Effects of Ayahuasca and its Alkaloids on Drug Dependence: A Systematic Literature Review of Quantitative Studies in Animals and Humans

References

• Aricioglu-Kartal, F., H. Kayir, and I. T. Uzbay. 2003. Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats. Life Science 73 (18):2363–71. doi:10.1016/S0024-3205(03)00647-7.
   PubMed Web of Science ®Google Scholar
• Barbosa, P. C., S. Mizumoto, M. P. Bogenschutz, and R. J. Strassman. 2012. Health status of ayahuasca users. Drug Testing Analysis 4 (7–8):601–09. doi:10.1002/dta.1383.
   PubMed Web of Science ®Google Scholar
• Biradar, S. M., H. Joshi, and K. C. Tarak. 2013. Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice. Pakistan Journal of Biological Sciences 16 (23):1687–97. doi:10.3923/pjbs.2013.1687.1697.
   PubMedGoogle Scholar
• Bogenschutz, M. P., A. A. Forcehimes, J. A. Pommy, C. E. Wilcox, P. C. R. Barbosa, and R. J. Strassman. 2015. Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study. Journal of Psychopharmacology 29 (3):289–99. doi:10.1177/0269881114565144.
   PubMed Web of Science ®Google Scholar
• Bouso, J. C., D. González, S. Fondevila, M. Cutchet, X. Fernández, P. C. R. Barbosa, M. A. Alcázar-Córcoles, W. S. Araújo, M. J. Barbanoj, J. M. Fábregas, and J. Riba. 2012. Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of Ayahuasca: A longitudinal study. PLoS One 7 (8):e42421. doi:10.1371/journal.pone.0042421.
   PubMed Web of Science ®Google Scholar
• Bouso, J. C., F. Palhano-Fontes, A. Rodríguez-Fornells, S. Ribeiro, R. Sanches, J. A. Crippa, J. E. Hallak, D. B. de Araujo, and J. Riba. 2015. Long-term use of psychedelic drugs is associated with differences in brain structure and persona in humans. European Neuropsychopharmacology 25 (4):483–92. doi:10.1016/j.euroneuro.2015.01.008.
   PubMed Web of Science ®Google Scholar
• Bouso, J. C., and J. Riba. 2014. Ayahuasca and the treatment of drug addiction. In The therapeutic use of ayahuasca, eds. B. C. Labate and C. Cavnar. Berlin: Springer-Verlag.
   Google Scholar
• Brierley, D. I., and C. Davidson. 2012. Developments in harmine pharmacology: Implications for ayahuasca use and drug-dependence treatment. Progress in Neuropsychopharmacology & Biological Psychiatry 39 (2):263–72. doi:10.1016/j.pnpbp.2012.06.001.
   PubMed Web of Science ®Google Scholar
• Brierley, D. I., and C. Davidson. 2013. Harmine augments electrically evoked dopamine efflux in the nucleus accumbens shell. Journal of Psychopharmacology 27 (1):98–108. doi:10.1177/0269881112463125.
   PubMed Web of Science ®Google Scholar
• Calabrese, J. D. 1997. Spiritual healing and human development in the Native American church: Toward a cultural psychiatry of peyote. Psychoanalytic Review 84 (2):237–55.
   PubMedGoogle Scholar
• da Silveira, D. X., C. S. Grob, M. D. de Rios, E. Lopez, L. K. Alonso, C. Tacla, and E. Doering- Silveira. 2005. Ayahuasca in adolescence: A preliminary psychiatric assessment. Journal of Psychoactive Drugs 37 (2):129–33. doi:10.1080/02791072.2005.10399792.
   PubMed Web of Science ®Google Scholar
• de Araujo, D. B., S. Ribeiro, G. A. Cecchi, F. M. Carvalho, T. A. Sanchez, J. P. Pinto, B. S. de Martinis, J. A. Crippa, J. E. C. Hallak, and A. C. Santos. 2012. Seeing with the eyes shut: Neural basis of enhanced imagery following ayahuasca ingestion. Human Brain Mapping 33 (11):2550–60. doi:10.1002/hbm.21381.
   PubMed Web of Science ®Google Scholar
• de Castro-Neto, E. F., R. H. da Cunha, D. X. da Silveira, M. Yonamine, T. L. Gouveia, E. A. Cavalheiro, D. Amado, and M. G. Naffah-Mazzacoratti. 2013. Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion. World Journal of Biological Chemistry 4 (4):141–47.
