friedel , S. , Gratacos , M. , Estivill , X. , Fichter , M. , Fernandez-Aranda , F. , Ehrlich , S. , Rappold , G. and Niesler , B. 2009 . Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders . Pharmacogenetics and Genomics , 19 ( 10 ) : 790 – 99 .
   PubMed Web of Science ®Google Scholar
• Hernandez , L. and Hoe bel , B. G. 1988 . Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens . Physiology and Behavior , 44 ( 4–5 ) : 599 – 606 .
   PubMed Web of Science ®Google Scholar
• Hinton , E. C. , Parkinson , J. A. , Holland , A. J. , Arana , F. S. , Roberts , A. C. and Owen , A. M. 2004 . Neural contributions to the motivational control of appetite in humans . European Journal of Neuroscience , 20 ( 5 ) : 1411 – 18 .
   PubMed Web of Science ®Google Scholar
• Hodgkins , C. C. , Jacobs , W. S. and Gold , M. S. 2003 . Weight gain after adolescent drug addiction treatment and supervised abstinence . Psychiatric Annals , 33 ( 2 ) : 112 – 16 .
   Web of Science ®Google Scholar
• Holland , A. J. , Treasure , J. , Coskeran , P. , Dallow , J. , Milton , N. and Hillhouse , E. 1993 . Measurement of excessive appetite and metabolic changes in Prader-Willi syndrome . International Journal of Obesity and Related Metabolic Disorders , 17 ( 9 ) : 527 – 32 .
   PubMed Web of Science ®Google Scholar
• Howlett , A. C. 2002 . The cannabinoid receptors . Prostaglandins and Other Lipid Mediators , 68–69 : 619 – 31 .
   PubMed Web of Science ®Google Scholar
• Jimerson , D. C. and Wolfe , B. E. 2004 . Neuropeptides in eating disorders . CNS Spectrum , 9 ( 7 ) : 516 – 22 .
   PubMed Web of Science ®Google Scholar
• Jimerson , D. C. , Lesem , M. D. , Kaye , W. H. and Brewerton , T. D. 1992 . Low serotonin and dopamine metabolite concentrations in cerebrospinal fuid from bulimic patients with frequent binge episodes . Archives of General Psychiatry , 49 ( 2 ) : 132 – 38 .
   PubMed Web of Science ®Google Scholar
• Johnson , W. G. 1974 . Effect of cue prominence and subject weight on human food-directed performance . Journal of Personality and Social Psychology , 29 ( 6 ) : 843 – 48 .
   PubMed Web of Science ®Google Scholar
• Jonas , J. M. and Gold , M. S. 1988 . Naltrexone treatment of bulimia: Clinical and theoretical findings linking eating disorders and substance abuse . Advances in Alcohol & Substance Abuse , 7 ( 1 ) : 29 – 37 .
   Google Scholar
• Joranby , L. , Pineda , K. F. and Gold , M. S. 2005 . Addiction to food and brain reward systems . Sexual Addiction & Compulsivity , 12 : 201 – 17 .
   Google Scholar
• Kalra , S. P. and Kalra , P. S. 2004a . NPY and cohorts in regulating appetite, obesity and metabolic syndrome: Beneficial effects of gene therapy . Neuropeptides , 38 ( 4 ) : 201 – 11 .
   PubMed Web of Science ®Google Scholar
• Kalra , S. P. and Kalra , P. S. 2004b . Overlapping and interactive pathways regulating appetite and craving . Journal of Addictive Diseases , 23 ( 3 ) : 5 – 21 .
   PubMed Web of Science ®Google Scholar
• Kalra , P. S. and Kalra , S. P. 2002 . Obesity and metabolic syndrome: Long-term benefits of central leptin gene therapy . Drugs Today (Bare) , 38 ( 11 ) : 745 – 57 .
   PubMed Web of Science ®Google Scholar
• Kalra , S. P. and Kalra , P. S. 1996 . Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network . Frontiers in Neuroendocrinology , 17 ( 4 ) : 371 – 401 .
   PubMed Web of Science ®Google Scholar
• Kalra , S. P. , Bagnasco , M. , Otukonyong , E. E. , Dube , M. G. and Kalra , P. S. 2003 . Rhythmic, reciprocal ghrelin and leptin signaling: New insight in the development of obesity . Regulatory Peptides , 111 ( 1–3 ) : 1 – 11 .
