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Acta Oncologica Volume 41, 2002 - Issue 2
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Research Article

Growth Factor-Induced Cell Motility in Tumor Invasion

Alan Wells From the Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, USA (A. Wells, J. Kassis, J. Solava), Department of Pathology, University of Alabama at Birmingham, USA (J. Kassis), Carver Research Institute, Tuskegee University, Tuskegee, AL, USA (T. Turner), Division of Bioengineering & Environmental Health and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (D.A. Lauffenburger)
,
Jareer Kassis From the Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, USA (A. Wells, J. Kassis, J. Solava), Department of Pathology, University of Alabama at Birmingham, USA (J. Kassis), Carver Research Institute, Tuskegee University, Tuskegee, AL, USA (T. Turner), Division of Bioengineering & Environmental Health and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (D.A. Lauffenburger)
,
James Solava From the Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, USA (A. Wells, J. Kassis, J. Solava), Department of Pathology, University of Alabama at Birmingham, USA (J. Kassis), Carver Research Institute, Tuskegee University, Tuskegee, AL, USA (T. Turner), Division of Bioengineering & Environmental Health and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (D.A. Lauffenburger)
,
Timothy Turner From the Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, USA (A. Wells, J. Kassis, J. Solava), Department of Pathology, University of Alabama at Birmingham, USA (J. Kassis), Carver Research Institute, Tuskegee University, Tuskegee, AL, USA (T. Turner), Division of Bioengineering & Environmental Health and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (D.A. Lauffenburger)
&
Douglas A. Lauffenburger From the Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, USA (A. Wells, J. Kassis, J. Solava), Department of Pathology, University of Alabama at Birmingham, USA (J. Kassis), Carver Research Institute, Tuskegee University, Tuskegee, AL, USA (T. Turner), Division of Bioengineering & Environmental Health and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (D.A. Lauffenburger)
Pages 124-130 | Published online: 08 Jul 2009

  • Aaronson SA. Growth factors and cancer. Science 1991; 254: 1146 -53.
  • Wells A. The epidermal growth factor receptor and its ligands. In: Benz S, Lui E, eds. Oncogenes. Boston: Kluwer Academic Publishers, 1989: 143-68.
  • Kim H, Turner T, Kassis J, Souto J, Wells A. EGF receptor signaling in prostate development. Histol Histopathol 1999; 14:1175-11782.
  • DeWitt AE, Dong JY, Wiley HS, Lauffenburger DA. Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture. J Cell Sci 2001;114:2301-13.
  • Wells A. Molecule in focus: EGF receptor. Int J Biochem Cell Biol 1999; 31: 637-43.
  • Glynne-Jones E, Goddard L, Harper ME. Comparative analysis of mRNA and protein expression for epidermal growth factor receptor and ligands relative to the proliferative index in human prostate tissue. Hum Pathol 1996; 27: 688-94.
  • Libermann TA, Razon N, Bartal AD, Yarden Y, Schlessinger J, Soreq H. Expression of epidermal growth factor receptors in human brain tumors. Cancer Res 1984; 44: 753-60.
  • Schlegel J, Merdes A, Stumm G, et al. Ampli? cation of the epidermal growth factor receptor gene correlates with different growth behavior in human glioblastoma. Int J Cancer 1994; 56:72-7.
  • Neal DE, Marsh C, Bennett MK, et al. Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and super? cial tumours. Lancet 1985; i: 366 -8.
  • Rao JY, Hemstreet GP 3rd, Hurst RE, et al. Alterations in phenotypic biochemical markers in bladder epithelium during tumorigenesis. Proceedings of the National Academy of Sciences (USA) 1993; 90: 8287-91.
  • Yasui W, Sumiyoshi H, Hata J, et al. Expression of epidermal growth factor receptor in human gastric and colon carcinomas. Cancer Res 1988; 48: 137-41.
  • Wells A. Tumor invasion: role of growth factor-induced cell motility. Adv Cancer Res 2000; 78: 31 -101.
