Perceived Benefits of MDMA-Assisted Psychotherapy beyond Symptom Reduction: Qualitative Follow-Up Study of a Clinical Trial for Individuals with Treatment-Resistant PTSD

References

• Beck, J., and M. Rosenbaum. 1994. The pursuit of ecstasy: The MDMA experience. New York: State University of New York Press.
   Google Scholar
• Belser, A. B., G. Agin-Liebes, T. C. Swift, S. Terrana, N. Devenot, H. L. Friedman, J. Guss, A. Bossis, and S. Ross. 2017. Patient experiences of psilocybin-assisted psychotherapy: An interpretative phenomenological analysis. Journal of Humanistic Psychology 57 (4):354–88. doi:10.1177/0022167817706884.
   Web of Science ®Google Scholar
• Berends, L., and J. Johnston. 2005. Using multiple coders to enhance qualitative analysis: The case of interviews with consumers of drug treatment. Addiction Research & Theory 13:373–81. doi:10.1080/1606635050010223z.
   Web of Science ®Google Scholar
• Biggerstaff, D., and A. R. Thompson. 2008. Interpretative phenomenological analysis (IPA): A qualitative methodology of choice in healthcare research. Qualitative Research in Psychology 5 (3):214–24. doi:10.1080/14780880802314304.
   Google Scholar
• Cohen, J. 1960. Kappa: Coefficient of concordance. Educational and Psychological Measurement 20:37–46. doi:10.1177/001316446002000104.
   Web of Science ®Google Scholar
• Corey, V. R., V. D. Pisano, and J. H. Halpern. 2016. Effects of 3, 4-methylenedioxymethamphetamine on patient utterances in a psychotherapeutic setting. The Journal of Nervous and Mental Disease 204 (7):519–23. doi:10.1097/NMD.0000000000000499.
   PubMed Web of Science ®Google Scholar
• De Vries, H., M. N. Elliott, D. E. Kanouse, and S. S. Teleki. 2008. Using pooled kappa to summarize interrater agreement across many items. Field Methods 20 (3):272–82. doi:10.1177/1525822X08317166.
   Web of Science ®Google Scholar
• Ditton, J., R. Hammersley, and F. Khan. 2002. Ecstasy and the rise of the chemical generation. London: Routledge.
   Google Scholar
• Foa, E. B., T. M. Keane, M. J. Friedman, and J. A. Cohen. 2009. Effective treatments for PTSD, practice guidelines from the international society for traumatic stress studies. 2nd ed. New York, NY: Guilford Press.
   Google Scholar
• Gasser, P., K. Kirchner, and T. Passie. 2015. LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects. Journal of Psychopharmacology 29 (1):57–68. doi:10.1177/0269881114555249.
   PubMed Web of Science ®Google Scholar
• Hamner, M. B., S. Robert, and B. C. Frueh. 2004. Treatment-resistant posttraumatic stress disorder: Strategies for intervention. CNS Spectrums 9 (10):740–52. doi:10.1017/S1092852900022380.
   PubMed Web of Science ®Google Scholar
• Leneghan, S. 2011. The varieties of ecstasy experience: An exploration of person, mind and body in Sydney’s club culture. Saarbrucken, Germany: Lap Lambert Academic Publishing.
   Google Scholar
• Merrick, E. 1999. An exploration of quality in qualitative research: Are ‘reliability’ and ‘validity’ relevant? In Using qualitative methods in psychology, ed. M. Koppala and L. A. Suzuki, 25–36. Thousand Oaks: Sage.
   Google Scholar
• Mithoefer, M. C. 2017. A Manual for MDMA-assisted psychotherapy in the treatment of posttraumatic stress disorder; Version 8.1. Available at https://s3-us-west-1.amazonaws.com/mapscontent/research-archive/mdma/TreatmentMaual_MDMAAssistedPsychotherapyVersion+8.1_22+Aug2017.pdf.
   Google Scholar
• Mithoefer, M. C., A. T. Mithoefer, A. A. Feduccia, L. Jerome, M. Wagner, J. Wymer, J. Holland, S. Hamilton, B. B. Yazar-Klosinski, A. Emerson, et al. 2018. 3, 4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: A randomised, double-blind, dose-response, phase 2 clinical trial. The Lancet Psychiatry 5 (6):486–97. doi:10.1016/S2215-0366(18)30135-4.
   PubMed Web of Science ®Google Scholar
• Mithoefer, M. C., C. S. Grob, and T. D. Brewerton. 2016. Novel psychopharmacological therapies for psychiatric disorders: Psilocybin and MDMA. Lancet Psychiatry 3 (5):481–88. doi:10.1016/S2215-0366(15)00576-3.
   PubMed Web of Science ®Google Scholar
• Mithoefer, M. C., M. T. Wagner, A. T. Mithoefer, L. Jerome, and R. Doblin. 2011. The safety and efficacy of 3, 4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: The first randomized controlled pilot study. Journal of Psychopharmacology 25 (4):439–52. doi:10.1177/0269881110378371.
   PubMed Web of Science ®Google Scholar
• Mithoefer, M. C., M. T. Wagner, A. T. Mithoefer, L. Jerome, S. F. Martin, B. B. Yazar-Klosinski, Y. Michel, T. D. Brewerton, and R. Doblin. 2013. Durability of improvement in posttraumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4 methylenedioxymethamphetamine-assisted psychotherapy: A prospective long-term follow-up study. Journal of Psychopharmacology 27 (1):28–39. doi:10.1177/0269881112456611.