   PubMedGoogle Scholar
• Kalra , S. P. , Dube , M. G. , Pu , S. , Xu , B. , Horvath , T. L. and Kalra , P. S. 1999 . Interacting appetite-regulating pathways in the hypothalamic regulation of body weight . Endocrinology Review , 20 ( 1 ) : 68 – 100 .
   PubMed Web of Science ®Google Scholar
• Kelley , A. E. 2004 . Memory and addiction: Shared neural circuitry and molecular mechanisms . Neuron , 44 ( 1 ) : 161 – 79 .
   PubMed Web of Science ®Google Scholar
• Killgore , W. D. , Young , A. D. , Femia , L. A. , Bogorodzki , P. , Rogowska , J. and Yurgelun-Todd , D. A. 2003 . Cortical and limbic activation during viewing of high- versus low-calorie foods . Neuroimage , 19 ( 4 ) : 1381 – 94 .
   PubMed Web of Science ®Google Scholar
• Kleiner , K. D. , Gold , M. S. , Frost-Pineda , K. , Lenz-Brunsman , B. , erri , M. G. and Jacobs , W. S. 2004 . Body mass index and alcohol use . Journal of Addictive Diseases , 3 ( 3 ) : 105 – 18 .
   Web of Science ®Google Scholar
• Koob , G. F. and Le Moal , M. 2005 . Neurobiology of Addiction. an Diego : Academic Press. .
   Google Scholar
• Kringelbach , M. L. , O'Doherty , J. , Rolls , E. T. and Andrews , C. 2003 . Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness . Cerebral Cortex , 13 ( 10 ) : 1064 – 71 .
   PubMed Web of Science ®Google Scholar
• Liu , Y. and Gold , M. S. 2003 . Human functional magnetic resonance imaging of eating and satiety in eating disorders and obesity . Psychiatric Annals , 33 ( 2 ) : 127 – 32 .
   Web of Science ®Google Scholar
• Liu , Y. , Frost-Pineda , K. , James , G. A. and Gold , M. S. 2004 . Functional MRI detection of brain changes related to the effectiveness of novel pharmacological treatments for obesity . Biological Psychiatry , 55 : 128
   Web of Science ®Google Scholar
• Liu , Y. , Gao , J. H. , Liu , H. L. and Fox , P. T. 2000 . The temporal response of the brain after eating revealed by functional MRI . Nature , 405 ( 6790 ) : 1058 – 62 .
   PubMed Web of Science ®Google Scholar
• Lutter , M. and Nestler , E. J. 2009 . Homeostatic and hedonic signals interact in the regulation of food intake . Journal of Nutrition , 139 ( 3 ) : 629 – 32 .
   PubMed Web of Science ®Google Scholar
• Mark , G. P. , Weinberg , J. B. , Rada , P. Y. and Hoebel , B. G. 1995 . Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus . Brain Research , 688 ( 1–2 ) : 184 – 88 .
   PubMed Web of Science ®Google Scholar
• Martásková , D. , Slachtova , L. , Kemlink , D. , Zahorakova , D. and Papezova , H. 2009 . Polymorphisms in serotonin-related genes in anorexia nervosa. The first study in Czech population and metaanalyses with previously performed studies . Folia Biologica (Praha) , 55 ( 5 ) : 192 – 97 .
   PubMed Web of Science ®Google Scholar
• Mazzeo , S. E. , Mitchell , K. S. , Bulik , C. M. , Reichborn-Kjennerud , T. , Kendler , K. S. and Neale , M. C. 2009 . Assessing the heritability of anorexia nervosa symptoms using a marginal maximal likelihood approach . Psychological Medicine , 39 ( 3 ) : 463 – 73 .
   PubMed Web of Science ®Google Scholar
• McDannald , M. A. , Saddoris , M. P. , Gallagher , M. and Holland , P. C. 2005 . Lesions of orbitofrontal cortex impair rats’ differential outcome expectancy learning but not conditioned stimulus-potentiated feeding . Journal of Neuroscience , 25 ( 18 ) : 4626 – 32 .
   PubMed Web of Science ®Google Scholar
• Meguid , M. M. , Fetissov , S. O. , Varma , M. , Sato , T. , Zhang , L. , Laviano , A. and Rossi-Fanelli , F. 2000 . Hypothalamic dopamine and serotonin in the regulation of food intake . Nutrition , 16 ( 10 ) : 843 – 57 .