   PubMedGoogle Scholar
• Doering-Silveira, E., C. S. Grob, M. D. de Rios, E. Lopez, L. K. Alonso, C. Tacla, and D. X. da Silveira. 2005. Report on psychoactive drug use among adolescents using ayahuasca within a religious context. Journal of Psychoactive Drugs 37 (2):141–44. doi:10.1080/02791072.2005.10399794.
   PubMed Web of Science ®Google Scholar
• dos Santos, R. G. 2011. Ayahuasca: Physiological and subjective effects, comparison with d-amphetamine, and repeated dose assessment. Doctoral thesis, Universitat Autònoma de Barcelona, Barcelona, Spain. https://www.educacion.gob.es/teseo/mostrarRef.do?ref=959049 ( accessed January 10, 2016).
   Google Scholar
• dos Santos, R. G. 2013. Safety and side effects of ayahuasca in humans: An overview focusing on developmental toxicology. Journal of Psychoactive Drugs 45 (1):68–78. doi:10.1080/02791072.2013.763564.
   PubMed Web of Science ®Google Scholar
• dos Santos, R. G., E. Grasa, M. Valle, M. R. Ballester, J. C. Bouso, J. F. Nomdedéu, R. Homs, M. J. Barbanoj, and J. Riba. 2012. Pharmacology of ayahuasca administered in two repeated doses. Psychopharmacology 219 (4):1039–53. doi:10.1007/s00213-011-2434-x.
   PubMed Web of Science ®Google Scholar
• dos Santos, R. G., J. Landeira-Fernandez, R. J. Strassman, V. Motta, and A. P. Cruz. 2007. Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members. Journal of Ethnopharmacology 112 (3):507–13. doi:10.1016/j.jep.2007.04.012.
   PubMed Web of Science ®Google Scholar
• dos Santos, R. G., F. L. Osório, J. A. Crippa, and J. E. Hallak. 2016. Antidepressive and anxiolytic effects of ayahuasca: A systematic literature review of animal and human studies. Revista Brasileira de Psiquiatria 38:65–72. doi:10.1590/1516-4446-2015-1701.
   PubMed Web of Science ®Google Scholar
• dos Santos, R. G., M. Valle, J. C. Bouso, J. F. Nomdedéu, J. RodrÍguez-Espinosa, E. H. McIlhenny, S. A. Barker, M. J. Barbanoj, and J. Riba. 2011. Autonomic, neuroendocrine, and immunological effects of ayahuasca: A comparative study with d-amphetamine. Journal of Clinical Psychopharmacology 31 (6):717–26. doi:10.1097/JCP.0b013e31823607f6.
   PubMed Web of Science ®Google Scholar
• Fábregas, J. M., D. González, S. Fondevila, M. Cutchet, X. Fernández, P. C. Barbosa, M. A. Alcázar-Córcoles, M. J. Barbanoj, J. Riba, and J. C. Bouso. 2010. Assessment of addiction severity among ritual users of ayahuasca. Drug and Alcohol Dependence 111 (3):257–61. doi:10.1016/j.drugalcdep.2010.03.024.
   PubMed Web of Science ®Google Scholar
• Fernández, X., R. G. dos Santos, M. Cutchet, S. Fondevila, D. González, M. A. Alcázar, J. Riba, J. C. Bouso, and J. M. Fábregas. 2014. Assessment of the psychotherapeutic effects of ritual ayahuasca use on drug dependency: A pilot study. In The therapeutic use of ayahuasca, eds. B. C. Labate and C. Cavnar. Berlin: Springer.
   Google Scholar
• Fortunato, J. J., G. Z. Réus, T. R. Kirsch, R. B. Stringari, L. Stertz, F. Kapczinski, J. P. Pinto, J. E. Hallak, A. W. Zuardi, J. A. Crippa, and J. Quevedo. 2009. Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. Progress in Neuropsychopharmacology & Biological Psychiatry 33 (8):1425–30. doi:10.1016/j.pnpbp.2009.07.021.
   PubMed Web of Science ®Google Scholar
• Garcia-Romeu, A., R. Roland, R. R. Griffiths, and M. W. Johnson. 2014. Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction. Current Drug Abuse Reviews 7 (3):157–64. doi:10.2174/1874473708666150107121331.
   PubMedGoogle Scholar
• Glennon, R. A., M. Dukat, B. Grella, S. Hong, L. Costantino, M. Teitler, C. Smith, C. Egan, K. Davis, and M. V. Mattson. 2000. Binding of β-carbolines and related agents at serotonin (5-HT2 and 5-HT1A), dopamine (D2) and benzodiazepine receptors. Drug and Alcohol Dependence 60 (2):121–32. doi:10.1016/S0376-8716(99)00148-9.
