Persistent Tinnitus after Inhaled N,N-dimethyltryptamine (DMT)

References

• Anderson, T., R. Petranker, A. Christopher, D. Rosenbaum, C. Weissman, L. A. Dinh-Williams, K. Hui, and E. Hapke. 2019. Psychedelic microdosing benefits and challenges: An empirical codebook. Harm Reduction Journal 16 (1):43. doi:10.1186/s12954-019-0308-4.
   PubMedGoogle Scholar
• Baguley, D., D. McFerran, and D. Hall. 2013. Tinnitus. The Lancet 382 (9904):1600–07. doi:10.1016/S0140-6736(13)60142-7.
   PubMed Web of Science ®Google Scholar
• Baldo, P., C. Doree, P. Molin, D. McFerran, and S. Cecco. 2012. Antidepressants for patients with tinnitus. Cochrane Database System Review (9):Cd003853.
   Google Scholar
• Cameron, L. P., A. Nazarian, and D. E. Olson. 2020. Psychedelic microdosing: Prevalence and subjective effects. Journal of Psychoactive Drugs 52(2):113-122..
   PubMed Web of Science ®Google Scholar
• Caperton, K. K., and A. M. Thompson. 2011. Activation of serotonergic neurons during salicylate-induced tinnitus. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology 32 (2):301–07. doi:10.1097/MAO.0b013e3182009d46.
   PubMed Web of Science ®Google Scholar
• Carbonaro, T. M., and M. B. Gatch. 2016. Neuropharmacology of N,N-dimethyltryptamine. Brain Research Bulletin 126 (Pt 1):74–88. doi:10.1016/j.brainresbull.2016.04.016.
   PubMed Web of Science ®Google Scholar
• Carhart-Harris, R. L., and G. M. Goodwin. 2017. The therapeutic potential of psychedelic drugs: Past, present, and future. Neuropsychopharmacology 42 (11):2105–13.
   PubMed Web of Science ®Google Scholar
• Clewes, J. 2012. A case report of onset of tinnitus following discontinuation of antidepressant and a review of the literature. The Primary Care Companion for CNS Disorders 14 (1):PCC.11br01218.
   PubMedGoogle Scholar
• Doherty, M. J. 2009. Algorithms for assessing the probability of an adverse drug reaction. Respiratory Medicine CME 2 (2):63–67. doi:10.1016/j.rmedc.2009.01.004.
   Google Scholar
• Dos Santos, R. G., J. C. Bouso, and J. E. C. Hallak. 2017. Ayahuasca, dimethyltryptamine, and psychosis: A systematic review of human studies. Therapeutic Advances in Psychopharmacology 7 (4):141–57. doi:10.1177/2045125316689030.
   PubMed Web of Science ®Google Scholar
• Eggermont, J. J. 2008. Role of auditory cortex in noise- and drug-induced tinnitus. American Journal of Audiology 17 (2):S162–169. doi:10.1044/1059-0889(2008/07-0025).
   PubMed Web of Science ®Google Scholar
• Entranced. (2017). “DMT is giving me tinnitus.” DMT Nexus.
   Google Scholar
• Fadiman, J., and S. Korb. 2019. Might microdosing psychedelics be safe and beneficial? An initial exploration. Journal of Psychoactive Drugs 51 (2):118–22. doi:10.1080/02791072.2019.1593561.
   PubMed Web of Science ®Google Scholar
• Felix, R. A., 2nd, B. Gourevitch, and C. V. Portfors. 2018. Subcortical pathways: Towards a better understanding of auditory disorders. Hearing Research 362:48–60. doi:10.1016/j.heares.2018.01.008.
   PubMed Web of Science ®Google Scholar
• Figueiredo, R. R., A. A. Azevedo, and N. D. O. Penido. 2016. Positive association between Tinnitus and arterial hypertension. Frontiers in Neurology 7:171–171. doi:10.3389/fneur.2016.00171.