  • Koshikawa N, Giannelli G, Cirulli V, Miyazaki K, Quaranta V. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. J Cell Biol 2000; 148: 615-24.
  • Jones FS, Jones PL. The tenascin family of ECM glyco-proteins: structure, function and regulation during embryonic development and tissue remodeling. Dev Dyn 2000; 218: 235-59.
  • Mercurio AM, Rabinovitz I. Towards a mechanistic understanding of tumor invasion--lessons from the a6b4 integrin. Semin Cancer Biol 2001; 11: 129-42.
  • Rabinovitz I, Mercurio AM. The integrin a6b4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J Cell Biol 1997; 139: 1873-84.
  • Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE. Geometric control of cell life and death. Science 1997; 276: 1425-8.
  • Maheshwari G, Brown G, Lauffenburger DA, Wells A, Grif? th LG. Cell adhesion and motility depend on nanoscale RGD clustering. J Cell Sci 2000; 113: 1677-86.
  • Stetler-Stevenson WG, Yu A. Proteases in invasion: matrix metalloproteinases. Semin Cancer Biol 2001; 11: 143-52.
  • Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997;89:1260-70.
  • Monsky WL, Kelly T, Lin CY, et al. Binding and localization of Mr 72000 matrix metalloproteinase at cell surface invadopodia. Cancer Res 1993; 53: 3159-64.
  • Nakahara H, Howard L, Thompson EW, et al. Transmem-brane:cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proceedings of the National Academy of Sciences (USA) 1997; 94: 7959-64.
  • Dong J, Opresko LK, Dempsey PJ, Lauffenburger DA, Coffey RJ, Wiley HS. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proceedings of the National Academy of Sciences (USA) 1999; 96: 6235-40.
  • Gianelli G, Falk-Marzillier J, Schiraldi O, Stetlet-Stevenson WG, Quaranta V. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 1997; 277: 225-8.
  • Swindle CS, Tran K, Johnson TD, et al. Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. J Cell Biol 2001; 154: 459-68.
  • Shrivastava A, Radziejewski C, Campbell E, et al. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Molecular Cell 1997; 1: 25-34.
  • Vogel W, Gish GD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1997; 1: 13-23.
  • Iozzo RV, Moscatello DK, McQuillan DJ, Eichstetter I. Decorin is a biological ligand for the epidermal growth factor receptor. J Biol Chem 1999; 274: 4489-92.
  • Lauffenburger DA, Horwitz AF. Cell migration: a physically integrated molecular process. Cell 1996; 84: 359-69.
  • Wells A, Gupta K, Chang P, Swindle S, Glading A, Shiraha H. Epidermal growth factor receptor-mediated motility in ? broblasts. Microsc Res Tech 1998; 43: 395-411.
  • Hall A. Rho GTPases and the actin cytoskeleton. Science 1998; 279: 509 -14.
  • Chen P, Xie H, Sekar MC, Gupta KB, Wells A. Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but MAP kinase activity is not suf? -cient for induced cell movement. J Cell Biol 1994; 127: 847 -57.
  • Kundra V, Escobedo JA, Kazlauskas A, et al. Regulation of chemotaxis by the platelet-derived growth factor receptor-b. Nature 1994; 367: 474-6.
  • Bornfeldt KE, Raines EW, Nakano T, Graves LM, Krebs EG, Ross R. Insulin-like growth factor-1 and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signalling pathways that are distinct from those of proliferation. J Clin Invest 1994; 93: 1266 -74.
  • Carloni V, Romanelli RG, Pinzani M, Laf? G, Gentilini P. Focal adhesion kinase and phospholipase Cg involvement in adhesion and migration of human hepatic stellate cells. Gastroenterology 1997; 112: 522 -31.
  • Chen P, Murphy-Ullrich J, Wells A. A role for gelsolin in actuating EGF receptor-mediated cell motility. J Cell Biol 1996;134:689-98.