   PubMed Web of Science ®Google Scholar
• Glick, S. D., M. E. Kuehne, J. Raucci, T. E. Wilson, D. Larson, R. W. Keller Jr., and J. N. Carlson. 1994. Effects of iboga alkaloids on morphine and cocaine self-administration in rats: Relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Research 657 (1–2):14–22. doi:10.1016/0006-8993(94)90948-2.
   PubMed Web of Science ®Google Scholar
• Goulart, S. L. 2011. The notion of cure in the Brazilian ayahuasca religions. In The ethnopharmacology of ayahuasca, ed. R. G. dos Santos. Trivandrum, India: Transworld Research Network.
   Google Scholar
• Grella, B., M. Dukat, R. Young, M. Teitler, K. Herrick-Davis, C. B. Gauthier, and R. A. Glennon. 1998. Investigation of hallucinogenic and related β-carbolines. Drug and Alcohol Dependence 50 (2):99–107. doi:10.1016/S0376-8716(97)00163-4.
   PubMed Web of Science ®Google Scholar
• Griffiths, R. R., M. W. Johnson, W. A. Richards, B. D. Richards, U. McCann, and R. Jesse. 2011. Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects. Psychopharmacology 218 (4):649–65. doi:10.1007/s00213-011-2358-5.
   PubMed Web of Science ®Google Scholar
• Grob, C. S., D. J. McKenna, J. C. Callaway, G. S. Brito, E. S. Neves, G. Oberlaender, O. L. Saide, E. Labigalini, C. Tacla, C. T. Miranda, R. J. Strassman, and K. B. Boone. 1996. Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. The Journal of Nervous and Mental Disease 184 (2):86–94. doi:10.1097/00005053-199602000-00004.
   PubMed Web of Science ®Google Scholar
• Halpern, J. H., A. R. Sherwood, J. I. Hudson, D. Yurgelun-Todd, and H. G. Pope Jr. 2005. Psychological and cognitive effects of long-term peyote use among Native Americans. Biological Psychiatry 58 (8):624–31. doi:10.1016/j.biopsych.2005.06.038.
   PubMed Web of Science ®Google Scholar
• Halpern, J. H., A. R. Sherwood, T. Passie, K. C. Blackwell, and A. J. Ruttenber. 2008. Evidence of health and safety in American members of a religion who use a hallucinogenic sacrament. Medical Science Monitor 14 (8):SR15–22.
   PubMed Web of Science ®Google Scholar
• Haubrich, D. R., and P. F. L. Wang. 1977. N,N-dimethyltryptamine lowers rat brain acetylcholine and dopamine. Brain Research 131 (1):158–1. doi:10.1016/0006-8993(77)90036-1.
   PubMed Web of Science ®Google Scholar
• Iurlo, M., M. G. Leone, B. Schilstrom, L. Linnér, G. G. Nomikos, P. Hertel, B. Silvestrini, and T. H. Svensson. 2001. Effects of harmine on dopamine output and metabolism in rat striatum: Role of monoamine oxidase-A inhibition. Psychopharmacology 159 (1):98–104. doi:10.1007/s002130100879.
   PubMed Web of Science ®Google Scholar
• Jenner, P., C. D. Marsden, and C. M. Thanki. 1980. Behavioural changes induced by N,N-dimethyltryptamine in rodents. British Journal of Pharmacology 69 (1):69–80. doi:10.1111/bph.1980.69.issue-1.
   PubMed Web of Science ®Google Scholar
• Johnson, M. W., A. Garcia-Romeu, M. P. Cosimano, and R. R. Griffiths. 2014. Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. Journal of Psychopharmacology 28 (11):983–92. doi:10.1177/0269881114548296.
   PubMed Web of Science ®Google Scholar
• Labate, B. C., R. G. dos Santos, B. Anderson, M. Mercante, and P. C. R. Barbosa. 2010. The treatment and handling of substance dependence with ayahuasca: Reflections on current and future research. In Ayahuasca, ritual and religion, eds. B. C. Labate and E. MacRae. London: Equinox.
   Google Scholar
• Labate, B. C., R. G. dos Santos, R. Strassman, B. T. Anderson, and S. Mizumoto. 2014. Effect of Santo Daime membership on substance dependence. In The therapeutic use of Ayahuasca, eds. B. C. Labate and C. Cavnar. Berlin: Springer.
   Google Scholar
• Labate, B. C., I. S. Rose, and R. G. dos Santos. 2009. Ayahuasca religions: A comprehensive bibliography and critical essays. Santa Cruz, CA: Multidisciplinary Association for Psychedelic Studies.
