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Original Article

Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration

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Pages 690-699 | Accepted 06 Dec 1996, Published online: 04 Jan 2010

References

  • Borg D. C., Cotzias G. C. Manganese metabolism in man. Rapid exchange of 56Mn with tissue as demonstrated by blood clearance and liver uptake. J. Clin. Invest. 1958; 37: 1269
  • Brurok H., Schojtt J., Berg K., Karlsson J. O., Jynge P. Effects of manganese dipyridoxyl diphosphate, dipyridoxyl diphosphate-, and manganese chloride on cardiac function. An experimental study in the Langendorff perfused rat heart. Invest. Radiol. 1995; 30: 159
  • Davidsson L., Cederblad A., Lönnerdal B., Sandström B. Manganese retention in man. A method for estimating manganese absorption in man. Am. J. Clin. Nutr. 1989; 49: 170
  • Dinoto D. R., Kennedy C. D., Johnson J. A., et al. Pharma-cokinetics and biotransformation of the MRI liver contrast agent mangafodipir trisodium injection in normal human male volunteers. 4th Int. 1 ISSX Meeting, Seattle, Washington, 1995; 8: 323
  • Gallez B., Bacic G., Swartz H. M. Evidence for the dissociation of the hepatobiliary MRI contrast agent Mn-DPDP. Magn. Reson. Imaging 1996; 35: 14
  • Gerdin B., McCann E., Lundberg C., Arfors K. E. Selective tissue accumulation of manganese and its effect on regional blood flow and haemodynamics after intravenous infusion of its chloride salt in the rat. Int. J. Tissue React. 1985; 7: 373
  • Gibbons R. A., Dixon S. N., Hallis K., Russell A. M., Sansom B. F., Symonds H. W. Manganese metabolism in cows and goats. Biochim. Biophys. Acta 1976; 444: 1
  • Grant D., Blazak W. F., Brown G. L. The reproductive toxicology of intravenously administered MnDPDP in the rat and rabbit. Acta Radiol. 1997; 38: 759
  • Grant D., Toft K. G., Martinsen I., Atzpodien E. Tissue distribution and general safety of MnDPDP in male beagle dogs, with or without total common bile duct obstruction. Acta Radiol. 1997; 38: 732
  • Grant D., Zech K., Holtz E. Biodistribution and in vivo stability of manganese dipyridoxyl diphosphate in relation to imaging efficacy. Invest. Radiol. 1994; 29: S249
  • Hamm B., Vogl T. J., Branding G., et al. Focal liver lesions. MR imaging with Mn-DPDP — Initial clinical results in 40 patients. Radiology 1992; 182: 167
  • Jynge P., Brurok H., Asplund A., Towart R., Refsum H., Karlsson J. O. G. Cardiovascular safety of MnDPDP and MnCl2. Acta Radiol. 1997; 38: 740
  • Larsen L. E., Grant D. General toxicology of MnDPDP. Acta Radiol. 1997; 38: 770
  • Leach R. M., Lilburn M. S. Manganese metabolism and its function. World Rev. Nutr. Diet. 1978; 32: 123
  • Malecki E. A., Radzanowski G. M., Radzanowski T. J., Gallaher D. D., Greger J. L. Biliary manganese excretion in conscious rats is affected by acute and chronic manganese intake but not by dietary fat. J. Nutr. 1996; 126: 489
  • McLachlan S. J., Eaton S., Desimone D. N. Pharmacok-inetic behaviour of gadoteridol injection. Invest. Radiol. 1992; 27: 12
  • Ni Y., Marchal G. Clinical implications of studies with MnDPDP in animal models of hepatic abnormalities. Acta Radiol. 1997; 38: 724
  • Ni Y., Petre C., Bosmans H., et al. Comparison of manganese biodistribution and MR contrast enhancement in rats after intravenous injection of MnDPDP and MnCl2. Acta Radiol. 1997; 38: 700
  • Onoda K., Hasegawa A., Sunouchi M., et al. Studies on the fate of poisonous metals in experimental animal (VII). Distribution and transplacental passage of manganese in pregnant rat and fetus. J. Food Hyg. Soc. 1978; 19: 208
  • Rofsky N. M., Weinreb J. C., Bernardino M. E., Young S. W., Lee J. K., Noz M. E. Hepatocellular tumors. Characterization with Mn-DPDP-enhanced MR imaging. Radiology 1993; 188: 53
  • Rowland M., Tozer T. N. Clinical pharmacokinetics. Concepts and applications, 2nd edn. Lea & Febiger, Philadelphia 1989
  • Rummeny E., Ehrenheim C., Gehl H. B., et al. Manganese-DPDP as a hepatobiliary contrast agent in the magnetic resonance imaging of liver tumors. Results of clinical phase II trials in Germany including 141 patients. Invest. Radiol. 1991; 26(Suppl. 1)S142
  • Rummeny E. J., Torres C. G., Kurdziel J. C., Nilsen G., Op De Beeck B., Lundby B. MnDPDP for MR imaging of the liver. Results of an independent image evaluation of the European phase III studies. Acta Radiol. 1997; 38: 638
  • Sherwin P. F., Hugo F. P., Robison R. O., et al. Safety, tolerance, and pharmacokinetics of high doses of gadodiamide injection, a nonionic magnetic resonance contrast agent. Acad. Radiol. 1994; 1: S2
  • Southon T. E., Grant D., Bjørnerud A., et al. NMR relaxation studies with MnDPDP. Acta Radiol. 1997; 38: 708
  • Tirkkonen B., Aukrust A., Couture E., et al. Physico-chemical characterisation of mangafodipir trisodium. Acta Radiol. 1997; 38: 780
  • Toft K. G., Hustvedt S. O., Grant D., Friisk G. A., Skotland T. Metabolism of mangafodipir trisodium (MnDPDP), a new contrast medium for magnetic resonance imaging, in beagle dogs. Eur. J. Drug Metab. Pharm. 1997; 22: 65
  • Toft K. G., Hustvedt S. O., Grant D., et al. Metabolism and pharmacokinetics of MnDPDP in man. Acta Radiol. 1997; 38: 677
  • Toft K. G., Kindberg G. M., Skotland T. Mangafodipir trisodium injection, a new contrast medium for magnetic resonance imaging. In vitro metabolism and protein binding studies of the active component MnDPDP in human blood. J. Pharmaceut. Biomed. Anal. 1997; 15: 983
  • Torres C. G., Lundby B., Sterud A. Tufte, McGill S., Gordon P. B., Bjerknes H. Strand. MnDPDP for MR imaging of the liver. Results from the European phase III studies. Acta Radiol. 1997; 38: 631
  • Vogl T. J., Hamm B., Schnell B., et al. Mn-DPDP enhancement patterns of hepatocellular lesions on MR images. J. Magn. Reson. Imaging 1993; 3: 51
  • Wang C., Gordon P. B., Hustvedt S. O., et al. MR imaging properties and pharmacokinetics of MnDPDP in healthy volunteers. Acta Radiol. 1997; 38: 665
  • Weinmann H. J., Laniado M., Mutzel W. Pharmacokinetics of Gd-DTPA dimeglumine after intravenous injection into healthy volunteers. Physiol. Chem. Phys. 1984; 16: 167

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