  • Wells A, Ware MF, Allen FD, Lauffenburger DA. Shaping up for shipping out: PLCg signaling of morphology changes in EGF-stimulated ? broblast migration. Cell Motil Cy-toskeleton 1999; 44: 227-33.
  • Chen P, Xie H, Wells A. Mitogenic signaling from the EGF receptor is attenuated by a motility-associated phospholipase C-g:protein kinase C feedback mechanism. Mol Biol Cell 1996;7:871-7881.
  • Glading A, Chang P, Lauffenburger DA, Wells A. Epidermal growth factor receptor activation of calpain is required for ? broblast motility and occurs via an ERK:MAP kinase signaling pathway. J Biol Chem 2000; 275: 2390 -8.
  • Shiraha H, Gupta K, Glading A, Wells A. Chemokine transmodulation of EGF receptor signaling: IP-10 inhibits motility by decreasing EGF-induced calpain activity. J Cell Biol 1999; 146: 243-53.
  • Huttenlocher A, Palecek SP, Lu Q, et al. Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem 1997; 272: 32719-22.
  • Xie H, Turner T, Wang M-H, Singh RK, Siegal GP, Wells A. In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals. Clin Exp Metastasis 1995; 13: 407-19.
  • Turner T, Chen P, Goodly LJ, Wells A. EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells. Clin Exp Metastasis 1996; 14: 409-18.
  • Kassis J, Moellinger J, Lo H, Greenberg N, Kim H-G, Wells A. A role for phospholipase C-g-mediated signaling in tumor cell invasion. Clin Cancer Res 1999; 5: 2251-60.
  • Turner T, VanEpps-Fung M, Kassis J, Wells A. Molecular inhibition of PLCg signaling abrogates DU-145 prostate tumor cell invasion. Clin Cancer Res 1997; 3: 2275-82.
  • Khoshyomn S, Penar PL, Rossi J, Wells A, Abramson DL, Bhushan A. Inhibition of PLC gamma-1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates. Neurosurgery 1999; 44: 568 -77.
  • Fidler IJ. The biology of human cancer metastasis. Acta Oncol 1991; 30: 668-75.
  • Radisky D, Hagios C, Bissell MJ. Tumors are unique organs de? ned by abnormal signaling and context. Semin Cancer Biol 2001; 11: 87 -96.
  • Tlsty TD. Stromal cells can contribute oncogenic signals. Semin Cancer Biol 2001; 11: 97-104.
  • Gleave ME, Hsieh JT, vonEschenbach AC, Chung LWK. Prostate and bone ? broblasts induce human prostate cancer growth in vivo: implications for bidirectional tumor-stromal cell interaction in prostate carcinoma growth and metastasis. J Urol 1992; 147: 1151-9.
  • Sharma Y, Agarwal C, Singh AK, Agarwal R. Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells. Mol Carcinog 2001; 30: 224 -36.
  • Bos M, Mendelsohn J, Kim YM, Albanell J, Fry DW, Baselga J. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res 1997; 3: 2099-106.
  • Chambers AF, MacDonald IC, Schmidt EE, Morris VL, Groom AC. Clinical targets for anti-metastasis therapy. Adv Cancer Res 2000; 79: 91-121.
  • Condeelis JS, Wyckoff JB, Bailly M, et al. Lamellipodia in invasion. Semin Cancer Biol 2001; 11: 119-28.
  • Wyckoff JB, Jones JG, Condeelis JS, Segall JE. A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. Cancer Res 2000; 60: 2504 -11.
  • Grif? th LG, Wu B, Cima MJ, Powers MJ, Chaignaud B, Vacanti JP. In vitro organogenesis of liver tissue. Ann NY Acad Sci 1997; 831: 382-97.
  • Kassis J, Lauffenburger DA, Turner T, Wells A. Tumor invasion as dysregulated cell motility. Semin Cancer Biol 2001;11:105-18.

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