   Google Scholar
• Loizaga-Velder, A., and R. Verres. 2014. Therapeutic effects of ritual ayahuasca use in the treatment of substance dependence: Qualitative results. Journal of Psychoactive Drugs 46 (1):63–72. doi:10.1080/02791072.2013.873157.
   PubMed Web of Science ®Google Scholar
• Luna, L. E. 2011. Indigenous and mestizo use of ayahuasca: An overview. In The ethnopharmacology of ayahuasca, ed. R. G. dos Santos. Trivandrum, India: Transworld Research Network.
   Google Scholar
• Mabit, J. 2002. Blending traditions: Using indigenous medicinal knowledge to treat drug addiction. Bulletin of the Multidisciplinary Association of Psychedelic Studies 12 (2):25–32. http://maps.org/newsletters/v12n2/12225mab.pdf ( accessed January 10, 2015).
   Google Scholar
• Mehta, H., K. S. Saravanan, and K. P. Mohanakumar. 2003. Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice. Behavioural Brain Research 145 (1–2):31–36. doi:10.1016/S0166-4328(03)00094-9.
   PubMed Web of Science ®Google Scholar
• Miranda, C. T., E. Labigalini Jr., and C. Tacla. 1995. Alternative religion and outcome of alcohol dependence in Brazil. Addiction 90 (6):847. doi:10.1111/add.1995.90.issue-6.
   PubMed Web of Science ®Google Scholar
• Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman. 2010. The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. International Journal of Surgery 8 (5):336–41. doi:10.1016/j.ijsu.2010.02.007.
   PubMed Web of Science ®Google Scholar
• Nutt, D. J., A. Lingford-Hughes, D. Erritzoe, and P. R. A. Stokes. 2015. The dopamine theory of addiction: 40 years of highs and lows. Nature Reviews Neuroscience 16 (5):305–12. doi:10.1038/nrn3939.
   PubMed Web of Science ®Google Scholar
• Oliveira-Lima, A. J., R. Santos, A. W. Hollais, C. A. Gerardi-Junior, M. A. Baldaia, R. Wuo- Silva, T. S. Yokoyama, J. L. Costa, E. L. Malpezzi-Marinho, P. C. R. Barbosa, L. F. Berro, R. Frussa-Filho, and E. A. Marinho. 2015. Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice. Physiology & Behavior 142:28–36. doi:10.1016/j.physbeh.2015.01.032.
   PubMed Web of Science ®Google Scholar
• Osório, F. L., R. F. Sanches, L. R. Macedo, R. G. dos Santos, J. P. Maia-de-Oliveira, L. Wichert-Ana, D. B. de Araujo, J. Riba, J. A. Crippa, and J. E. Hallak. 2015. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: A preliminary report. Revista Brasileira de Psiquiatria 37 (1):13–20. doi:10.1590/1516-4446-2014-1496.
   PubMed Web of Science ®Google Scholar
• Owaisat, S., R. B. Raffa, and S. M. Rawls. 2012. In vivo comparison of harmine efficacy against psychostimulants: Preferential inhibition of the cocaine response through a glutamatergic mechanism. Neuroscience Letters 525 (1):12–16. doi:10.1016/j.neulet.2012.07.052.
   PubMed Web of Science ®Google Scholar
• Palhano-Fontes, F., K. C. Andrade, L. F. Tofoli, A. C. Santos, J. A. Crippa, J. E. Hallak, S. Ribeiro, and D. B. de Araujo. 2015. The psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network. PLoS One 10 (2):e0118143. doi:10.1371/journal.pone.0118143.
   PubMed Web of Science ®Google Scholar
• Panzini, R. G., N. S. da Rocha, D. R. Bandeira, and M. P. A. Fleck. 2007. Quality of life and spirituality. Revista de Psiquiatria Clínica 34 (supl 1):105–15. doi:10.1590/S0101-60832007000700014.
   Google Scholar
• Pimpinella, G., and M. Palmery. 1995. Interaction of β-carbolines with central dopaminergic transmission in mice: Structure-activity relationships. Neuroscience Letters 189 (2):121–24. doi:10.1016/0304-3940(95)11469-D.
   PubMed Web of Science ®Google Scholar
• Riba, J. 2003. Human pharmacology of ayahuasca. Doctoral thesis, Universitat Autònoma de Barcelona, Barcelona, Spain. http://www.tdx.cesca.es/TDX-0701104-165104/ ( accessed January 10, 2016).