   PubMed Web of Science ®Google Scholar
• Merlo , L. J. and Gold , M. S. 2009 . Weighing in on ‘conditioned hypereating’ . A review of The End of Overeating: Taking Control of the Insatiable American Appetite. Cerebrum. , http://www.dana.org/news/cerebrum/detail.aspx?id=23666Available at
   Google Scholar
• Merlo , L. J. , Stone , A. M. and Gold , M. S. 2009 . “ Co-occurring addictions and eating disorders. ” . In Principles of Addiction Medicine, , Fourth Edition. Edited by: Ries , R. K. , Fiellin , D. , Miller , S. C. and Saitz , R. Philadelphia : Lippincott, Williams & Wilkins. .
   Google Scholar
• Miller , J. , Gold , M. S. and Silverstein , J. 2003 . Pediatric overeating and obesity: An epidemic . Psychiatric Annals , 33 ( 2 ) : 95 – 99 .
   Web of Science ®Google Scholar
• Miller , J. , Kranzler , J. , Liu , Y. , Schmalfuss , I. , Theriaque , D. W. , Shuster , J. J. , Hatfield , A. , Mueller , O. T. , Goldstone , A. P. , Sahoo , T. , Beaudet , A. L. and Driscoll , D. J. 2006 . Neurocognitive findings in Prader-Willi syndrome and early-onset morbid obesity . Journal of Pediatrics , 149 ( 2 ) : 192 – 98 .
   PubMed Web of Science ®Google Scholar
• Miller , J. L. , Couch , J. A. , Schmalfuss , I. , He , G. , Liu , Y. and Driscoll , D. J. 2007a . Intracranial abnormalities detected by three-dimensional magnetic resonance imaging in Prader-Willi syndrome . American Journal of Medical Genetics Part A , 143 ( 5 ) : 476 – 83 .
   Web of Science ®Google Scholar
• Miller , J. L. , James , G. A. , Goldstone , A. P. , Couch , J. A. , He , G. , Driscoll , D. J. and Liu , Y. 2007b . Enhanced activation of reward mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome . Journal of Neurology. Neurosurgury and Psychiatry , 78 ( 6 ) : 615 – 19 .
   PubMed Web of Science ®Google Scholar
• Mogenson , G. J. 1982 . “ Studies of the nucleus accumbens and its mesolimbic dopaminergic affects in relation to ingestive behaviors and reward. ” . In The Neural Basis of Feeding and Reward. Edited by: Hoebel , G. B. and Nov , D. Brunswick, ME : Haer Institute. .
   Google Scholar
• Morley , J. E. 1987 . Neuropeptide regulation of appetite and weight . Endocrine Reviews , 8 ( 3 ) : 256 – 87 .
   PubMed Web of Science ®Google Scholar
• Morris , J. S. and Dolan , R. J. 2001 . Involvement of human amygdala and orbitofrontal cortex in hunger-enhanced memory for food stimuli . Journal of Neuroscience , 21 ( 14 ) : 5304 – 10 .
   PubMed Web of Science ®Google Scholar
• Nicholls , R. D. and Knepper , J. L. 2001 . Genome organization, function, and imprinting in Prader-Willi and Angel man syndromes . Annual Review of Genomics and Human Genetics , 2 : 153 – 75 .
   PubMed Web of Science ®Google Scholar
• Nielsen , S. J. , Siega-Riz , A. M. and Popkin , B. M. 2002 . Trends in food locations and sources among adolescents and young adults . Preventive Medicine , 35 ( 2 ) : 107 – 113 .
   PubMed Web of Science ®Google Scholar
• Nixon , G. M. and Brouillette , R. T. 2002 . Sleep and breathing in Prader-Willi syndrome . Pediatric Pulmonology , 34 ( 3 ) : 209 – 17 .
   PubMed Web of Science ®Google Scholar
• Noble , E. P. , Noble , R. E. , Ritchie , T. , Syndulko , K. , Bohlman , M. C. , Noble , L. A. , Zhang , Y. , Sparkes , R. S. and Grandy , D. K. 1994 . D2 dopamine receptor gene and obesity . International Journal of Eating Disorders , 15 ( 3 ) : 205 – 17 .
   PubMed Web of Science ®Google Scholar
• Noble , E. P. , Blum , K. , Ritchie , T. , Montgomery , A. and Sheridan , P. J. 1991 . Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism . Archives of General Psychiatry , 48 ( 7 ) : 648 – 54 .