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration (FDA). (2020). FDA requests the withdrawal of the weight-loss drug Belviq, Belviq XR (lorcaserin) from the market.
   Google Scholar
• Fuentes, J. J., F. Fonseca, M. Elices, M. Farré, and M. Torrens. 2020. Therapeutic use of LSD in psychiatry: A systematic review of randomized-controlled clinical trials 10(943).
   Google Scholar
• Haider, H. F., T. Bojić, S. F. Ribeiro, J. Paço, D. A. Hall, and A. J. Szczepek. 2018. Pathophysiology of subjective Tinnitus: Triggers and maintenance 12(866).
   Google Scholar
• Halpern, J. H., A. G. Lerner, and T. Passie. 2018. A review of hallucinogen persisting perception disorder (HPPD) and an exploratory study of subjects claiming symptoms of HPPD. Current Topics in Behavioral Neurosciences 36:333–60.
   PubMedGoogle Scholar
• Hutcheson, J. D., V. Setola, B. L. Roth, and W. D. Merryman. 2011. Serotonin receptors and heart valve disease–it was meant 2B. Pharmacology & Therapeutics 132 (2):146–57. doi:10.1016/j.pharmthera.2011.03.008.
   PubMed Web of Science ®Google Scholar
• Hutten, N., N. L. Mason, P. C. Dolder, and K. P. C. Kuypers. 2019. Motives and side-effects of microdosing with psychedelics among users. The International Journal Of Neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 22 (7):426–34. doi:10.1093/ijnp/pyz029.
   PubMed Web of Science ®Google Scholar
• Joedirt. (2011). “Tinnitus/Ear Ringing.” DMT Nexus.
   Google Scholar
• Krebs, T. S., and P.-Ø. Johansen. 2013a. Over 30 million psychedelic users in the United States”. F1000Researchart 2:98–98.doi: 10.12688/f1000research.2-98.v1
   Google Scholar
• Krebs, T. S., P. O. Johansen, and L. Lu. 2013b. Psychedelics and mental health: A population study. PLoS One 8 (8):e63972. doi:10.1371/journal.pone.0063972
   PubMed Web of Science ®Google Scholar
• Kuypers, K. P., L. Ng, D. Erritzoe, G. M. Knudsen, C. D. Nichols, D. E. Nichols, L. Pani, A. Soula, and D. Nutt. 2019. Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. Journal of Psychopharmacology 33 (9):1039-1057. (Oxford, England) 269881119857204.
   Google Scholar
• Liechti, M. E. 2017. Modern Clinical Research on LSD. Neuropsychopharmacology 42 (11):2114–27. doi:10.1038/npp.2017.86.
   PubMed Web of Science ®Google Scholar
• Luo, B., L. Hu, C. Liu, Y. Guo, and H. Wang. 2016. Activation of 5-HT2A/C receptor reduces glycine receptor-mediated currents in cultured auditory cortical neurons. Amino Acids 48 (2):349–56. doi:10.1007/s00726-015-2086-y.
   PubMed Web of Science ®Google Scholar
• Malcolm, B. J., and K. C. Lee. 2017. Ayahuasca: An ancient sacrament for treatment of contemporary psychiatric illness? Mental Health Clinician 7 (1):39–45. doi:10.9740/mhc.2017.01.039.
   PubMedGoogle Scholar
• Meikle, M. B., J. A. Henry, S. E. Griest, B. J. Stewart, H. B. Abrams, R. McArdle, P. J. Myers, C. W. Newman, S. Sandridge, D. C. Turk, et al. 2012. The tinnitus functional index: Development of a new clinical measure for chronic, intrusive tinnitus. Ear and Hearing 33 (2):153–76.
   PubMed Web of Science ®Google Scholar
• Mithoefer, M. C., A. A. Feduccia, L. Jerome, A. Mithoefer, M. Wagner, Z. Walsh, S. Hamilton, B. Yazar-Klosinski, A. Emerson, and R. Doblin. 2019. MDMA-assisted psychotherapy for treatment of PTSD: Study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials. Psychopharmacology 236:2735–45. doi:10.1007/s00213-019-05249-5.