   Google Scholar
• Riba, J., H. E. McIlhenny, J. C. Bouso, and S. A. Barker. 2015. Metabolism and urinary disposition of N,N-dimethyltryptamine after oral and smoked administration: A comparative study. Drug Testing and Analysis 7 (5):401–06. doi:10.1002/dta.1685.
   PubMed Web of Science ®Google Scholar
• Riba, J., A. Rodríguez-Fornells, G. Urbano, A. Morte, R. Antonijoan, M. Montero, J. C. Callaway, and M. J. Barbanoj. 2001. Subjective effects and tolerability of the South American psychoactive beverage ayahuasca in healthy volunteers. Psychopharmacology 154 (1):85–95. doi:10.1007/s002130000606.
   PubMed Web of Science ®Google Scholar
• Riba, J., S. Romero, E. Grasa, E. Mena, I. Carrió, and M. J. Barbanoj. 2006. Increased frontal and paralimbic activation following ayahuasca, the pan-Amazonian inebriant. Psychopharmacology 186 (1):93–98. doi:10.1007/s00213-006-0358-7.
   PubMed Web of Science ®Google Scholar
• Riba, J., M. Valle, G. Urbano, M. Yritia, A. Morte, and M. J. Barbanoj. 2003. Human pharmacology of ayahuasca: Subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics 306 (1):73–83. doi:10.1124/jpet.103.049882.
   PubMed Web of Science ®Google Scholar
• Riba, J., M. Valle, G. Urbano, M. Yritia, A. Morte, and M. J. Barbanoj. 2004. Effects of the South American psychoactive beverage ayahuasca on regional brain electrical activity in humans: A functional neuroimaging study using low-resolution electromagnetic tomography. Neuropsychobiology 50 (1):89–101. doi:10.1159/000077946.
   PubMed Web of Science ®Google Scholar
• Sanches, R. F., F. L. Osório, R. G. dos Santos, L. R. H. Macedo, J. P. Maia-de-Oliveira, L. Wichert-Ana, D. B. de Araujo, J. Riba, J. A. S. Crippa, and J. E. C. Hallak. 2016. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: A SPECT study. Journal of Clinical Psychopharmacology 36 (1):77–81. doi:10.1097/JCP.0000000000000436.
   PubMed Web of Science ®Google Scholar
• Schenberg, E. E., J. F. Alexandre, R. Filev, A. M. Cravo, J. R. Sato, S. D. Muthukumaraswamy, M. Yonamine, M. Waguespack, I. Lomnicka, S. A. Barker, and D. X. da Silveira. 2015. Acute biphasic effects of ayahuasca. PLoS One 10 (9):e0137202. doi:10.1371/journal.pone.0137202.
   PubMed Web of Science ®Google Scholar
• Schultes, R. E. 1986. El desarrollo histórico de la identificación de las malpigiáceas empleadas como alucinógenos [The historical development of the identification of malpighiaceous used as hallucinogens]. América Indígena 46 (1):9–47.
   PubMedGoogle Scholar
• Schultes, R. E., and A. Hofmann. 1992. Plants of the gods: Their sacred, healing, and hallucinogenic powers. Rochester, NY: Healing Arts Press.
   Google Scholar
• Schwarz, M. J., P. J. Houghton, S. Rose, P. Jenner, and A. D. Lees. 2003. Activities of extract and constituents of Banisteriopsis caapi relevant to Parkinsonism. Pharmacology, Biochemistry & Behavior 75 (3):627–33. doi:10.1016/S0091-3057(03)00129-1.
   PubMed Web of Science ®Google Scholar
• Thomas, G., P. Lucas, N. R. Capler, K. W. Tupper, and G. Martin. 2013. Ayahuasca-assisted therapy for addiction: Results from a preliminary observational study in Canada. Current Drug Abuse Reviews 6 (1):30–42. doi:10.2174/15733998113099990003.
   PubMedGoogle Scholar
• Vollenweider, F. X., P. Vontobel, D. Hell, and K. L. Leenders. 1999. 5-HT Modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man: A PET study with [11C]raclopride. Neuropsychopharmacology 20 (5):424–33. doi:10.1016/S0893-133X(98)00108-0.
   PubMed Web of Science ®Google Scholar
• Waldmeier, P. C., and L. Maitre. 1977. Neurochemical investigations of the interaction of N,N-dimethyltryptamine with dopaminergic system in rat brain. Psychopharmacology 52 (2):137–44. doi:10.1007/BF00439100.
   PubMed Web of Science ®Google Scholar