   PubMed Web of Science ®Google Scholar
• O'Doherty , J. P. 2004 . Reward representations and reward-related learning in the human brain: Insights from neuroimaging . Current Opinions in Neurobiology , 14 ( 6 ) : 769 – 76 .
   PubMed Web of Science ®Google Scholar
• Ogura , K. , Shinohara , M. , Ohno , K. and Mori , E. 2008 . Frontal behavioral syndromes in Prader-Willi syndrome . Brain Development , 30 ( 7 ) : 469 – 76 .
   PubMed Web of Science ®Google Scholar
• Ongür , D and Price , J. L. 2000 . The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans . Cerebral Cortex , 10 ( 3 ) : 206 – 19 .
   PubMed Web of Science ®Google Scholar
• Pagliardini , S. , Ren , J. , Wevrick , R. and Greer , J. J. 2005 . Developmental abnormalities of neuronal structure and function in prenatal mice lacking the Prader-Willi syndrome gene necdin . American Journal of Pathology , 167 ( 1 ) : 175 – 91 .
   PubMed Web of Science ®Google Scholar
• Parham , E. S. 1995 . “ Compulsive eating: Applying a medical addiction model. ” . In Obesity: New Directions in Assessment and Management. Edited by: Van Itallie , T. B. and Simopoulos , A. P. Philadelphia, PA : The Charles Press, Publishers. .
   Google Scholar
• Petrovich , G. D. and Gallagher , M. 2007 . Control of food consumption by learned cues: A forebrain-hypothalamic network . Physiology and Behavior , 91 ( 4 ) : 397 – 403 .
   PubMed Web of Science ®Google Scholar
• Petrovich , G. D. , Holland , P. C. and Gallagher , M. 2005 . Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eating . Journal of Neuroscience , 25 ( 36 ) : 8295 – 302 .
   PubMed Web of Science ®Google Scholar
• Petrovich , G. D. , Canteras , N. S. and Swanson , L. W. 2001 . Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systems . Brain Research Brain Research Reviews , 38 ( 1–2 ) : 247 – 89 .
   PubMedGoogle Scholar
• Petrovich , G. D. , Ross , C. A. , Holland , P. C. and Gallagher , M. 2007 . Medial prefrontal cortex is necessary for an appetitive contextual conditioned stimulus to promote eating in sated rats . Journal of Neuroscience , 27 ( 24 ) : 6436 – 41 .
   PubMed Web of Science ®Google Scholar
• Petrovich , G. D. , Setlow , B. , Holland , P. C. and Gallagher , M. 2002 . Amygdalohypothalamic circuit allows learned cues to override satiety and promote eating . Journal of Neuroscience , 22 ( 19 ) : 8748 – 53 .
   PubMed Web of Science ®Google Scholar
• Proto , C. , Romualdi , D. , Cento , R. M. , Romano , C. , Campagna , G. and Lanzone , A. 2007 . Free and total leptin serum levels and soluble leptin receptors levels in two models of genetic obesity: The Prader-Willi and the Down syndromes . Metabolism , 56 ( 8 ) : 1076 – 80 .
   PubMed Web of Science ®Google Scholar
• Rada , P. V. and Hoebel , B. G. 2000 . Supraadditive effect of d-fenfluramine plus phentennine on extracellular acetylcholine in the nucleus accumbens: Possible mechanism for inhibition of excessive feeding and drug abuse . Pharmacology, Biochemistry and Behavior , 65 ( 3 ) : 369 – 73 .
   PubMed Web of Science ®Google Scholar
• Rada , P. , Avena , N. M. and Hoebel , B. G. 2005 . Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell . Neuroscience , 134 ( 3 ) : 737 – 44 .
   PubMed Web of Science ®Google Scholar
• Roitman , M. F. , van Dijk , G. , Thiele , T. E. and Bernstein , I. L. 2001 . Dopamine mediation of the feeding response to violations of spatial and temporal expectancies . Behavioral Brain Research , 122 ( 2 ) : 193 – 99 .
   PubMed Web of Science ®Google Scholar
• Saad , M. F. , Khan , A. , Sharma , A. , Michael , R. , Riad-Gabriel , M. G. , Boyadjian , R. , Jinagouda , S. D. , Steil , G. M. and Kamdar , V. 1998 . Physiological insulinemia acutely modulates plasma leptin . Diabetes , 47 ( 4 ) : 544 – 49 .