   PubMed Web of Science ®Google Scholar
• Nichols, D. E. 2016. Psychedelics. Pharmacological Reviews 68 (2):264–355.
   PubMed Web of Science ®Google Scholar
• Parrott, A. C. 2012. MDMA and 5-HT neurotoxicity: The empirical evidence for its adverse effects in humans - no need for translation. British Journal of Pharmacology discussion 1521-1512. 166 (5):1518–20. doi:10.1111/j.1476-5381.2012.01941.x.
   PubMed Web of Science ®Google Scholar
• Polito, V., R. J. Stevenson, and D. Arnone. 2019. A systematic study of microdosing psychedelics. PLoS One 14 (2):e0211023. doi:10.1371/journal.pone.0211023.
   PubMed Web of Science ®Google Scholar
• Reddit. (2017). “DMT does actually gives you permanent Tinnitus (ear ringing)?” Accessed July 15th, 2020. https://www.reddit.com/r/DMT/comments/5zjlgp/dmt_does_actually_gives_you_permanent_tinnitus/.
   Google Scholar
• Reddit. (2019). “Deaf friend with Tinnitus will be trying DMT next month. His Tinnitus gets worse during LSD and shroom trips and he can feel sound at the base of his skull. Has anyone found Tinnitus to be unbearable on DMT?” Accessed https://www.reddit.com/search/?q=dmt%20and%20tinnitus
   Google Scholar
• Salling, M. C., and N. L. Harrison. 2014. Strychnine-sensitive glycine receptors on pyramidal neurons in layers II/III of the mouse prefrontal cortex are tonically activated. Journal of Neurophysiology 112 (5):1169–78. doi:10.1152/jn.00714.2013.
   PubMed Web of Science ®Google Scholar
• Seligmann, H., L. Podoshin, J. Ben-David, M. Fradis, and M. Goldsher. 1996. Drug-induced tinnitus and other hearing disorders. Drug Safety : An International Journal of Medical Toxicology and Drug Experience 14 (3):198–212. doi:10.2165/00002018-199614030-00006.
   PubMed Web of Science ®Google Scholar
• Sessa, B. 2015. Turn on and tune in to evidence-based psychedelic research. Lancet Psychiatry 2 (1):10–12. doi:10.1016/S2215-0366(14)00120-5.
   PubMed Web of Science ®Google Scholar
• Shargorodsky, J., G. C. Curhan, and W. R. Farwell. 2010. Prevalence and characteristics of Tinnitus among US Adults. The American Journal of Medicine 123 (8):711–18. doi:10.1016/j.amjmed.2010.02.015.
   PubMed Web of Science ®Google Scholar
• Strassman, R. J., C. R. Qualls, E. H. Uhlenhuth, and R. Kellner. 1994. Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale. Archives of General Psychiatry 51 (2):98–108.
   PubMed Web of Science ®Google Scholar
• Tang, Z. Q., and L. O. Trussell. 2015. Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 35 (11):4540–51. doi:10.1523/JNEUROSCI.4825-14.2015.
   PubMed Web of Science ®Google Scholar
• Thomas, K., B. Malcolm, and D. Lastra. 2017. Psilocybin-assisted therapy: A review of a novel treatment for psychiatric disorders. Journal of Psychoactive Drugs 49 (5):1–10.
   PubMed Web of Science ®Google Scholar
• Winne, J., B. C. Boerner, T. Malfatti, E. Brisa, J. Doerl, I. Nogueira, K. E. Leao, and R. N. Leao. 2020. Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT. Experimental Neurology 326:113175. doi:10.1016/j.expneurol.2020.113175.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., Q. Song, X. Li, and C. Li. 2016. Neural hyperactivity of the central auditory system in response to peripheral damage. Neural Plasticity 2016:2162105. doi:10.1155/2016/2162105.
   PubMed Web of Science ®Google Scholar