   PubMed Web of Science ®Google Scholar
• Muhr, T. 2014. ATLAS.ti (Version 8.2.4). Berlin, Germany: Scientific software development.
   Google Scholar
• Multidisciplinary association for psychedelic studies. 2013. In Protocol: A randomized, triple- blind, phase-2 pilot study comparing 3 different doses of MDMA in conjunction with manualized psychotherapy in 24 veterans, firefighters, and police officers with chronic, treatment-resistant posttraumatic stress disorder (PTSD), 5th ed. Santa Cruz, CA: MAPS. Available at https://s3-us-west-1.amazonaws.com/mapscontent/research-archive/published/MP-8_FINAL_Protocol_Amendment+5_16Aug13_REDACTED.pdf.
   Google Scholar
• Najt, P., P. Fusar-Poli, and P. Brambilla. 2011. Co-occurring mental and substance abuse disorders: A review on the potential predictors and clinical outcomes. Psychiatry Research 186 (2–3):159–64. doi:10.1016/j.psychres.2010.07.042.
   PubMed Web of Science ®Google Scholar
• Noorani, T., A. Garcia-Romeu, T. C. Swift, R. R. Griffiths, and M. W. Johnson. 2018. Psychedelic therapy for smoking cessation: Qualitative analysis of participant accounts. Journal of Psychopharmacology 32 (7):756–69. doi:10.1177/0269881118780612.
   PubMed Web of Science ®Google Scholar
• Norman, S. B., S., . R. Tate, K. C. Wilkins, K. Cummins, and S. A. Brown. 2010. Posttraumatic stress disorder’s role in integrated substance dependence and depression treatment outcomes. Journal of Substance Abuse Treatment 38 (4):346–55. doi:10.1016/j.jsat.2010.01.013.
   PubMed Web of Science ®Google Scholar
• Oehen, P., R. Traber, V. Widmer, and U. Schnyder. 2013. A randomized, controlled pilot study of MDMA (±3,4-methylenedioxymethamphetamine)- assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD). Journal of Psychopharmacology 27 (1):40–52. doi:10.1177/0269881112464827.
   PubMed Web of Science ®Google Scholar
• Ot’alora, G., M., . J. Grigsby, B. Poulter, J. W. Van Derveer, S. G. Iii, G. L. Jerome, A. A. Feduccia, S. Hamilton, B. B. Yazar-Klosinski, A. Emerson, et al. 2018. 3, 4-methylenedioxymethamphetamine-assisted psychotherapy for treatment of chronic posttraumatic stress disorder: A randomized phase 2 controlled trial. Journal of Psychopharmacology 0269881118806297. doi:10.1177/0269881118806297.
   Web of Science ®Google Scholar
• Passie, T. 2012. Healing with entactogens: Therapist and patient perspectives on MDMA-assisted group psychotherapy. Santa Cruz, CA: Multidisciplinary Association for Psychedelic Studies (MAPS).
   Google Scholar
• Perrone, D. 2010. The high life: Club kids, harm and drug policy. Boulder, CO: Lynne Rienner Publishers.
   Google Scholar
• Pietkiewicz, I., and J. A. Smith. 2014. A practical guide to using interpretative phenomenological analysis in qualitative research psychology. Psychological Journal 20 (1):7–14. doi:10.14691/CPPJ.20.1.7.
   Google Scholar
• Sareen, J., B. J. Cox, M. B. Stein, T. O. Afifi, C. Fleet, and G. J. Asmundson. 2007. Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample. Psychosomatic Medicine 69 (3):242–48. doi:10.1097/PSY.0b013e31803146d8.
   PubMed Web of Science ®Google Scholar
• Smith, J. A. 2004. Reflecting on the development of interpretative phenomenological analysis and its contribution to qualitative research in psychology. Qualitative Research in Psychology 1:39–54. doi:10.1191/1478088704qp004oa.
   Web of Science ®Google Scholar
• Sola, E. 2017. MDMA-assisted Psychotherapy for PTSD: A thematic analysis of transformation in combat veterans. PhD diss., California Institute of Integral Studies.
   Google Scholar
• Stein, D. J., J. C. Ipser, S. Seedat, C. Sager, and T. Amos. 2006. Pharmacotherapy for posttraumatic stress disorder (PTSD). Cochrane Database of Systematic Reviews 1. doi:10.1002/14651858.CD002795.pub2.
   Web of Science ®Google Scholar
• Swift, T. C., A. B. Belser, G. Agin-Liebes, N. Devenot, S. Terrana, H. L. Friedman, J. Guss, A. P. Bossis, and S. Ross. 2017. Cancer at the dinner table: Experiences of psilocybin-assisted psychotherapy for the treatment of cancer-related distress. Journal of Humanistic Psychology 57 (5):488–519. doi:10.1177/0022167817706884.
   Web of Science ®Google Scholar
• Watts, R., C. Day, J. Krzanowski, D. Nutt, and R. Carhart-Harris. 2017. Patients’ accounts of increased “Connectedness” and “Acceptance” After psilocybin for treatment-resistant depression. Journal of Humanistic Psychology 57 (5):520–64. doi:10.1177/0022167817709585.
   Web of Science ®Google Scholar
• Weathers, F., T. Keane, and J. R. Davidson. 2001. Clinician-administered PTSD scale: A review of the first ten years of research. Depression and Anxiety 13:132–56. doi:10.1002/da.1029.
   PubMed Web of Science ®Google Scholar
• Willig, C. 2008. Introducing qualitative research in psychology. 2nd ed. Maidenhead, England: Open University Press.
   Google Scholar