   PubMed Web of Science ®Google Scholar
• Sahu , A. and Kalra , S. P. 1993 . Neuropeptidergic regulation of feeding behavior neuropeptide Y . Trends Endocrinology and Metabolism , 4 ( 7 ) : 217 – 24 .
   PubMed Web of Science ®Google Scholar
• Salamone , J. D. , Cousins , M. S. and Snyder , B. J. 1997 . Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis . Neuroscience and Biobehavioral Reviews , 21 ( 3 ) : 341 – 59 .
   PubMed Web of Science ®Google Scholar
• Sato , Y. , Ito , T. , Udaka , N. , Kanisawa , M. , Noguchi , Y. , Cushman , S. W. and Satoh , S. 1996 . Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets . Tissue Cell , 28 ( 6 ) : 637 – 43 .
   PubMed Web of Science ®Google Scholar
• Schwartz , M. W. , Woods , S. C. , Porte , D. Jr. , Seeley , R. J. and Baskin , D. G. 2000 . Central nervous system control of food intake . Nature , 404 ( 6778 ) : 661 – 71 .
   PubMed Web of Science ®Google Scholar
• Scislowski , P. W. , Tozzo , E. , Zhang , Y. , Phaneuf , S. , Prevelige , R. and Cincotta , A. H. 1999 . Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists . International Journal of Obesity and Related Metabolic Disorders , 23 ( 4 ) : 425 – 31 .
   PubMed Web of Science ®Google Scholar
• Selikowitz , M. , Sunman , J. , Pendergast , A. and Wright , S. 1990 . Fenfluramine in Prader-Willi syndrome: A double blind. placebo controlled trial . Archives of Disease in Childhood , 65 ( 1 ) : 112 – 14 .
   PubMed Web of Science ®Google Scholar
• Setlow , B. , Gallagher , M. and Holland , P. C. 2002 . The basolateral complex of the amygdala is necessary for acquisition but not expression of CS motivational value in appetitive Pavlovian second-order conditioning . European Journal of Neuroscience , 15 ( 11 ) : 1841 – 53 .
   PubMed Web of Science ®Google Scholar
• Shapira , N. A. , Lessig , M. C. , He , A. G. , James , G. A. , Driscoll , D. J. and Liu , Y. 2005 . Satiety dysfunction in Prader-Willi syndrome demonstrated by fMRI . Journal of Neurology, Neurosurgury and Psychiatry , 76 ( 2 ) : 260 – 2 .
   PubMed Web of Science ®Google Scholar
• Simmons , W. K. , Martin , A. and Barsalou , L. W. 2005 . Pictures of appetizing foods activate gustatory cortices for taste and reward . Cerebral Cortex , 15 : 1602 – 08 .
   PubMed Web of Science ®Google Scholar
• Singh , N. N. , Lancioni , G. E. , Singh , A. N. , Winton , A. S.W. , Singh , J. , McAleavey , K. M. and Adkins , A. D. 2008 . A mindfulness-based health wellness program for an adolescent with Prader-Willi syndrome . Behavior Modification , 32 ( 2 ) : 167 – 81 .
   PubMed Web of Science ®Google Scholar
• Sobik , L. , Hutchison , K. and Craighead , L. 2005 . Cue-elicited craving for food: A fresh approach to the study of binge eating . Appetite , 44 ( 3 ) : 253 – 61 .
   PubMed Web of Science ®Google Scholar
• Solinas , M. and Goldberg , S. R. 2005 . Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems . Neuropsychopharnacology , 30 ( 11 ) : 2035 – 45 .
   PubMed Web of Science ®Google Scholar
• Spring , B. , Schneider , K. , Smith , M. , Kendzor , D. , Appelhans , B. , Hedeker , D. and Pagoto , S. 2008 . Abuse potential of carbohydrates for overweight carbohydrate cravers . Psychopharmacology (Berl) , 197 ( 4 ) : 637 – 47 .
   PubMed Web of Science ®Google Scholar
• Swaab , D. F. , Purba , J. S. and Hofman , M. A. 1995 . Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: A study of five cases . Journal of Clinical Endocrinology and Metabolism , 80 ( 2 ) : 573 – 79 .
   PubMed Web of Science ®Google Scholar
• Swanson , L. W. and Petrovich , G. D. 1998 . What is the amygdala? . Trends in Neuroscience , 21 : 323 – 31 .
   PubMed Web of Science ®Google Scholar
• Tartar , R. E. , Ammerman , R. T. and Ott , P. J. 1998 . Handbook of Substance Abuse: Neurobehavioral Pharmacology. New York : Premium Press. .
   Google Scholar
• Tataranni , P. A. and DeiParigi , A. 2003 . Functional neuroimaging: A new generation of human brain studies in obesity research . Obesity Review , 4 ( 4 ) : 229 – 38 .
   PubMedGoogle Scholar
• Tiggemann , M. and Kemps , E. 2005 . The phenomenology of food cravings: The role of mental imagery . Appetite , 45 ( 3 ) : 305 – 13 .
   PubMed Web of Science ®Google Scholar
• Volkow , N. D. , Wang , G. J. , Fowler , J. S. , Logan , J. , Jayne , M. , Franceschi , D. , Wong , C. , Gatley , S. J. , Gifford , A. N. , Ding , Y. S. and Pappas , N. 2002 . “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect . Synapse , 44 ( 3 ) : 175 – 80 .
   PubMed Web of Science ®Google Scholar
• von Deneen , K. M. , Gold , M. S. and Liu , Y. 2009 . Food addiction and cues in Prader-Willi syndrome . Journal of Addiction Medicine , 3 ( 1 ) : 19 – 21 .
   PubMed Web of Science ®Google Scholar
• Wang , G. J. , Volkow , N. D. , Thanos , P. K. and Fowler , J. S. 2004 . Similarity between obesity and drug addiction as assessed by neurofunctional imaging: A concept review . Journal of Addictive Diseases , 23 ( 3 ) : 39 – 53 .
   PubMed Web of Science ®Google Scholar
• Wang , G. J. , Volkow , N. D. , Felder , C. , Fowler , J. S. , Levy , A. V. , Pappas , N. R. , Wong , C. T. , Zhu , W. and Netusil , N. 2002 . Enhanced resting activity of the oral somatosensory cortex in obese subjects . Neuroreport , 13 ( 9 ) : 1151 – 55 .
   PubMed Web of Science ®Google Scholar
• Wang , G. J. , Volkow , N. D. , Logan , J. , Pappas , N. R. , Wong , C. T. , Zhu , W. , Netusil , N. and Fowler , J. S. 2001 . Brain dopamine and obesity . Lancet , 357 ( 9253 ) : 354 – 57 .
   PubMed Web of Science ®Google Scholar
• Warren , M. W. and Gold , M. S. 2007 . The relationship between obesity and drug use . American Journal of Psychiatry , 164 ( 8 ) : 1268
   PubMed Web of Science ®Google Scholar
• Weingarten , H. P. and Elston , D. 1990 . The phenomenology of food cravings . Appetite , 15 ( 3 ) : 231 – 46 .
   PubMed Web of Science ®Google Scholar
• Wilson , G. T. 1999 . Eating disorders and addiction . Drugs & Society , 15 : 87 – 101 .
   Google Scholar
• Wilson , G. T. 1991 . The addiction model of eating disorders: A critical analysis . Advances in Behavior Research and Therapy , 13 : 27 – 72 .
   Web of Science ®Google Scholar
• Wise , R. A. 2004 . Dopamine, learning and motivation . Nature Reviews Neuroscience , 5 ( 6 ) : 483 – 94 .
   PubMed Web of Science ®Google Scholar
• Wurtman , R. J. and Wurtman , J. J. 1996 . Brain serotonin, carbohydrate-craving, obesity and depression . Advances in Experimental Medicine and Biology , 398 : 35 – 41 .
   PubMedGoogle Scholar
• Wurtman , R. J. and Wurtman , J. J. 1995 . Brain serotonin, carbohydrate-craving, obesity and depression . Obesity Research , 3 ( Suppl 4 ) : 477S – 480S .
   PubMedGoogle Scholar
• Zipf , W. B. , O'Dorisio , T. M. , Cataland , S. and Dixon , K. 1983 . Pancreatic polypeptide responses to protein meal challenges in obese but otherwise normal children and obese children with Prader-Willi syndrome . Journal of Clinical Endocrinology and Metabolism , 57 ( 5 ) : 1074 – 80 .
   PubMed Web of Science ®Google Scholar